{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,7]],"date-time":"2026-04-07T18:10:51Z","timestamp":1775585451520,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T00:00:00Z","timestamp":1518134400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council of Taiwan","doi-asserted-by":"crossref","award":["NSC 98-2320-B-002-019-MY3"],"award-info":[{"award-number":["NSC 98-2320-B-002-019-MY3"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0192740","type":"journal-article","created":{"date-parts":[[2018,2,9]],"date-time":"2018-02-09T19:03:57Z","timestamp":1518203037000},"page":"e0192740","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":14,"title":["Magnolol-mediated regulation of plasma triglyceride through affecting lipoprotein lipase activity in apolipoprotein A5 knock-in mice"],"prefix":"10.1371","volume":"13","author":[{"given":"Chun-Kai","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xiu-Ru","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yen-Lin","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Woei-Horng","family":"Fang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shu-Wha","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6009-6724","authenticated-orcid":true,"given":"Sui-Yuan","family":"Chang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jau-Tsuen","family":"Kao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,2,9]]},"reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1179","DOI":"10.1016\/S0002-9149(96)00159-2","article-title":"Hypertriglyceridemia and elevated lipoprotein(a) are risk factors for major coronary events in middle-aged men","volume":"77","author":"G Assmann","year":"1996","journal-title":"Am J Cardiol"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1097\/00043798-199604000-00014","article-title":"Plasma triglyceride level is a risk factor for cardiovascular disease independent of high-density lipoprotein cholesterol level: a meta-analysis of population-based prospective studies","volume":"3","author":"JE Hokanson","year":"1996","journal-title":"J Cardiovasc Risk"},{"issue":"11","key":"ref3","doi-asserted-by":"crossref","first-page":"1029","DOI":"10.1161\/01.CIR.97.11.1029","article-title":"Triglyceride concentration and ischemic heart disease: an eight-year follow-up in the Copenhagen Male Study","volume":"97","author":"J Jeppesen","year":"1998","journal-title":"Circulation"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.atherosclerosis.2008.08.040","article-title":"Plasma triglyceride levels and risk of stroke and carotid atherosclerosis: a systematic review of the epidemiological studies","volume":"203","author":"J Labreuche","year":"2009","journal-title":"Atherosclerosis"},{"issue":"5540","key":"ref5","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1126\/science.1064852","article-title":"An apolipoprotein influencing triglycerides in humans and mice revealed by comparative sequencing","volume":"294","author":"LA Pennacchio","year":"2001","journal-title":"Science"},{"issue":"24","key":"ref6","doi-asserted-by":"crossref","first-page":"3031","DOI":"10.1093\/hmg\/11.24.3031","article-title":"Two independent apolipoprotein A5 haplotypes influence human plasma triglyceride levels","volume":"11","author":"LA Pennacchio","year":"2002","journal-title":"Hum Mol Genet"},{"issue":"24","key":"ref7","doi-asserted-by":"crossref","first-page":"3039","DOI":"10.1093\/hmg\/11.24.3039","article-title":"Relative contribution of variation within the APOC3\/A4\/A5 gene cluster in determining plasma triglycerides","volume":"11","author":"PJ Talmud","year":"2002","journal-title":"Hum Mol Genet"},{"issue":"9","key":"ref8","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1093\/clinchem\/48.9.1597","article-title":"Newly identified apolipoprotein AV gene predisposes to high plasma triglycerides in familial combined hyperlipidemia","volume":"48","author":"J Ribalta","year":"2002","journal-title":"Clin Chem"},{"issue":"19","key":"ref9","doi-asserted-by":"crossref","first-page":"2533","DOI":"10.1093\/hmg\/ddg255","article-title":"A novel genetic variant in the apolipoprotein A5 gene is associated with hypertriglyceridemia","volume":"12","author":"JT Kao","year":"2003","journal-title":"Hum Mol Genet"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1016\/j.atherosclerosis.2005.05.031","article-title":"Genetic variations of apolipoprotein A5 gene is associated with the risk of coronary artery disease among Chinese in Taiwan","volume":"185","author":"LA Hsu","year":"2006","journal-title":"Atherosclerosis"},{"issue":"1\u20132","key":"ref11","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1016\/j.cca.2011.09.045","article-title":"Functional importance of apolipoprotein A5 185G in the activation of lipoprotein lipase","volume":"413","author":"YJ Huang","year":"2012","journal-title":"Clin Chim Acta"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"549","DOI":"10.1016\/0006-2952(94)90187-2","article-title":"Magnolol and honokiol isolated from Magnolia officinalis protect rat heart mitochondria against lipid peroxidation","volume":"47","author":"YC Lo","year":"1994","journal-title":"Biochem Pharmacol"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1002\/jcb.20361","article-title":"Magnolol stimulates lipolysis in lipid-laden RAW 264.7 macrophages","volume":"94","author":"JS Chen","year":"2005","journal-title":"J Cell Biochem"},{"issue":"25\u201326","key":"ref14","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.lfs.2009.04.001","article-title":"Magnolol enhances adipocyte differentiation and glucose uptake in 3T3-L1 cells","volume":"84","author":"SS Choi","year":"2009","journal-title":"Life Sci"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"e28253","DOI":"10.1371\/journal.pone.0028253","article-title":"Molecular determinants of magnolol targeting both RXRalpha and PPARgamma","volume":"6","author":"H Zhang","year":"2011","journal-title":"PLoS One"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0021-9258(18)66011-9","article-title":"Clearing factor, a heparin-activated lipoprotein lipase. I. Isolation and characterization of the enzyme from normal rat heart","volume":"215","author":"ED Korn","year":"1955","journal-title":"J Biol Chem"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.bbrc.2004.05.003","article-title":"Mechanism of triglyceride lowering in mice expressing human apolipoprotein A5","volume":"319","author":"J Fruchart-Najib","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1101\/gr.749203","article-title":"A highly efficient recombineering-based method for generating conditional knockout mutations","volume":"13","author":"P Liu","year":"2003","journal-title":"Genome Res"},{"issue":"1\u20133","key":"ref19","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1016\/j.ejphar.2010.03.056","article-title":"In vivo efficacy of acyl CoA: diacylglycerol acyltransferase (DGAT) 1 inhibition in rodent models of postprandial hyperlipidemia","volume":"637","author":"AJ King","year":"2010","journal-title":"Eur J Pharmacol"},{"key":"ref20","article-title":"Magnolol Protects against MPTP\/MPP(+)-Induced Toxicity via Inhibition of Oxidative Stress in In Vivo and In Vitro Models of Parkinson&apos;s Disease","volume":"2012","author":"A Muroyama","year":"2012","journal-title":"Parkinsons Dis"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"559","DOI":"10.1124\/mol.109.062141","article-title":"Computer-aided discovery, validation, and mechanistic characterization of novel neolignan activators of peroxisome proliferator-activated receptor gamma","volume":"77","author":"N Fakhrudin","year":"2010","journal-title":"Mol Pharmacol"},{"issue":"19","key":"ref22","doi-asserted-by":"crossref","first-page":"5336","DOI":"10.1002\/j.1460-2075.1996.tb00918.x","article-title":"PPARalpha and PPARgamma activators direct a distinct tissue-specific transcriptional response via a PPRE in the lipoprotein lipase gene","volume":"15","author":"K Schoonjans","year":"1996","journal-title":"EMBO J"},{"key":"ref23","article-title":"The Metabolic and Molecular Bases of Inherited Disease","author":"JD Brunzell","year":"1995"},{"issue":"23","key":"ref24","doi-asserted-by":"crossref","first-page":"1265","DOI":"10.1056\/NEJM197806082982301","article-title":"Hypertriglyceridemia associated with deficiency of apolipoprotein C-II","volume":"298","author":"WC Breckenridge","year":"1978","journal-title":"N Engl J Med"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"435","DOI":"10.1111\/j.0954-6820.1986.tb03337.x","article-title":"Deficiency of hepatic lipase activity in post-heparin plasma in familial hyper-alpha-triglyceridemia","volume":"219","author":"LA Carlson","year":"1986","journal-title":"Acta Med Scand"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1016\/S0021-9150(02)00252-6","article-title":"The genetic effect of the apoprotein AV gene on the serum triglyceride level in Japanese","volume":"165","author":"T Nabika","year":"2002","journal-title":"Atherosclerosis"},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1016\/j.atherosclerosis.2005.06.026","article-title":"A genetic variant c.553G &gt; T in the apolipoprotein A5 gene is associated with an increased risk of coronary artery disease and altered triglyceride levels in a Chinese population","volume":"185","author":"Y Tang","year":"2006","journal-title":"Atherosclerosis"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1017\/S000711450774268X","article-title":"Dietary, physiological, genetic and pathological influences on postprandial lipid metabolism","volume":"98","author":"J Lopez-Miranda","year":"2007","journal-title":"Br J Nutr"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.atherosclerosis.2011.08.012","article-title":"Postprandial lipemia and cardiovascular disease risk: Interrelationships between dietary, physiological and genetic determinants","volume":"220","author":"KG Jackson","year":"2012","journal-title":"Atherosclerosis"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.atherosclerosissup.2010.03.002","article-title":"Update on genetics of postprandial lipemia","volume":"11","author":"P Perez-Martinez","year":"2010","journal-title":"Atheroscler Suppl"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1161\/01.CIR.60.3.473","article-title":"Atherogenesis: a postprandial phenomenon","volume":"60","author":"DB Zilversmit","year":"1979","journal-title":"Circulation"},{"issue":"1","key":"ref32","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1046\/j.1365-2796.2002.00926.x","article-title":"Interleukin-1 receptor antagonist is detectable in human carotid artery plaques and is related to triglyceride levels and Chlamydia pneumoniae IgA antibodies","volume":"251","author":"A Gottsater","year":"2002","journal-title":"J Intern Med"},{"issue":"6890","key":"ref33","doi-asserted-by":"crossref","first-page":"750","DOI":"10.1038\/nature00804","article-title":"Subendothelial retention of atherogenic lipoproteins in early atherosclerosis","volume":"417","author":"K Skalen","year":"2002","journal-title":"Nature"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"D332","DOI":"10.2741\/A614","article-title":"Postprandial lipoproteins and atherosclerosis","volume":"6","author":"KC Yu","year":"2001","journal-title":"Front Biosci"},{"issue":"9","key":"ref35","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1210\/jc.2011-3213","article-title":"Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline","volume":"97","author":"L Berglund","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"5","key":"ref36","doi-asserted-by":"crossref","first-page":"867","DOI":"10.1016\/j.bbalip.2011.10.002","article-title":"Serum triglycerides and risk of cardiovascular disease","volume":"1821","author":"AC Boullart","year":"2012","journal-title":"Biochim Biophys Acta"},{"issue":"11","key":"ref37","doi-asserted-by":"crossref","first-page":"1345","DOI":"10.1093\/eurheartj\/ehr112","article-title":"Triglyceride-rich lipoproteins and high-density lipoprotein cholesterol in patients at high risk of cardiovascular disease: evidence and guidance for management","volume":"32","author":"MJ Chapman","year":"2011","journal-title":"Eur Heart J"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1001\/jama.298.3.299","article-title":"Nonfasting triglycerides and risk of myocardial infarction, ischemic heart disease, and death in men and women","volume":"298","author":"BG Nordestgaard","year":"2007","journal-title":"JAMA"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1001\/jama.298.3.309","article-title":"Fasting compared with nonfasting triglycerides and risk of cardiovascular events in women","volume":"298","author":"S Bansal","year":"2007","journal-title":"JAMA"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1007\/s10654-010-9501-1","article-title":"Nonfasting triglycerides and risk of cardiovascular death in men and women from the Norwegian Counties Study","volume":"25","author":"AS Lindman","year":"2010","journal-title":"Eur J Epidemiol"},{"issue":"4","key":"ref41","doi-asserted-by":"crossref","first-page":"427","DOI":"10.1016\/j.jacc.2012.08.1026","article-title":"Remnant cholesterol as a causal risk factor for ischemic heart disease","volume":"61","author":"A Varbo","year":"2013","journal-title":"J Am Coll Cardiol"},{"issue":"24","key":"ref42","doi-asserted-by":"crossref","first-page":"1826","DOI":"10.1093\/eurheartj\/ehs431","article-title":"Genetically elevated non-fasting triglycerides and calculated remnant cholesterol as causal risk factors for myocardial infarction","volume":"34","author":"AB Jorgensen","year":"2013","journal-title":"Eur Heart J"},{"issue":"4","key":"ref43","doi-asserted-by":"crossref","first-page":"628","DOI":"10.1002\/ana.22384","article-title":"Nonfasting triglycerides, cholesterol, and ischemic stroke in the general population","volume":"69","author":"A Varbo","year":"2011","journal-title":"Ann Neurol"},{"issue":"11","key":"ref44","doi-asserted-by":"crossref","first-page":"648","DOI":"10.1038\/nrcardio.2013.140","article-title":"Demystifying the management of hypertriglyceridaemia","volume":"10","author":"GF Watts","year":"2013","journal-title":"Nat Rev Cardiol"},{"issue":"17","key":"ref45","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1056\/NEJMoa1001282","article-title":"Effects of combination lipid therapy in type 2 diabetes mellitus","volume":"362","author":"AS Group","year":"2010","journal-title":"N Engl J Med"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"493","DOI":"10.2337\/dc08-1543","article-title":"Effects of fenofibrate treatment on cardiovascular disease risk in 9,795 individuals with type 2 diabetes and various components of the metabolic syndrome: the Fenofibrate Intervention and Event Lowering in Diabetes (FIELD) study","volume":"32","author":"R Scott","year":"2009","journal-title":"Diabetes Care"},{"issue":"9729","key":"ref47","doi-asserted-by":"crossref","first-page":"1875","DOI":"10.1016\/S0140-6736(10)60656-3","article-title":"Effects of fibrates on cardiovascular outcomes: a systematic review and meta-analysis","volume":"375","author":"M Jun","year":"2010","journal-title":"Lancet"},{"issue":"17","key":"ref48","doi-asserted-by":"crossref","first-page":"1279","DOI":"10.1093\/eurheartj\/eht055","article-title":"HPS2-THRIVE randomized placebo-controlled trial in 25 673 high-risk patients of ER niacin\/laropiprant: trial design, pre-specified muscle and liver outcomes, and reasons for stopping study treatment","volume":"34","year":"2013","journal-title":"Eur Heart J"},{"issue":"10","key":"ref49","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1001\/2012.jama.11374","article-title":"Association between omega-3 fatty acid supplementation and risk of major cardiovascular disease events: a systematic review and meta-analysis","volume":"308","author":"EC Rizos","year":"2012","journal-title":"JAMA"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0192740","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,14]],"date-time":"2022-08-14T04:23:53Z","timestamp":1660451033000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0192740"}},"subtitle":[],"editor":[{"given":"Ying-Mei","family":"Feng","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,9]]},"references-count":49,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0192740","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,9]]}}}