{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,24]],"date-time":"2026-04-24T12:19:44Z","timestamp":1777033184470,"version":"3.51.4"},"reference-count":58,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T00:00:00Z","timestamp":1522195200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD-041230"],"award-info":[{"award-number":["HD-041230"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD-081206"],"award-info":[{"award-number":["HD-081206"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HD-089714"],"award-info":[{"award-number":["HD-089714"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-HD-08722"],"award-info":[{"award-number":["U01-HD-08722"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["U01-HD-08722"],"award-info":[{"award-number":["U01-HD-08722"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","award":["URFP"],"award-info":[{"award-number":["URFP"]}],"id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100007185","name":"University of California, Los Angeles","doi-asserted-by":"publisher","award":["URSP"],"award-info":[{"award-number":["URSP"]}],"id":[{"id":"10.13039\/100007185","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0193583","type":"journal-article","created":{"date-parts":[[2018,3,28]],"date-time":"2018-03-28T17:46:47Z","timestamp":1522259207000},"page":"e0193583","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Humanin (HN) and glucose transporter 8 (GLUT8) in pregnancies complicated by intrauterine growth restriction"],"prefix":"10.1371","volume":"13","author":[{"given":"Carla","family":"Janzen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margarida Y. Y.","family":"Lei","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5465-6185","authenticated-orcid":true,"given":"Il Seok D.","family":"Jeong","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Amit","family":"Ganguly","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peggy","family":"Sullivan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vladislava","family":"Paharkova","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gina","family":"Capodanno","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hiromi","family":"Nakamura","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alix","family":"Perry","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bo-Chul","family":"Shin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kuk-Wha","family":"Lee","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sherin U.","family":"Devaskar","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,3,28]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1186\/1824-7288-37-41","article-title":"Intrauterine growth retardation\u2014small events, big consequences","volume":"37","author":"T Saleem","year":"2011","journal-title":"Italian journal of pediatrics"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1159\/000106488","article-title":"Role of oxidative stress in intrauterine growth restriction","volume":"64","author":"A Biri","year":"2007","journal-title":"Gynecologic and obstetric investigation"},{"issue":"Suppl A","key":"ref3","doi-asserted-by":"crossref","first-page":"S25","DOI":"10.1053\/plac.1999.0522","article-title":"Oxygen and placental development during the first trimester: implications for the pathophysiology of pre-eclampsia","volume":"21","author":"I Caniggia","year":"2000","journal-title":"Placenta"},{"issue":"5332","key":"ref4","doi-asserted-by":"crossref","first-page":"1669","DOI":"10.1126\/science.277.5332.1669","article-title":"Regulation of human placental development by oxygen tension","volume":"277","author":"O Genbacev","year":"1997","journal-title":"Science"},{"issue":"2","key":"ref5","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.bbrc.2013.08.055","article-title":"A humanin analog decreases oxidative stress and preserves mitochondrial integrity in cardiac myoblasts","volume":"440","author":"LE Klein","year":"2013","journal-title":"Biochemical and biophysical research communications"},{"issue":"10","key":"ref6","doi-asserted-by":"crossref","first-page":"1940","DOI":"10.1161\/ATVBAHA.110.205997","article-title":"Acute humanin therapy attenuates myocardial ischemia and reperfusion injury in mice","volume":"30","author":"RH Muzumdar","year":"2010","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1093\/cvr\/cvq191","article-title":"Humanin is expressed in human vascular walls and has a cytoprotective effect against oxidized LDL-induced oxidative stress","volume":"88","author":"AR Bachar","year":"2010","journal-title":"Cardiovascular research"},{"issue":"3","key":"ref8","doi-asserted-by":"crossref","first-page":"560","DOI":"10.1016\/j.diabres.2014.09.020","article-title":"Protection effect of [Gly14]-Humanin from apoptosis induced by high glucose in human umbilical vein endothelial cells","volume":"106","author":"Y Xie","year":"2014","journal-title":"Diabetes research and clinical practice"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"6336","DOI":"10.1073\/pnas.101133498","article-title":"A rescue factor abolishing neuronal cell death by a wide spectrum of familial Alzheimer\u2019s disease genes and Abeta","volume":"98","author":"Y Hashimoto","year":"2001","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"6938","key":"ref10","doi-asserted-by":"crossref","first-page":"456","DOI":"10.1038\/nature01627","article-title":"Humanin peptide suppresses apoptosis by interfering with Bax activation","volume":"423","author":"B Guo","year":"2003","journal-title":"Nature"},{"issue":"22","key":"ref11","doi-asserted-by":"crossref","first-page":"13042","DOI":"10.1073\/pnas.2135111100","article-title":"Interaction between the Alzheimer\u2019s survival peptide humanin and insulin-like growth factor-binding protein 3 regulates cell survival and apoptosis","volume":"100","author":"M Ikonen","year":"2003","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"R11","DOI":"10.1530\/JME-12-0203","article-title":"The emerging role of the mitochondrial-derived peptide humanin in stress resistance","volume":"50","author":"K Yen","year":"2013","journal-title":"Journal of molecular endocrinology"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1007\/s10038-006-0397-2","article-title":"Humanin expression in skeletal muscles of patients with chronic progressive external ophthalmoplegia","volume":"51","author":"T Kin","year":"2006","journal-title":"Journal of human genetics"},{"issue":"23","key":"ref14","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.13063","article-title":"Humanin skeletal muscle protein levels increase after resistance training in men with impaired glucose metabolism","volume":"4","author":"EK Gidlund","year":"2016","journal-title":"Physiological reports"},{"key":"ref15","first-page":"1","article-title":"Serum humanin concentrations in women with pre-eclampsia compared to women with uncomplicated pregnancies","author":"P Nikolakopoulos","year":"2017","journal-title":"The journal of maternal-fetal & neonatal medicine: the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstet"},{"issue":"9","key":"ref16","doi-asserted-by":"crossref","DOI":"10.14814\/phy2.12796","article-title":"Humanin: a mitochondrial signaling peptide as a biomarker for impaired fasting glucose-related oxidative stress","volume":"4","author":"A Voigt","year":"2016","journal-title":"Physiological reports"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"R237","DOI":"10.1152\/ajpregu.00093.2014","article-title":"Differential regulation of GLUT1 and GLUT8 expression by hypoxia in mammary epithelial cells","volume":"307","author":"Y Shao","year":"2014","journal-title":"American journal of physiology Regulatory, integrative and comparative physiology"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"E242","DOI":"10.1152\/ajpendo.90388.2008","article-title":"The facilitative glucose transporter GLUT3: 20 years of distinction","volume":"295","author":"IA Simpson","year":"2008","journal-title":"American journal of physiology Endocrinology and metabolism"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1016\/S0006-291X(05)81022-8","article-title":"Erythrocyte\/HepG2-type glucose transporter is concentrated in cells of blood-tissue barriers","volume":"173","author":"K Takata","year":"1990","journal-title":"Biochemical and biophysical research communications"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1203\/00006450-199201000-00001","article-title":"The mammalian glucose transporters","volume":"31","author":"SU Devaskar","year":"1992","journal-title":"Pediatr Res"},{"issue":"30","key":"ref21","doi-asserted-by":"crossref","first-page":"15245","DOI":"10.1016\/S0021-9258(19)37577-5","article-title":"Evidence for a family of human glucose transporter-like proteins. Sequence and gene localization of a protein expressed in fetal skeletal muscle and other tissues","volume":"263","author":"T Kayano","year":"1988","journal-title":"The Journal of biological chemistry"},{"issue":"12","key":"ref22","doi-asserted-by":"crossref","first-page":"1041","DOI":"10.1016\/j.placenta.2011.09.014","article-title":"Glucose transporter 3 (GLUT3) protein expression in human placenta across gestation","volume":"32","author":"K Brown","year":"2011","journal-title":"Placenta"},{"issue":"8","key":"ref23","first-page":"2689","article-title":"The GLUT3 glucose transporter isoform is differentially expressed within human placental cell types","volume":"82","author":"S Hauguel-de Mouzon","year":"1997","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"521","DOI":"10.1093\/humrep\/deh596","article-title":"Glucose transporter isoform 4 is expressed in the syncytiotrophoblast of first trimester human placenta","volume":"20","author":"A Ericsson","year":"2005","journal-title":"Hum Reprod"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.placenta.2003.08.012","article-title":"Characterization of glucose transporter 8 (GLUT8) in the ovine placenta of normal and growth restricted fetuses","volume":"25","author":"SW Limesand","year":"2004","journal-title":"Placenta"},{"issue":"11","key":"ref26","doi-asserted-by":"crossref","first-page":"1072","DOI":"10.1016\/j.placenta.2013.08.010","article-title":"Placental glucose transporter 3 (GLUT3) is up-regulated in human pregnancies complicated by late-onset intrauterine growth restriction","volume":"34","author":"C Janzen","year":"2013","journal-title":"Placenta"},{"issue":"13","key":"ref27","doi-asserted-by":"crossref","first-page":"7313","DOI":"10.1073\/pnas.97.13.7313","article-title":"GLUT8 is a glucose transporter responsible for insulin-stimulated glucose uptake in the blastocyst","volume":"97","author":"MO Carayannopoulos","year":"2000","journal-title":"Proceedings of the National Academy of Sciences of the United States of America"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"1122","DOI":"10.1097\/01.AOG.0000429658.85846.f9","article-title":"ACOG Practice bulletin no. 134: fetal growth restriction","volume":"121","year":"2013","journal-title":"Obstetrics and gynecology"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"1571","DOI":"10.1016\/j.ajog.2006.03.069","article-title":"Fetal growth risk curves: defining levels of fetal growth restriction by neonatal death risk","volume":"195","author":"SL Boulet","year":"2006","journal-title":"American journal of obstetrics and gynecology"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"R766","DOI":"10.1152\/ajpregu.00097.2007","article-title":"Placental HIF-1 alpha, HIF-2 alpha, membrane and soluble VEGF receptor-1 proteins are not increased in normotensive pregnancies complicated by late-onset intrauterine growth restriction","volume":"293","author":"A Rajakumar","year":"2007","journal-title":"American journal of physiology Regulatory, integrative and comparative physiology"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1006\/excr.1993.1139","article-title":"Establishment and characterization of first trimester human trophoblast cells with extended lifespan","volume":"206","author":"CH Graham","year":"1993","journal-title":"Experimental cell research"},{"issue":"10","key":"ref32","doi-asserted-by":"crossref","first-page":"e76605","DOI":"10.1371\/journal.pone.0076605","article-title":"Autophagy induced by HIF1alpha overexpression supports trophoblast invasion by supplying cellular energy","volume":"8","author":"M Yamanaka-Tatematsu","year":"2013","journal-title":"PloS one"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"E935","DOI":"10.1152\/ajpendo.00342.2004","article-title":"GLUT4 expression and subcellular localization in the intrauterine growth-restricted adult rat female offspring","volume":"288","author":"M Thamotharan","year":"2005","journal-title":"American journal of physiology Endocrinology and metabolism"},{"issue":"14","key":"ref34","doi-asserted-by":"crossref","first-page":"3729","DOI":"10.1111\/j.1742-4658.2009.07089.x","article-title":"Lysosomal localization of GLUT8 in the testis\u2014the EXXXLL motif of GLUT8 is sufficient for its intracellular sorting via AP1- and AP2-mediated interaction","volume":"276","author":"MK Diril","year":"2009","journal-title":"The FEBS journal"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.ygeno.2009.05.006","article-title":"Evidence for potential functionality of nuclearly-encoded humanin isoforms","volume":"94","author":"M Bodzioch","year":"2009","journal-title":"Genomics"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/S0304-3940(02)00199-4","article-title":"Evidence for in vivo production of Humanin peptide, a neuroprotective factor against Alzheimer\u2019s disease-related insults","volume":"324","author":"H Tajima","year":"2002","journal-title":"Neuroscience letters"},{"issue":"23","key":"ref37","doi-asserted-by":"crossref","first-page":"9235","DOI":"10.1523\/JNEUROSCI.21-23-09235.2001","article-title":"Detailed characterization of neuroprotection by a rescue factor humanin against various Alzheimer\u2019s disease-relevant insults","volume":"21","author":"Y Hashimoto","year":"2001","journal-title":"The Journal of neuroscience: the official journal of the Society for Neuroscience"},{"issue":"1","key":"ref38","doi-asserted-by":"crossref","first-page":"e16259","DOI":"10.1371\/journal.pone.0016259","article-title":"A humanin derivative reduces amyloid beta accumulation and ameliorates memory deficit in triple transgenic mice","volume":"6","author":"T Niikura","year":"2011","journal-title":"PloS one"},{"issue":"5\u20136","key":"ref39","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.lfs.2012.07.010","article-title":"Humanin prevents intra-renal microvascular remodeling and inflammation in hypercholesterolemic ApoE deficient mice","volume":"91","author":"X Zhang","year":"2012","journal-title":"Life sciences"},{"issue":"3","key":"ref40","doi-asserted-by":"crossref","first-page":"343","DOI":"10.1016\/j.metabol.2009.08.001","article-title":"The neurosurvival factor Humanin inhibits beta-cell apoptosis via signal transducer and activator of transcription 3 activation and delays and ameliorates diabetes in nonobese diabetic mice","volume":"59","author":"PT Hoang","year":"2010","journal-title":"Metabolism: clinical and experimental"},{"issue":"10","key":"ref41","doi-asserted-by":"crossref","first-page":"2613","DOI":"10.1161\/01.STR.0000242772.94277.1f","article-title":"Humanin is a novel neuroprotective agent against stroke","volume":"37","author":"X Xu","year":"2006","journal-title":"Stroke; a journal of cerebral circulation"},{"issue":"5","key":"ref42","first-page":"376","article-title":"Oxidative stress in neurodegenerative diseases","volume":"7","author":"X Chen","year":"2012","journal-title":"Neural regeneration research"},{"issue":"16","key":"ref43","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1161\/01.CIR.0000093660.86242.BB","article-title":"Oxidative stress and cardiovascular injury: Part I: basic mechanisms and in vivo monitoring of ROS","volume":"108","author":"KK Griendling","year":"2003","journal-title":"Circulation"},{"issue":"3","key":"ref44","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1002\/dmrr.196","article-title":"The role of oxidative stress in the onset and progression of diabetes and its complications: a summary of a Congress Series sponsored by UNESCO-MCBN, the American Diabetes Association and the German Diabetes Society","volume":"17","author":"P Rosen","year":"2001","journal-title":"Diabetes\/metabolism research and reviews"},{"issue":"7","key":"ref45","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.freeradbiomed.2010.07.011","article-title":"Oxidative stress in development: nature or nurture?","volume":"49","author":"PA Dennery","year":"2010","journal-title":"Free radical biology & medicine"},{"issue":"3","key":"ref46","doi-asserted-by":"crossref","first-page":"287","DOI":"10.1016\/j.bpobgyn.2010.10.016","article-title":"Oxidative stress","volume":"25","author":"GJ Burton","year":"2011","journal-title":"Best practice & research Clinical obstetrics & gynaecology"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.mce.2015.06.015","article-title":"Rat Humanin is encoded and translated in mitochondria and is localized to the mitochondrial compartment where it regulates ROS production","volume":"413","author":"V Paharkova","year":"2015","journal-title":"Molecular and cellular endocrinology"},{"issue":"21","key":"ref48","doi-asserted-by":"crossref","first-page":"16275","DOI":"10.1074\/jbc.275.21.16275","article-title":"GLUT8, a novel member of the sugar transport facilitator family with glucose transport activity","volume":"275","author":"H Doege","year":"2000","journal-title":"The Journal of biological chemistry"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/S0169-328X(02)00487-4","article-title":"Insulin-responsive glucose transporters-GLUT8 and GLUT4 are expressed in the developing mammalian brain","volume":"107","author":"R Sankar","year":"2002","journal-title":"Brain research Molecular brain research"},{"issue":"6","key":"ref50","doi-asserted-by":"crossref","first-page":"835","DOI":"10.1002\/jnr.20054","article-title":"Glucose transporter GLUT8 translocation in neurons is not insulin responsive","volume":"75","author":"BC Shin","year":"2004","journal-title":"Journal of neuroscience research"},{"issue":"4","key":"ref51","doi-asserted-by":"crossref","first-page":"E614","DOI":"10.1152\/ajpendo.91019.2008","article-title":"GLUT8, the enigmatic intracellular hexose transporter","volume":"296","author":"S Schmidt","year":"2009","journal-title":"American journal of physiology Endocrinology and metabolism"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"367","DOI":"10.1007\/s00401-004-0965-5","article-title":"Humanin detected in skeletal muscles of MELAS patients: a possible new therapeutic agent","volume":"109","author":"S Kariya","year":"2005","journal-title":"Acta neuropathologica"},{"issue":"8","key":"ref53","doi-asserted-by":"crossref","first-page":"2762","DOI":"10.1096\/fj.10-156075","article-title":"Poor maternal nutrition leads to alterations in oxidative stress, antioxidant defense capacity, and markers of fibrosis in rat islets: potential underlying mechanisms for development of the diabetic phenotype in later life","volume":"24","author":"JL Tarry-Adkins","year":"2010","journal-title":"Faseb J"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"149","DOI":"10.3389\/fphar.2014.00149","article-title":"The placental pursuit for an adequate oxidant balance between the mother and the fetus","volume":"5","author":"EA Herrera","year":"2014","journal-title":"Frontiers in pharmacology"},{"issue":"14","key":"ref55","doi-asserted-by":"crossref","first-page":"565","DOI":"10.1152\/physiolgenomics.00034.2013","article-title":"Intrauterine calorie restriction affects placental DNA methylation and gene expression","volume":"45","author":"PY Chen","year":"2013","journal-title":"Physiological genomics"},{"issue":"3","key":"ref56","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1080\/09687680701855405","article-title":"Targeted disruption of Slc2a8 (GLUT8) reduces motility and mitochondrial potential of spermatozoa","volume":"25","author":"V Gawlik","year":"2008","journal-title":"Molecular membrane biology"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1095\/biolreprod.111.097675","article-title":"Slc2a8 deficiency in mice results in reproductive and growth impairments","volume":"87","author":"KL Adastra","year":"2012","journal-title":"Biology of reproduction"},{"issue":"2","key":"ref58","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1002\/jcp.20672","article-title":"Anti-apoptotic factor humanin is expressed in the testis and prevents cell-death in leydig cells during the first wave of spermatogenesis","volume":"208","author":"E Colon","year":"2006","journal-title":"Journal of cellular physiology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0193583","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,17]],"date-time":"2022-08-17T07:32:59Z","timestamp":1660721579000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0193583"}},"subtitle":[],"editor":[{"given":"V\u00edctor","family":"S\u00e1nchez-Margalet","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,28]]},"references-count":58,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0193583","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,28]]}}}