{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,3]],"date-time":"2026-09-03T21:24:33Z","timestamp":1788470673659,"version":"build-2803163510"},"reference-count":81,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T00:00:00Z","timestamp":1515628800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D12CA-044"],"award-info":[{"award-number":["D12CA-044"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D12CA-044"],"award-info":[{"award-number":["D12CA-044"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D12CA-044"],"award-info":[{"award-number":["D12CA-044"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001250","name":"Morris Animal Foundation","doi-asserted-by":"publisher","award":["D12CA-044"],"award-info":[{"award-number":["D12CA-044"]}],"id":[{"id":"10.13039\/100001250","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["01986"],"award-info":[{"award-number":["01986"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["01986"],"award-info":[{"award-number":["01986"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["01986"],"award-info":[{"award-number":["01986"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100001458","name":"American Kennel Club Canine Health Foundation","doi-asserted-by":"publisher","award":["01986"],"award-info":[{"award-number":["01986"]}],"id":[{"id":"10.13039\/100001458","id-type":"DOI","asserted-by":"publisher"}]},{"name":"American Shetland Sheepdog Association"},{"name":"Collie Health Foundation"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0191076","type":"journal-article","created":{"date-parts":[[2018,1,11]],"date-time":"2018-01-11T15:03:17Z","timestamp":1515682997000},"page":"e0191076","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":34,"title":["Qualitative metabolomics profiling of serum and bile from dogs with gallbladder mucocele formation"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2911-0874","authenticated-orcid":true,"given":"Jody L.","family":"Gookin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kyle G.","family":"Mathews","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John","family":"Cullen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Seiler","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,11]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1002\/cphy.c120019","article-title":"Physiology of cholangiocytes","volume":"3","author":"JH Tabibian","year":"2013","journal-title":"Comprehensive Physiology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1498","DOI":"10.1002\/hep.510300619","article-title":"Phase I and phase II drug-metabolizing enzymes are expressed and heterogeneously distributed in the biliary epithelium","volume":"30","author":"F Lakehal","year":"1999","journal-title":"Hepatology"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"467","DOI":"10.5326\/15473317-31-6-467","article-title":"Gallbladder mucocele causing biliary obstruction in two dogs: ultrasonographic, scintigraphic, and pathological findings","volume":"31","author":"SM Newell","year":"1995","journal-title":"J Am Anim Hosp Assoc"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"574","DOI":"10.1177\/030098586500200605","article-title":"Cystic mucinous hypertrophy of the mucosa of the gall bladder in the dog","volume":"2","author":"RM Kovatch","year":"1965","journal-title":"Pathologia veterinaria"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"79","DOI":"10.2460\/javma.231.1.79","article-title":"Gallbladder disease in Shetland Sheepdogs: 38 cases (1995\u20132005)","volume":"231","author":"AL Aguirre","year":"2007","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"6","key":"ref6","doi-asserted-by":"crossref","first-page":"644","DOI":"10.1111\/j.1532-950X.2004.04087.x","article-title":"Variables associated with outcome in dogs undergoing extrahepatic biliary surgery: 60 cases (1988\u20132002)","volume":"33","author":"SJ Mehler","year":"2004","journal-title":"Vet Surg"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1615","DOI":"10.2460\/javma.2004.224.1615","article-title":"Gallbladder mucocele in dogs: 30 cases (2000\u20132002)","volume":"224","author":"FS Pike","year":"2004","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"7","key":"ref8","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1111\/j.1532-950X.2008.00428.x","article-title":"Laparoscopic cholecystectomy for management of uncomplicated gall bladder mucocele in six dogs","volume":"37","author":"PD Mayhew","year":"2008","journal-title":"Vet Surg"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"1418","DOI":"10.2460\/javma.2004.225.1418","article-title":"Surgical management of gallbladder mucoceles in dogs: 22 cases (1999\u20132003)","volume":"225","author":"DR Worley","year":"2004","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"12","key":"ref10","doi-asserted-by":"crossref","first-page":"630","DOI":"10.1111\/j.1748-5827.2009.00811.x","article-title":"Gall bladder mucoceles and their association with endocrinopathies in dogs: a retrospective case-control study","volume":"50","author":"ML Mesich","year":"2009","journal-title":"J Small Anim Pract"},{"issue":"10","key":"ref11","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1292\/jvms.001295","article-title":"Correlation between ultrasonographic imaging of the gallbladder and gallbladder content in eleven cholecystectomised dogs and their prognoses","volume":"71","author":"T Uno","year":"2009","journal-title":"J Vet Med Sci"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"359","DOI":"10.2460\/javma.234.3.359","article-title":"Clinical, ultrasonographic, and laboratory findings associated with gallbladder disease and rupture in dogs: 45 cases (1997\u20132007)","volume":"234","author":"LJ Crews","year":"2009","journal-title":"Journal of the American Veterinary Medical Association"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1111\/j.1740-8261.2000.tb01489.x","article-title":"Ultrasonographic appearance and clinical findings in 14 dogs with gallbladder mucocele","volume":"41","author":"JG Besso","year":"2000","journal-title":"Vet Radiol Ultrasound"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1111\/j.1532-950X.2012.01072.x","article-title":"Clinical findings and prognostic factors for dogs undergoing cholecystectomy for gall bladder mucocele","volume":"42","author":"S Malek","year":"2013","journal-title":"Vet Surg"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"1166","DOI":"10.1016\/S0016-5085(83)80086-9","article-title":"Pigment sludge and stone formation in the acutely ligated dog gallbladder","volume":"85","author":"RA Bernhoft","year":"1983","journal-title":"Gastroenterology"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1111\/j.1740-8261.2011.01868.x","article-title":"Decreased gallbladder emptying in dogs with biliary sludge or gallbladder mucocele","volume":"53","author":"T Tsukagoshi","year":"2012","journal-title":"Vet Radiol Ultrasound"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1177\/1040638714532099","article-title":"Lack of association of ABCB4 insertion mutation with gallbladder mucoceles in dogs","volume":"26","author":"JM Cullen","year":"2014","journal-title":"Journal of veterinary diagnostic investigation: official publication of the American Association of Veterinary Laboratory Diagnosticians, Inc"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1016\/j.tvjl.2013.10.019","article-title":"The association between gall bladder mucoceles and hyperlipidaemia in dogs: a retrospective case control study","volume":"199","author":"M Kutsunai","year":"2014","journal-title":"Veterinary journal"},{"issue":"6","key":"ref19","doi-asserted-by":"crossref","first-page":"1464","DOI":"10.1111\/jvim.13649","article-title":"Association of gallbladder mucocele histologic diagnosis with selected drug use in dogs: a matched case-control study","volume":"29","author":"JL Gookin","year":"2015","journal-title":"Journal of veterinary internal medicine \/ American College of Veterinary Internal Medicine"},{"issue":"10","key":"ref20","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1111\/j.1751-0813.2007.00182.x","article-title":"Gallbladder mucocoele and concurrent hepatic lipidosis in a cat","volume":"85","author":"SL Bennett","year":"2007","journal-title":"Aust Vet J"},{"issue":"3","key":"ref21","first-page":"269","article-title":"Congenital duplex gallbladder and biliary mucocele associated with partial hepatic cholestasis and cholelithiasis in a cat","volume":"53","author":"KS Woods","year":"2012","journal-title":"Can Vet J"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"e0138988","DOI":"10.1371\/journal.pone.0138988","article-title":"Excess secretion of gel-forming mucins and associated innate defense proteins with defective mucin un-packaging underpin gallbladder mucocele formation in dogs","volume":"10","author":"M Kesimer","year":"2015","journal-title":"PloS one"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1172\/JCI73193","article-title":"Defective goblet cell exocytosis contributes to murine cystic fibrosis-associated intestinal disease","volume":"125","author":"J Liu","year":"2015","journal-title":"The Journal of clinical investigation"},{"issue":"6198","key":"ref24","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1126\/science.1255825","article-title":"Impaired mucus detachment disrupts mucociliary transport in a piglet model of cystic fibrosis","volume":"345","author":"MJ Hoegger","year":"2014","journal-title":"Science"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1016\/j.ajpath.2014.01.035","article-title":"Gastrointestinal pathology in juvenile and adult CFTR-knockout ferrets","volume":"184","author":"X Sun","year":"2014","journal-title":"Am J Pathol"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"1377","DOI":"10.2353\/ajpath.2010.090849","article-title":"Pathology of gastrointestinal organs in a porcine model of cystic fibrosis","volume":"176","author":"DK Meyerholz","year":"2010","journal-title":"Am J Pathol"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"1451","DOI":"10.1111\/jvim.14792","article-title":"Association between gallbladder ultrasound findings and bacterial culture of bile in 70 cats and 202 dogs","volume":"31","author":"R Policelli Smith","year":"2017","journal-title":"Journal of veterinary internal medicine \/ American College of Veterinary Internal Medicine"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1186\/1471-2156-11-49","article-title":"An application of Random Forests to a genome-wide association dataset: methodological considerations & new findings","volume":"11","author":"BA Goldstein","year":"2010","journal-title":"BMC genetics"},{"issue":"16","key":"ref29","doi-asserted-by":"crossref","first-page":"9440","DOI":"10.1073\/pnas.1530509100","article-title":"Statistical significance for genomewide studies","volume":"100","author":"JD Storey","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1 Pt 1","key":"ref30","first-page":"G1","article-title":"Biliary catabolism of glutathione and differential reabsorption of its amino acid constituents","volume":"254","author":"N Ballatori","year":"1988","journal-title":"The American journal of physiology"},{"issue":"4","key":"ref31","first-page":"273","article-title":"Biliary amino acid excretion in rats before and after bilateral nephrectomy","volume":"41","author":"C Fleck","year":"1992","journal-title":"Physiol Res"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"319","DOI":"10.1007\/BF00579853","article-title":"Active amino-acid and sugar uptake by gall bladder epithelium in dog, guinea-pig and man","volume":"355","author":"V Mirkovitch","year":"1975","journal-title":"Pflugers Arch"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1016\/j.jhep.2011.01.031","article-title":"Serum metabolomics reveals gamma-glutamyl dipeptides as biomarkers for discrimination among different forms of liver disease","volume":"55","author":"T Soga","year":"2011","journal-title":"Journal of hepatology"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"1248","DOI":"10.1073\/pnas.67.3.1248","article-title":"The gamma-glutamyl cycle: a possible transport system for amino acids","volume":"67","author":"M Orlowski","year":"1970","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1\u20132","key":"ref35","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.mam.2008.08.004","article-title":"Plasma membrane glutathione transporters and their roles in cell physiology and pathophysiology","volume":"30","author":"N Ballatori","year":"2009","journal-title":"Molecular aspects of medicine"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"L1123","DOI":"10.1152\/ajplung.2001.281.5.L1123","article-title":"Chlorzoxazone or 1-EBIO increases Na(+) absorption across cystic fibrosis airway epithelial cells","volume":"281","author":"L Gao","year":"2001","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"1 Pt 1","key":"ref37","first-page":"G22","article-title":"Relation between biliary glutathione excretion and bile acid-independent bile flow","volume":"256","author":"N Ballatori","year":"1989","journal-title":"The American journal of physiology"},{"issue":"6","key":"ref38","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1152\/jappl.1993.75.6.2419","article-title":"Systemic deficiency of glutathione in cystic fibrosis","volume":"75","author":"JH Roum","year":"1993","journal-title":"Journal of applied physiology"},{"issue":"10","key":"ref39","doi-asserted-by":"crossref","first-page":"3691","DOI":"10.1073\/pnas.0308393100","article-title":"Vitamin C controls the cystic fibrosis transmembrane conductance regulator chloride channel","volume":"101","author":"H Fischer","year":"2004","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"8","key":"ref40","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.biochi.2005.04.002","article-title":"Catabolism of intracellular N-terminal acetylated proteins: involvement of acylpeptide hydrolase and acylase","volume":"87","author":"J Perrier","year":"2005","journal-title":"Biochimie"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"e25888","DOI":"10.1371\/journal.pone.0025888","article-title":"Acylpeptide hydrolase inhibition as targeted strategy to induce proteasomal down-regulation","volume":"6","author":"G Palmieri","year":"2011","journal-title":"PloS one"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"773","DOI":"10.1016\/j.biochi.2007.12.006","article-title":"N-acetylamino acid utilization by kidney aminoacylase-1","volume":"90","author":"HA Lindner","year":"2008","journal-title":"Biochimie"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1016\/S0300-9084(00)00191-7","article-title":"The distribution of aminoacylase I among mammalian species and localization of the enzyme in porcine kidney","volume":"82","author":"H Lindner","year":"2000","journal-title":"Biochimie"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"295","DOI":"10.1042\/BJ20091352","article-title":"Regulation of mRNA cap methylation","volume":"425","author":"VH Cowling","year":"2010","journal-title":"Biochemical Journal"},{"issue":"1\u20132","key":"ref45","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/0300-9084(96)88104-1","article-title":"Enzymatic formation of N2,N2-dimethylguanosine in eukaryotic tRNA: importance of the tRNA architecture","volume":"77","author":"J Edqvist","year":"1995","journal-title":"Biochimie"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"2519","DOI":"10.1016\/S0021-9258(17)40489-3","article-title":"Dependence of mitochondrial protein synthesis initiation on formylation of the initiator methionyl-tRNAf","volume":"252","author":"R Bianchetti","year":"1977","journal-title":"The Journal of biological chemistry"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"144","DOI":"10.3389\/fgene.2014.00144","article-title":"Methylated nucleosides in tRNA and tRNA methyltransferases","volume":"5","author":"H Hori","year":"2014","journal-title":"Frontiers in genetics"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"G785","DOI":"10.1152\/ajpgi.00293.2006","article-title":"Cloning, purification, and identification of the liver canalicular ecto-ATPase as NTPDase8","volume":"292","author":"M Fausther","year":"2007","journal-title":"American journal of physiology Gastrointestinal and liver physiology"},{"issue":"3","key":"ref49","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1055\/s-2002-34503","article-title":"Adenosine triphosphate release and purinergic regulation of cholangiocyte transport","volume":"22","author":"AP Feranchak","year":"2002","journal-title":"Semin Liver Dis"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.bbamcr.2008.01.024","article-title":"Nucleotide- and nucleoside-converting ectoenzymes: Important modulators of purinergic signalling cascade","volume":"1783","author":"GG Yegutkin","year":"2008","journal-title":"Biochimica et biophysica acta"},{"issue":"2","key":"ref51","doi-asserted-by":"crossref","first-page":"423","DOI":"10.1292\/jvms1939.52.423","article-title":"Bile acid composition of dog and cat gall-bladder bile","volume":"52","author":"T Washizu","year":"1990","journal-title":"Nihon juigaku zasshi The Japanese journal of veterinary science"},{"issue":"12","key":"ref52","doi-asserted-by":"crossref","first-page":"1607","DOI":"10.2460\/ajvr.72.12.1607","article-title":"Effect of twice-daily oral administration of hydrocortisone on the bile acids composition of gallbladder bile in dogs","volume":"72","author":"PH Kook","year":"2011","journal-title":"American journal of veterinary research"},{"issue":"5","key":"ref53","doi-asserted-by":"crossref","first-page":"2495","DOI":"10.1021\/pr801078a","article-title":"Application of ultra performance liquid chromatography-mass spectrometry to profiling rat and dog bile","volume":"8","author":"RS Plumb","year":"2009","journal-title":"Journal of proteome research"},{"issue":"2","key":"ref54","doi-asserted-by":"crossref","first-page":"223","DOI":"10.2460\/ajvr.78.2.223","article-title":"Bile acid composition of gallbladder contents in dogs with gallbladder mucocele and biliary sludge","volume":"78","author":"T Kakimoto","year":"2017","journal-title":"American journal of veterinary research"},{"issue":"7","key":"ref55","doi-asserted-by":"crossref","first-page":"1581","DOI":"10.1053\/j.gastro.2012.02.033","article-title":"Defects in gallbladder emptying and bile Acid homeostasis in mice with cystic fibrosis transmembrane conductance regulator deficiencies","volume":"142","author":"D Debray","year":"2012","journal-title":"Gastroenterology"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"264","DOI":"10.1016\/0016-5085(95)90293-7","article-title":"Model bile and bile salts accelerate mucin secretion by cultured dog gallbladder epithelial cells","volume":"109","author":"JH Klinkspoor","year":"1995","journal-title":"Gastroenterology"},{"issue":"2\u20133","key":"ref57","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1007\/s12016-014-8443-x","article-title":"TGR5: pathogenetic role and\/or therapeutic target in fibrosing cholangitis?","volume":"48","author":"V Keitel","year":"2015","journal-title":"Clinical reviews in allergy & immunology"},{"issue":"1","key":"ref58","doi-asserted-by":"crossref","first-page":"179","DOI":"10.1016\/S0016-5085(99)70242-8","article-title":"Bile acid feeding induces cholangiocyte proliferation and secretion: evidence for bile acid-regulated ductal secretion","volume":"116","author":"G Alpini","year":"1999","journal-title":"Gastroenterology"},{"issue":"2","key":"ref59","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1002\/hep.21042","article-title":"Bicarbonate-rich choleresis induced by secretin in normal rat is taurocholate-dependent and involves AE2 anion exchanger","volume":"43","author":"JM Banales","year":"2006","journal-title":"Hepatology"},{"issue":"22","key":"ref60","doi-asserted-by":"crossref","first-page":"20413","DOI":"10.1074\/jbc.M302108200","article-title":"Agonist-induced coordinated trafficking of functionally related transport proteins for water and ions in cholangiocytes","volume":"278","author":"PS Tietz","year":"2003","journal-title":"The Journal of biological chemistry"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1159\/000324687","article-title":"Biliary bicarbonate secretion constitutes a protective mechanism against bile acid-induced injury in man","volume":"29","author":"S Hohenester","year":"2011","journal-title":"Digestive diseases"},{"issue":"3","key":"ref62","doi-asserted-by":"crossref","first-page":"879","DOI":"10.1172\/JCI83922","article-title":"Acidic pH increases airway surface liquid viscosity in cystic fibrosis","volume":"126","author":"XX Tang","year":"2016","journal-title":"The Journal of clinical investigation"},{"issue":"3","key":"ref63","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1111\/j.1939-1676.1997.tb00090.x","article-title":"Use of ursodeoxycholic acids in a dog with chronic hepatitis: effects on serum hepatic tests and endogenous bile acid composition","volume":"11","author":"DJ Meyer","year":"1997","journal-title":"Journal of veterinary internal medicine \/ American College of Veterinary Internal Medicine"},{"issue":"4","key":"ref64","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1016\/S0006-291X(03)01296-8","article-title":"ABCG5 and ABCG8 are expressed in gallbladder epithelial cells","volume":"307","author":"A Tauscher","year":"2003","journal-title":"Biochemical and biophysical research communications"},{"issue":"3 Pt 1","key":"ref65","first-page":"G410","article-title":"Bidirectional transport of cholesterol between gallbladder epithelial cells and model bile","volume":"271","author":"A Hayashi","year":"1996","journal-title":"The American journal of physiology"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"551","DOI":"10.1016\/0305-0491(86)90295-6","article-title":"Relationships between bile salts hydrophilicity and phospholipid composition in bile of various animal species","volume":"83","author":"D Alvaro","year":"1986","journal-title":"Comp Biochem Physiol B"},{"issue":"7","key":"ref67","doi-asserted-by":"crossref","first-page":"1413","DOI":"10.1023\/A:1005524624411","article-title":"Role of phospholipase A2 in cholesterol gallstone formation is associated with biliary phospholipid species selection at the site of hepatic excretion: indirect evidence","volume":"45","author":"Y Hattori","year":"2000","journal-title":"Dig Dis Sci"},{"issue":"1","key":"ref68","first-page":"G92","article-title":"Arachidonic acid stimulates mucin secretion in prairie dog gallbladder","volume":"245","author":"JT LaMont","year":"1983","journal-title":"The American journal of physiology"},{"issue":"6 Pt 1","key":"ref69","first-page":"G998","article-title":"PGE generates intracellular cAMP and accelerates mucin secretion by cultured dog gallbladder epithelial cells","volume":"267","author":"R Kuver","year":"1994","journal-title":"The American journal of physiology"},{"issue":"1","key":"ref70","doi-asserted-by":"crossref","first-page":"52","DOI":"10.1016\/0005-2760(88)90245-7","article-title":"Free fatty acids: a stimulus for mucin hypersecretion in cholesterol gallstone biles","volume":"958","author":"G Mingrone","year":"1988","journal-title":"Biochimica et biophysica acta"},{"issue":"4","key":"ref71","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/S1542-3565(03)00133-2","article-title":"Prostaglandin E receptors in bile ducts of hepatolithiasis patients and the pathobiological significance for cholangitis","volume":"1","author":"J Shoda","year":"2003","journal-title":"Clin Gastroenterol Hepatol"},{"issue":"5","key":"ref72","doi-asserted-by":"crossref","first-page":"600","DOI":"10.1165\/rcmb.2005-0421OC","article-title":"Adenosine regulation of cystic fibrosis transmembrane conductance regulator through prostenoids in airway epithelia","volume":"34","author":"Y Li","year":"2006","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"6","key":"ref73","doi-asserted-by":"crossref","first-page":"490","DOI":"10.1139\/y00-014","article-title":"Inhibition of cystic fibrosis transmembrane conductance regulator chloride channel currents by arachidonic acid","volume":"78","author":"P Linsdell","year":"2000","journal-title":"Can J Physiol Pharmacol"},{"issue":"5","key":"ref74","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1016\/j.plipres.2008.03.003","article-title":"Fatty acid composition of adipose tissue and blood in humans and its use as a biomarker of dietary intake","volume":"47","author":"L Hodson","year":"2008","journal-title":"Progress in lipid research"},{"issue":"12","key":"ref75","doi-asserted-by":"crossref","first-page":"1417","DOI":"10.1038\/sj.ejcn.1602256","article-title":"Evaluation of the odd fatty acids 15:0 and 17:0 in serum and adipose tissue as markers of intake of milk and dairy fat","volume":"59","author":"A Brevik","year":"2005","journal-title":"European journal of clinical nutrition"},{"issue":"6","key":"ref76","doi-asserted-by":"crossref","first-page":"743","DOI":"10.1007\/BF01799166","article-title":"Plasma total odd-chain fatty acids in the monitoring of disorders of propionate, methylmalonate and biotin metabolism","volume":"19","author":"M Coker","year":"1996","journal-title":"J Inherit Metab Dis"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1016\/j.ceb.2015.02.003","article-title":"Acetyl-CoA and the regulation of metabolism: mechanisms and consequences","volume":"33","author":"L Shi","year":"2015","journal-title":"Current opinion in cell biology"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1101\/sqb.2011.76.010769","article-title":"On acetyl-CoA as a gauge of cellular metabolic state","volume":"76","author":"L Cai","year":"2011","journal-title":"Cold Spring Harbor symposia on quantitative biology"},{"issue":"10","key":"ref79","doi-asserted-by":"crossref","first-page":"1986","DOI":"10.1194\/jlr.R046920","article-title":"Novel lysophosphoplipid receptors: their structure and function","volume":"55","author":"K Makide","year":"2014","journal-title":"J Lipid Res"},{"issue":"40","key":"ref80","doi-asserted-by":"crossref","first-page":"30516","DOI":"10.1074\/jbc.M110.140806","article-title":"Metabolomic profiling reveals biochemical pathways and biomarkers associated with pathogenesis in cystic fibrosis cells","volume":"285","author":"DR Wetmore","year":"2010","journal-title":"The Journal of biological chemistry"},{"issue":"4","key":"ref81","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1093\/ije\/dyt094","article-title":"Metabolomic markers reveal novel pathways of ageing and early development in human populations","volume":"42","author":"C Menni","year":"2013","journal-title":"Int J Epidemiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0191076","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,12]],"date-time":"2022-08-12T04:01:59Z","timestamp":1660276919000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0191076"}},"subtitle":[],"editor":[{"given":"Juan J","family":"Loor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":81,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0191076","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}