{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T16:13:44Z","timestamp":1779380024849,"version":"3.53.1"},"reference-count":37,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T00:00:00Z","timestamp":1520985600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["81260681"],"award-info":[{"award-number":["81260681"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundations of China","doi-asserted-by":"crossref","award":["81560687"],"award-info":[{"award-number":["81560687"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"crossref"}]},{"name":"Autonomous Region High Technology Research and Development Program of China","award":["201517109"],"award-info":[{"award-number":["201517109"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0193845","type":"journal-article","created":{"date-parts":[[2018,3,14]],"date-time":"2018-03-14T17:38:41Z","timestamp":1521049121000},"page":"e0193845","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Cardioprotection of tilianin ameliorates myocardial ischemia-reperfusion injury: Role of the apoptotic signaling pathway"],"prefix":"10.1371","volume":"13","author":[{"given":"Cheng","family":"Zeng","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wen","family":"Jiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruifang","family":"Zheng","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chenghui","family":"He","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jianguang","family":"Li","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5711-5664","authenticated-orcid":true,"given":"Jianguo","family":"Xing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,3,14]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1002\/cphy.c160006","article-title":"Ischemia\/Reperfusion","volume":"7","author":"T Kalogeris","year":"2016","journal-title":"Compr Physiol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"745","DOI":"10.3945\/ajcn.114.095117","article-title":"WHO guidelines for a healthy diet and mortality from cardiovascular disease in European and American elderly: the CHANCES project","volume":"102","author":"N Jankovic","year":"2015","journal-title":"Am J Clin Nutr"},{"issue":"3","key":"ref3","doi-asserted-by":"crossref","first-page":"203","DOI":"10.7555\/JBR.28.20140037","article-title":"GYY4137 protects against myocardial ischemia and reperfusion injury by attenuating oxidative stress and apoptosis in rats","volume":"29","author":"G Meng","year":"2015","journal-title":"J Biomed Res"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"9858","DOI":"10.1038\/srep09858","article-title":"Pharmacological postconditioning with lactic acid and hydrogen rich saline alleviates myocardial reperfusion injury in rats","volume":"5","author":"G Zhang","year":"2015","journal-title":"Sci Rep"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.tox.2012.11.006","article-title":"Hyaluronic acid-dependent protection in H9C2 cardiomyocytes: a cell model of heart ischemia-reperfusion injury and treatment","volume":"303","author":"CH Law","year":"2013","journal-title":"Toxocology"},{"issue":"12","key":"ref6","doi-asserted-by":"crossref","first-page":"e0168219","DOI":"10.1371\/journal.pone.0168219","article-title":"Ginkgolide B Exerts Cardioprotective Properties against Doxorubicin-Induced Cardiotoxicity by Regulating Reactive Oxygen Species, Akt and Calcium Signaling Pathways In Vitro and In Vivo","volume":"11","author":"J Gao","year":"2016","journal-title":"PLos One"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1186\/s13287-015-0134-x","article-title":"let-7b suppresses apoptosis and autophagy of human mesenchymal stem cells transplanted into ischemia\/reperfusion injured heart 7by targeting caspase-3","volume":"6","author":"O Ham","year":"2015","journal-title":"Stem Cell Res Ther"},{"issue":"13\u201314","key":"ref8","doi-asserted-by":"crossref","first-page":"572","DOI":"10.1016\/j.lfs.2011.01.019","article-title":"In vivo gene delivery of XIAP protects against myocardial apoptosis and infarction following ischemia\/reperfusion in conscious rabbits","volume":"88","author":"SJ Kim","year":"2011","journal-title":"Life Sci"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"1433","DOI":"10.1007\/s10495-015-1174-5","article-title":"The cardioprotective effect of salidroside against myocardial ischemia reperfusion injury in rats by inhibiting apoptosis and inflammation","volume":"20","author":"L Zhu","year":"2015","journal-title":"Apoptosis"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"713","DOI":"10.1016\/j.yjmcc.2009.02.005","article-title":"Cardioprotection against myocardial infarction with PTD-BIR3\/RING, a XIAP mimicking protein","volume":"46","author":"R Souktani","year":"2009","journal-title":"J Mol Cell Cardiol"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"e0144733","DOI":"10.1371\/journal.pone.0144733","article-title":"The Long-Term Consumption of Ginseng Extract Reduces the Susceptibility of Intermediate-Aged Hearts to Acute Ischemia Reperfusion Injury","volume":"10","author":"P Luo","year":"2015","journal-title":"PLos One"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.jep.2012.12.029","article-title":"Dose-dependent antihypertensive determination and toxicological studies of tilianin isolated from Agastache mexicana","volume":"146","author":"O Hern\u00e1ndez-Abreu","year":"2013","journal-title":"J Ethnopharmacol"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"908","DOI":"10.1016\/j.jep.2012.03.028","article-title":"Neuropharmacological study of Dracocephalum moldavica L. (Lamiaceae) in mice: sedative effect and chemical analysis of an aqueous extract","volume":"141","author":"M Mart\u00ednez-V\u00e1zquez","year":"2012","journal-title":"J Ethnopharmacol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1007\/s12012-013-9221-3","article-title":"Antioxidative and cardioprotective effects of total flavonoids extracted from Dracocephalum moldavica L. against acute ischemia\/reperfusion-induced myocardial injury in isolated rat heart","volume":"14","author":"J Jiang","year":"2014","journal-title":"Cardiovasc Toxicol"},{"issue":"40","key":"ref15","doi-asserted-by":"crossref","first-page":"477","DOI":"10.4103\/0973-1296.141817","article-title":"The treatment of Uygur medicine Dracocephalum moldavica L on chronic mountain sickness rat model","volume":"10","author":"D Maimaitiyiming","year":"2014","journal-title":"Pharmacogn Mag"},{"issue":"1","key":"ref16","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1002\/ptr.5494","article-title":"Badiranji Buya Keli, a Traditional Uyghur Medicine, Induces Vasodilation in Rat Artery: Signaling Mediated by Nitric Oxide Production in Endothelial Cells","volume":"30","author":"A Miernisha","year":"2016","journal-title":"Phytother Res"},{"key":"ref17","first-page":"974039","article-title":"Simultaneous Determination of Six Active Compounds in Yixin Badiranjibuya Granules, a Traditional Chinese Medicine, by RP-HPLC-UV Method","volume":"2015","author":"N Yu","year":"2015","journal-title":"J Anal Methods Chem"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"667","DOI":"10.1016\/j.biopha.2016.07.023","article-title":"Antidiabetic, antihyperlipidemic and anti-inflammatory effects of tilianin in streptozotocin-nicotinamide diabetic rats","volume":"83","author":"JA Garc\u00eda-D\u00edaz","year":"2016","journal-title":"Biomed Pharmacother"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1016\/j.ejps.2016.02.007","article-title":"Optimization of the process variables of tilianin-loaded composite phospholipid liposomes based on response surface-central composite design and pharmacokinetic study","volume":"85","author":"C Zeng","year":"2016","journal-title":"Eur J Pharm Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3253","DOI":"10.2147\/IJN.S131893","article-title":"Development of solid lipid nanoparticles containing total flavonoid extract from Dracocephalum moldavica L. and their therapeutic effect against myocardial ischemia-reperfusion injury in rats","volume":"12","author":"ME Tan","year":"2017","journal-title":"Int J Nanomedicine"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"2227","DOI":"10.3892\/mmr.2014.2954","article-title":"Cardioprotective effects of tilianin in rat myocardial ischemia-reperfusion injury","volume":"11","author":"X Guo","year":"2015","journal-title":"Mol Med Rep"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"160","DOI":"10.1016\/j.jep.2017.05.028","article-title":"Crude terpene glycoside component from Radix paeoniae rubra protects against isoproterenol-induced myocardial ischemic injury via activation of the PI3K\/AKT\/mTOR signaling pathway","volume":"206","author":"Z Ke","year":"2017","journal-title":"J Ethnopharmacol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jep.2014.08.023","article-title":"Study of the protective mechanisms of Compound Danshen Tablet (Fufang Danshen Pian) against myocardial ischemia\/reperfusion injury via the Akt-eNOS signaling pathway in rats","volume":"156","author":"Q Ren-an","year":"2014","journal-title":"J Ethnopharmacol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"481405","DOI":"10.1155\/2015\/481405","article-title":"Protective Effects of Kaempferol against Myocardial Ischemia\/Reperfusion Injury in Isolated Rat Heart via Antioxidant Activity and Inhibition of Glycogen Synthase Kinase-3\u03b2","volume":"2015","author":"M Zhou","year":"2015","journal-title":"Oxid Med Cell Longev"},{"issue":"12","key":"ref25","doi-asserted-by":"crossref","first-page":"e0189307","DOI":"10.1371\/journal.pone.0189307","article-title":"EhprinA1-Fc attenuates myocardial ischemia\/reperfusion injury in mice","volume":"12","author":"A DuSablon","year":"2017","journal-title":"PLoS One"},{"issue":"13","key":"ref26","doi-asserted-by":"crossref","first-page":"3383","DOI":"10.1111\/bph.13130","article-title":"Toll-interacting protein contributes to mortality following myocardial infarction through promoting inflammation and apoptosis","volume":"172","author":"N Wan","year":"2015","journal-title":"Br J Pharmacol"},{"issue":"1\u20132","key":"ref27","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1007\/s11010-013-1918-x","article-title":"Mitigation of postischemic cardiac contractile dysfunction by CaMKII inhibition: effects on programmed necrotic and apoptotic cell death","volume":"388","author":"A Szobi","year":"2014","journal-title":"Mol Cell Biochem"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"516","DOI":"10.1159\/000369716","article-title":"Protective effects of Millettia pulchra flavonoids on myocardial ischemia in vitro and in vivo","volume":"35","author":"J Huang","year":"2015","journal-title":"Cell Physiol Biochem"},{"issue":"7","key":"ref29","doi-asserted-by":"crossref","first-page":"1037","DOI":"10.1007\/s12272-009-1709-9","article-title":"Protective effects of caspase-9 and poly (ADP-ribose) polymerase inhibitors on ischemia-reperfusion-induced myocardial injury","volume":"32","author":"RK Sodhi","year":"2009","journal-title":"Arch Pharm Res"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"449","DOI":"10.1016\/j.yexmp.2015.08.010","article-title":"Hypercholesterolemia aggravates myocardial ischemia reperfusion injury via activating endoplasmic reticulum stress-mediated apoptosis","volume":"99","author":"N Wu","year":"2015","journal-title":"Exp Mol Pathol"},{"issue":"4","key":"ref31","doi-asserted-by":"crossref","first-page":"420","DOI":"10.1111\/jpi.12272","article-title":"Membrane receptor-dependent Notch1\/Hes1 activation by melatonin protects against myocardial ischemia-reperfusion injury: in vivo and in vitro studies","volume":"59","author":"L Yu","year":"2015","journal-title":"J Pineal Res"},{"issue":"3\u20134","key":"ref32","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1159\/000330068","article-title":"Luteolin inhibits apoptosis and improves cardiomyocyte contractile function through the PI3K\/Akt pathway in simulated ischemia\/reperfusion","volume":"88","author":"F Fang","year":"2011","journal-title":"Pharmacology"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"1365","DOI":"10.1159\/000443080","article-title":"The Antioxidant, Anti-Inflammatory and Anti-Apoptotic Activities of the Bauhinia Championii Flavone are Connected with Protection Against Myocardial Ischemia\/Reperfusion Injury","volume":"38","author":"J Jian","year":"2016","journal-title":"Cell Physiol Biochem"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1111\/j.1755-5922.2008.00052.x","article-title":"Activation of HtrA2, a mitochondrial serine protease mediates apoptosis: current knowledge on HtrA2 mediated myocardial ischemia\/reperfusion injury","volume":"26","author":"MS Bhuiyan","year":"2008","journal-title":"Cardiovasc Ther"},{"issue":"2\u20133","key":"ref35","doi-asserted-by":"crossref","first-page":"168","DOI":"10.1016\/j.ejphar.2006.10.067","article-title":"Inhibition of HtrA2\/Omi ameliorates heart dysfunction following ischemia\/reperfusion injury in rat heart in vivo","volume":"557","author":"MS Bhuiyan","year":"2007","journal-title":"Eur J Pharmacol"},{"key":"ref36","first-page":"1232103","article-title":"Hydroxytyrosol Protects against Myocardial Ischemia\/Reperfusion Injury through a PI3K\/Akt-Dependent Mechanism","volume":"2016","author":"YH Pei","year":"2016","journal-title":"Mediators Inflamm"},{"issue":"6","key":"ref37","doi-asserted-by":"crossref","first-page":"2320","DOI":"10.1159\/000374035","article-title":"Nicorandil Protects the Heart from Ischemia\/Reperfusion Injury by Attenuating Endoplasmic Reticulum Response-induced Apoptosis Through PI3K\/Akt Signaling Pathway","volume":"35","author":"H Wu","year":"2015","journal-title":"Cell Physiol Biochem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0193845","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T16:17:15Z","timestamp":1693585035000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0193845"}},"subtitle":[],"editor":[{"given":"Guo-Chang","family":"Fan","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,14]]},"references-count":37,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0193845","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,14]]}}}