{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T11:15:43Z","timestamp":1789557343707,"version":"build-2803163510"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T00:00:00Z","timestamp":1518652800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0192904","type":"journal-article","created":{"date-parts":[[2018,2,15]],"date-time":"2018-02-15T18:50:54Z","timestamp":1518720654000},"page":"e0192904","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Probiotic effect of Pichia pastoris X-33 produced in parboiled rice effluent and YPD medium on broiler chickens"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9844-7411","authenticated-orcid":true,"given":"Diego","family":"Gil de los Santos","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Rodrigo","family":"Gil de los Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carlos","family":"Gil-Turnes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giana","family":"Gaboardi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luiza","family":"Fernandes Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rodrigo","family":"Fran\u00e7a","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cristina","family":"Gevehr Fernandes","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabricio","family":"Rochedo Concei\u00e7\u00e3o","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,2,15]]},"reference":[{"key":"ref1","unstructured":"Council of European Union. Regulation (Ec) no 1831\/2003 of the European Parliament and of the Council of 22 September 2003 on additives for use in animal nutrition.Avaliable:<ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?qid=1502462309818&uri=CELEX:32004R0882\" xlink:type=\"simple\">http:\/\/eur-lex.europa.eu\/legal-content\/EN\/TXT\/?qid=1502462309818&amp;uri=CELEX:32004R0882<\/ext-link> Accessed August 10, 2017."},{"issue":"2","key":"ref2","first-page":"135","article-title":"The effect of probiotic and probiotic feed supplementation on chicken health and gut microflora: a review","volume":"4","author":"EI Ohimain","year":"2012","journal-title":"J Anim Vet Adv"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"494","DOI":"10.1080\/00071660500181461","article-title":"<italic>Bacillus cereus<\/italic> var. toyoii and <italic>Saccharomyces boulardii<\/italic> increased feed efficiency in broilers infected with <italic>Salmonella enteritidis<\/italic>","volume":"46","author":"JR Gil de los Santos","year":"2005","journal-title":"Br Poult Sci"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1016\/j.vetmic.2011.11.019","article-title":"Evaluation in broilers of the probiotic properties of <italic>Pichia pastoris<\/italic> and a recombinant <italic>P<\/italic>. <italic>pastoris<\/italic> containing the <italic>Clostridium perfringens<\/italic> alpha toxin gene","volume":"156","author":"JR Gil de los Santos","year":"2012","journal-title":"Vet Microbiol"},{"issue":"7","key":"ref5","doi-asserted-by":"crossref","first-page":"1404","DOI":"10.3945\/jn.109.105007","article-title":"Prebiotics modulate immune responses in the gut-associated lymphoid tissue of chickens","volume":"139","author":"V Janardhana","year":"2009","journal-title":"J Nutr"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.3382\/ps.2010-00732","article-title":"Effect of dietary prebiotic supplementation on the performance, intestinal microflora, and immune response of broilers","volume":"90","author":"GB Kim","year":"2011","journal-title":"Poult Sci"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"2246","DOI":"10.2527\/jas.2011-4184","article-title":"The effect of microbial-nutrient interaction on the immune system of young chicks after early probiotic and organic acid administration","volume":"90","author":"JC Rodr\u00edguez-Lecompte","year":"2012","journal-title":"J Anim Sci"},{"issue":"1","key":"ref8","first-page":"5","article-title":"Study on efficacy of probiotic in broiler chickens diet","volume":"3","author":"SMSM Taklimi","year":"2012","journal-title":"Agric Sci"},{"key":"ref9","unstructured":"BAAP\u2014Brazilian Association of Animal Protein. Annual Report 2017. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/abpa-br.com.br\/setores\/avicultura\/mercado-mundial\" xlink:type=\"simple\">http:\/\/abpa-br.com.br\/setores\/avicultura\/mercado-mundial<\/ext-link>. Accessed August 10, 2017."},{"key":"ref10","unstructured":"USDA\u2014United States Department of Agriculture, Foreign Agricultural Service; Livestock and Poultry: World Markets and Trade, April, 2017. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.fas.usda.gov\/data\/livestock-and-poultry-world-markets-and-trade\" xlink:type=\"simple\">http:\/\/www.fas.usda.gov\/data\/livestock-and-poultry-world-markets-and-trade<\/ext-link>. Accessed: August 10, 2017."},{"key":"ref11","unstructured":"Alltech. Alltech Global Feed Survey 2016. Avaliable: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/go.alltech.com\/pesquisa-global-2017\" xlink:type=\"simple\">https:\/\/go.alltech.com\/pesquisa-global-2017<\/ext-link>. August 10, 2017."},{"issue":"3","key":"ref12","first-page":"407","article-title":"Production of food grade yeasts","volume":"44","author":"A Bekatorou","year":"2006","journal-title":"Food Technol Biotechnol"},{"issue":"31","key":"ref13","article-title":"Role of cultivation media in the development of yeast strains for large scale industrial use","volume":"4","author":"B Hahn-H\u00e4gerdal","year":"2005","journal-title":"Microb Cell Fact"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"231","DOI":"10.1016\/S0960-8524(99)00049-8","article-title":"Growth of <italic>Pichia guilliermondii<\/italic> A9, an osmotolerant yeast, in waste brine generated from kimchi production","volume":"70","author":"MH Choi","year":"1999","journal-title":"Bioresour Technol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"815","DOI":"10.1023\/A:1008926700452","article-title":"Yeast cultivation in lettuce brine","volume":"16","author":"W Suntornsuk","year":"2000","journal-title":"World J Microb Biotechnol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1016\/S0961-9534(02)00194-0","article-title":"Production of yeast biomass using waste Chinese cabbage","volume":"25","author":"MH Choi","year":"2003","journal-title":"Biomass and Bioener"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1016\/j.biortech.2006.04.021","article-title":"Protein enrichment of potato processing waste through yeast fermentation","volume":"98","author":"P G\u00e9linas","year":"2007","journal-title":"Bioresour Technol"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2985","DOI":"10.1021\/ie071613o","article-title":"Use of Biodiesel Byproduct Crude Glycerol as the Carbon Source for Fermentation Processes by Recombinant Pichia pastoris","volume":"47","author":"E \u00c7elik","year":"2008","journal-title":"Ind Eng Chem Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"492925","DOI":"10.1100\/2012\/492925","article-title":"Bioremediation of parboiled rice effluent supplemented with biodiesel-derived glycerol using <italic>Pichia pastoris<\/italic> X-33","volume":"2012","author":"D Gil de los Santos","year":"2012","journal-title":"Scient World J"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1743","DOI":"10.1016\/j.biortech.2005.01.006","article-title":"Supplementation of waste tea fungal biomass as a dietary ingredient for broiler chicks","volume":"96","author":"GS Murugesan","year":"2005","journal-title":"Bioresour Technol"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.3382\/ps.2011-01732","article-title":"Effect of killed whole yeast cell prebiotic supplementation on broiler performance and intestinal immune cell parameters","volume":"91","author":"R Shanmugasundaram","year":"2012","journal-title":"Poult Sci"},{"issue":"19","key":"ref22","doi-asserted-by":"crossref","first-page":"7953","DOI":"10.1007\/s00253-015-6696-9","article-title":"<italic>Pichia pastoris<\/italic> X-33 has probiotic properties with remarkable antibacterial activity against <italic>Salmonella<\/italic> Typhimurium","volume":"99","author":"RC Fran\u00e7a","year":"2015","journal-title":"Appl Microbiol Biotechnol"},{"issue":"8","key":"ref23","doi-asserted-by":"crossref","first-page":"2084","DOI":"10.3382\/ps.2012-02947","article-title":"Supplementation of direct-fed microbials as an alternative to antibiotic on growth performance, immune response, cecal microbial population, and ileal morphology of broiler chickens","volume":"92","author":"HM Salim","year":"2013","journal-title":"Poult Sci"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"663","DOI":"10.3382\/ps.2012-02813","article-title":"Effects of probiotic-supplemented diets on growth performance and intestinal immune characteristics of broiler chickens","volume":"92","author":"SP Bai","year":"2013","journal-title":"Poult Sci"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1292\/jvms.12-0368","article-title":"Effect of different levels of supplemental yeast on body weight, thyroid hormone metabolism and lipid profile of broiler chickens","volume":"75","author":"T Aluwong","year":"2013","journal-title":"J Vet Med Sci"},{"issue":"14","key":"ref26","doi-asserted-by":"crossref","first-page":"6477","DOI":"10.1007\/s00253-013-4970-2","article-title":"Effects of <italic>Clostridium butyricum<\/italic> and <italic>Enterococcus faecium<\/italic> on growth performance, lipid metabolism, and cecal microbiota of broiler chickens","volume":"97","author":"X Zhao","year":"2013","journal-title":"Appl Microbiol Biotechnol."},{"issue":"2","key":"ref27","doi-asserted-by":"crossref","first-page":"341","DOI":"10.1002\/jsfa.6365","article-title":"Effects of dietary prebiotics, probiotic and synbiotics on performance, caecal bacterial populations and caecal fermentation concentrations of broiler chickens","volume":"94","author":"S Mookiah","year":"2014","journal-title":"J Sci Food Agric"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/09540100220145151","article-title":"Effect of probiotic Cenbiot on the humoral response to an <italic>Escherichia coli<\/italic> bacterin","volume":"14","author":"FR Concei\u00e7\u00e3o","year":"2002","journal-title":"Food and Agric Immunol"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1080\/09540100500244138","article-title":"Effect of <italic>Saccharomyces boulardii<\/italic> and <italic>Bacillus cereus<\/italic> var toyoi on the humoral and cellular response of mice to vaccines","volume":"16","author":"MM Copolla","year":"2005","journal-title":"Food and Agric Immunol"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1080\/09540100903443691","article-title":"Effect of <italic>Bacillus cereus<\/italic> var. toyoi and <italic>Saccharomyces boulardii<\/italic> on the immune response of sheep to vaccines","volume":"21","author":"TB Roos","year":"2010","journal-title":"Food Agric Immunol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"2173","DOI":"10.1016\/j.vaccine.2012.01.007","article-title":"The immune modulation of <italic>Bacillus cereus<\/italic> var. Toyoi in mice immunized with experimental inactivated Bovine Herpesvirus Type 5 vaccine","volume":"30","author":"TB Roos","year":"2012","journal-title":"Vaccine"},{"issue":"12","key":"ref32","doi-asserted-by":"crossref","first-page":"1387","DOI":"10.1128\/CDLI.12.12.1387-1392.2005","article-title":"Modulation of antibody-mediated immune response by probiotics in chickens","volume":"12","author":"HR Haghighi","year":"2005","journal-title":"Clin Diagn Lab Immunol"},{"issue":"9","key":"ref33","doi-asserted-by":"crossref","first-page":"975","DOI":"10.1128\/CVI.00161-06","article-title":"Probiotics stimulate production of natural antibodies in chickens","volume":"13","author":"HR Haghighi","year":"2006","journal-title":"Clin and Vaccine Immunol"},{"issue":"2","key":"ref34","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/03079457.2012.661403","article-title":"Current status of vaccines against infectious bursal disease","volume":"41","author":"H M\u00fcller","year":"2012","journal-title":"Avian Pathol"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1093\/ps\/85.8.1364","article-title":"Maternal antibody transfer from dams to their egg yolks, egg whites, and chicks in meat lines of chickens","volume":"85","author":"KR Hamal","year":"2006","journal-title":"Poult Sci"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"874","DOI":"10.2307\/1593060","article-title":"Antibody titers to infectious bursal disease virus in broiler chicks after vaccination at one day of age with infectious bursal disease virus and Marek&apos;s disease virus","volume":"44","author":"HV Knoblich","year":"2000","journal-title":"Avian Dis"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"105","DOI":"10.1007\/s12010-007-0003-x","article-title":"Expression of recombinant proteins in <italic>Pichia Pastoris<\/italic>","volume":"142","author":"P Li","year":"2007","journal-title":"Appl Biochem Biotechnol"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"2116","DOI":"10.3389\/fmicb.2016.02116","article-title":"Catalytic interactions and molecular docking of bile salt hydrolase (BSH) from <italic>L<\/italic>. <italic>plantarum<\/italic> RYPR1 and its prebiotic utilization","volume":"7","author":"R Yadav","year":"2017","journal-title":"Front. Microbiol"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1186\/1475-2859-11-116","article-title":"Influence of fermentation conditions on the surface properties and adhesion of <italic>Lactobacillus rhamnosus<\/italic> GG","volume":"11","author":"G Deepika","year":"2012","journal-title":"Microb Cell Fact"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1038\/ismej.2009.128","article-title":"Exposure of different bacterial inocula to newborn chicken affects gut microbiota development and ileum gene expression","volume":"4","author":"Y Yeshi","year":"2010","journal-title":"ISME J"},{"issue":"7","key":"ref41","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1128\/IAI.01375-10","article-title":"Immune response of chicken gut to natural colonization by gut microflora and to <italic>Salmonella enterica<\/italic> serovar Enteritidis infection","volume":"79","author":"M Crhanova","year":"2001","journal-title":"Infect Immun"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0192904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,28]],"date-time":"2020-10-28T05:51:56Z","timestamp":1603864316000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0192904"}},"subtitle":[],"editor":[{"given":"Pratyoosh","family":"Shukla","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,15]]},"references-count":41,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,15]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0192904","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,15]]}}}