{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T19:04:58Z","timestamp":1789153498810,"version":"build-2803163510"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"1","license":[{"start":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T00:00:00Z","timestamp":1516838400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Fonds de Recherche du Qu\u00e9bec","award":["Sant\u00e9-FRQS-ARQ #34939"],"award-info":[{"award-number":["Sant\u00e9-FRQS-ARQ #34939"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0191822","type":"journal-article","created":{"date-parts":[[2018,1,25]],"date-time":"2018-01-25T18:46:51Z","timestamp":1516906011000},"page":"e0191822","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Diagnostic performance of intravoxel incoherent motion diffusion-weighted imaging and dynamic contrast-enhanced MRI for assessment of anal fistula activity"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2939-7956","authenticated-orcid":true,"given":"Philippe","family":"Lefran\u00e7ois","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Zummo-Soucy","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Damien","family":"Olivi\u00e9","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean-S\u00e9bastien","family":"Billiard","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guillaume","family":"Gilbert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juliette","family":"Garel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emmanuel","family":"Vis\u00e9e","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Perrine","family":"Manchec","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"An","family":"Tang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,1,25]]},"reference":[{"issue":"4","key":"ref1","first-page":"219","article-title":"Fistula-in-ano in a defined population. Incidence and epidemiological aspects","volume":"73","author":"P Sainio","year":"1984","journal-title":"Annales chirurgiae et gynaecologiae"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"175","DOI":"10.1148\/rg.321115040","article-title":"MR imaging evaluation of perianal fistulas: spectrum of imaging features","volume":"32","author":"J de Miguel Criado","year":"2012","journal-title":"Radiographics: a review publication of the Radiological Society of North America, Inc."},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"1381","DOI":"10.1136\/gutjnl-2013-306709","article-title":"A global consensus on the classification, diagnosis and multidisciplinary treatment of perianal fistulising Crohn's disease","volume":"63","author":"KB Gecse","year":"2014","journal-title":"Gut"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1148\/radiol.2391041043","article-title":"Imaging of fistula in ano","volume":"239","author":"S Halligan","year":"2006","journal-title":"Radiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1186\/s40001-014-0078-0","article-title":"Magnetic resonance imaging and endorectal ultrasound for diagnosis of rectal lesions","volume":"20","author":"F Burdan","year":"2015","journal-title":"European journal of medical research"},{"issue":"2","key":"ref6","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1148\/radiology.200.2.8685344","article-title":"Fistula in ano: endoanal sonography versus endoanal MR imaging in classification","volume":"200","author":"SM Hussain","year":"1996","journal-title":"Radiology"},{"issue":"5","key":"ref7","doi-asserted-by":"crossref","first-page":"999","DOI":"10.2214\/ajr.152.5.999","article-title":"Diagnosis of fistulae and sinus tracts in patients with Crohn disease: value of MR imaging","volume":"152","author":"G Koelbel","year":"1989","journal-title":"AJR American journal of roentgenology"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"1064","DOI":"10.1053\/gast.2001.28676","article-title":"A comparison of endoscopic ultrasound, magnetic resonance imaging, and exam under anesthesia for evaluation of Crohn's perianal fistulas","volume":"121","author":"DA Schwartz","year":"2001","journal-title":"Gastroenterology"},{"issue":"6","key":"ref9","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1097\/RCT.0b013e31828bea16","article-title":"Diagnostic value of diffusion-weighted magnetic resonance imaging in pelvic abscesses","volume":"37","author":"TL Nguyen","year":"2013","journal-title":"Journal of computer assisted tomography"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"125","DOI":"10.1002\/jmri.22804","article-title":"Diffusion-weighted MRI: role in detecting abdominopelvic internal fistulas and sinus tracts","volume":"35","author":"C Schmid-Tannwald","year":"2012","journal-title":"Journal of magnetic resonance imaging: JMRI"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1055\/s-2008-1081000","article-title":"Magnetic resonance imaging in the management of anal fistula and anorectal sepsis","volume":"21","author":"M Joyce","year":"2008","journal-title":"Clinics in colon and rectal surgery"},{"issue":"12","key":"ref12","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1155\/2011\/931316","article-title":"Update on anal fistulae: surgical perspectives for the gastroenterologist","volume":"25","author":"H Tabry","year":"2011","journal-title":"Canadian journal of gastroenterology = Journal canadien de gastroenterologie"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"623","DOI":"10.1148\/radiographics.20.3.g00mc15623","article-title":"MR imaging classification of perianal fistulas and its implications for patient management","volume":"20","author":"J Morris","year":"2000","journal-title":"Radiographics: a review publication of the Radiological Society of North America, Inc."},{"issue":"9346","key":"ref14","doi-asserted-by":"crossref","first-page":"1661","DOI":"10.1016\/S0140-6736(02)11605-9","article-title":"Effect of MRI on clinical outcome of recurrent fistula-in-ano","volume":"360","author":"G Buchanan","year":"2002","journal-title":"Lancet"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"674","DOI":"10.1148\/radiol.2333031724","article-title":"Clinical examination, endosonography, and MR imaging in preoperative assessment of fistula in ano: comparison with outcome-based reference standard","volume":"233","author":"GN Buchanan","year":"2004","journal-title":"Radiology"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1148\/radiol.2016151491","article-title":"MR Imaging of Perianal Crohn Disease","volume":"282","author":"SP Sheedy","year":"2017","journal-title":"Radiology"},{"issue":"8816","key":"ref17","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1016\/0140-6736(92)91472-K","article-title":"Magnetic resonance imaging of anal fistulae","volume":"340","author":"PJ Lunniss","year":"1992","journal-title":"Lancet"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1148\/radiol.15141662","article-title":"Perianal Sepsis in Hematologic Malignancy: MR Imaging Appearances and Distinction from Cryptoglandular Infection in Immunocompetent Patients","volume":"276","author":"AA Plumb","year":"2015","journal-title":"Radiology"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1002\/jmri.10436","article-title":"Assessment of anal fistulas with high-resolution subtraction MR-fistulography: comparison with surgical findings","volume":"19","author":"O Schaefer","year":"2004","journal-title":"Journal of magnetic resonance imaging: JMRI"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"735","DOI":"10.2214\/ajr.167.3.8751692","article-title":"Dynamic contrast-enhanced MR imaging of perianal fistulas","volume":"167","author":"JA Spencer","year":"1996","journal-title":"AJR American journal of roentgenology"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"880","DOI":"10.1002\/jmri.21725","article-title":"Free-breathing diffusion-weighted imaging for the assessment of inflammatory activity in Crohn's disease","volume":"29","author":"S Kiryu","year":"2009","journal-title":"Journal of magnetic resonance imaging: JMRI"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"1021","DOI":"10.1002\/jmri.21934","article-title":"Diffusion-weighted MRI: a new tool for the diagnosis of fistula in ano","volume":"30","author":"M Hori","year":"2009","journal-title":"Journal of magnetic resonance imaging: JMRI"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/j.ejrad.2011.06.052","article-title":"Diffusion-weighted MRI for evaluating perianal fistula activity: feasibility study","volume":"81","author":"T Yoshizako","year":"2012","journal-title":"European journal of radiology"},{"issue":"11","key":"ref24","doi-asserted-by":"crossref","first-page":"2906","DOI":"10.1007\/s00330-014-3302-y","article-title":"Diffusion-weighted MR imaging for the diagnosis of abscess complicating fistula-in-ano: preliminary experience","volume":"24","author":"A Dohan","year":"2014","journal-title":"Eur Radiol"},{"key":"ref25","article-title":"Diffusion-weighted MRI in Crohn's disease: Current status and recommendations","author":"A Dohan","year":"2016","journal-title":"Journal of magnetic resonance imaging: JMRI"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"e29084","DOI":"10.5812\/iranjradiol.29084","article-title":"Perianal Fistula With and Without Abscess: Assessment of Fistula Activity Using Diffusion-Weighted Magnetic Resonance Imaging","volume":"12","author":"S Bakan","year":"2015","journal-title":"Iranian journal of radiology: a quarterly journal published by the Iranian Radiological Society"},{"issue":"4","key":"ref27","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.2214\/AJR.08.1038.1","article-title":"MRI safety update 2008: part 1, MRI contrast agents and nephrogenic systemic fibrosis","volume":"191","author":"FG Shellock","year":"2008","journal-title":"AJR American journal of roentgenology"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1148\/radiology.168.2.3393671","article-title":"Separation of diffusion and perfusion in intravoxel incoherent motion MR imaging","volume":"168","author":"D Le Bihan","year":"1988","journal-title":"Radiology"},{"issue":"2","key":"ref29","first-page":"147","article-title":"Dynamic contrast-enhanced magnetic resonance imaging: fundamentals and application to the evaluation of the peripheral perfusion","volume":"4","author":"Y Gordon","year":"2014","journal-title":"Cardiovascular diagnosis and therapy"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"124301","DOI":"10.1118\/1.4898202","article-title":"Models and methods for analyzing DCE-MRI: a review","volume":"41","author":"F Khalifa","year":"2014","journal-title":"Med Phys"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"1384","DOI":"10.2214\/AJR.04.1454","article-title":"Dynamic contrast-enhanced MRI of the bowel wall for assessment of disease activity in Crohn's disease","volume":"186","author":"J Florie","year":"2006","journal-title":"AJR American journal of roentgenology"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1007\/s00261-010-9624-6","article-title":"Dynamic MRI of the small bowel: usefulness of quantitative contrast-enhancement parameters and time-signal intensity curves for differentiating between active and inactive Crohn's disease","volume":"35","author":"S Giusti","year":"2010","journal-title":"Abdominal imaging"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.clinimag.2010.09.003","article-title":"Evaluation of an MRI-based score of disease activity in perianal fistulizing Crohn's disease","volume":"35","author":"K Horsthuis","year":"2011","journal-title":"Clinical imaging"},{"key":"ref34","article-title":"Magnetization transfer ratio for the assessment of perianal fistula activity in Crohn's disease","author":"C Pinson","year":"2016","journal-title":"Eur Radiol"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1002\/jmri.22435","article-title":"Active Crohn's disease in the small bowel: evaluation by diffusion weighted imaging and quantitative dynamic contrast enhanced MR imaging","volume":"33","author":"A Oto","year":"2011","journal-title":"Journal of magnetic resonance imaging: JMRI"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1007\/s00330-010-2017-y","article-title":"Liver diffusion-weighted MR imaging: the tower of Babel?","volume":"21","author":"B Guiu","year":"2011","journal-title":"Eur Radiol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1016\/S0002-9270(02)05909-9","article-title":"Magnetic resonance imaging of the effects of infliximab on perianal fistulizing Crohn's disease","volume":"98","author":"G Van Assche","year":"2003","journal-title":"The American journal of gastroenterology"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1080\/02841850701630300","article-title":"Post-processing of dynamic gadolinium-enhanced magnetic resonance imaging exams of the liver: explanation and potential clinical applications for color-coded qualitative and quantitative analysis","volume":"49","author":"L Wang","year":"2008","journal-title":"Acta radiologica"},{"issue":"5","key":"ref39","doi-asserted-by":"crossref","first-page":"1033","DOI":"10.1007\/s00261-012-9965-4","article-title":"MRI of perianal fistulas: bridging the radiological-surgical divide","volume":"38","author":"KL Gage","year":"2013","journal-title":"Abdominal imaging"},{"issue":"10","key":"ref40","doi-asserted-by":"crossref","first-page":"1396","DOI":"10.1002\/bjs.1800831022","article-title":"Prospective evaluation of dynamic contrast enhanced magnetic resonance imaging in the evaluation of fistula in ano","volume":"83","author":"IJ Beckingham","year":"1996","journal-title":"The British journal of surgery"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"W170","DOI":"10.2214\/AJR.11.8276","article-title":"Dynamic contrast-enhanced MRI in determining disease activity in perianal fistulizing Crohn disease: a pilot study","volume":"200","author":"ML Ziech","year":"2013","journal-title":"AJR American journal of roentgenology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0191822","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T05:27:43Z","timestamp":1589002063000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0191822"}},"subtitle":[],"editor":[{"given":"Quan","family":"Jiang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,1,25]]},"references-count":41,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2018,1,25]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0191822","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,1,25]]}}}