{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,27]],"date-time":"2026-01-27T22:37:54Z","timestamp":1769553474882,"version":"3.49.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003725","name":"National Research Foundation of Korea","doi-asserted-by":"publisher","award":["2017RA2A2A07001272"],"award-info":[{"award-number":["2017RA2A2A07001272"]}],"id":[{"id":"10.13039\/501100003725","id-type":"DOI","asserted-by":"publisher"}]},{"name":"World Class Smart Lab research grant"},{"name":"Grant from Asan institute for Life sciences","award":["2016-329"],"award-info":[{"award-number":["2016-329"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0192430","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T18:41:14Z","timestamp":1518720074000},"page":"e0192430","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":21,"title":["EW-7197 eluting nano-fiber covered self-expandable metallic stent to prevent granulation tissue formation in a canine urethral model"],"prefix":"10.1371","volume":"13","author":[{"given":"Kichang","family":"Han","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Hoon","family":"Park","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Su-Geun","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0355-0449","authenticated-orcid":true,"given":"Deok Hee","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiaywei","family":"Tsauo","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kun Yung","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Min Tae","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung Gwon","family":"Gang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dae-Kee","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dong-Hyun","family":"Kim","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ho-Young","family":"Song","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1016\/j.gie.2007.04.031","article-title":"Self-expanding plastic stents in treatment of benign esophageal conditions","volume":"67","author":"AN Holm","year":"2008","journal-title":"Gastrointest Endosc"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"4249","DOI":"10.1007\/s00330-016-4289-3","article-title":"Over-the-wire versus through-the-scope stents for the palliation of malignant gastric outlet obstruction: A retrospective comparison study","volume":"26","author":"JH Park","year":"2016","journal-title":"Eur Radiol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1380","DOI":"10.2214\/AJR.10.6306","article-title":"Polytetrafluoroethylene-covered retrievable expandable nitinol stents for malignant esophageal obstructions: factors influencing the outcome of 270 patients","volume":"199","author":"JH Park","year":"2012","journal-title":"AJR Am J Roentgenol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1148\/radiology.193.3.7526414","article-title":"Covered, expandable esophageal metallic stent tubes: experiences in 119 patients","volume":"193","author":"HY Song","year":"1994","journal-title":"Radiology"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1148\/radiol.2262012160","article-title":"Recurrent traumatic urethral strictures near the external sphincter: treatment with a covered, retrievable, expandable nitinol stent\u2014initial results","volume":"226","author":"HY Song","year":"2003","journal-title":"Radiology"},{"key":"ref6","first-page":"3415","article-title":"Management of recurrent bulbar urethral stricture-a 54 patients study with Allium bulbar urethral stent (BUS)","volume":"7","author":"M Culha","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"130","DOI":"10.1016\/j.juro.2013.01.014","article-title":"Effect of a temporary thermo-expandable stent on urethral patency after dilation or internal urethrotomy for recurrent bulbar urethral stricture: results from a 1-year randomized trial","volume":"190","author":"GH Jordan","year":"2013","journal-title":"J Urol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"W55","DOI":"10.2214\/AJR.11.6792","article-title":"Retrospective comparison of internally and externally covered retrievable stent placement for patients with benign urethral strictures caused by traumatic injury","volume":"198","author":"HK Na","year":"2012","journal-title":"AJR Am J Roentgenol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1378\/chest.129.5.1298","article-title":"High-level expression of matrix-associated transforming growth factor-beta1 in benign airway stenosis","volume":"129","author":"C Karagiannidis","year":"2006","journal-title":"Chest"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"123","DOI":"10.2174\/1566523044578004","article-title":"TGF-beta: a fibrotic factor in wound scarring and a potential target for anti-scarring gene therapy","volume":"4","author":"W Liu","year":"2004","journal-title":"Curr Gene Ther"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2301","DOI":"10.1046\/j.1523-1755.2000.00414.x","article-title":"Antibody to transforming growth factor-beta ameliorates tubular apoptosis in unilateral ureteral obstruction","volume":"58","author":"A Miyajima","year":"2000","journal-title":"Kidney Int"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1053\/jhep.2002.32673","article-title":"Dose-dependent inhibition of hepatic fibrosis in mice by a TGF-beta soluble receptor: implications for antifibrotic therapy","volume":"35","author":"Y Yata","year":"2002","journal-title":"Hepatology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"4213","DOI":"10.1021\/jm500115w","article-title":"Discovery of N-((4-([1,2,4]triazolo[1,5-a]pyridin-6-yl)-5-(6-methylpyridin-2-yl)-1H-imidazol-2 -yl)methyl)-2-fluoroaniline (EW-7197): a highly potent, selective, and orally bioavailable inhibitor of TGF-beta type I receptor kinase as cancer immunotherapeutic\/antifibrotic agent","volume":"57","author":"CH Jin","year":"2014","journal-title":"J Med Chem"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"5228","DOI":"10.1016\/j.bmcl.2015.09.058","article-title":"Synthesis and biological evaluation of 5-(fluoro-substituted-6-methylpyridin-2-yl)-4-([1,2,4]triazolo[1,5-a]pyridin-6-yl) imidazoles as inhibitors of transforming growth factor-beta type I receptor kinase","volume":"25","author":"M Krishnaiah","year":"2015","journal-title":"Bioorg Med Chem Lett"},{"key":"ref15","article-title":"EW-7197, an activin-like kinase 5 inhibitor, suppresses granulation tissue after stent placement in rat esophagus","author":"EJ Jun","year":"2017","journal-title":"Gastrointest Endosc"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2023","DOI":"10.1007\/s00018-014-1798-6","article-title":"EW-7197 inhibits hepatic, renal, and pulmonary fibrosis by blocking TGF-beta\/Smad and ROS signaling","volume":"72","author":"SA Park","year":"2015","journal-title":"Cell Mol Life Sci"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1210","DOI":"10.1007\/s13233-011-1112-5","article-title":"Polymeric nanofiber coated esophageal stent for sustained delivery of an anticancer drug","volume":"19","author":"CG Park","year":"2011","journal-title":"Macromolecular research"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1148\/radiol.2231010734","article-title":"Covered, retrievable, expandable urethral nitinol stent: feasibility study in dogs","volume":"223","author":"GY Ko","year":"2002","journal-title":"Radiology"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1257","DOI":"10.1016\/j.jvir.2014.03.023","article-title":"Polydioxanone biodegradable stent placement in a canine urethral model: analysis of inflammatory reaction and biodegradation","volume":"25","author":"JH Park","year":"2014","journal-title":"J Vasc Interv Radiol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"438","DOI":"10.1148\/radiol.2342040006","article-title":"Tissue hyperplasia: influence of a paclitaxel-eluting covered stent\u2014preliminary study in a canine urethral model","volume":"234","author":"JH Shin","year":"2005","journal-title":"Radiology"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1517","DOI":"10.2214\/AJR.07.2149","article-title":"Management of recurrent urethral strictures with covered retrievable expandable nitinol stents: long-term results","volume":"189","author":"EK Choi","year":"2007","journal-title":"AJR Am J Roentgenol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"396","DOI":"10.1148\/radiol.12120361","article-title":"IN-1233-eluting covered metallic stent to prevent hyperplasia: experimental study in a rabbit esophageal model","volume":"267","author":"EY Kim","year":"2013","journal-title":"Radiology"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1007\/s10544-014-9894-9","article-title":"Paclitaxel-eluting nanofiber-covered self-expanding nonvascular stent for palliative chemotherapy of gastrointestinal cancer and its related stenosis","volume":"16","author":"SY Kim","year":"2014","journal-title":"Biomed Microdevices"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"3603","DOI":"10.1016\/j.biomaterials.2011.01.070","article-title":"An acetylated polysaccharide-PTFE membrane-covered stent for the delivery of gemcitabine for treatment of gastrointestinal cancer and related stenosis","volume":"32","author":"S Moon","year":"2011","journal-title":"Biomaterials"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"790","DOI":"10.1038\/nrd3810","article-title":"Targeting the TGFbeta signalling pathway in disease","volume":"11","author":"RJ Akhurst","year":"2012","journal-title":"Nat Rev Drug Discov"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1159\/000438651","article-title":"TGF-beta Type I Receptor Kinase Inhibitor EW-7197 Suppresses Cholestatic Liver Fibrosis by Inhibiting HIF1alpha-Induced Epithelial Mesenchymal Transition","volume":"38","author":"MJ Kim","year":"2016","journal-title":"Cell Physiol Biochem"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1148\/radiol.09090670","article-title":"IN-1233, an ALK-5 inhibitor: prevention of granulation tissue formation after bare metallic stent placement in a rat urethral model","volume":"255","author":"JH Kim","year":"2010","journal-title":"Radiology"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1241","DOI":"10.1007\/s00330-004-2564-1","article-title":"Influence of a dexamethasone-eluting covered stent on tissue reaction: an experimental study in a canine bronchial model","volume":"15","author":"JH Shin","year":"2005","journal-title":"Eur Radiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0192430","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T02:07:09Z","timestamp":1588990029000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0192430"}},"subtitle":[],"editor":[{"given":"Wenguo","family":"Cui","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":28,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0192430","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]}}}