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Washington (DC)2007."},{"key":"ref2","unstructured":"2016 Premature Birth Report Card. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.marchofdimes.org\/materials\/premature-birth-report-card-united-states.pdf2016\" xlink:type=\"simple\">http:\/\/www.marchofdimes.org\/materials\/premature-birth-report-card-united-states.pdf2016<\/ext-link>."},{"issue":"6198","key":"ref3","doi-asserted-by":"crossref","first-page":"760","DOI":"10.1126\/science.1251816","article-title":"Preterm labor: one syndrome, many causes","volume":"345","author":"R Romero","year":"2014","journal-title":"Science"},{"issue":"10","key":"ref4","first-page":"1247","article-title":"Bacterial vaginosis and spontaneous preterm birth","volume":"45","author":"G Brabant","year":"2016","journal-title":"Journal de gynecologie, obstetrique et biologie de la 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