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Academic Press ISBN 9780124079014."},{"key":"ref15","unstructured":"Nifurtimox Drug Information, Professional. www.drugs.com<\/ext-link> accessed 12th May, 2017. www.drugs.com\/mmx\/nifurtimox.html<\/ext-link>."},{"issue":"8","key":"ref16","doi-asserted-by":"crossref","first-page":"1056","DOI":"10.1093\/cid\/ciw477","article-title":"Safety profile of nifurtimox for treatment of Chagas diseases in the United States","volume":"63","author":"CJ Forsyth","year":"2016","journal-title":"Clinical Infectious Disease"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1590\/S0074-02761999000700070","article-title":"Treatment of Trypanosoma cruzi<\/italic> infection in the undetermined phase. Experience and current guidelines of treatment in Argentina","volume":"94","author":"SS Estani","year":"1999","journal-title":"Memorias do Instituto Oswaldo Cruz"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1006\/expr.2001.4666","article-title":"Measure of molecular diversity within the Trypanosoma brucei subspecies Trypanosoma brucei brucei<\/italic> and T<\/italic>. b<\/italic>. gambiense<\/italic> as revealed by genotypic characterisation","volume":"99","author":"EC Agbo","year":"2001","journal-title":"Experimental Parasitology"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.2174\/1389450003349290","article-title":"Cysteine proteinase of Trypanosome<\/italic> parasites: novel targets for chemotherapy","volume":"1","author":"CR Caffrey","year":"2000","journal-title":"Current Drugs Targets"},{"issue":"3","key":"ref20","first-page":"467","article-title":"Trypanosoma brucei brucei","volume":"169","author":"JD Lonsdale-Eccles","year":"1987","journal-title":"European Journal of Biochemistry"},{"issue":"7","key":"ref21","doi-asserted-by":"crossref","first-page":"e479","DOI":"10.1371\/journal.pntd.0000479","article-title":"Protease Activated Receptor Signaling Is Required for African Trypanosome Traversal of Human Brain Microvascular Endothelial Cells","volume":"3","author":"DJ Grab","year":"2009","journal-title":"PLoS Negl Trop Dis"},{"issue":"2","key":"ref22","doi-asserted-by":"crossref","first-page":"261","DOI":"10.4314\/bcse.v22i2.61295","article-title":"Synthesis, characterization, antiplasmodial and antitrypanosomal activity of some metal (III) complexes of sulfadiazine","volume":"22","author":"PA Ajibade","year":"2008","journal-title":"Bulletin of the Chemical Society of Ethiopia"},{"issue":"11","key":"ref23","doi-asserted-by":"crossref","first-page":"5554","DOI":"10.1021\/jm300508n","article-title":"Novel 3-nitro-1H<\/italic>-1,2,4-triazole-based amides and sulphonamides as potential antitrypanosomal agents","volume":"55","author":"MV Papadopoulou","year":"2012","journal-title":"Journal of Medicinal Chemistry"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"1325","DOI":"10.1124\/mol.64.6.1325","article-title":"Selective antimicrotubule activity of N1-phenyl-3,5-dinitro-N4,N4-di-n-propylsulphanilamide (GB-11-5) against kinetoplastid parasites","volume":"64","author":"KA Werbovetz","year":"2003","journal-title":"Molecular Pharmacology"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/ja.2008.52","article-title":"Selective and Potent in vitro<\/italic> Antitrypanosomal Activities of Ten Microbial Metabolites","volume":"61","author":"K Otoguro","year":"2008","journal-title":"The Journal of Antibiotics"},{"key":"ref26","first-page":"153","article-title":"Fundamentals of Experimental Pharmacology Scientific Book Agency","author":"M Ghosh","year":"1984"},{"key":"ref27","first-page":"1273","article-title":"Cultivation in a semi-defined medium of animal infective forms of Trypanosoma brucei<\/italic>, T<\/italic>. equiperdum<\/italic>, T<\/italic>. evansi<\/italic>, T<\/italic>. rhodesiense<\/italic> and T<\/italic>. gambiense<\/italic>","volume":"4","author":"T Baltz","year":"1985"},{"key":"ref28","first-page":"3","article-title":"Adv Drug Deliv Rev","volume":"46","author":"CA Lipinski","year":"2001","journal-title":"Adv Drug Deliv Rev"},{"key":"ref29","first-page":"2615","article-title":"J. Med. Chem","volume":"45","author":"DF Veber","year":"2002","journal-title":"J. Med. Chem"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e1700025","DOI":"10.1002\/ardp.201700025","article-title":"Synthesis, anti-inflammatory activity and COX-1\/2 inhibition profile of some novel non-acidic polysubstituted pyrazoles and pyrano[2,3-c]pyrazoles","volume":"350","author":"HM Faidallah","year":"2017","journal-title":"Archiv der Pharmazie"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"1446","DOI":"10.1023\/A:1020444330011","article-title":"Pharm Res","volume":"19","author":"Y Zhao","year":"2002","journal-title":"Pharm Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0191234","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:05:12Z","timestamp":1540209912000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0191234"}},"subtitle":[],"editor":[{"given":"Giovanni","family":"Maga","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,11]]},"references-count":31,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0191234","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,11]]}}}