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BioEdit: a user-friendly biological sequence alignment editor and analysis program for Windows 95\/98\/NT. 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Microbiol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"1207","DOI":"10.1093\/clinids\/20.5.1207","article-title":"Disseminated Acanthamoeba infection in patients with AIDS: case reports and review","volume":"20","author":"JP Sison","year":"1995","journal-title":"Clin Infect Dis"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"834","DOI":"10.1038\/sj.bjp.0701138","article-title":"Antinociceptive and immunosuppressive effects of opiate drugs: a structure\u2010related activity study","volume":"121","author":"P Sacerdote","year":"1997","journal-title":"Br J Pharmacol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1038\/nature01470","article-title":"Antibody neutralization and escape by HIV-1","volume":"422","author":"X Wei","year":"2003","journal-title":"Nature"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"3907","DOI":"10.4049\/jimmunol.138.11.3907","article-title":"Opioid-mediated suppression of cultured peripheral blood 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