{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,12]],"date-time":"2026-10-12T16:05:02Z","timestamp":1791821102287,"version":"4.3.4"},"reference-count":96,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG027810"],"award-info":[{"award-number":["AG027810"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG042124"],"award-info":[{"award-number":["AG042124"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG042139"],"award-info":[{"award-number":["AG042139"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG042140"],"award-info":[{"award-number":["AG042140"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG042143"],"award-info":[{"award-number":["AG042143"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG042145"],"award-info":[{"award-number":["AG042145"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG042168"],"award-info":[{"award-number":["AG042168"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG030474"],"award-info":[{"award-number":["AG030474"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL40489"],"award-info":[{"award-number":["HL40489"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL071194"],"award-info":[{"award-number":["HL071194"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL070848"],"award-info":[{"award-number":["HL070848"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL070847"],"award-info":[{"award-number":["HL070847"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL070842"],"award-info":[{"award-number":["HL070842"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL070841"],"award-info":[{"award-number":["HL070841"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL070837"],"award-info":[{"award-number":["HL070837"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL070838"],"award-info":[{"award-number":["HL070838"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000050","name":"National Heart, Lung, and Blood Institute","doi-asserted-by":"publisher","award":["HL070839"],"award-info":[{"award-number":["HL070839"]}],"id":[{"id":"10.13039\/100000050","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000025","name":"National Institute of Mental Health","doi-asserted-by":"publisher","award":["MH093500"],"award-info":[{"award-number":["MH093500"]}],"id":[{"id":"10.13039\/100000025","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0191281","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T18:38:52Z","timestamp":1516905532000},"page":"e0191281","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":24,"title":["APOE\u03b54 and slow wave sleep in older adults"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5520-812X","authenticated-orcid":true,"given":"Gregory J.","family":"Tranah","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine","family":"Yaffe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Caroline M.","family":"Nievergelt","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neeta","family":"Parimi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"M. Maria","family":"Glymour","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kristine E.","family":"Ensrud","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jane A.","family":"Cauley","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sonia","family":"Ancoli-Israel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara","family":"Mariani","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Redline","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katie L.","family":"Stone","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"the Osteoporotic Fractures in Men Study (MrOS) Research Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1093\/sleep\/18.6.425","article-title":"Sleep complaints among elderly persons: an epidemiologic study of three communities","volume":"18","author":"DJ Foley","year":"1995","journal-title":"Sleep"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1946","DOI":"10.1164\/ajrccm.152.6.8520760","article-title":"Sleep-disordered breathing in African-American elderly","volume":"152","author":"S Ancoli-Israel","year":"1995","journal-title":"Am J Respir Crit Care Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1093\/sleep\/14.6.486","article-title":"Sleep-disordered breathing in community-dwelling elderly","volume":"14","author":"S Ancoli-Israel","year":"1991","journal-title":"Sleep"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1093\/sleep\/16.suppl_8.S25","article-title":"Natural history of sleep disordered breathing in community dwelling elderly","volume":"16","author":"S Ancoli-Israel","year":"1993","journal-title":"Sleep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1097\/00019442-200505000-00001","article-title":"Sleep and aging","volume":"13","author":"S Ancoli-Israel","year":"2005","journal-title":"Am J Geriatr Psychiatry"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1007\/BF00999989","article-title":"Prevalent sleep problems in the aged","volume":"16","author":"S Ancoli-Israel","year":"1991","journal-title":"Biofeedback Self Regul"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1093\/aje\/155.5.387","article-title":"Snoring as a risk factor for type II diabetes mellitus: a prospective study","volume":"155","author":"WK Al-Delaimy","year":"2002","journal-title":"Am J Epidemiol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"380","DOI":"10.2337\/diacare.26.2.380","article-title":"A prospective study of self-reported sleep duration and incident diabetes in women","volume":"26","author":"NT Ayas","year":"2003","journal-title":"Diabetes Care"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1046\/j.1365-2796.2000.00683.x","article-title":"The role of habitual snoring and obesity in the development of diabetes: a 10-year follow-up study in a male population","volume":"248","author":"A Elmasry","year":"2000","journal-title":"J Intern Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1183\/09031936.98.11010014","article-title":"Obstructive sleep apnoea and diabetes mellitus: the role of cardiovascular autonomic neuropathy","volume":"11","author":"JH Ficker","year":"1998","journal-title":"Eur Respir J"},{"key":"ref11","first-page":"410","article-title":"Impact of obstructive sleep apnea and sleepiness on metabolic and cardiovascular risk factors in the Swedish Obese Subjects (SOS) Study","volume":"19","author":"RR Grunstein","year":"1995","journal-title":"Int J Obes Relat Metab Disord"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1093\/ije\/22.3.439","article-title":"Snoring, sleep apnoea and cardiovascular risk factors: the MONICA II Study","volume":"22","author":"P Jennum","year":"1993","journal-title":"Int J Epidemiol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1111\/j.1532-5415.1997.tb00970.x","article-title":"Sleep disturbance, psychosocial correlates, and cardiovascular disease in 5201 older adults: the Cardiovascular Health Study","volume":"45","author":"AB Newman","year":"1997","journal-title":"J Am Geriatr Soc"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1093\/aje\/154.1.50","article-title":"Relation of sleep-disordered breathing to cardiovascular disease risk factors: the Sleep Heart Health Study","volume":"154","author":"AB Newman","year":"2001","journal-title":"Am J Epidemiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1111\/j.1532-5415.2000.tb03901.x","article-title":"Daytime sleepiness predicts mortality and cardiovascular disease in older adults. The Cardiovascular Health Study Research Group","volume":"48","author":"AB Newman","year":"2000","journal-title":"J Am Geriatr Soc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1164\/ajrccm.163.1.2001008","article-title":"Sleep-disordered breathing and cardiovascular disease: cross-sectional results of the Sleep Heart Health Study","volume":"163","author":"E Shahar","year":"2001","journal-title":"Am J Respir Crit Care Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1093\/sleep\/19.4.277","article-title":"Morbidity, mortality and sleep-disordered breathing in community dwelling elderly","volume":"19","author":"S Ancoli-Israel","year":"1996","journal-title":"Sleep"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1001\/archpsyc.59.2.131","article-title":"Mortality associated with sleep duration and insomnia","volume":"59","author":"DF Kripke","year":"2002","journal-title":"Arch Gen Psychiatry"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"318","DOI":"10.1159\/000022184","article-title":"Sleep patterns and mortality among elderly patients in a geriatric hospital","volume":"46","author":"K Manabe","year":"2000","journal-title":"Gerontology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1093\/sleep\/18.6.433","article-title":"Four-year follow-up of mortality and sleep-related respiratory disturbance in non-demented seniors","volume":"18","author":"A Mant","year":"1995","journal-title":"Sleep"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"639","DOI":"10.1046\/j.1532-5415.2001.49125.x","article-title":"Sleep disturbances and mortality: results from the Canadian Study of Health and Aging","volume":"49","author":"K Rockwood","year":"2001","journal-title":"J Am Geriatr Soc"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"604","DOI":"10.1111\/j.1532-5415.2008.02171.x","article-title":"Self-reported sleep and nap habits and risk of mortality in a large cohort of older women","volume":"57","author":"KL Stone","year":"2009","journal-title":"J Am Geriatr Soc"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"405","DOI":"10.1093\/gerona\/61.4.405","article-title":"Poor sleep is associated with impaired cognitive function in older women: the study of osteoporotic fractures","volume":"61","author":"T Blackwell","year":"2006","journal-title":"J Gerontol A Biol Sci Med Sci"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1185","DOI":"10.1046\/j.1532-5415.2001.49235.x","article-title":"The impact of insomnia on cognitive functioning in older adults","volume":"49","author":"M Cricco","year":"2001","journal-title":"J Am Geriatr Soc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1093\/sleep\/18.2.109","article-title":"Sleep disturbance in elderly patients with cognitive impairment, decreased daily activity and periventricular white matter lesions","volume":"18","author":"K Meguro","year":"1995","journal-title":"Sleep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1001\/archinte.162.2.201","article-title":"Daytime sleepiness and cognitive impairment in the elderly population","volume":"162","author":"MM Ohayon","year":"2002","journal-title":"Arch Intern Med"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"S65","DOI":"10.1093\/sleep\/16.suppl_8.S65","article-title":"Cognitive effects of sleep and sleep fragmentation","volume":"16","author":"MH Bonnet","year":"1993","journal-title":"Sleep"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"485","DOI":"10.1016\/S0031-9384(98)00316-3","article-title":"Slow-wave sleep and waking cognitive performance among older adults with and without insomnia complaints","volume":"66","author":"MC Crenshaw","year":"1999","journal-title":"Physiol Behav"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1287","DOI":"10.1111\/j.1532-5415.1996.tb01397.x","article-title":"Breathing disorders during sleep and cognitive performance in an older community sample: the EVA Study","volume":"44","author":"MJ Dealberto","year":"1996","journal-title":"J Am Geriatr Soc"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/S0031-9384(00)00238-9","article-title":"Slow-wave sleep and waking cognitive performance II: Findings among middle-aged adults with and without insomnia complaints","volume":"70","author":"JD Edinger","year":"2000","journal-title":"Physiol Behav"},{"key":"ref31","first-page":"S102","article-title":"Cognitive function in the sleep apnea\/hypopnea syndrome (SAHS)","volume":"4","author":"HM Engleman","year":"2000","journal-title":"Sleep 23 Suppl"},{"key":"ref32","first-page":"632","article-title":"Sleep loss and cognitive performance","volume":"30","author":"P Granat","year":"1990","journal-title":"J Fam Pract"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1082","DOI":"10.1016\/0006-3223(92)90153-Q","article-title":"Sleep deprivation and impaired cognition. Possible role of brain catecholamines","volume":"31","author":"UD McCann","year":"1992","journal-title":"Biol Psychiatry"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1126\/science.1241224","article-title":"Sleep drives metabolite clearance from the adult brain","volume":"342","author":"L Xie","year":"2013","journal-title":"Science"},{"key":"ref35","article-title":"APOE genotype and early beta-amyloid accumulation in older adults without dementia","author":"YY Lim","year":"2017","journal-title":"Neurology"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"829","DOI":"10.1212\/01.wnl.0000343853.00346.a4","article-title":"APOE epsilon2 is associated with intact cognition but increased Alzheimer pathology in the oldest old","volume":"72","author":"DJ Berlau","year":"2009","journal-title":"Neurology"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"921","DOI":"10.1126\/science.8346443","article-title":"Gene dose of apolipoprotein E type 4 allele and the risk of Alzheimer's disease in late onset families","volume":"261","author":"EH Corder","year":"1993","journal-title":"Science"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"8718","DOI":"10.1073\/pnas.0803526105","article-title":"Apolipoprotein (apo) E4 enhances HIV-1 cell entry in vitro, and the APOE epsilon4\/epsilon4 genotype accelerates HIV disease progression","volume":"105","author":"TD Burt","year":"2008","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"507","DOI":"10.1146\/annurev.genom.1.1.507","article-title":"Apolipoprotein E: far more than a lipid transport protein","volume":"1","author":"RW Mahley","year":"2000","journal-title":"Annu Rev Genomics Hum Genet"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"9758","DOI":"10.1073\/pnas.85.24.9758","article-title":"Familial defective apolipoprotein B-100: enhanced binding of monoclonal antibody MB47 to abnormal low density lipoproteins","volume":"85","author":"KH Weisgraber","year":"1988","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"1842","DOI":"10.1212\/01.wnl.0000304038.37421.cc","article-title":"APOE epsilon 4 allele predicts faster cognitive decline in mild Alzheimer disease","volume":"70","author":"S Cosentino","year":"2008","journal-title":"Neurology"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/j.1600-0404.2006.00679.x","article-title":"Apolipoprotein (apo) E4 and Alzheimer's disease: unique conformational and biophysical properties of apoE4 can modulate neuropathology","volume":"185","author":"RW Mahley","year":"2006","journal-title":"Acta Neurol Scand Suppl"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"831","DOI":"10.1016\/j.sleep.2007.10.015","article-title":"The APOE epsilon4 allele increases the risk of impaired spatial working memory in obstructive sleep apnea","volume":"9","author":"FI Cosentino","year":"2008","journal-title":"Sleep Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1093\/sleep\/29.8.1003","article-title":"Genetically increased risk of sleep disruption in Alzheimer's disease","volume":"29","author":"D Craig","year":"2006","journal-title":"Sleep"},{"key":"ref45","first-page":"1447","article-title":"Relationship between apolipoprotein E epsilon4 and sleep-disordered breathing at different ages","volume":"286","author":"DJ Foley","year":"2001","journal-title":"Jama"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"243","DOI":"10.1212\/01.wnl.0000265818.88703.83","article-title":"APOE epsilon 4 allele, cognitive dysfunction, and obstructive sleep apnea in children","volume":"69","author":"D Gozal","year":"2007","journal-title":"Neurology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"2888","DOI":"10.1001\/jama.285.22.2888","article-title":"Association between apolipoprotein E epsilon4 and sleep-disordered breathing in adults","volume":"285","author":"H Kadotani","year":"2001","journal-title":"Jama"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1002\/gepi.20127","article-title":"Apolipoprotein E and obstructive sleep apnea: evaluating whether a candidate gene explains a linkage peak","volume":"30","author":"EK Larkin","year":"2006","journal-title":"Genet Epidemiol"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1111\/j.1399-0004.1998.tb02663.x","article-title":"No relation between apolipoprotein E alleles and obstructive sleep apnea","volume":"53","author":"S Saarelainen","year":"1998","journal-title":"Clin Genet"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"664","DOI":"10.1212\/01.WNL.0000134671.99649.32","article-title":"APOE epsilon4 is associated with obstructive sleep apnea\/hypopnea: the Sleep Heart Health Study","volume":"63","author":"DJ Gottlieb","year":"2004","journal-title":"Neurology"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.sleep.2007.05.001","article-title":"Association of ApoE genetic variants with obstructive sleep apnea in children","volume":"9","author":"M Kalra","year":"2008","journal-title":"Sleep Med"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"2766","DOI":"10.1523\/JNEUROSCI.5548-07.2008","article-title":"A role for non-rapid-eye-movement sleep homeostasis in perceptual learning","volume":"28","author":"D Aeschbach","year":"2008","journal-title":"J Neurosci"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"1273","DOI":"10.1093\/sleep\/32.10.1273","article-title":"Sleep-dependent improvement in visuomotor learning: a causal role for slow waves","volume":"32","author":"EC Landsness","year":"2009","journal-title":"Sleep"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"676","DOI":"10.1126\/science.8036517","article-title":"Reactivation of hippocampal ensemble memories during sleep","volume":"265","author":"MA Wilson","year":"1994","journal-title":"Science"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1037\/h0030914","article-title":"Effect of sleep on memory. II. Differential effect of the first and second half of the night","volume":"88","author":"R Yaroush","year":"1971","journal-title":"J Exp Psychol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.smrv.2008.08.002","article-title":"The whats and whens of sleep-dependent memory consolidation","volume":"13","author":"S Diekelmann","year":"2009","journal-title":"Sleep Med Rev"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1111\/j.1749-6632.2009.04416.x","article-title":"The role of sleep in cognition and emotion","volume":"1156","author":"MP Walker","year":"2009","journal-title":"Ann N Y Acad Sci"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"72","DOI":"10.1016\/0140-6736(93)92555-8","article-title":"Bone density at various sites for prediction of hip fractures. The Study of Osteoporotic Fractures Research Group","volume":"341","author":"SR Cummings","year":"1993","journal-title":"Lancet"},{"key":"ref59","first-page":"189","article-title":""Mini-mental state". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1093\/sleep\/32.4.483","article-title":"Association between sleep architecture and measures of body composition","volume":"32","author":"MN Rao","year":"2009","journal-title":"Sleep"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1037\/0022-006X.55.1.96","article-title":"Alzheimer's dementia: performance on the Mini-Mental State Examination","volume":"55","author":"EL Teng","year":"1987","journal-title":"J Consult Clin Psychol"},{"key":"ref62","first-page":"314","article-title":"The Modified Mini-Mental State (3MS) examination","volume":"48","author":"EL Teng","year":"1987","journal-title":"J Clin Psychiatry"},{"key":"ref63","first-page":"189","article-title":""Mini-mental state". A practical method for grading the cognitive state of patients for the clinician","volume":"12","author":"MF Folstein","year":"1975","journal-title":"J Psychiatr Res"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1093\/sleep\/31.2.283","article-title":"Comparison of sleep parameters from actigraphy and polysomnography in older women: the SOF study","volume":"31","author":"T Blackwell","year":"2008","journal-title":"Sleep"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1111\/j.1532-5415.2007.01290.x","article-title":"Prevalence and correlates of sleep-disordered breathing in older men: osteoporotic fractures in men sleep study","volume":"55","author":"R Mehra","year":"2007","journal-title":"J Am Geriatr Soc"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"759","DOI":"10.1093\/sleep\/21.7.759","article-title":"Methods for obtaining and analyzing unattended polysomnography data for a multicenter study. Sleep Heart Health Research Group","volume":"21","author":"S Redline","year":"1998","journal-title":"Sleep"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"305","DOI":"10.1046\/j.1440-1819.2001.00810.x","article-title":"Proposed supplements and amendments to 'A Manual of Standardized Terminology, Techniques and Scoring System for Sleep Stages of Human Subjects', the Rechtschaffen & Kales (1968) standard","volume":"55","author":"T Hori","year":"2001","journal-title":"Psychiatry Clin Neurosci"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1093\/sleep\/15.2.173","article-title":"EEG arousals: scoring rules and examples: a preliminary report from the Sleep Disorders Atlas Task Force of the American Sleep Disorders Association","volume":"15","year":"1992","journal-title":"Sleep"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"191","DOI":"10.5664\/jcsm.2474","article-title":"Obstructive sleep apnea during rapid eye movement sleep, daytime sleepiness, and quality of life in older men in Osteoporotic Fractures in Men (MrOS) Sleep Study","volume":"9","author":"A Khan","year":"2013","journal-title":"J Clin Sleep Med"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1111\/j.1469-8986.1979.tb02991.x","article-title":"Systematic trends across the night in human sleep cycles","volume":"16","author":"I Feinberg","year":"1979","journal-title":"Psychophysiology"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"431","DOI":"10.5665\/sleep.2466","article-title":"Common Genetic Variants in ARNTL and NPAS2 and at Chromosome 12p13 are Associated with Objectively Measured Sleep Traits in the Elderly","volume":"36","author":"DS Evans","year":"2013","journal-title":"Sleep"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1111\/j.1532-5415.2011.03731.x","article-title":"Associations between sleep architecture and sleep-disordered breathing and cognition in older community-dwelling men: the Osteoporotic Fractures in Men Sleep Study","volume":"59","author":"T Blackwell","year":"2011","journal-title":"J Am Geriatr Soc"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1037\/a0028830","article-title":"Sleep, memory, and aging: the link between slow-wave sleep and episodic memory changes from younger to older adults","volume":"28","author":"MK Scullin","year":"2013","journal-title":"Psychol Aging"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.brainresbull.2003.09.004","article-title":"Sleep and synaptic homeostasis: a hypothesis","volume":"62","author":"G Tononi","year":"2003","journal-title":"Brain Res Bull"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1159\/000336149","article-title":"Brain plasticity, sleep and aging","volume":"58","author":"C Cirelli","year":"2012","journal-title":"Gerontology"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1126\/science.1166657","article-title":"Use-dependent plasticity in clock neurons regulates sleep need in Drosophila","volume":"324","author":"JM Donlea","year":"2009","journal-title":"Science"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"109","DOI":"10.1126\/science.1166673","article-title":"Widespread changes in synaptic markers as a function of sleep and wakefulness in Drosophila","volume":"324","author":"GF Gilestro","year":"2009","journal-title":"Science"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"3410","DOI":"10.1073\/pnas.0507313103","article-title":"AMPA receptor downscaling at the onset of Alzheimer's disease pathology in double knockin mice","volume":"103","author":"EH Chang","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"12011","DOI":"10.1073\/pnas.0914984107","article-title":"ApoE4 reduces glutamate receptor function and synaptic plasticity by selectively impairing ApoE receptor recycling","volume":"107","author":"Y Chen","year":"2010","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"5644","DOI":"10.1073\/pnas.0600549103","article-title":"Apolipoprotein E4: a causative factor and therapeutic target in neuropathology, including Alzheimer's disease","volume":"103","author":"RW Mahley","year":"2006","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"850","DOI":"10.1038\/nrn2009","article-title":"Reelin, lipoprotein receptors and synaptic plasticity","volume":"7","author":"J Herz","year":"2006","journal-title":"Nat Rev Neurosci"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"8209","DOI":"10.1523\/JNEUROSCI.1951-05.2005","article-title":"Reelin modulates NMDA receptor activity in cortical neurons","volume":"25","author":"Y Chen","year":"2005","journal-title":"J Neurosci"},{"key":"ref83","doi-asserted-by":"crossref","first-page":"441","DOI":"10.1152\/physiolgenomics.00275.2006","article-title":"Macromolecule biosynthesis: a key function of sleep","volume":"31","author":"M Mackiewicz","year":"2007","journal-title":"Physiol Genomics"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"447","DOI":"10.1093\/sleep\/25.4.437","article-title":"A distinctive interaction between memory and chronic daytime somnolence in asymptomatic APOE e4 homozygotes","volume":"25","author":"RJ Caselli","year":"2002","journal-title":"Sleep"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1177\/0891988703261994","article-title":"Sleep\/wake disruption in Alzheimer's disease: APOE status and longitudinal course","volume":"17","author":"JA Yesavage","year":"2004","journal-title":"J Geriatr Psychiatry Neurol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/B978-0-444-53752-2.00012-6","article-title":"Age-related changes in the cognitive function of sleep","volume":"191","author":"EF Pace-Schott","year":"2011","journal-title":"Prog Brain Res"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1093\/sleep\/9.1.66","article-title":"Significance of slow wave sleep: considerations from a clinical viewpoint","volume":"9","author":"R Spiegel","year":"1986","journal-title":"Sleep"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"1159","DOI":"10.1097\/WNR.0b013e32830867c4","article-title":"Is there a link between sleep changes and memory in Alzheimer's disease?","volume":"19","author":"G Rauchs","year":"2008","journal-title":"Neuroreport"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1111\/j.1365-2869.2008.00634.x","article-title":"Changes in the density of stage 2 sleep spindles following motor learning in young and older adults","volume":"17","author":"KR Peters","year":"2008","journal-title":"J Sleep Res"},{"key":"ref90","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1212\/WNL.32.4.407","article-title":"Effect of height on nerve conduction velocity","volume":"32","author":"R Soudmand","year":"1982","journal-title":"Neurology"},{"key":"ref91","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/0166-4328(95)00005-E","article-title":"An integrative analysis to sleep functions","volume":"69","author":"ZJ Cai","year":"1995","journal-title":"Behav Brain Res"},{"key":"ref92","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1046\/j.1365-2869.1999.00154.x","article-title":"Word recall correlates with sleep cycles in elderly subjects","volume":"8","author":"G Mazzoni","year":"1999","journal-title":"J Sleep Res"},{"key":"ref93","doi-asserted-by":"crossref","first-page":"283","DOI":"10.1016\/0022-3956(74)90011-9","article-title":"Changes in sleep cycle patterns with age","volume":"10","author":"I Feinberg","year":"1974","journal-title":"J Psychiatr Res"},{"key":"ref94","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1111\/j.1365-2869.1993.tb00090.x","article-title":"Symposium: Normal and abnormal REM sleep regulation: Dreaming and REM sleep","volume":"2","author":"D Foulkes","year":"1993","journal-title":"J Sleep Res"},{"key":"ref95","doi-asserted-by":"crossref","first-page":"7883","DOI":"10.1523\/JNEUROSCI.1265-08.2008","article-title":"Sequence reactivation in the hippocampus is impaired in aged rats","volume":"28","author":"JL Gerrard","year":"2008","journal-title":"J Neurosci"},{"key":"ref96","doi-asserted-by":"crossref","first-page":"e18387","DOI":"10.1371\/journal.pone.0018387","article-title":"Deep sleep and parietal cortex gene expression changes are related to cognitive deficits with age","volume":"6","author":"HM Buechel","year":"2011","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0191281","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,26]],"date-time":"2020-10-26T03:47:39Z","timestamp":1603684059000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0191281"}},"subtitle":[],"editor":[{"given":"Stephen D","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,25]]},"references-count":96,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0191281","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,25]]}}}