{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,29]],"date-time":"2026-04-29T05:38:34Z","timestamp":1777441114681,"version":"3.51.4"},"reference-count":19,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006285","name":"Magnus Bergvalls Stiftelse","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100006285","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100007687","name":"Svenska L\u00e4kares\u00e4llskapet","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100007687","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Bengt Ihres stiftelse"},{"name":"Rut och Richard Julins stiftelse"},{"DOI":"10.13039\/100010823","name":"Tore Nilsons Stiftelse f\u00f6r Medicinsk Forskning","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100010823","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100009791","name":"Stiftelsen Apotekare Hedbergs Fond","doi-asserted-by":"crossref","id":[{"id":"10.13039\/501100009791","id-type":"DOI","asserted-by":"crossref"}]},{"name":"The Swedish Coeliac Society"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0193764","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T17:36:49Z","timestamp":1521049009000},"page":"e0193764","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["Altered peripheral amino acid profile indicate a systemic impact of active celiac disease and a possible role of amino acids in disease pathogenesis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0504-6492","authenticated-orcid":true,"given":"\u00c5sa","family":"Torinsson Naluai","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ladan","family":"Saadat Vafa","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Audur H.","family":"Gudjonsdottir","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Henrik","family":"Arnell","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Browaldh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Staffan","family":"Nilsson","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Agardh","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"797","DOI":"10.1038\/nm0797-797","article-title":"Identification of tissue transglutaminase as the autoantigen of celiac disease","volume":"3","author":"W Dieterich","year":"1997","journal-title":"Nat Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"116","DOI":"10.1097\/MOG.0b013e3283365263","article-title":"Celiac disease","volume":"26","author":"A Rubio-Tapia","year":"2010","journal-title":"Curr Opin Gastroenterol"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0070174","article-title":"A Possible Mechanism behind Autoimmune Disorders Discovered By Genome-Wide Linkage and Association Analysis in Celiac Disease","volume":"8","author":"M \u00d6stensson","year":"2013","journal-title":"PLoS One"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1447","DOI":"10.1016\/j.clinbiochem.2013.05.045","article-title":"Obesity and diabetes related plasma amino acid alterations","volume":"46","author":"Y Zhou","year":"2013","journal-title":"Clin Biochem"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e133","DOI":"10.1038\/nutd.2014.32","article-title":"Plasma amino acid profiles are associated with insulin, C-peptide and adiponectin levels in type 2 diabetic patients","volume":"4","author":"H Nakamura","year":"2014","journal-title":"Nutr Diabetes"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1016\/j.regpep.2009.08.001","article-title":"Selective amino acid deficiency in patients with impaired glucose tolerance and type 2 diabetes","volume":"160","author":"BA Menge","year":"2010","journal-title":"Regul Pept"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1139\/y04-067","article-title":"Amino acid metabolism in the Zucker diabetic fatty rat: effects of insulin resistance and of type 2 diabetes","volume":"82","author":"EP Wijekoon","year":"2004","journal-title":"Can J Physiol Pharmacol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"213","DOI":"10.1007\/s00726-006-0409-8","article-title":"Free amino acid and dipeptide changes in the body fluids from Alzheimer\u2019s disease subjects","volume":"32","author":"AN Fonteh","year":"2007","journal-title":"Amino Acids"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1023\/A:1022238706604","article-title":"Plasma amino acid levels in children with autism and their families","volume":"33","author":"S Aldred","year":"2003","journal-title":"J Autism Dev Disord"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"557","DOI":"10.1021\/pr500782g","article-title":"LC-MS metabolomics of psoriasis patients reveals disease severity-dependent increases in circulating amino acids that are ameliorated by anti-TNF?? treatment","volume":"14","author":"MA Kamleh","year":"2015","journal-title":"J Proteome Res"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"605","DOI":"10.2337\/DC11-1577","article-title":"Metabolomic Profiling of Fatty Acid and Amino Acid Metabolism in Youth With Obesity and Type 2 Diabetes: Evidence for enhanced mitochondrial oxidation","volume":"35","author":"SJ Mihalik","year":"2012","journal-title":"Diabetes Care"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1038\/nm.2307","article-title":"Metabolite profiles and the risk of developing diabetes","volume":"17","author":"TJ Wang","year":"2011","journal-title":"Nat Med"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2821","DOI":"10.1016\/j.febslet.2006.04.068","article-title":"The amino acid sensitive TOR pathway from yeast to mammals","author":"SG Dann","year":"2006","journal-title":"FEBS Letters"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"991","DOI":"10.1146\/annurev.iy.12.040194.005015","article-title":"Tolerance, Danger, and the Extended Family","volume":"12","author":"P Matzinger","year":"1994","journal-title":"Annu Rev Immunol"},{"key":"ref15","article-title":"Validity of histology for the diagnosis of paediatric coeliac disease: a Swedish multicentre study","author":"C Mont\u00e9n","year":"2015"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"2975","DOI":"10.1084\/jem.20081800","article-title":"Dysregulation of lipid and amino acid metabolism precedes islet autoimmunity in children who later progress to type 1 diabetes","volume":"205","author":"M Ore\u0161i\u010d","year":"2008","journal-title":"J Exp Med"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1021\/jf60116a020","article-title":"Amino Acid Composition of Proteins in Wheat Gluten","volume":"9","author":"JH Woychik","year":"1961","journal-title":"J Agric Food Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"2397","DOI":"10.1093\/clinchem\/43.12.2397","article-title":"Age-specific distribution of plasma amino acid concentrations in a healthy pediatric population","volume":"43","author":"N Lepage","year":"1997","journal-title":"Clin Chem"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"170","DOI":"10.1021\/pr800548z","article-title":"The metabonomic signature of celiac disease","volume":"8","author":"I Bertini","year":"2009","journal-title":"J Proteome Res"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0193764","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,10,29]],"date-time":"2020-10-29T08:12:28Z","timestamp":1603959148000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0193764"}},"subtitle":[],"editor":[{"given":"James D.","family":"Clelland","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":19,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0193764","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,14]]}}}