{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T08:18:41Z","timestamp":1790756321568,"version":"4.1.0"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Instituto de Ciencia y Tecnologia del Distrito Federal (MX)","award":["PICSA 12-164"],"award-info":[{"award-number":["PICSA 12-164"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0192878","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T13:50:13Z","timestamp":1518702613000},"page":"e0192878","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":37,"title":["Virome and bacteriome characterization of children with pneumonia and asthma in Mexico City during winter seasons 2014 and 2015"],"prefix":"10.1371","volume":"13","author":[{"given":"Jose A.","family":"Romero-Espinoza","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yazmin","family":"Moreno-Valencia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo H.","family":"Coronel-Tellez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manuel","family":"Castillejos-Lopez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andres","family":"Hernandez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aaron","family":"Dominguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angel","family":"Miliar-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Arturo","family":"Barbachano-Guerrero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rogelio","family":"Perez-Padilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandro","family":"Alejandre-Garcia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8508-3698","authenticated-orcid":true,"given":"Joel A.","family":"Vazquez-Perez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1186\/1743-422X-11-31","article-title":"Molecular detection of human rhinoviruses in respiratory samples: a comparison of Taqman probe-, SYBR green I- and BOXTO-based real-time PCR assays","volume":"11","author":"J Dupouey","year":"2014","journal-title":"Virol J"},{"key":"ref2","article-title":"Detection and Characterization of respiratory viruses causing Acute Respiratory Illness and Asthma Exacerbation in children during Three Different Season (2011\u20132014) in Mexico City","author":"Y Moreno-Valencia","year":"2015","journal-title":"Influenza Other Respir Viruses"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1089\/ped.2014.0463","article-title":"Respiratory Severity Score Separates Upper Versus Lower Respiratory Tract Infections and Predicts Measures of Disease Severity","volume":"28","author":"AS Feldman","year":"2015","journal-title":"Pediatr Allergy Immunol Pulmonol"},{"issue":"18","key":"ref4","first-page":"264","article-title":"Characterization of acute respiratory infections among 340 infants in Wuxi, Jiangsu Province","volume":"3","author":"X Ge","year":"2015","journal-title":"Ann Transl Med"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"144","DOI":"10.1016\/j.gpb.2014.06.001","article-title":"Human pharyngeal microbiome may play a protective role in respiratory tract infections","volume":"12","author":"Z Gao","year":"2014","journal-title":"Genomics Proteomics Bioinformatics"},{"issue":"10","key":"ref6","first-page":"1251","article-title":"Simple predictors to differentiate acute asthma from ARI in children: implications for refining case management in the ARI Control Programme","volume":"31","author":"HP Sachdev","year":"1994","journal-title":"Indian Pediatr"},{"issue":"1","key":"ref7","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/emph\/eow007","article-title":"The role of respiratory viruses in the etiology of bacterial pneumonia: An ecological perspective","volume":"2016","author":"KH Lee","year":"2016","journal-title":"Evol Med Public Health"},{"issue":"5","key":"ref8","doi-asserted-by":"crossref","first-page":"652","DOI":"10.1111\/cmi.12589","article-title":"Host-microbiome interactions in acute and chronic respiratory infections","volume":"18","author":"SL Taylor","year":"2016","journal-title":"Cell Microbiol"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"196","DOI":"10.1097\/MCP.0000000000000268","article-title":"The lung microbiome and exacerbations of COPD","volume":"22","author":"R Dy","year":"2016","journal-title":"Curr Opin Pulm Med"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"e8578","DOI":"10.1371\/journal.pone.0008578","article-title":"Disordered microbial communities in asthmatic airways","volume":"5","author":"M Hilty","year":"2010","journal-title":"PloS One"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"e93827","DOI":"10.1371\/journal.pone.0093827","article-title":"Strengths and limitations of 16S rRNA gene amplicon sequencing in revealing temporal microbial community dynamics","volume":"9","author":"R Poretsky","year":"2014","journal-title":"PloS One"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"e27735","DOI":"10.1371\/journal.pone.0027735","article-title":"Sequence analysis of the human virome in febrile and afebrile children","volume":"7","author":"KM Wylie","year":"2012","journal-title":"PloS One"},{"issue":"10","key":"ref13","doi-asserted-by":"crossref","first-page":"3463","DOI":"10.1128\/JCM.00273-11","article-title":"Unbiased parallel detection of viral pathogens in clinical samples by use of a metagenomic approach","volume":"49","author":"J Yang","year":"2011","journal-title":"J Clin Microbiol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.jcv.2015.02.010","article-title":"Direct multiplexed whole genome sequencing of respiratory tract samples reveals full viral genomic information","volume":"66","author":"J Zoll","year":"2015","journal-title":"J Clin Virol"},{"issue":"10","key":"ref15","first-page":"964","article-title":"Human bocavirus infection as a cause of severe acute respiratory tract infection in children","volume":"21","author":"FM Moesker","year":"2015","journal-title":"Clin Microbiol Infect Off Publ Eur Soc Clin Microbiol Infect Dis"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"458","DOI":"10.1016\/j.cmi.2016.01.006","article-title":"Metagenomic analysis of viral genetic diversity in respiratory samples from children with severe acute respiratory infection in China","volume":"22","author":"Y Wang","year":"2016","journal-title":"Clin Microbiol Infect"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"S5","DOI":"10.1016\/j.jcv.2016.08.010","article-title":"Metagenomic analysis of the respiratory virome associated with acute respiratory illness of unknown etiology in infants","volume":"82","author":"A Bal","year":"2016","journal-title":"Journal of Clinical Virology"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"e113570","DOI":"10.1371\/journal.pone.0113570","article-title":"Is there still room for novel viral pathogens in pediatric respiratory tract infections?","volume":"9","author":"B Taboada","year":"2014","journal-title":"PloS One"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"704","DOI":"10.1016\/j.chom.2015.03.008","article-title":"The infant nasopharyngeal microbiome impacts severity of lower respiratory infection and risk of asthma development","volume":"17","author":"SM Teo","year":"2015","journal-title":"Cell Host Microbe"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"154","DOI":"10.1111\/irv.12384","article-title":"EV-D68 infection in children with asthma exacerbation and pneumonia in Mexico City during 2014 autumn","volume":"10","author":"JA Vazquez-Perez","year":"2016","journal-title":"Influenza Other Respir Viruses"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"465","DOI":"10.1016\/B978-0-12-407863-5.00021-6","article-title":"Microbial community analysis using MEGAN","volume":"531","author":"DH Huson","year":"2013","journal-title":"Methods Enzymol"},{"issue":"2","key":"ref22","first-page":"189","article-title":"MEGA: Molecular Evolutionary Genetics Analysis software for microcomputers","volume":"10","author":"S Kumar","year":"1994","journal-title":"Comput Appl Biosci CABIOS"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"e4219","DOI":"10.1371\/journal.pone.0004219","article-title":"Direct metagenomic detection of viral pathogens in nasal and fecal specimens using an unbiased high-throughput sequencing approach","volume":"4","author":"S Nakamura","year":"2009","journal-title":"PloS One"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"470","DOI":"10.1183\/09031936.00107212","article-title":"Potential implication of new torque teno mini viruses in parapneumonic empyema in children","volume":"42","author":"J Galm\u00e8s","year":"2013","journal-title":"Eur Respir J"},{"issue":"7","key":"ref25","doi-asserted-by":"crossref","first-page":"1141","DOI":"10.1086\/444389","article-title":"Associations between nasal torquetenovirus load and spirometric indices in children with asthma","volume":"192","author":"M Pifferi","year":"2005","journal-title":"J Infect Dis"},{"issue":"10","key":"ref26","first-page":"3461","article-title":"The presence of Torque teno virus in chronic obstructive pulmonary disease","volume":"7","author":"B Feyzio\u011flu","year":"2014","journal-title":"Int J Clin Exp Med"},{"key":"ref27","article-title":"Cytomegalovirus DNA is highly prevalent in the blood of patients with asthma and is associated with age and asthma traits","author":"ML Kowalski","year":"2017","journal-title":"Allergy"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"29","DOI":"10.3345\/kjp.2014.57.1.29","article-title":"Prevalence of respiratory viral infection in children hospitalized for acute lower respiratory tract diseases, and association of rhinovirus and influenza virus with asthma exacerbations","volume":"57","author":"J-M Kwon","year":"2014","journal-title":"Korean J Pediatr"},{"issue":"2","key":"ref29","doi-asserted-by":"crossref","first-page":"287","DOI":"10.3346\/jkms.2017.32.2.287","article-title":"Characteristics of Adenovirus Pneumonia in Korean Military Personnel, 2012\u20132016","volume":"32","author":"H Yoon","year":"2017","journal-title":"J Korean Med Sci"},{"issue":"10","key":"ref30","first-page":"299","article-title":"Obstructive respiratory tract diseases in children and Parvovirus B19 infections","volume":"59","author":"S Wiersbitzky","year":"1991","journal-title":"Kinderarztl Prax"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"e30875","DOI":"10.1371\/journal.pone.0030875","article-title":"Characterization of the viral microbiome in patients with severe lower respiratory tract infections, using metagenomic sequencing","volume":"7","author":"F Lysholm","year":"2012","journal-title":"PLoS ONE"},{"issue":"15","key":"ref32","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1056\/NEJMoa052632","article-title":"Childhood asthma after bacterial colonization of the airway in neonates","volume":"357","author":"H Bisgaard","year":"2007","journal-title":"N Engl J Med"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"e1003057","DOI":"10.1371\/journal.ppat.1003057","article-title":"Viral and Bacterial Interactions in the Upper Respiratory Tract","volume":"9","author":"AATM Bosch","year":"2013","journal-title":"PLOS Pathogens"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0192878","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T19:05:16Z","timestamp":1588964716000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0192878"}},"subtitle":[],"editor":[{"given":"Oliver","family":"Schildgen","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":33,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0192878","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]}}}