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Zhu","year":"2006","journal-title":"Process Biochem"},{"issue":"8","key":"ref47","doi-asserted-by":"crossref","first-page":"4712","DOI":"10.1021\/jf904456r","article-title":"Amino acid composition and antioxidant properties of pea seed (<italic>Pisum sativum<\/italic> L.) enzymatic protein hydrolysate fractions","volume":"58","author":"T L Pownall","year":"2010","journal-title":"J Agric Food Chem"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1016\/j.phrs.2003.07.012","article-title":"Buyukokuroglu, In vitro antioxidant properties of morphine","volume":"49","author":"S Gulcin","year":"2004","journal-title":"Pharmacol Res"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.jnutbio.2006.02.006","article-title":"Purification and characterization of antioxidant peptide from hoki (<italic>Johnius belengerii<\/italic>) frame protein by gastrointestinal digestion","volume":"18","author":"S Y Kim","year":"2007","journal-title":"The 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Geneva: WHO."},{"key":"ref51","doi-asserted-by":"crossref","first-page":"1770","DOI":"10.1016\/j.foodchem.2011.06.051","article-title":"Purification and identification of ACE inhibitory peptides from Haruan (<italic>Channa striatus<\/italic>) myofibrillar protein hydrolysate using HPLC-ESI-TOF MS\/MS","volume":"129","author":"M Ghassem","year":"2011","journal-title":"Food Chem"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1575","DOI":"10.1016\/S0140-6736(00)02212-1","article-title":"Long-term ACE-inhibitor therapy in patients with heart failure or left-ventricular dysfunction: A systematic overview of data from individual patients","volume":"355","author":"M D Flather","year":"2000","journal-title":"The Lancet"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"48","DOI":"10.1016\/j.jff.2016.11.021","article-title":"Purification, characterization, synthesis, in vitro ACE inhibition and <italic>in vivo<\/italic> antihypertensive activity of bioactive peptides derived from oil palm kernel glutelin-2 hydrolysates","volume":"28","author":"Z Yajun","year":"2017","journal-title":"J of Functional Foods"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"888","DOI":"10.2337\/diacare.23.7.888","article-title":"Therapeutic benefits of ACE inhibitors and other antihypertensive drugs in patients with type 2 diabetes","volume":"23","author":"M Pahor","year":"2000","journal-title":"Diabetes Care"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1854","DOI":"10.1016\/j.jff.2013.09.006","article-title":"Isolation of antioxidative and ACE inhibitory peptides from protein hydrolysate of skipjack (<italic>Katsuwana pelamis<\/italic>) roe","volume":"5","author":"R Intarasirisawat","year":"2013","journal-title":"J Funct Foods"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"5255","DOI":"10.1016\/j.biortech.2009.05.057","article-title":"Purification and characterization of angiotensin I converting enzyme inhibitory peptides from the rotifer, <italic>Brachionus rotundiformis<\/italic>","volume":"100","author":"JK Lee","year":"2009","journal-title":"Bioresource Tech"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1016\/j.foodchem.2004.09.048","article-title":"Angiotensin I-converting enzyme inhibitory peptide from yellowfin sole (<italic>Limanda aspera<\/italic>) frame protein and its antihypertensive effect in spontaneously hypertensive rats","volume":"94","author":"W K Jung","year":"2006","journal-title":"Food Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.3390\/md8041080","article-title":"Angiotensin-I-converting enzyme (ACE) inhibitors from marine resources: Prospects in the pharmaceutical industry","volume":"8","author":"W Isuru","year":"2010","journal-title":"Marine Drugs"},{"key":"ref59","first-page":"2","article-title":"An intuitive look at the relationship of ki and ic50: a more general use for the dixon plot","volume":"80","author":"T B Benjamin","year":"2003","journal-title":"J Chem Educ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0191265","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,1]],"date-time":"2024-07-01T00:37:58Z","timestamp":1719794278000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0191265"}},"subtitle":[],"editor":[{"given":"Gabriel","family":"Agbor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,6]]},"references-count":59,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0191265","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,6]]}}}