{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T11:44:28Z","timestamp":1792669468262,"version":"4.5.0"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T00:00:00Z","timestamp":1521158400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008792","name":"Novartis Pharma","doi-asserted-by":"publisher","id":[{"id":"10.13039\/100008792","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0193961","type":"journal-article","created":{"date-parts":[[2018,3,16]],"date-time":"2018-03-16T17:25:50Z","timestamp":1521221150000},"page":"e0193961","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Individual and temporal variability of the retina after chronic bilateral common carotid artery occlusion (BCCAO)"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8640-9135","authenticated-orcid":true,"given":"Sergio","family":"Crespo-Garcia","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nadine","family":"Reichhart","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergej","family":"Skosyrski","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marco","family":"Foddis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jim","family":"Wu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aleksandar","family":"Figura","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christina","family":"Herrspiegel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina","family":"F\u00fcchtemeier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Celeste","family":"Sassi","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ulrich","family":"Dirnagl","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Antonia M.","family":"Joussen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Olaf","family":"Strauss","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,3,16]]},"reference":[{"issue":"2\u20133","key":"ref1","doi-asserted-by":"crossref","first-page":"255","DOI":"10.1080\/08830180212065","article-title":"Imaging ocular immune responses by intravital microscopy","volume":"21","author":"JT Rosenbaum","year":"2002","journal-title":"International reviews of immunology"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1023\/A:1024448314608","article-title":"Electrophysiological analysis of visual function in mutant mice","volume":"107","author":"NS Peachey","year":"2003","journal-title":"Documenta ophthalmologica Advances in ophthalmology"},{"issue":"5","key":"ref3","doi-asserted-by":"crossref","first-page":"051403","DOI":"10.1117\/1.2793736","article-title":"Optical coherence tomography: a review of clinical development from bench to bedside","volume":"12","author":"AM Zysk","year":"2007","journal-title":"Journal of biomedical optics"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1016\/j.preteyeres.2011.11.003","article-title":"From oxygen to erythropoietin: relevance of hypoxia for retinal development, health and disease","volume":"31","author":"C Caprara","year":"2012","journal-title":"Progress in retinal and eye research"},{"issue":"1\u20132","key":"ref5","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/0304-3940(92)90731-L","article-title":"Retinal ischemia induced by occlusion of both common carotid arteries in rats as demonstrated by electroretinography","volume":"144","author":"F Block","year":"1992","journal-title":"Neuroscience letters"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"476","DOI":"10.1038\/jcbfm.2014.221","article-title":"Vascular change and opposing effects of the angiotensin type 2 receptor in a mouse model of vascular cognitive impairment","volume":"35","author":"M Fuchtemeier","year":"2015","journal-title":"Journal of cerebral blood flow and metabolism: official journal of the International Society of Cerebral Blood Flow and Metabolism"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"180","DOI":"10.3109\/01658107.2014.908928","article-title":"Bilateral Common Carotid Artery Occlusion in the Rat as a Model of Retinal Ischaemia","volume":"38","author":"Y Huang","year":"2014","journal-title":"Neuro-ophthalmology"},{"issue":"2","key":"ref8","first-page":"199","article-title":"Chronic bilateral common carotid artery occlusion: a model for ocular ischemic syndrome in the rat. Graefe&apos;s archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle","volume":"244","author":"D Lavinsky","year":"2006","journal-title":"Ophthalmologie"},{"issue":"5","key":"ref9","doi-asserted-by":"crossref","first-page":"1022","DOI":"10.1161\/01.STR.25.5.1022","article-title":"Chronic cerebral hypoperfusion and impaired neuronal function in rats","volume":"25","author":"LH Sekhon","year":"1994","journal-title":"Stroke"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"767","DOI":"10.1016\/j.exer.2005.09.019","article-title":"Complex neurodegeneration in retina following moderate ischemia induced by bilateral common carotid artery occlusion in Wistar rats","volume":"82","author":"H Yamamoto","year":"2006","journal-title":"Experimental eye research"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"1155","DOI":"10.1182\/blood-2002-02-0569","article-title":"A macrophage colony-stimulating factor receptor-green fluorescent protein transgene is expressed throughout the mononuclear phagocyte system of the mouse","volume":"101","author":"RT Sasmono","year":"2003","journal-title":"Blood"},{"issue":"6","key":"ref12","doi-asserted-by":"crossref","first-page":"2921","DOI":"10.1167\/iovs.12-9662","article-title":"The Rd8 mutation of the Crb1 gene is present in vendor lines of C57BL\/6N mice and embryonic stem cells, and confounds ocular induced mutant phenotypes","volume":"53","author":"MJ Mattapallil","year":"2012","journal-title":"Investigative ophthalmology & visual science"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.exer.2015.07.012","article-title":"In vivo analysis of the time and spatial activation pattern of microglia in the retina following laser-induced choroidal neovascularization","volume":"139","author":"S Crespo-Garcia","year":"2015","journal-title":"Experimental eye research"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"6","DOI":"10.1016\/j.exer.2015.06.023","article-title":"Angiography reveals novel features of the retinal vasculature in healthy and diabetic mice","volume":"138","author":"S McLenachan","year":"2015","journal-title":"Experimental eye research"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/nprot.2008.73","article-title":"Analyzing real-time PCR data by the comparative C(T) method","volume":"3","author":"TD Schmittgen","year":"2008","journal-title":"Nature protocols"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"18828","DOI":"10.1038\/srep18828","article-title":"Lack of netrin-4 modulates pathologic neovascularization in the eye","volume":"6","author":"N Kociok","year":"2016","journal-title":"Scientific reports"},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"544","DOI":"10.3390\/ijms11020544","article-title":"Novel neuroprotective strategies in ischemic retinal lesions","volume":"11","author":"K Szabadfi","year":"2010","journal-title":"International journal of molecular sciences"},{"issue":"1","key":"ref18","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1007\/s12640-009-9049-6","article-title":"Protection against chronic hypoperfusion-induced retinal neurodegeneration by PARP inhibition via activation of PI-3-kinase Akt pathway and suppression of JNK and p38 MAP kinases","volume":"16","author":"L Mester","year":"2009","journal-title":"Neurotoxicity research"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"563812","DOI":"10.1155\/2014\/563812","article-title":"Investigation of PACAP Fragments and Related Peptides in Chronic Retinal Hypoperfusion","volume":"2014","author":"D Werling","year":"2014","journal-title":"Journal of ophthalmology"},{"issue":"4\u20135","key":"ref20","doi-asserted-by":"crossref","first-page":"497","DOI":"10.1016\/j.brainresbull.2009.09.004","article-title":"Evaluation of the protective effects of PACAP with cell-specific markers in ischemia-induced retinal degeneration","volume":"81","author":"T Atlasz","year":"2010","journal-title":"Brain research bulletin"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/j.neuroscience.2008.06.038","article-title":"Neurodegeneration and cellular stress in the retina and optic nerve in rat cerebral ischemia and hypoperfusion models","volume":"155","author":"G Kalesnykas","year":"2008","journal-title":"Neuroscience"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"457","DOI":"10.1007\/s11910-002-0073-7","article-title":"Transgenic mouse models of neurodegenerative disease: opportunities for therapeutic development","volume":"2","author":"JL Jankowsky","year":"2002","journal-title":"Current neurology and neuroscience reports"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.ejphar.2009.10.020","article-title":"Searching for new animal models of Alzheimer&apos;s disease","volume":"626","author":"R Epis","year":"2010","journal-title":"European journal of pharmacology"},{"issue":"1","key":"ref24","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1016\/j.brainresrev.2007.01.003","article-title":"Permanent, bilateral common carotid artery occlusion in the rat: a model for chronic cerebral hypoperfusion-related neurodegenerative diseases","volume":"54","author":"E Farkas","year":"2007","journal-title":"Brain research reviews"},{"issue":"6","key":"ref25","doi-asserted-by":"crossref","first-page":"500","DOI":"10.1016\/j.preteyeres.2010.05.003","article-title":"Animal models of choroidal and retinal neovascularization","volume":"29","author":"HE Grossniklaus","year":"2010","journal-title":"Progress in retinal and eye research"},{"issue":"3","key":"ref26","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1007\/s12031-014-0296-5","article-title":"PACAP application improves functional outcome of chronic retinal ischemic injury in rats-evidence from electroretinographic measurements","volume":"54","author":"B Danyadi","year":"2014","journal-title":"Journal of molecular neuroscience: MN"},{"issue":"1","key":"ref27","doi-asserted-by":"crossref","first-page":"83","DOI":"10.1016\/S0014-4835(95)80061-1","article-title":"Prolonged bilateral carotid artery occlusion induces electrophysiological and immunohistochemical changes to the rat retina without causing histological damage","volume":"61","author":"NL Barnett","year":"1995","journal-title":"Experimental eye research"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"3565","DOI":"10.1167\/iovs.17-22191","article-title":"Inter-Relationship of Arterial Supply to Human Retina, Choroid, and Optic Nerve Head Using Micro Perfusion and Labeling","volume":"58","author":"PK Yu","year":"2017","journal-title":"Investigative ophthalmology & visual science"}],"updated-by":[{"DOI":"10.1371\/journal.pone.0196538","type":"correction","label":"Correction","source":"publisher","updated":{"date-parts":[[2018,4,23]],"date-time":"2018-04-23T00:00:00Z","timestamp":1524441600000}}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0193961","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,8]],"date-time":"2020-05-08T21:28:48Z","timestamp":1588973328000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0193961"}},"subtitle":[],"editor":[{"given":"Alfred S.","family":"Lewin","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,16]]},"references-count":28,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,16]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0193961","relation":{"correction":[{"id-type":"doi","id":"10.1371\/journal.pone.0196538","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,16]]}}}