{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,9,28]],"date-time":"2025-09-28T08:31:32Z","timestamp":1759048292533,"version":"3.37.3"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Wildermuth Foundation for Pediatric Research"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0193539","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T17:28:26Z","timestamp":1522085306000},"page":"e0193539","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":15,"title":["Suppressed plasmablast responses in febrile infants, including children with Kawasaki disease"],"prefix":"10.1371","volume":"13","author":[{"given":"Meghan","family":"Martin","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian H.","family":"Wrotniak","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1768-5419","authenticated-orcid":true,"given":"Mark","family":"Hicar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"issue":"4","key":"ref1","doi-asserted-by":"crossref","first-page":"538","DOI":"10.1203\/00006450-200110000-00019","article-title":"Surface and cytoplasmic immunoglobulin expression in circulating B-lymphocytes in acute Kawasaki disease","volume":"50","author":"D Shingadia","year":"2001","journal-title":"Pediatr Res"},{"issue":"3","key":"ref2","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1161\/01.CIR.0000079166.93475.5F","article-title":"Prognostic impact of vascular leakage in acute Kawasaki disease","volume":"108","author":"M Terai","year":"2003","journal-title":"Circulation"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"369","DOI":"10.3345\/kjp.2015.58.10.369","article-title":"Diagnostic characteristics of supplemental laboratory criteria for incomplete Kawasaki disease in children with complete Kawasaki disease","volume":"58","author":"HO Jun","year":"2015","journal-title":"Korean J Pediatr"},{"issue":"12","key":"ref4","doi-asserted-by":"crossref","first-page":"e0144603","DOI":"10.1371\/journal.pone.0144603","article-title":"High-Dose Aspirin Is Associated with Anemia and Does Not Confer Benefit to Disease Outcomes in Kawasaki Disease","volume":"10","author":"HC Kuo","year":"2015","journal-title":"PLoS One"},{"issue":"9","key":"ref5","doi-asserted-by":"crossref","first-page":"891","DOI":"10.1111\/j.1348-0421.1987.tb03150.x","article-title":"High levels of IgA-containing circulating immune complex and secretory IgA in Kawasaki disease","volume":"31","author":"G Ohshio","year":"1987","journal-title":"Microbiol Immunol"},{"issue":"8","key":"ref6","doi-asserted-by":"crossref","first-page":"e72037","DOI":"10.1371\/journal.pone.0072037","article-title":"Replication and meta-analysis of GWAS identified susceptibility loci in Kawasaki disease confirm the importance of B lymphoid tyrosine kinase (BLK) in disease susceptibility","volume":"8","author":"CJ Chang","year":"2013","journal-title":"PLoS One"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"e305","DOI":"10.1542\/peds.2013-1638","article-title":"Long-term cardiovascular outcomes in survivors of Kawasaki disease","volume":"133","author":"TJ Holve","year":"2014","journal-title":"Pediatrics"},{"issue":"3","key":"ref8","first-page":"263","article-title":"Curr Opin Infect Dis","volume":"21","author":"GS Pinna","year":"2008","journal-title":"Curr Opin Infect Dis"},{"issue":"17","key":"ref9","doi-asserted-by":"crossref","first-page":"1836","DOI":"10.1161\/CIRCULATIONAHA.110.978213","article-title":"Long-term prognosis of patients with Kawasaki disease complicated by giant coronary aneurysms: a single-institution experience","volume":"123","author":"K Suda","year":"2011","journal-title":"Circulation"},{"issue":"1","key":"ref10","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1017\/S1047951110001502","article-title":"Acute coronary syndrome in adult patients with coronary artery lesions caused by Kawasaki disease: review of case reports","volume":"21","author":"E Tsuda","year":"2011","journal-title":"Cardiol Young"},{"issue":"20","key":"ref11","doi-asserted-by":"crossref","first-page":"2447","DOI":"10.1161\/CIRCULATIONAHA.111.082107","article-title":"Prevalence of Kawasaki disease in young adults with suspected myocardial ischemia","volume":"125","author":"LB Daniels","year":"2012","journal-title":"Circulation"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1097\/00006454-200306000-00001","article-title":"Hospitalizations for Kawasaki syndrome among children in the United States, 1997\u20132007","volume":"29","author":"RC Holman","year":"2010","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"239","DOI":"10.2188\/jea.JE20140089","article-title":"Descriptive epidemiology of Kawasaki disease in Japan, 2011\u20132012: from the results of the 22nd nationwide survey","volume":"25","author":"N Makino","year":"2015","journal-title":"J Epidemiol"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"493","DOI":"10.3349\/ymj.2009.50.4.493","article-title":"Immunoglobulin V(H) chain gene analysis of peripheral blood IgM-producing B cells in patients with Kawasaki disease","volume":"50","author":"HH Lee","year":"2009","journal-title":"Yonsei Med J"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1038\/srep00152","article-title":"Association of Kawasaki disease with tropospheric wind patterns","volume":"1","author":"X Rodo","year":"2011","journal-title":"Sci Rep"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1097\/01.ede.0000152901.06689.d4","article-title":"Seasonality and temporal clustering of Kawasaki syndrome","volume":"16","author":"JC Burns","year":"2005","journal-title":"Epidemiology"},{"issue":"1","key":"ref17","first-page":"153","article-title":"Summary and abstracts of the Seventh International Kawasaki Disease Symposium: December 4\u20137, 2001, Hakone, Japan","volume":"53","author":"JW Newburger","year":"2003","journal-title":"Pediatr Res"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","DOI":"10.1542\/peds.2015-3919","article-title":"Breastfeeding and Risk of Kawasaki Disease: A Nationwide Longitudinal Survey in Japan","volume":"137","author":"T Yorifuji","year":"2016","journal-title":"Pediatrics"},{"issue":"2","key":"ref19","doi-asserted-by":"crossref","first-page":"246","DOI":"10.1111\/j.1365-2249.2009.04073.x","article-title":"Unique activation status of peripheral blood mononuclear cells at acute phase of Kawasaki disease","volume":"160","author":"K Ikeda","year":"2010","journal-title":"Clin Exp Immunol"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/ng.2227","article-title":"Two new susceptibility loci for Kawasaki disease identified through genome-wide association analysis","volume":"44","author":"YC Lee","year":"2012","journal-title":"Nature genetics"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"517","DOI":"10.1038\/ng.2220","article-title":"A genome-wide association study identifies three new risk loci for Kawasaki disease","volume":"44","author":"Y Onouchi","year":"2012","journal-title":"Nat Genet"},{"issue":"23","key":"ref22","doi-asserted-by":"crossref","first-page":"2890","DOI":"10.4161\/cc.6.23.4952","article-title":"Homeostatic and maturation-associated proliferation in the peripheral B-cell compartment","volume":"6","author":"MC van Zelm","year":"2007","journal-title":"Cell Cycle"},{"issue":"3","key":"ref23","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1038\/nri3795","article-title":"The generation of antibody-secreting plasma cells","volume":"15","author":"SL Nutt","year":"2015","journal-title":"Nature reviews Immunology"},{"issue":"7195","key":"ref24","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1038\/nature06890","article-title":"Rapid cloning of high-affinity human monoclonal antibodies against influenza virus","volume":"453","author":"J Wrammert","year":"2008","journal-title":"Nature"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"e29430","DOI":"10.1371\/journal.pone.0029430","article-title":"Dengue virus activates polyreactive, natural IgG B cells after primary and secondary infection","volume":"6","author":"T Balakrishnan","year":"2011","journal-title":"PLoS One"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"1659","DOI":"10.1086\/657158","article-title":"Circulating antibody-secreting cells during acute respiratory syncytial virus infection in adults","volume":"202","author":"FE Lee","year":"2010","journal-title":"J Infect Dis"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1111\/imm.12713","article-title":"Massive plasmablast response elicited in the acute phase of hantavirus pulmonary syndrome","volume":"151","author":"M Garcia","year":"2017","journal-title":"Immunology"},{"issue":"6","key":"ref28","doi-asserted-by":"crossref","first-page":"2911","DOI":"10.1128\/JVI.06075-11","article-title":"Rapid and massive virus-specific plasmablast responses during acute dengue virus infection in humans","volume":"86","author":"J Wrammert","year":"2012","journal-title":"J Virol"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1016\/j.immuni.2015.06.013","article-title":"Salmonella Infection Drives Promiscuous B Cell Activation Followed by Extrafollicular Affinity Maturation","volume":"43","author":"R Di Niro","year":"2015","journal-title":"Immunity"},{"issue":"6","key":"ref30","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.02021-16","article-title":"Single-Cell Analysis of the Plasmablast Response to Vibrio cholerae Demonstrates Expansion of Cross-Reactive Memory B Cells","volume":"7","author":"RC Kauffman","year":"2016","journal-title":"MBio"},{"issue":"11","key":"ref31","doi-asserted-by":"crossref","first-page":"2237","DOI":"10.1084\/jem.20110363","article-title":"Initial antibodies binding to HIV-1 gp41 in acutely infected subjects are polyreactive and highly mutated","volume":"208","author":"HX Liao","year":"2011","journal-title":"J Exp Med"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"1691","DOI":"10.3389\/fimmu.2017.01691","article-title":"Circulating Plasmablasts from Chronically Human Immunodeficiency Virus-Infected Individuals Predominantly Produce Polyreactive\/Autoreactive Antibodies","volume":"8","author":"H Liao","year":"2017","journal-title":"Front Immunol"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"1614","DOI":"10.1182\/blood-2004-07-2507","article-title":"Generation of migratory antigen-specific plasma blasts and mobilization of resident plasma cells in a secondary immune response","volume":"105","author":"M Odendahl","year":"2005","journal-title":"Blood"},{"issue":"24","key":"ref34","doi-asserted-by":"crossref","first-page":"4998","DOI":"10.1182\/blood-2009-03-211052","article-title":"Appearance of peripheral blood plasma cells and memory B cells in a primary and secondary immune response in humans","volume":"114","author":"G Blanchard-Rohner","year":"2009","journal-title":"Blood"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"78","DOI":"10.3389\/fimmu.2012.00078","article-title":"Origin and Function of Circulating Plasmablasts during Acute Viral Infections","volume":"3","author":"K Fink","year":"2012","journal-title":"Front Immunol"},{"issue":"1","key":"ref36","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1007\/s00401-016-1627-0","article-title":"Peripheral VH4+ plasmablasts demonstrate autoreactive B cell expansion toward brain antigens in early multiple sclerosis patients","volume":"133","author":"JR Rivas","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"12","key":"ref37","doi-asserted-by":"crossref","first-page":"2381","DOI":"10.1002\/ibd.22962","article-title":"Plasmablast frequency and trafficking receptor expression are altered in pediatric ulcerative colitis","volume":"18","author":"NJ Tarlton","year":"2012","journal-title":"Inflamm Bowel Dis"},{"issue":"2","key":"ref38","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1111\/j.1365-2249.2010.04290.x","article-title":"Increased numbers of immature plasma cells in peripheral blood specifically overexpress chemokine receptor CXCR3 and CXCR4 in patients with ulcerative colitis","volume":"163","author":"S Hosomi","year":"2011","journal-title":"Clin Exp Immunol"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"679","DOI":"10.1016\/j.jaci.2014.03.034","article-title":"De novo oligoclonal expansions of circulating plasmablasts in active and relapsing IgG4-related disease","volume":"134","author":"H Mattoo","year":"2014","journal-title":"J Allergy Clin Immunol"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1136\/annrheumdis-2014-205233","article-title":"Plasmablasts as a biomarker for IgG4-related disease, independent of serum IgG4 concentrations","volume":"74","author":"ZS Wallace","year":"2015","journal-title":"Ann Rheum Dis"},{"issue":"Suppl 1","key":"ref41","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1016\/j.jcpa.2007.04.004","article-title":"The challenges of vaccine responses in early life: selected examples","volume":"137","author":"CA Siegrist","year":"2007","journal-title":"J Comp Pathol"},{"issue":"1","key":"ref42","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1111\/j.1365-2567.2008.02934.x","article-title":"Plasma and memory B-cell kinetics in infants following a primary schedule of CRM 197-conjugated serogroup C meningococcal polysaccharide vaccine","volume":"127","author":"DF Kelly","year":"2009","journal-title":"Immunology"},{"issue":"8","key":"ref43","doi-asserted-by":"crossref","first-page":"2642","DOI":"10.1182\/blood-2006-01-009282","article-title":"CRM197-conjugated serogroup C meningococcal capsular polysaccharide, but not the native polysaccharide, induces persistent antigen-specific memory B cells","volume":"108","author":"DF Kelly","year":"2006","journal-title":"Blood"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1038\/nprot.2009.3","article-title":"Rapid generation of fully human monoclonal antibodies specific to a vaccinating antigen","volume":"4","author":"K Smith","year":"2009","journal-title":"Nat Protoc"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1186\/s12969-017-0163-3","article-title":"Observational study of Interleukin-21 (IL-21) does not distinguish Kawasaki disease from other causes of fever in children","volume":"15","author":"R Engelberg","year":"2017","journal-title":"Pediatr Rheumatol Online J"},{"issue":"17","key":"ref46","doi-asserted-by":"crossref","first-page":"e927","DOI":"10.1161\/CIR.0000000000000484","article-title":"Diagnosis, Treatment, and Long-Term Management of Kawasaki Disease: A Scientific Statement for Health Professionals From the American Heart Association","volume":"135","author":"BW McCrindle","year":"2017","journal-title":"Circulation"},{"issue":"12","key":"ref47","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1097\/INF.0b013e31822d4f56","article-title":"Evolution of laboratory values in patients with Kawasaki disease","volume":"30","author":"AH Tremoulet","year":"2011","journal-title":"Pediatr Infect Dis J"},{"issue":"3","key":"ref48","doi-asserted-by":"crossref","first-page":"189","DOI":"10.2188\/jea.JE20140128","article-title":"Cardiac lesions and initial laboratory data in Kawasaki disease: a nationwide survey in Japan","volume":"25","author":"M Kuwabara","year":"2015","journal-title":"J Epidemiol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"e234","DOI":"10.1542\/peds.2009-0606","article-title":"Performance of 2004 American Heart Association recommendations for treatment of Kawasaki disease","volume":"125","author":"ES Yellen","year":"2010","journal-title":"Pediatrics"},{"issue":"3","key":"ref50","doi-asserted-by":"crossref","first-page":"346","DOI":"10.1111\/j.1365-2249.2010.04297.x","article-title":"Increased frequency of immunoglobulin (Ig)A-secreting cells following Toll-like receptor (TLR)-9 engagement in patients with Kawasaki disease","volume":"163","author":"L Giordani","year":"2011","journal-title":"Clin Exp Immunol"},{"issue":"12","key":"ref51","doi-asserted-by":"crossref","first-page":"5946","DOI":"10.4049\/jimmunol.159.12.5946","article-title":"IgA plasma cells in vascular tissue of patients with Kawasaki syndrome","volume":"159","author":"AH Rowley","year":"1997","journal-title":"J Immunol"},{"issue":"2","key":"ref52","doi-asserted-by":"crossref","first-page":"1334","DOI":"10.4049\/jimmunol.166.2.1334","article-title":"Oligoclonal IgA response in the vascular wall in acute Kawasaki disease","volume":"166","author":"AH Rowley","year":"2001","journal-title":"J Immunol"},{"issue":"6","key":"ref53","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1001\/jama.280.6.527","article-title":"Deficiency of the humoral immune response to measles vaccine in infants immunized at age 6 months","volume":"280","author":"HA Gans","year":"1998","journal-title":"JAMA"},{"issue":"12","key":"ref54","doi-asserted-by":"crossref","first-page":"7867","DOI":"10.4049\/jimmunol.175.12.7867","article-title":"IL-21 induces differentiation of human naive and memory B cells into antibody-secreting plasma cells","volume":"175","author":"R Ettinger","year":"2005","journal-title":"J Immunol"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"351","DOI":"10.4168\/aair.2012.4.6.351","article-title":"Elevated Serum Levels of IL-21 in Kawasaki Disease","volume":"4","author":"YJ Bae","year":"2012","journal-title":"Allergy Asthma Immunol Res"},{"issue":"6","key":"ref56","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1007\/s00281-017-0654-9","article-title":"Vaccine responses in newborns","volume":"39","author":"A Saso","year":"2017","journal-title":"Semin Immunopathol"},{"issue":"5","key":"ref57","doi-asserted-by":"crossref","first-page":"2755","DOI":"10.1182\/blood-2007-09-110858","article-title":"APRIL is critical for plasmablast survival in the bone marrow and poorly expressed by early-life bone marrow stromal cells","volume":"111","author":"E Belnoue","year":"2008","journal-title":"Blood"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1038\/nri2508","article-title":"B-cell responses to vaccination at the extremes of age","volume":"9","author":"CA Siegrist","year":"2009","journal-title":"Nat Rev Immunol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.coi.2016.04.004","article-title":"Vaccination in early life: standing up to the challenges","volume":"41","author":"E Mohr","year":"2016","journal-title":"Curr Opin Immunol"},{"issue":"6","key":"ref60","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1212\/WNL.0b013e318228c136","article-title":"Analysis of complement and plasma cells in the brain of patients with anti-NMDAR encephalitis","volume":"77","author":"E Martinez-Hernandez","year":"2011","journal-title":"Neurology"},{"issue":"1","key":"ref61","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1097\/BOR.0b013e3283412f60","article-title":"Autoimmune pancreatitis and IgG4-related sclerosing cholangitis","volume":"23","author":"K Takuma","year":"2011","journal-title":"Curr Opin Rheumatol"},{"issue":"11","key":"ref62","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1038\/nrneurol.2012.203","article-title":"B cells and antibodies in multiple sclerosis pathogenesis and therapy","volume":"8","author":"M Krumbholz","year":"2012","journal-title":"Nat Rev Neurol"},{"issue":"22","key":"ref63","doi-asserted-by":"crossref","first-page":"2394","DOI":"10.1001\/jama.1977.03280230058024","article-title":"Rheumatoid pericarditis. Rapid deterioration with evidence of local vasculitis","volume":"238","author":"S Butman","year":"1977","journal-title":"JAMA"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0193539","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T09:55:35Z","timestamp":1719914135000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0193539"}},"subtitle":[],"editor":[{"given":"Ravi","family":"Jhaveri","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":63,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0193539","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,3,26]]}}}