{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T13:31:59Z","timestamp":1794317519084,"version":"4.9.0"},"reference-count":82,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T00:00:00Z","timestamp":1521504000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0194044","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T17:22:39Z","timestamp":1521566559000},"page":"e0194044","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":42,"title":["Genome-wide association analysis identifies multiple loci associated with kidney disease-related traits in Korean populations"],"prefix":"10.1371","volume":"13","author":[{"given":"Jeonghwan","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Young","family":"Lee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Boram","family":"Park","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sungho","family":"Won","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jin Suk","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nam Ju","family":"Heo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,3,20]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1038\/sj.ki.5002343","article-title":"Chronic kidney disease as a global public health problem: approaches and initiatives\u2014a position statement from Kidney Disease Improving Global Outcomes","volume":"72","author":"AS Levey","year":"2007","journal-title":"Kidney Int"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"173","DOI":"10.1186\/s12882-017-0591-9","article-title":"Diagnostic performance of serum blood urea nitrogen to creatinine ratio for distinguishing prerenal from intrinsic acute kidney injury in the emergency department","volume":"18","author":"G Manoeuvrier","year":"2017","journal-title":"BMC Nephrol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"223","DOI":"10.1016\/S0733-8627(20)30997-4","article-title":"Blood urea nitrogen and creatinine","volume":"4","author":"JL Lyman","year":"1986","journal-title":"Emerg Med Clin North Am"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"523","DOI":"10.1161\/CIRCGENETICS.109.934455","article-title":"Multiple genetic loci influence serum urate levels and their relationship with gout and cardiovascular disease risk factors","volume":"3","author":"Q Yang","year":"2010","journal-title":"Circ Cardiovasc Genet"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.1016\/j.metabol.2005.05.007","article-title":"Genome-wide search for genes affecting serum uric acid levels: the Framingham Heart Study","volume":"54","author":"Q Yang","year":"2005","journal-title":"Metabolism"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"612","DOI":"10.1111\/j.1365-2796.2009.02197.x","article-title":"Risk factors for end-stage renal disease in a community-based population: 26-year follow-up of 25,821 men and women in eastern Finland","volume":"267","author":"M Kastarinen","year":"2010","journal-title":"J Intern Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1111\/j.1525-139X.2007.00282.x","article-title":"Familial clustering of chronic kidney disease","volume":"20","author":"SG Satko","year":"2007","journal-title":"Semin Dial"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"155","DOI":"10.1053\/j.ackd.2005.02.002","article-title":"Evidence for different susceptibility genes for proteinuria and ESRD in type 2 diabetes","volume":"12","author":"G Placha","year":"2005","journal-title":"Adv Chronic Kidney Dis"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1175","DOI":"10.1038\/ng.226","article-title":"MYH9 is a major-effect risk gene for focal segmental glomerulosclerosis","volume":"40","author":"JB Kopp","year":"2008","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1038\/ng.377","article-title":"Multiple loci associated with indices of renal function and chronic kidney disease","volume":"41","author":"A Kottgen","year":"2009","journal-title":"Nat Genet"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng1847","article-title":"Principal components analysis corrects for stratification in genome-wide association studies","volume":"38","author":"AL Price","year":"2006","journal-title":"Nat Genet"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"527","DOI":"10.1038\/ng.357","article-title":"A large-scale genome-wide association study of Asian populations uncovers genetic factors influencing eight quantitative traits","volume":"41","author":"YS Cho","year":"2009","journal-title":"Nat Genet"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"138","DOI":"10.5808\/GI.2016.14.4.138","article-title":"Risk Prediction Using Genome-Wide Association Studies on Type 2","volume":"14","author":"S Choi","year":"2016","journal-title":"Diabetes. Genomics Inform"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"187","DOI":"10.5808\/GI.2014.12.4.187","article-title":"Genome-wide association study of metabolic syndrome in koreans","volume":"12","author":"SW Jeong","year":"2014","journal-title":"Genomics Inform"},{"issue":"Suppl 1","key":"ref15","doi-asserted-by":"crossref","first-page":"S10","DOI":"10.1186\/1471-2350-8-S1-S10","article-title":"A genome-wide association for kidney function and endocrine-related traits in the NHLBI&apos;s Framingham Heart Study","volume":"8","author":"SJ Hwang","year":"2007","journal-title":"BMC Med Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1358\/mf.2007.29.1.1063490","article-title":"Genetic polymorphisms of the urea transporter gene are associated with antihypertensive response to nifedipine GITS","volume":"29","author":"X Hong","year":"2007","journal-title":"Methods Find Exp Clin Pharmacol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"2157","DOI":"10.1093\/hmg\/10.19.2157","article-title":"Genetic variation in the human urea transporter-2 is associated with variation in blood pressure","volume":"10","author":"K Ranade","year":"2001","journal-title":"Hum Mol Genet"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"904","DOI":"10.1038\/ng.2352","article-title":"Meta-analysis identifies multiple loci associated with kidney function-related traits in east Asian populations","volume":"44","author":"Y Okada","year":"2012","journal-title":"Nat Genet"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"7983","DOI":"10.1167\/iovs.12-10409","article-title":"A genome-wide association study provides evidence for association of chromosome 8p23 (MYP10) and 10q21.1 (MYP15) with high myopia in the French Population","volume":"53","author":"W Meng","year":"2012","journal-title":"Invest Ophthalmol Vis Sci"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"990","DOI":"10.1038\/ng.939","article-title":"Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits","volume":"43","author":"YJ Kim","year":"2011","journal-title":"Nat Genet"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1038\/ng.566","article-title":"Genetic loci influencing kidney function and chronic kidney disease","volume":"42","author":"JC Chambers","year":"2010","journal-title":"Nat Genet"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"e45112","DOI":"10.1371\/journal.pone.0045112","article-title":"Multiple loci associated with renal function in African Americans","volume":"7","author":"D Shriner","year":"2012","journal-title":"PLoS One"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"150","DOI":"10.2215\/CJN.02300213","article-title":"Generalization of associations of kidney-related genetic loci to American Indians","volume":"9","author":"N Franceschini","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"609","DOI":"10.1038\/ng.122","article-title":"Many sequence variants affecting diversity of adult human height","volume":"40","author":"DF Gudbjartsson","year":"2008","journal-title":"Nat Genet"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1186\/1471-2350-11-96","article-title":"The role of height-associated loci identified in genome wide association studies in the determination of pediatric stature","volume":"11","author":"J Zhao","year":"2010","journal-title":"BMC Med Genet"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/ng.568","article-title":"New loci associated with kidney function and chronic kidney disease","volume":"42","author":"A Kottgen","year":"2010","journal-title":"Nat Genet"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"111S","DOI":"10.1111\/j.1530-0277.2004.tb03227.x","article-title":"ALDH2\/ADH2 polymorphism associated with vasculopathy and neuropathy in type 2 diabetes","volume":"28","author":"Y Suzuki","year":"2004","journal-title":"Alcohol Clin Exp Res"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1093\/alcalc\/agm173","article-title":"Association of alcohol dehydrogenase 2 and aldehyde dehydrogenase 2 genotypes with fasting plasma glucose levels in Japanese male and female workers","volume":"43","author":"M Dakeishi","year":"2008","journal-title":"Alcohol Alcohol"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"104","DOI":"10.1007\/s10038-005-0330-0","article-title":"ALDH2 and CYP2E1 genotypes, urinary acetaldehyde excretion and the health consequences in moderate alcohol consumers","volume":"51","author":"Y Yamada","year":"2006","journal-title":"J Hum Genet"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"1401","DOI":"10.1097\/TP.0b013e3182000085","article-title":"Single-nucleotide polymorphisms, acute rejection, and severity of tubulitis in kidney transplantation, accounting for center-to-center variation","volume":"90","author":"A Israni","year":"2010","journal-title":"Transplantation"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"306","DOI":"10.2133\/dmpk.23.306","article-title":"Influence of ALDH2 genetic polymorphisms on aciclovir pharmacokinetics following oral administration of valaciclovir in Japanese end-stage renal disease patients","volume":"23","author":"K Hara","year":"2008","journal-title":"Drug Metab Pharmacokinet"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1038\/jhg.2009.116","article-title":"Identification of 15 loci influencing height in a Korean population","volume":"55","author":"JJ Kim","year":"2010","journal-title":"J Hum Genet"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"e1000409","DOI":"10.1371\/journal.pgen.1000409","article-title":"Genetic determinants of height growth assessed longitudinally from infancy to adulthood in the northern Finland birth cohort 1966","volume":"5","author":"U Sovio","year":"2009","journal-title":"PLoS Genet"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"501","DOI":"10.1038\/ng.2606","article-title":"Genome-wide meta-analysis identifies 11 new loci for anthropometric traits and provides insights into genetic architecture","volume":"45","author":"SI Berndt","year":"2013","journal-title":"Nat Genet"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"10023","DOI":"10.1038\/ncomms10023","article-title":"Genetic associations at 53 loci highlight cell types and biological pathways relevant for kidney function","volume":"7","author":"C Pattaro","year":"2016","journal-title":"Nat Commun"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"2105","DOI":"10.1681\/ASN.2012100983","article-title":"Common variants in Mendelian kidney disease genes and their association with renal function","volume":"24","author":"A Parsa","year":"2013","journal-title":"J Am Soc Nephrol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"210","DOI":"10.1038\/ng.531","article-title":"Genome-wide association study of hematological and biochemical traits in a Japanese population","volume":"42","author":"Y Kamatani","year":"2010","journal-title":"Nat Genet"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"1363","DOI":"10.1136\/annrheumdis-2015-208111","article-title":"Hyperuricaemia: contributions of urate transporter ABCG2 and the fractional renal clearance of urate","volume":"75","author":"DR Kannangara","year":"2016","journal-title":"Ann Rheum Dis"},{"key":"ref39","first-page":"9812","article-title":"A meta-analysis of the associations between the Q141K and Q126X ABCG2 gene variants and gout risk","volume":"8","author":"R Li","year":"2015","journal-title":"Int J Clin Exp Pathol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"159","DOI":"10.1007\/s10067-015-3105-9","article-title":"Genetic variation in the ABCG2 gene is associated with gout risk in the Chinese Han population","volume":"35","author":"M Jiri","year":"2016","journal-title":"Clin Rheumatol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1111\/j.1469-1809.2011.00698.x","article-title":"Genome-wide association of serum uric acid concentration: replication of sequence variants in an island population of the Adriatic coast of Croatia","volume":"76","author":"R Karns","year":"2012","journal-title":"Ann Hum Genet"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"1461","DOI":"10.1093\/rheumatology\/keq096","article-title":"The rs2231142 variant of the ABCG2 gene is associated with uric acid levels and gout among Japanese people","volume":"49","author":"K Yamagishi","year":"2010","journal-title":"Rheumatology (Oxford)"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1007\/s00439-009-0760-4","article-title":"Genetic analysis of ABCG2 gene C421A polymorphism with gout disease in Chinese Han male population","volume":"127","author":"B Wang","year":"2010","journal-title":"Hum Genet"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"4813","DOI":"10.1093\/hmg\/ddq412","article-title":"A strong role for the ABCG2 gene in susceptibility to gout in New Zealand Pacific Island and Caucasian, but not Maori, case and control sample sets","volume":"19","author":"AJ Phipps-Green","year":"2010","journal-title":"Hum Mol Genet"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"10338","DOI":"10.1073\/pnas.0901249106","article-title":"Identification of a urate transporter, ABCG2, with a common functional polymorphism causing gout","volume":"106","author":"OM Woodward","year":"2009","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"e7729","DOI":"10.1371\/journal.pone.0007729","article-title":"Common polymorphisms influencing serum uric acid levels contribute to susceptibility to gout, but not to coronary artery disease","volume":"4","author":"K Stark","year":"2009","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"5ra11","DOI":"10.1126\/scitranslmed.3000237","article-title":"Common defects of ABCG2, a high-capacity urate exporter, cause gout: a function-based genetic analysis in a Japanese population","volume":"1","author":"H Matsuo","year":"2009","journal-title":"Sci Transl Med"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"1953","DOI":"10.1016\/S0140-6736(08)61343-4","article-title":"Association of three genetic loci with uric acid concentration and risk of gout: a genome-wide association study","volume":"372","author":"A Dehghan","year":"2008","journal-title":"Lancet"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1159\/000318943","article-title":"Association of four genetic loci with uric acid levels and reduced renal function: the J-SHIPP Suita study","volume":"32","author":"Y Tabara","year":"2010","journal-title":"Am J Nephrol"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"e1000504","DOI":"10.1371\/journal.pgen.1000504","article-title":"Meta-analysis of 28,141 individuals identifies common variants within five new loci that influence uric acid concentrations","volume":"5","author":"M Kolz","year":"2009","journal-title":"PLoS Genet"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"805","DOI":"10.1016\/j.humimm.2012.05.004","article-title":"Pathway analysis of genome-wide association studies on uric acid concentrations","volume":"73","author":"YH Lee","year":"2012","journal-title":"Hum Immunol"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"1335","DOI":"10.1007\/s12013-014-0353-2","article-title":"Association of an Exon SNP of SLC2A9 Gene with Hyperuricemia Complicated with Type 2 Diabetes Mellitus in the Chinese Male Han Population","volume":"71","author":"SC Xing","year":"2015","journal-title":"Cell Biochem Biophys"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"e0128593","DOI":"10.1371\/journal.pone.0128593","article-title":"SLC2A9 Genotype Is Associated with SLC2A9 Gene Expression and Urinary Uric Acid Concentration","volume":"10","author":"EB Ware","year":"2015","journal-title":"PLoS One"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"725","DOI":"10.3945\/ajcn.114.095364","article-title":"Serum uric acid concentrations and SLC2A9 genetic variation in Hispanic children: the Viva La Familia Study","volume":"101","author":"VS Voruganti","year":"2015","journal-title":"Am J Clin Nutr"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1016\/j.numecd.2015.08.004","article-title":"A genetic marker of hyperuricemia predicts cardiovascular events in a meta-analysis of three cohort studies in high risk patients","volume":"25","author":"A Testa","year":"2015","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.numecd.2014.10.016","article-title":"Synergism between asymmetric dimethylarginine (ADMA) and a genetic marker of uric acid in CKD progression","volume":"25","author":"A Testa","year":"2015","journal-title":"Nutr Metab Cardiovasc Dis"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"15292","DOI":"10.1074\/jbc.M114.611178","article-title":"Critical Roles of Two Hydrophobic Residues within Human Glucose Transporter 9 (hSLC2A9) in Substrate Selectivity and Urate Transport","volume":"290","author":"W Long","year":"2015","journal-title":"J Biol Chem"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"e009360","DOI":"10.1136\/bmjopen-2015-009360","article-title":"Discovery of URAT1 SNPs and association between serum uric acid levels and URAT1","volume":"5","author":"SK Cho","year":"2015","journal-title":"BMJ Open"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"5061","DOI":"10.1093\/hmg\/ddu227","article-title":"Abundant local interactions in the 4p16.1 region suggest functional mechanisms underlying SLC2A9 associations with human serum uric acid","volume":"23","author":"WH Wei","year":"2014","journal-title":"Hum Mol Genet"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"1059","DOI":"10.2215\/CJN.11041013","article-title":"Association of a polymorphism in a gene encoding a urate transporter with CKD progression","volume":"9","author":"A Testa","year":"2014","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"862","DOI":"10.1002\/ana.24281","article-title":"Mendelian randomization of serum urate and parkinson disease progression","volume":"76","author":"KC Simon","year":"2014","journal-title":"Ann Neurol"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1186\/1471-2431-14-73","article-title":"Recurrent exercise-induced acute kidney injury by idiopathic renal hypouricemia with a novel mutation in the SLC2A9 gene and literature review","volume":"14","author":"H Shen","year":"2014","journal-title":"BMC Pediatr"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"17","DOI":"10.1186\/1755-8794-4-17","article-title":"A genome-wide association study of serum uric acid in African Americans","volume":"4","author":"BA Charles","year":"2011","journal-title":"BMC Med Genomics"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1136\/jmg.2009.068619","article-title":"Multiple single nucleotide polymorphisms in the human urate transporter 1 (hURAT1) gene are associated with hyperuricaemia in Han Chinese","volume":"47","author":"C Li","year":"2010","journal-title":"J Med Genet"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"23","DOI":"10.3325\/cmj.2009.50.23","article-title":"Genome-wide association study of biochemical traits in Korcula Island, Croatia","volume":"50","author":"T Zemunik","year":"2009","journal-title":"Croat Med J"},{"key":"ref66","doi-asserted-by":"crossref","first-page":"3485","DOI":"10.1002\/art.24938","article-title":"Role of the urate transporter SLC2A9 gene in susceptibility to gout in New Zealand Maori, Pacific Island, and Caucasian case-control sample sets","volume":"60","author":"JE Hollis-Moffatt","year":"2009","journal-title":"Arthritis Rheum"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"139","DOI":"10.1016\/j.ajhg.2007.11.001","article-title":"Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia","volume":"82","author":"C Wallace","year":"2008","journal-title":"Am J Hum Genet"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"437","DOI":"10.1038\/ng.106","article-title":"SLC2A9 is a newly identified urate transporter influencing serum urate concentration, urate excretion and gout","volume":"40","author":"V Vitart","year":"2008","journal-title":"Nat Genet"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"2874","DOI":"10.1002\/art.23752","article-title":"Association of a common nonsynonymous variant in GLUT9 with serum uric acid levels in old order amish","volume":"58","author":"PF McArdle","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1038\/ng.107","article-title":"SLC2A9 influences uric acid concentrations with pronounced sex-specific effects","volume":"40","author":"A Doring","year":"2008","journal-title":"Nat Genet"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"e194","DOI":"10.1371\/journal.pgen.0030194","article-title":"The GLUT9 gene is associated with serum uric acid levels in Sardinia and Chianti cohorts","volume":"3","author":"S Li","year":"2007","journal-title":"PLoS Genet"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"4056","DOI":"10.1093\/hmg\/ddr307","article-title":"Genome-wide association study for serum urate concentrations and gout among African Americans identifies genomic risk loci and a novel URAT1 loss-of-function allele","volume":"20","author":"A Tin","year":"2011","journal-title":"Hum Mol Genet"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"661","DOI":"10.1111\/j.1440-1797.2008.01029.x","article-title":"Prevalence of hypouricaemia and SLC22A12 mutations in healthy Korean subjects","volume":"13","author":"JH Lee","year":"2008","journal-title":"Nephrology (Carlton)"},{"key":"ref74","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.cca.2008.09.008","article-title":"T6092C polymorphism of SLC22A12 gene is associated with serum uric acid concentrations in Korean male subjects","volume":"398","author":"WC Jang","year":"2008","journal-title":"Clin Chim Acta"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"215","DOI":"10.1093\/rheumatology\/kel205","article-title":"Molecular analysis of the SLC22A12 (URAT1) gene in patients with primary gout","volume":"46","author":"J Vazquez-Mellado","year":"2007","journal-title":"Rheumatology (Oxford)"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"2234","DOI":"10.1016\/j.lfs.2006.07.030","article-title":"Association between intronic SNP in urate-anion exchanger gene, SLC22A12, and serum uric acid levels in Japanese","volume":"79","author":"Y Shima","year":"2006","journal-title":"Life Sci"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1002\/art.21499","article-title":"Association of the human urate transporter 1 with reduced renal uric acid excretion and hyperuricemia in a German Caucasian population","volume":"54","author":"J Graessler","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"36681","DOI":"10.18632\/oncotarget.9160","article-title":"OTUB1-catalyzed deubiquitination of FOXM1 facilitates tumor progression and predicts a poor prognosis in ovarian cancer","volume":"7","author":"Y Wang","year":"2016","journal-title":"Oncotarget"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"288","DOI":"10.15252\/emmm.201505972","article-title":"OTUB1 triggers lung cancer development by inhibiting RAS monoubiquitination","volume":"8","author":"MF Baietti","year":"2016","journal-title":"EMBO Mol Med"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"258","DOI":"10.1186\/1476-4598-13-258","article-title":"OTUB1 promotes metastasis and serves as a marker of poor prognosis in colorectal cancer","volume":"13","author":"Y Zhou","year":"2014","journal-title":"Mol Cancer"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"770","DOI":"10.1016\/j.prp.2014.05.008","article-title":"Colon cancer bears overexpression of OTUB1","volume":"210","author":"X Liu","year":"2014","journal-title":"Pathol Res Pract"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1038\/ng.789","article-title":"Genome-wide association study identifies 12 new susceptibility loci for primary biliary cirrhosis","volume":"43","author":"GF Mells","year":"2011","journal-title":"Nat Genet"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0194044","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,16]],"date-time":"2022-08-16T11:32:47Z","timestamp":1660649567000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0194044"}},"subtitle":[],"editor":[{"given":"Cheng","family":"Hu","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,20]]},"references-count":82,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,20]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0194044","relation":{"has-part":[{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.g001","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.g002","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.g003","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.t001","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.t002","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.t003","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.t004","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.t005","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.t006","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.s001","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.s002","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.s003","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.s004","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.s005","asserted-by":"subject"},{"id-type":"doi","id":"https:\/\/doi.org\/10.1371\/journal.pone.0194044.s006","asserted-by":"subject"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,20]]}}}