{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,27]],"date-time":"2026-09-27T05:23:43Z","timestamp":1790486623600,"version":"4.1.0"},"reference-count":44,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T00:00:00Z","timestamp":1518480000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"FAPESP","doi-asserted-by":"crossref","award":["2013\/2504813"],"award-info":[{"award-number":["2013\/2504813"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0192769","type":"journal-article","created":{"date-parts":[[2018,2,13]],"date-time":"2018-02-13T13:42:42Z","timestamp":1518529362000},"page":"e0192769","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["Novel animal model for Achilles tendinopathy: Controlled experimental study of serial injections of collagenase in rabbits"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6037-0685","authenticated-orcid":true,"given":"Cesar","family":"de Cesar Netto","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alexandre Leme","family":"Godoy-Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro","family":"Augusto Pontin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renato Jose Mendon\u00e7a","family":"Natalino","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cesar Augusto Martins","family":"Pereira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Diego de Oliveira","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucas Furtado","family":"da Fonseca","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jackson Rucker","family":"Staggers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Muntada","family":"Cavinatto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lew Charles","family":"Schon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olavo Pires","family":"de Camargo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"T\u00falio Diniz","family":"Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,2,13]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"669","DOI":"10.1111\/j.1600-0838.2012.01509.x","article-title":"Epidemiology of ankle and foot overuse injuries in sports: A systematic review","volume":"23","author":"S Sobhani","year":"2012","journal-title":"Scand J Med Sci Sports"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.2165\/00007256-199418030-00004","article-title":"Achilles tendon injuries in athletes","volume":"18","author":"M Kvist","year":"1994","journal-title":"Sports Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"135","DOI":"10.2165\/00007256-200029020-00005","article-title":"Chronic Achilles tendinosis: recommendations for treatment and prevention","volume":"29","author":"H Alfredson","year":"2000","journal-title":"Sports Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1177\/036354658701500213","article-title":"Injuries in runners","volume":"15","author":"J Lysholm","year":"1987","journal-title":"American Journal of Sports Medicine"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.fas.2011.04.007","article-title":"Epidemiologic investigation of 1394 feet: Coincidence of hindfoot malalignment and Achilles tendon disorders","volume":"18","author":"U Waldecker","year":"2012","journal-title":"Foot and Ankle Surgery. European Foot and Ankle Society"},{"key":"ref6","first-page":"188","article-title":"Achilles tendon injuries in athletes","volume":"80","author":"M Kvist","year":"1991","journal-title":"Ann Chir Gynaecol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1093\/rheumatology\/keg448","article-title":"The pathogenesis of tendinopathy. A molecular perspective","volume":"43","author":"G Riley","year":"2004","journal-title":"Rheumatology (Oxford)"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"670","DOI":"10.1152\/japplphysiol.00259.2009","article-title":"Tendinopathy alters mechanical and material properties of the Achilles tendon","volume":"108","author":"S Arya","year":"2010","journal-title":"J Appl Physiol"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1016\/S0278-5919(03)00004-8","article-title":"Types and epidemiology of tendinopathy","volume":"22","author":"N Maffulli","year":"2003","journal-title":"Clinics in Sports Medicine"},{"key":"ref10","first-page":"187","article-title":"Tendon injury and tendinopathy: healing and repair","volume":"87","author":"P Sharma","year":"2005","journal-title":"J Bone Joint Surg Am"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1136\/bjsm.2008.051193","article-title":"Is tendon pathology a continuum? A pathology model to explain the clinical presentation of load-induced tendinopathy","volume":"43","author":"JL Cook","year":"2009","journal-title":"Br J Sports Med"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1111\/iep.12029","article-title":"Continuum model of tendon pathology\u2014where are we now?","volume":"94","author":"K McCreesh","year":"2013","journal-title":"Int J Exp Pathol"},{"key":"ref13","first-page":"141","article-title":"Models for the study of tendinopathy","volume":"11","author":"RC Dirks","year":"2011","journal-title":"J Musculoskelet Neuronal Interact"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"193","DOI":"10.1302\/2046-3758.36.2000281","article-title":"The role of animal models in tendon research","volume":"3","author":"MW Hast","year":"2014","journal-title":"Bone Joint Res"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"989","DOI":"10.1007\/s10103-012-1189-x","article-title":"Low-level laser therapy in experimental model of collagenase-induced tendinitis in rats: effects in acute and chronic inflammatory phases","volume":"28","author":"HL Casalechi","year":"2012","journal-title":"Lasers Med Sci"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1177\/0363546509355402","article-title":"Expression of sensory neuropeptides in tendon is associated with failed healing and activity-related tendon pain in collagenase-induced tendon injury","volume":"38","author":"PPY Lui","year":"2010","journal-title":"The American Journal of Sports Medicine"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"42","DOI":"10.1186\/1475-925X-13-42","article-title":"Human multipotent mesenchymal stem cells improve healing after collagenase tendon injury in the rat","volume":"13","author":"L Machova Urdzikova","year":"2014","journal-title":"Biomed Eng Online"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"1945","DOI":"10.1002\/jor.22156","article-title":"Low-level laser therapy in collagenase-induced Achilles tendinitis in rats: Analyses of biochemical and biomechanical aspects","volume":"30","author":"RL Marcos","year":"2012","journal-title":"J Orthop Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"e0161590","DOI":"10.1371\/journal.pone.0161590","article-title":"Dose-Related and Time-Dependent Development of Collagenase-Induced Tendinopathy in Rats","volume":"11","author":"C Perucca Orfei","year":"2016","journal-title":"PLoS ONE"},{"key":"ref20","first-page":"402692","article-title":"Direct radiofrequency application improves pain and gait in collagenase-induced acute achilles tendon injury","volume":"2013","author":"Y-P Tsai","year":"2013","journal-title":"Evidence-Based Complementary and Alternative Medicine"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"1530","DOI":"10.1080\/09638280701785460","article-title":"Animal models of tendinopathy","volume":"30","author":"SP Lake","year":"2008","journal-title":"Disabil Rehabil"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"91","DOI":"10.1369\/jhc.2008.952143","article-title":"Chondrocyte phenotype and ectopic ossification in collagenase-induced tendon degeneration","volume":"57","author":"PPY Lui","year":"2009","journal-title":"J Histochem Cytochem"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"313","DOI":"10.1097\/00005768-199703000-00005","article-title":"Rat tendon morphologic and functional changes resulting from soft tissue mobilization","volume":"29","author":"CJ Davidson","year":"1997","journal-title":"Med Sci Sports Exerc"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"910","DOI":"10.1016\/S0736-0266(02)00009-8","article-title":"Insulin-like growth factor-I improves cellular and molecular aspects of healing in a collagenase-induced model of flexor tendinitis","volume":"20","author":"LA Dahlgren","year":"2002","journal-title":"J Orthop Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1720","DOI":"10.1152\/japplphysiol.00301.2006","article-title":"Early voluntary exercise does not promote healing in a rat model of Achilles tendon injury","volume":"101","author":"C Godbout","year":"2006","journal-title":"J Appl Physiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1016\/j.jneumeth.2009.02.011","article-title":"The use of motion analysis to measure pain-related behaviour in a rat model of degenerative tendon injuries","volume":"179","author":"SC Fu","year":"2009","journal-title":"J Neurosci Methods"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1076","DOI":"10.1089\/scd.2012.0555","article-title":"Altered fate of tendon-derived stem cells isolated from a failed tendon-healing animal model of tendinopathy","volume":"22","author":"YF Rui","year":"2013","journal-title":"Stem Cells Dev"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1002\/jor.22222","article-title":"Dose-response effect of an intra-tendon application of recombinant human platelet-derived growth factor-BB (rhPDGF-BB) in a rat Achilles tendinopathy model","volume":"31","author":"V Shah","year":"2013","journal-title":"J Orthop Res"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1002\/jor.22483","article-title":"Comparison of the effect of intra-tendon applications of recombinant human platelet-derived growth factor-BB, platelet-rich plasma, steroids in a rat achilles tendon collagenase model","volume":"32","author":"LA Solchaga","year":"2014","journal-title":"J Orthop Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/S0736-0266(01)00031-6","article-title":"Neutrophils and macrophages accumulate sequentially following Achilles tendon injury","volume":"19","author":"D Marsolais","year":"2001","journal-title":"J Orthop Res"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1302\/0301-620X.42B2.360","article-title":"Anatomy of the calcaneal tendon of the rabbit","volume":"42-B","author":"NW NISBET","year":"1960","journal-title":"J Bone Joint Surg Br"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1002\/jor.1100170204","article-title":"Cytokine\u2010induced tendinitis: a preliminary study in rabbits","volume":"17","author":"D Stone","year":"1999","journal-title":"J Orthop Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1148\/radiology.200.3.8756939","article-title":"Patellar tendinosis (jumper's knee): findings at histopathologic examination, US, and MR imaging. Victorian Institute of Sport Tendon Study Group","volume":"200","author":"KM Khan","year":"1996","journal-title":"Radiology"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"393","DOI":"10.2165\/00007256-199927060-00004","article-title":"Histopathology of common tendinopathies. Update and implications for clinical management","volume":"27","author":"KM Khan","year":"1999","journal-title":"Sports Med"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1016\/j.jsams.2013.07.008","article-title":"The Bonar score revisited: Region of evaluation significantly influences the standardized assessment of tendon degeneration","volume":"17","author":"A Fearon","year":"2014","journal-title":"Journal of Science and Medicine in Sport"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2037","DOI":"10.1089\/ten.tea.2010.0492","article-title":"Autologous tenocyte therapy for experimental Achilles tendinopathy in a rabbit model","volume":"17","author":"J Chen","year":"2011","journal-title":"Tissue Eng Part A"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1715","DOI":"10.1016\/S0142-9612(03)00507-6","article-title":"Animal models of tendon and ligament injuries for tissue engineering applications","volume":"25","author":"JE Carpenter","year":"2004","journal-title":"Biomaterials"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1136\/bjsm.2006.032342","article-title":"Animal models for the study of tendinopathy","volume":"41","author":"SJ Warden","year":"2007","journal-title":"Br J Sports Med"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1111\/j.1600-0838.2010.01164.x","article-title":"What are the validated animal models for tendinopathy?","volume":"21","author":"PPY Lui","year":"2011","journal-title":"Scand J Med Sci Sports"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1016\/S1058-2746(96)80070-X","article-title":"Development and use of an animal model for investigations on rotator cuff disease","volume":"5","author":"LJ Soslowsky","year":"1996","journal-title":"J Shoulder Elbow Surg"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1002\/jor.20000","article-title":"Expression of insulin-like growth factor binding proteins in healing tendon lesions","volume":"24","author":"LA Dahlgren","year":"2006","journal-title":"J Orthop Res"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1093\/rheumatology\/kep384","article-title":"Sustained expression of proteoglycans and collagen type III\/type I ratio in a calcified tendinopathy model","volume":"49","author":"PPY Lui","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1187","DOI":"10.1136\/bjsports-2015-095422","article-title":"Revisiting the continuum model of tendon pathology: what is its merit in clinical practice and research?","volume":"50","author":"JL Cook","year":"2016","journal-title":"Br J Sports Med"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"854","DOI":"10.1016\/j.orthres.2003.10.013","article-title":"Extracorporeal shock waves promote healing of collagenase-induced Achilles tendinitis and increase TGF-beta1 and IGF-I expression","volume":"22","author":"Y-J Chen","year":"2004","journal-title":"J Orthop Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0192769","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,10]],"date-time":"2019-10-10T18:35:51Z","timestamp":1570732551000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0192769"}},"subtitle":[],"editor":[{"given":"Chunfeng","family":"Zhao","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,13]]},"references-count":44,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,13]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0192769","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,13]]}}}