{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,19]],"date-time":"2026-02-19T19:05:13Z","timestamp":1771527913344,"version":"3.50.1"},"reference-count":43,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["DFG HO 2464\/3-1"],"award-info":[{"award-number":["DFG HO 2464\/3-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Deutsche Forschungsgemeinschaft (DE) und University of Freiburg","award":["funding programme Open Access Publishing"],"award-info":[{"award-number":["funding programme Open Access Publishing"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0192896","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T19:02:48Z","timestamp":1519326168000},"page":"e0192896","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":39,"title":["Sevoflurane posttreatment prevents oxidative and inflammatory injury in ventilator-induced lung injury"],"prefix":"10.1371","volume":"13","author":[{"given":"Julie","family":"Wagner","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Karl M.","family":"Strosing","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sashko G.","family":"Spassov","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ziwei","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Helen","family":"Engelstaedter","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sabine","family":"Tacke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexander","family":"Hoetzel","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5345-8523","authenticated-orcid":true,"given":"Simone","family":"Faller","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"2155","DOI":"10.1097\/CCM.0000000000001189","article-title":"Lung-Protective Ventilation With Low Tidal Volumes and the Occurrence of Pulmonary Complications in Patients Without Acute Respiratory Distress Syndrome: A Systematic Review and Individual Patient Data Analysis","volume":"43","author":"AS Neto","year":"2015","journal-title":"Crit Care Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"66","DOI":"10.1097\/ALN.0000000000000706","article-title":"Protective versus Conventional Ventilation for Surgery: A Systematic Review and Individual Patient Data Meta-analysis","volume":"123","author":"NA Serpa","year":"2015","journal-title":"Anesthesiology"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"L834","DOI":"10.1152\/ajplung.00069.2005","article-title":"Cyclic mechanical strain increases reactive oxygen species production in pulmonary epithelial cells","volume":"289","author":"KE Chapman","year":"2005","journal-title":"Am J Physiol Lung Cell Mol Physiol"},{"issue":"Suppl 10","key":"ref4","doi-asserted-by":"crossref","first-page":"85","DOI":"10.1289\/ehp.94102s1085","article-title":"Interactions of oxygen radicals with airway epithelium","volume":"102","author":"DT Wright","year":"1994","journal-title":"Environ Health Perspect"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"82","DOI":"10.1097\/00075198-200502000-00013","article-title":"Overview of ventilator-induced lung injury mechanisms","volume":"11","author":"V Lionetti","year":"2005","journal-title":"Curr Opin Crit Care"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"2s","DOI":"10.1183\/09031936.03.00420103","article-title":"Ventilator-induced lung injury","volume":"42","author":"JD Ricard","year":"2003","journal-title":"Eur Respir J Suppl"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1055\/s-2006-948289","article-title":"The role of cytokines during the pathogenesis of ventilator-associated and ventilator-induced lung injury","volume":"27","author":"JA Belperio","year":"2006","journal-title":"Semin Respir Crit Care Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1301","DOI":"10.1056\/NEJM200005043421801","article-title":"Ventilation with lower tidal volumes as compared with traditional tidal volumes for acute lung injury and the acute respiratory distress syndrome","volume":"342","year":"2000","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1164\/rccm.200607-915OC","article-title":"Tidal hyperinflation during low tidal volume ventilation in acute respiratory distress syndrome","volume":"175","author":"PP Terragni","year":"2007","journal-title":"Am J Respir Crit Care Med"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"933","DOI":"10.1007\/s00134-011-2187-3","article-title":"Long-term sedation in intensive care unit: a randomized comparison between inhaled sevoflurane and intravenous propofol or midazolam","volume":"37","author":"M Mesnil","year":"2011","journal-title":"Intensive Care Med"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"395","DOI":"10.1097\/ACO.0b013e3282efa69d","article-title":"Anesthetics and brain protection","volume":"20","author":"BP Head","year":"2007","journal-title":"Curr Opin Anaesthesiol"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"3127","DOI":"10.1016\/j.jtcvs.2014.07.085","article-title":"Volatile anesthetics in preventing acute kidney injury after cardiac surgery: a systematic review and meta-analysis","volume":"148","author":"J Cai","year":"2014","journal-title":"J Thorac Cardiovasc Surg"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"108","DOI":"10.2174\/157016108783955284","article-title":"Cardiac protection by volatile anaesthetics: a review","volume":"6","author":"G Landoni","year":"2008","journal-title":"Curr Vasc Pharmacol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1093\/bja\/aep365","article-title":"Sevoflurane pre- and post-conditioning protect the brain via the mitochondrial K ATP channel","volume":"104","author":"S Adamczyk","year":"2010","journal-title":"Br J Anaesth"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1097\/01.shk.0000248595.17130.24","article-title":"Isoflurane improves survival and protects against renal and hepatic injury in murine septic peritonitis","volume":"27","author":"HT Lee","year":"2007","journal-title":"Shock"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.1053\/j.jvca.2010.09.017","article-title":"Delayed cardioprotection by inhaled anesthetics","volume":"25","author":"PS Pagel","year":"2011","journal-title":"J Cardiothorac Vasc Anesth"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"747","DOI":"10.1213\/ANE.0b013e31824762f0","article-title":"The volatile anesthetic isoflurane prevents ventilator-induced lung injury via phosphoinositide 3-kinase\/Akt signaling in mice","volume":"114","author":"S Faller","year":"2012","journal-title":"Anesth Analg"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1213\/ANE.0000000000001296","article-title":"Inhaled Anesthetics Exert Different Protective Properties in a Mouse Model of Ventilator-Induced Lung Injury","volume":"123","author":"KM Strosing","year":"2016","journal-title":"Anesth Analg"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.2147\/IJN.S41625","article-title":"Sevoflurane attenuates pulmonary inflammation and ventilator-induced lung injury by upregulation of HO-1 mRNA expression in mice","volume":"6","author":"XQ Xiong","year":"2013","journal-title":"Int J Nanomedicine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"19016","DOI":"10.4238\/2015.December.29.9","article-title":"Sevoflurane downregulates interleukin-6 and interleukin-8 levels in patients after cardiopulmonary bypass surgery: a meta-analysis","volume":"14","author":"QB Yu","year":"2015","journal-title":"Genet Mol Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"6417","DOI":"10.1007\/s11033-012-1447-9","article-title":"Sevoflurane postconditioning attenuates reperfusion-induced ventricular arrhythmias in isolated rat hearts exposed to ischemia\/reperfusion injury","volume":"39","author":"JS Gong","year":"2012","journal-title":"Mol Biol Rep"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1111\/j.1440-1681.2008.04952.x","article-title":"Sevoflurane post-conditioning protects against myocardial reperfusion injury by activation of phosphatidylinositol-3-kinase signal transduction","volume":"35","author":"H Li","year":"2008","journal-title":"Clin Exp Pharmacol Physiol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"1186","DOI":"10.3181\/0902-RM-58","article-title":"Comparison of isoflurane-, sevoflurane-, and desflurane-induced pre- and postconditioning against myocardial infarction in mice in vivo","volume":"234","author":"A Redel","year":"2009","journal-title":"Exp Biol Med (Maywood)"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"1504","DOI":"10.1038\/aps.2014.78","article-title":"Sevoflurane post-conditioning protects isolated rat hearts against ischemia-reperfusion injury via activation of the ERK1\/2 pathway","volume":"35","author":"H Xie","year":"2014","journal-title":"Acta Pharmacol Sin"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2439","DOI":"10.1007\/s11033-009-9755-4","article-title":"Sevoflurane postconditioning protects isolated rat hearts against ischemia-reperfusion injury: the role of radical oxygen species, extracellular signal-related kinases 1\/2 and mitochondrial permeability transition pore","volume":"37","author":"YT Yao","year":"2010","journal-title":"Mol Biol Rep"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"216","DOI":"10.1016\/j.jns.2014.12.011","article-title":"Neuroprotection induced by sevoflurane-delayed post-conditioning is attributable to increased phosphorylation of mitochondrial GSK-3beta through the PI3K\/Akt survival pathway","volume":"348","author":"Z Ye","year":"2015","journal-title":"J Neurol Sci"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.lfs.2017.02.006","article-title":"Pharmacological postconditioning with sevoflurane activates PI3K\/AKT signaling and attenuates cardiopulmonary bypass-induced lung injury in dog","volume":"173","author":"Y Zhang","year":"2017","journal-title":"Life Sci"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"1555","DOI":"10.1213\/ANE.0000000000002034","article-title":"Sevoflurane Posttreatment Attenuates Lung Injury Induced by Oleic Acid in Dogs","volume":"124","author":"G Du","year":"2017","journal-title":"Anesth Analg"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1097\/ALN.0b013e3181de7107","article-title":"Inhaled hydrogen sulfide protects against ventilator-induced lung injury","volume":"113","author":"S Faller","year":"2010","journal-title":"Anesthesiology"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"621","DOI":"10.2169\/internalmedicine.48.1741","article-title":"Acute lung injury review","volume":"48","author":"K Tsushima","year":"2009","journal-title":"Intern Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"999","DOI":"10.1038\/labinvest.2012.55","article-title":"Kinetic effects of carbon monoxide inhalation on tissue protection in ventilator-induced lung injury","volume":"92","author":"S Faller","year":"2012","journal-title":"Lab Invest"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1136\/thx.2007.079608","article-title":"Protection from experimental ventilator-induced acute lung injury by IL-1 receptor blockade","volume":"63","author":"JA Frank","year":"2008","journal-title":"Thorax"},{"key":"ref33","first-page":"3301","article-title":"A2B adenosine receptor signaling attenuates acute lung injury by enhancing alveolar fluid clearance in mice","volume":"118","author":"T Eckle","year":"2008","journal-title":"J Clin Invest"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"e0151211","DOI":"10.1371\/journal.pone.0151211","article-title":"Assessing the Relationship between Lung Density and Function with Oxygen-Enhanced Magnetic Resonance Imaging in a Mouse Model of Emphysema","volume":"11","author":"M Zurek","year":"2016","journal-title":"PLoS One"},{"issue":"Suppl 1","key":"ref35","doi-asserted-by":"crossref","first-page":"S3","DOI":"10.1513\/AnnalsATS.201407-340MG","article-title":"Mechanisms and clinical consequences of acute lung injury","volume":"12","author":"V Fanelli","year":"2015","journal-title":"Ann Am Thorac Soc"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"977","DOI":"10.1111\/j.1399-6576.2008.01665.x","article-title":"Lung injury following thoracic aortic occlusion: comparison of sevoflurane and propofol anaesthesia","volume":"52","author":"T Annecke","year":"2008","journal-title":"Acta Anaesthesiol Scand"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"454","DOI":"10.1017\/S0265021508003682","article-title":"Preconditioning, but not postconditioning, with Sevoflurane reduces pulmonary neutrophil accumulation after lower body ischaemia\/reperfusion injury in rats","volume":"25","author":"R Kalb","year":"2008","journal-title":"Eur J Anaesthesiol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"e0134666","DOI":"10.1371\/journal.pone.0134666","article-title":"Protective Effect of Sevoflurane Postconditioning against Cardiac Ischemia\/Reperfusion Injury via Ameliorating Mitochondrial Impairment, Oxidative Stress and Rescuing Autophagic Clearance","volume":"10","author":"P Yu","year":"2015","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"3715037","DOI":"10.1155\/2017\/3715037","article-title":"Hydrogen Sulfide Prevents Formation of Reactive Oxygen Species through PI3K\/Akt Signaling and Limits Ventilator-Induced Lung Injury","volume":"2017","author":"SG Spassov","year":"2017","journal-title":"Oxid Med Cell Longev"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1213\/01.ane.0000255046.06058.58","article-title":"The immunomodulatory effect of sevoflurane in endotoxin-injured alveolar epithelial cells","volume":"104","author":"D Suter","year":"2007","journal-title":"Anesth Analg"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"2435","DOI":"10.3892\/mmr.2014.2094","article-title":"Post-conditioning with sevoflurane induces heme oxygenase-1 expression via the PI3K\/Akt pathway in lipopolysaccharide-induced acute lung injury","volume":"9","author":"S Zhao","year":"2014","journal-title":"Mol Med Rep"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"408","DOI":"10.3892\/br.2015.428","article-title":"Volatile anesthetic sevoflurane ameliorates endotoxin-induced acute lung injury via microRNA modulation in rats","volume":"3","author":"T Otsuki","year":"2015","journal-title":"Biomed Rep"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"1238","DOI":"10.1097\/ALN.0b013e3181bdf857","article-title":"Sevoflurane ameliorates gas exchange and attenuates lung damage in experimental lipopolysaccharide-induced lung injury","volume":"111","author":"S Voigtsberger","year":"2009","journal-title":"Anesthesiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0192896","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,1]],"date-time":"2025-07-01T23:42:35Z","timestamp":1751413355000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0192896"}},"subtitle":[],"editor":[{"given":"Tobias","family":"Eckle","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,22]]},"references-count":43,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,22]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0192896","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,22]]}}}