{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T03:49:09Z","timestamp":1788839349132,"version":"build-2803163510"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T00:00:00Z","timestamp":1516665600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0191465","type":"journal-article","created":{"date-parts":[[2018,1,23]],"date-time":"2018-01-23T18:29:07Z","timestamp":1516732147000},"page":"e0191465","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":6,"title":["Does directly administered antiretroviral therapy represent good value for money in sub-Saharan Africa? A cost-utility and value of information analysis"],"prefix":"10.1371","volume":"13","author":[{"given":"Rashidah T.","family":"Uthman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Sutton","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Louise J.","family":"Jackson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8567-3081","authenticated-orcid":true,"given":"Olalekan A.","family":"Uthman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,23]]},"reference":[{"key":"ref1","unstructured":"Fact sheet, Global Statistics [Internet]. 2014. Available from: http:\/\/www.unaids.org\/en\/resources\/campaigns\/2014\/2014gapreport\/factsheet<\/ext-link>."},{"key":"ref2","unstructured":"UNAID Gap Report [Internet]. 2014. Available from: http:\/\/www.unaids.org\/en\/resources\/campaigns\/2014\/2014gapreport\/factsheet<\/ext-link>."},{"key":"ref3","unstructured":"Regional Fact Sheets [Internet]. 2012. Available from: http:\/\/www.unaids.org\/sites\/default\/files\/en\/media\/unaids\/contentassets\/documents\/epidemiology\/2012\/gr2012\/2012_FS_regional_ssa_en.pdf<\/ext-link>."},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1001\/jama.300.5.555","article-title":"Antiretroviral treatment of adult HIV infection: 2008 recommendations of the International AIDS Society-USA panel","volume":"300","author":"SM Hammer","year":"2008","journal-title":"Jama"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1097\/QAI.0b013e3181d9a330","article-title":"Effect of directly observed therapy for highly active antiretroviral therapy on virologic, immunologic, and adherence outcomes: a meta-analysis and systematic review","volume":"54","author":"JE Hart","year":"2010","journal-title":"Journal of acquired immune deficiency syndromes (1999)"},{"issue":"Suppl 1","key":"ref6","doi-asserted-by":"crossref","first-page":"S127","DOI":"10.1097\/01.qai.0000248349.25630.3d","article-title":"Treatment supporter to improve adherence to antiretroviral therapy in HIV-infected South African adults. A qualitative study","volume":"43","author":"JB Nachega","year":"2006","journal-title":"Journal of acquired immune deficiency syndromes (1999)"},{"issue":"13","key":"ref7","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1056\/NEJM199803263381301","article-title":"Declining morbidity and mortality among patients with advanced human immunodeficiency virus infection. HIV Outpatient Study Investigators","volume":"338","author":"FJ Palella Jr.","year":"1998","journal-title":"The New England journal of medicine"},{"issue":"1","key":"ref8","doi-asserted-by":"crossref","first-page":"47","DOI":"10.1097\/00042560-200109010-00008","article-title":"Trust and the acceptance of and adherence to antiretroviral therapy","volume":"28","author":"FL Altice","year":"2001","journal-title":"Journal of acquired immune deficiency syndromes (1999)"},{"issue":"1","key":"ref9","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1080\/09540120412331305098","article-title":"Quality of life in HIV-infected individuals receiving antiretroviral therapy is related to adherence","volume":"17","author":"SB Mannheimer","year":"2005","journal-title":"AIDS care"},{"issue":"6","key":"ref10","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1001\/jama.296.6.679","article-title":"Adherence to antiretroviral therapy in sub-Saharan Africa and North America: a meta-analysis","volume":"296","author":"EJ Mills","year":"2006","journal-title":"Jama"},{"issue":"2\u20133","key":"ref11","doi-asserted-by":"crossref","first-page":"192","DOI":"10.1016\/j.drugalcdep.2010.07.025","article-title":"Directly observed antiretroviral therapy improves adherence and viral load in drug users attending methadone maintenance clinics: a randomized controlled trial","volume":"113","author":"KM Berg","year":"2011","journal-title":"Drug and alcohol dependence"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1365-2648.2007.04526.x","article-title":"Health literacy, complication awareness, and diabetic control in patients with type 2 diabetes mellitus","volume":"62","author":"YH Tang","year":"2008","journal-title":"Journal of advanced nursing"},{"issue":"Suppl 1","key":"ref13","doi-asserted-by":"crossref","first-page":"S23","DOI":"10.1097\/01.qai.0000248342.05438.52","article-title":"Efficacy of interventions in improving highly active antiretroviral therapy adherence and HIV-1 RNA viral load. A meta-analytic review of randomized controlled trials","volume":"43","author":"JM Simoni","year":"2006","journal-title":"Journal of acquired immune deficiency syndromes (1999)"},{"key":"ref14","year":"1994"},{"issue":"9707","key":"ref15","doi-asserted-by":"crossref","first-page":"2064","DOI":"10.1016\/S0140-6736(09)61671-8","article-title":"Directly observed antiretroviral therapy: a systematic review and meta-analysis of randomised clinical trials","volume":"374","author":"N Ford","year":"2009","journal-title":"Lancet"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1177\/0272989X08315241","article-title":"The half-cycle correction explained: two alternative pedagogical approaches","volume":"28","author":"DM Naimark","year":"2008","journal-title":"Med Decis Making"},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"961","DOI":"10.1177\/0272989X13501558","article-title":"The half-cycle correction revisited: redemption of a kludge","volume":"33","author":"DM Naimark","year":"2013","journal-title":"Med Decis Making"},{"issue":"9585","key":"ref18","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/S0140-6736(07)60948-9","article-title":"Normalisation of CD4 counts in patients with HIV-1 infection and maximum virological suppression who are taking combination antiretroviral therapy: an observational cohort study","volume":"370","author":"A Mocroft","year":"2007","journal-title":"Lancet"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1002\/(SICI)1099-1050(200004)9:3<235::AID-HEC502>3.0.CO;2-O","article-title":"Development of WHO guidelines on generalized cost-effectiveness analysis","volume":"9","author":"CJ Murray","year":"2000","journal-title":"Health economics"},{"issue":"7525","key":"ref20","doi-asserted-by":"crossref","first-page":"1137","DOI":"10.1136\/bmj.331.7525.1137","article-title":"Methods to assess the costs and health effects of interventions for improving health in developing countries","volume":"331","author":"Evans DB","year":"2005","journal-title":"BMJ (Clinical research ed)"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"269","DOI":"10.6339\/JDS.2013.11(2).1136","article-title":"Modelling Progression of HIV\/AIDS Disease Stages Using Semi-Markov Processes","volume":"11","author":"AT Goshu","year":"2013","journal-title":"Data Science"},{"key":"ref22","doi-asserted-by":"crossref","DOI":"10.1093\/oso\/9780198526629.001.0001","article-title":"Decision Modelling for Health Economic Evaluation","author":"AH Briggs","year":"2006"},{"key":"ref23","article-title":"The ASSA2008 AIDS and Demographic model","year":"2008"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"1887","DOI":"10.1097\/QAD.0b013e32833b25ed","article-title":"Cost-effectiveness of routine and low-cost CD4 T-cell count compared with WHO clinical staging of HIV to guide initiation of antiretroviral therapy in resource-limited settings","volume":"24","author":"E Athan","year":"2010","journal-title":"AIDS (London, England)"},{"issue":"2","key":"ref25","doi-asserted-by":"crossref","first-page":"271","DOI":"10.1016\/S0167-6296(01)00130-8","article-title":"The estimation of a preference-based measure of health from the SF-36","volume":"21","author":"J Brazier","year":"2002","journal-title":"Journal of health economics"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"1115","DOI":"10.1016\/S0895-4356(98)00103-6","article-title":"Deriving a preference-based single index from the UK SF-36 Health Survey","volume":"51","author":"J Brazier","year":"1998","journal-title":"Journal of clinical epidemiology"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"579","DOI":"10.1080\/09540120412331319714","article-title":"An investigation into the health-related quality of life of individuals living with HIV who are receiving HAART","volume":"17","author":"J Jelsma","year":"2005","journal-title":"AIDS care"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1186\/1741-7015-12-46","article-title":"Comparative effectiveness and cost-effectiveness of antiretroviral therapy and pre-exposure prophylaxis for HIV prevention in South Africa","volume":"12","author":"SS Alistar","year":"2014","journal-title":"BMC medicine"},{"key":"ref29","unstructured":"Medecins SF. UNTANGLING THE WEB OF ANTIRETROVIRAL PRICE REDUCTIONS 2014 [March 15, 2015]. 17:[Available from: http:\/\/www.msfaccess.org\/content\/untangling-web-antiretroviral-price-reductions-17th-edition-%E2%80%93-july-2014<\/ext-link>."},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e19","DOI":"10.4081\/jphia.2011.e19","article-title":"The provider cost of treating tuberculosis in Bauchi, Nigeria","volume":"2","author":"N Umar","year":"2011","journal-title":"Public Health in Africa"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1097\/QAI.0b013e3181342564","article-title":"Cost-effectiveness of alternative strategies for initiating and monitoring highly active antiretroviral therapy in the developing world","volume":"46","author":"A Vijayaraghavan","year":"2007","journal-title":"Journal of acquired immune deficiency syndromes (1999)"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"e4","DOI":"10.1371\/journal.pmed.0030004","article-title":"Cost-effectiveness of highly active antiretroviral therapy in South Africa","volume":"3","author":"M Badri","year":"2006","journal-title":"PLoS medicine"},{"key":"ref33","unstructured":"Coin News Media. US Inflation Calculator: http:\/\/www.usinflationcalculator.com\/<\/ext-link> [accessed November 20, 2015] 2015."},{"key":"ref34","article-title":"The Global State of Harm Reduction 2014","year":"2014"},{"issue":"Suppl 1","key":"ref35","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1186\/1471-2458-9-S1-S5","article-title":"HIV prevention cost-effectiveness: a systematic review","volume":"9","author":"O Galarraga","year":"2009","journal-title":"BMC public health"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"e10154","DOI":"10.1371\/journal.pone.0010154","article-title":"The cost-effectiveness of directly observed highly-active antiretroviral therapy in the third trimester in HIV-infected pregnant women","volume":"5","author":"CJ McCabe","year":"2010","journal-title":"PloS one"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"d1766","DOI":"10.1136\/bmj.d1766","article-title":"Economic evaluation using decision analytical modelling: design, conduct, analysis, and reporting","volume":"342","author":"S Petrou","year":"2011","journal-title":"BMJ (Clinical research ed)"},{"issue":"4","key":"ref38","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1007\/s10198-007-0078-x","article-title":"Decision-analytical modelling in health-care economic evaluations","volume":"9","author":"X Sun","year":"2008","journal-title":"The European journal of health economics: HEPAC: health economics in prevention and care"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1177\/0272989X02238300","article-title":"A meta-analysis of utility estimates for HIV\/AIDS","volume":"22","author":"TO Tengs","year":"2002","journal-title":"Med Decis Making"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0191465","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,6,30]],"date-time":"2024-06-30T18:04:49Z","timestamp":1719770689000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0191465"}},"subtitle":[],"editor":[{"given":"Marcel","family":"Yotebieng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,23]]},"references-count":39,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,23]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0191465","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,23]]}}}