{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,16]],"date-time":"2026-10-16T00:07:17Z","timestamp":1792109237795,"version":"4.4.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"2","license":[{"start":{"date-parts":[[2018,2,21]],"date-time":"2018-02-21T00:00:00Z","timestamp":1519171200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"the Veterans Medical Research Institute, VHS Medical Center","award":["grant number VHSMC16012"],"award-info":[{"award-number":["grant number VHSMC16012"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0193299","type":"journal-article","created":{"date-parts":[[2018,2,23]],"date-time":"2018-02-23T11:07:06Z","timestamp":1519384026000},"page":"e0193299","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":17,"title":["Reduced NK cell IFN-\u03b3 secretion and psychological stress are independently associated with herpes zoster"],"prefix":"10.1371","volume":"13","author":[{"given":"Choon Kwan","family":"Kim","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Youn Mi","family":"Choi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eunsin","family":"Bae","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihn Sook","family":"Jue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hyung Seok","family":"So","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9562-4577","authenticated-orcid":true,"given":"Eung-Soo","family":"Hwang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,2,21]]},"reference":[{"issue":"Suppl 1","key":"ref1","doi-asserted-by":"crossref","first-page":"S2","DOI":"10.1016\/S1386-6532(10)70002-0","article-title":"Advances in the understanding of the pathogenesis and epidemiology of herpes zoster","volume":"48","author":"AA Gershon","year":"2010","journal-title":"J Clin Virol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1001\/archinte.1982.00340150091017","article-title":"Immune responses to varicella-zoster in the aged","volume":"142","author":"BL Burke","year":"1982","journal-title":"Arch Intern Med"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"1336","DOI":"10.1086\/379048","article-title":"Decline in varicella-zoster virus (VZV)-specific cell-mediated immunity with increasing age and boosting with a high-dose VZV vaccine","volume":"188","author":"MJ Levin","year":"2003","journal-title":"J Infect Dis"},{"issue":"Suppl 1","key":"ref4","doi-asserted-by":"crossref","first-page":"S14","DOI":"10.1016\/S1386-6532(10)70004-4","article-title":"Prevention strategies for herpes zoster and post-herpetic neuralgia","volume":"48","author":"MJ Levin","year":"2010","journal-title":"J Clin Virol"},{"key":"ref5","first-page":"341","article-title":"VZV T cell-mediated immunity","volume":"342","author":"A Weinberg","year":"2010","journal-title":"Curr Top Microbiol Immunol"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"235","DOI":"10.3389\/fimmu.2016.00235","article-title":"\u201cNatural regulators\u201d: NK cells as modulators of T cell immunity","volume":"7","author":"IS Schuster","year":"2016","journal-title":"Front Immunol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"383","DOI":"10.1002\/ijc.2910290404","article-title":"Studies of human natural killer cells. I. In vivo parameters affecting normal cytotoxic function","volume":"29","author":"HF Pross","year":"1982","journal-title":"Int J Cancer"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1188","DOI":"10.1111\/j.1532-5415.1990.tb01497.x","article-title":"Are stressful life events risk factors for herpes zoster?","volume":"38","author":"K Schmader","year":"1990","journal-title":"J Am Geriatr Soc"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"601","DOI":"10.1037\/0033-2909.130.4.601","article-title":"Psychological stress and the human immune system: a meta-analytic study of 30 years of inquiry","volume":"130","author":"SC Segerstrom","year":"2004","journal-title":"Psychol Bull"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1007\/BF00919268","article-title":"Changes of natural killer cells during acute psychological stress","volume":"13","author":"M Schedlowski","year":"1993","journal-title":"J Clin Immunol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.psyneuen.2006.09.011","article-title":"Psychologic stress, reduced NK cell activity, and cytokine dysregulation in women experiencing diagnostic breast biopsy","volume":"32","author":"L Witek-Janusek","year":"2007","journal-title":"Psychoneuroendocrinology"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1761","DOI":"10.1086\/317624","article-title":"Reactivation and shedding of cytomegalovirus in astronauts during spaceflight","volume":"182","author":"SK Mehta","year":"2000","journal-title":"J Infect Dis"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"1394","DOI":"10.1080\/21645515.2015.1037999","article-title":"Cytomegalovirus seropositivity is associated with herpes zoster","volume":"11","author":"B Ogunjimi","year":"2015","journal-title":"Hum Vaccin Immunother"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"e78049","DOI":"10.1371\/journal.pone.0078049","article-title":"Reduction of the CD16(-)CD56bright NK cell subset precedes NK cell dysfunction in prostate cancer","volume":"8","author":"KC Koo","year":"2013","journal-title":"PLOS One"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1016\/j.bbrc.2014.02.040","article-title":"A high-throughput assay of NK cell activity in whole blood and its clinical application","volume":"445","author":"SB Lee","year":"2014","journal-title":"Biochem Biophys Res Commun"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"384","DOI":"10.3349\/ymj.2006.47.3.384","article-title":"Development of the stress-induced cognition scale","volume":"47","author":"KB Koh","year":"2006","journal-title":"Yonsei Med J"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1150","DOI":"10.1038\/ni857","article-title":"NKG2D recruits two distinct adapters to trigger NK cell activation and costimulation","volume":"3","author":"S Gilfillan","year":"2002","journal-title":"Nat Immunol"},{"key":"ref18","first-page":"8708","article-title":"Association between natural killer cell activity and prostate cancer: a pilot study","volume":"24","author":"J Barkin","year":"2017","journal-title":"Can J Urol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"980","DOI":"10.1053\/j.gastro.2017.06.009","article-title":"Association between natural killer cell activity and colorectal cancer in high-risk subjects undergoing colonoscopy","volume":"153","author":"G Jobin","year":"2017","journal-title":"Gastroenterology"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1111\/j.1442-200X.1989.tb01349.x","article-title":"Natural killing of varicella-zoster virus (VZV)-infected fibroblasts in normal children, children with VZV infections, and children with Hodgkin\u2019s disease","volume":"31","author":"T Ihara","year":"1989","journal-title":"Acta Paediatr Jpn"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/jmv.1890390312","article-title":"Depressed immune functions in the early phase of varicella-zoster virus reactivation","volume":"39","author":"T Saibara","year":"1993","journal-title":"J Med Virol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7932","DOI":"10.1128\/JVI.00292-15","article-title":"Varicella-zoster virus and herpes simplex virus 1 differentially modulate NKG2D ligand expression during productive infection","volume":"89","author":"TM Campbell","year":"2015","journal-title":"J Virol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"390","DOI":"10.3389\/fimmu.2017.00390","article-title":"Disarming cellular alarm systems-manipulation of stress-induced NKG2D ligands by human herpesviruses","volume":"8","author":"D Schmiedel","year":"2017","journal-title":"Front Immunol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1093\/cid\/ciu889","article-title":"Psychological stress as a trigger for herpes zoster: might the conventional wisdom be wrong?","volume":"60","author":"R Harpaz","year":"2015","journal-title":"Clin Infect Dis"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1111\/j.1365-2222.2001.01005.x","article-title":"Stress effects on immunity and its application to clinical immunology","volume":"31","author":"SK Agarwal","year":"2001","journal-title":"Clin Exp Allergy"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"9748","DOI":"10.1007\/s11357-015-9748-2","article-title":"NK cell immunesenescence is increased by psychological but not physical stress in older adults associated with raised cortisol and reduced perforin expression","volume":"37","author":"NA Duggal","year":"2015","journal-title":"Age"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"515","DOI":"10.1016\/j.jaci.2013.07.020","article-title":"Natural killer cell deficiency","volume":"132","author":"JS Orange","year":"2013","journal-title":"J Allergy Clin Immunol"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1186\/1742-4933-4-2","article-title":"Role of persistent CMV infection in configuring T cell immunity in the elderly","volume":"4","author":"S Vasto","year":"2007","journal-title":"Immun Ageing"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1093\/infdis\/jiv480","article-title":"Cellular and humoral responses to a second dose of herpes zoster vaccine administered 10 years after the first dose among older adults","volume":"213","author":"MJ Levin","year":"2016","journal-title":"J Infect Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0193299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T00:51:20Z","timestamp":1540342280000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0193299"}},"subtitle":[],"editor":[{"given":"Graciela","family":"Andrei","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,2,21]]},"references-count":29,"journal-issue":{"issue":"2","published-online":{"date-parts":[[2018,2,21]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0193299","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,2,21]]}}}