{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,19]],"date-time":"2026-06-19T14:40:01Z","timestamp":1781880001341,"version":"3.54.5"},"reference-count":77,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T00:00:00Z","timestamp":1520467200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL127449"],"award-info":[{"award-number":["R01HL127449"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["R01HL125186"],"award-info":[{"award-number":["R01HL125186"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000009","name":"Foundation for the National Institutes of Health","doi-asserted-by":"publisher","award":["R01CA1689"],"award-info":[{"award-number":["R01CA1689"]}],"id":[{"id":"10.13039\/100000009","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000002","name":"National Institutes of Health","doi-asserted-by":"publisher","award":["HL67330, HL089934, HL70694"],"award-info":[{"award-number":["HL67330, HL089934, HL70694"]}],"id":[{"id":"10.13039\/100000002","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Scientific Research Grant, Connecticut Children\u2019s Medical Center, Hartford, Connecticut"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0194053","type":"journal-article","created":{"date-parts":[[2018,3,8]],"date-time":"2018-03-08T13:37:45Z","timestamp":1520516265000},"page":"e0194053","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":33,"title":["Cell-intrinsic sphingosine kinase 2 promotes macrophage polarization and renal inflammation in response to unilateral ureteral obstruction"],"prefix":"10.1371","volume":"13","author":[{"given":"Mallika","family":"Ghosh","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shobha","family":"Thangada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oisharya","family":"Dasgupta","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kamal M.","family":"Khanna","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Harold T.","family":"Yamase","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Kashgarian","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Timothy","family":"Hla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4590-4671","authenticated-orcid":true,"given":"Linda H.","family":"Shapiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fernando A.","family":"Ferrer","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,3,8]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"1080","DOI":"10.1016\/j.chembiol.2012.09.002","article-title":"Fine-tuning S1P therapeutics","volume":"19","author":"H Obinata","year":"2012","journal-title":"Chem Biol"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"733","DOI":"10.1038\/ki.2013.435","article-title":"Sphingosine-1-phosphate receptor signaling during acute kidney injury: the tissue is the issue","volume":"85","author":"K Bartels","year":"2014","journal-title":"Kidney international"},{"issue":"1","key":"ref3","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1042\/BJ20120609","article-title":"Sphingosine kinase type 2 inhibition elevates circulating sphingosine 1-phosphate","volume":"447","author":"Y Kharel","year":"2012","journal-title":"The Biochemical journal"},{"issue":"21","key":"ref4","doi-asserted-by":"crossref","first-page":"5317","DOI":"10.1111\/febs.12314","article-title":"Roles, regulation and inhibitors of sphingosine kinase 2","volume":"280","author":"HA Neubauer","year":"2013","journal-title":"Febs J"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"955","DOI":"10.1681\/ASN.2009060662","article-title":"Activation of sphingosine-1-phosphate 1 receptor in the proximal tubule protects against ischemia-reperfusion injury","volume":"21","author":"A Bajwa","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"7503","key":"ref6","doi-asserted-by":"crossref","first-page":"58","DOI":"10.1038\/nature13475","article-title":"Sphingolipid metabolites in inflammatory disease","volume":"510","author":"M Maceyka","year":"2014","journal-title":"Nature"},{"issue":"4","key":"ref7","doi-asserted-by":"crossref","first-page":"1879","DOI":"10.1021\/jm501760d","article-title":"Structure-activity relationship studies and in vivo activity of guanidine-based sphingosine kinase inhibitors: discovery of SphK1- and SphK2-selective inhibitors","volume":"58","author":"NN Patwardhan","year":"2015","journal-title":"J Med Chem"},{"key":"ref8","article-title":"Sphingosine Kinase 2 Deficiency Attenuates Kidney Fibrosis via IFN-gamma","author":"A Bajwa","year":"2016","journal-title":"J Am Soc Nephrol"},{"key":"ref9","article-title":"Sphingosine kinase-2 deficiency ameliorates kidney fibrosis by up-regulating Smad7 in a mouse model of unilateral ureteral obstruction","author":"S Schwalm","year":"2017","journal-title":"Am J Pathol"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"1256","DOI":"10.1046\/j.1523-1755.2003.00874.x","article-title":"Activation of the ERK pathway precedes tubular proliferation in the obstructed rat kidney","volume":"63","author":"T Masaki","year":"2003","journal-title":"Kidney international"},{"issue":"3","key":"ref11","doi-asserted-by":"crossref","first-page":"198","DOI":"10.1097\/00007890-198303000-00002","article-title":"An experimental model for assessment of renal recovery from warm ischemia","volume":"35","author":"P Jablonski","year":"1983","journal-title":"Transplantation"},{"issue":"5 Suppl","key":"ref12","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1016\/j.juro.2013.10.072","article-title":"Treatment with the immunomodulator FTY720 (fingolimod) significantly reduces renal inflammation in murine unilateral ureteral obstruction","volume":"191","author":"S Thangada","year":"2014","journal-title":"J Urol"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"4466","DOI":"10.4049\/jimmunol.1403133","article-title":"CD13 Restricts TLR4 Endocytic Signal Transduction in Inflammation","volume":"194","author":"M Ghosh","year":"2015","journal-title":"Journal of immunology"},{"issue":"76","key":"ref14","article-title":"Investigation of macrophage polarization using bone marrow derived macrophages","author":"W Ying","year":"2013","journal-title":"Journal of visualized experiments JoVE"},{"issue":"9","key":"ref15","doi-asserted-by":"crossref","first-page":"3425","DOI":"10.1172\/JCI57582","article-title":"Renal collecting duct epithelial cells regulate inflammation in tubulointerstitial damage in mice","volume":"121","author":"K Fujiu","year":"2011","journal-title":"The Journal of clinical investigation"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"e00264","DOI":"10.1128\/mBio.00264-13","article-title":"Macrophage M1\/M2 polarization dynamically adapts to changes in cytokine microenvironments in Cryptococcus neoformans infection","volume":"4","author":"MJ Davis","year":"2013","journal-title":"MBio"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1097\/MOL.0b013e32834a77b4","article-title":"Macrophage polarization in metabolic disorders: functions and regulation","volume":"22","author":"G Chinetti-Gbaguidi","year":"2011","journal-title":"Curr Opin Lipidol"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"7884","DOI":"10.1074\/jbc.M113.522037","article-title":"Metabolic reprogramming of macrophages: glucose transporter 1 (GLUT1)-mediated glucose metabolism drives a proinflammatory phenotype","volume":"289","author":"AJ Freemerman","year":"2014","journal-title":"J Biol Chem"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.jss.2015.03.034","article-title":"Epigallocatechin-3-gallate reduces tubular cell apoptosis in mice with ureteral obstruction","volume":"197","author":"Y Wang","year":"2015","journal-title":"J Surg Res"},{"issue":"11","key":"ref20","doi-asserted-by":"crossref","first-page":"2043","DOI":"10.1093\/ndt\/gfu240","article-title":"Tamoxifen ameliorates renal tubulointerstitial fibrosis by modulation of estrogen receptor alpha-mediated transforming growth factor-beta1\/Smad signaling pathway","volume":"29","author":"D Kim","year":"2014","journal-title":"Nephrol Dial Transplant"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"262","DOI":"10.1038\/labinvest.3700383","article-title":"Renoprotective effect of a dopamine D3 receptor antagonist in experimental type II diabetes","volume":"86","author":"ML Gross","year":"2006","journal-title":"Lab Invest"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"463740","DOI":"10.1155\/2013\/463740","article-title":"Both ERK\/MAPK and TGF-Beta\/Smad signaling pathways play a role in the kidney fibrosis of diabetic mice accelerated by blood glucose fluctuation","volume":"2013","author":"X Cheng","year":"2013","journal-title":"J Diabetes Res"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1186\/1476-9255-7-19","article-title":"Role of inflammation in tubulo-interstitial damage associated to obstructive nephropathy","volume":"7","author":"MT Grande","year":"2010","journal-title":"J Inflamm (Lond)"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1681\/ASN.2008121226","article-title":"New insights into epithelial-mesenchymal transition in kidney fibrosis","volume":"21","author":"Y Liu","year":"2010","journal-title":"J Am Soc Nephrol"},{"issue":"1","key":"ref25","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1084\/jem.20151570","article-title":"Immunometabolism governs dendritic cell and macrophage function","volume":"213","author":"LA O'Neill","year":"2016","journal-title":"J Exp Med"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1124\/jpet.115.225862","article-title":"Sphingosine Kinase 2 Inhibition and Blood Sphingosine 1-Phosphate Levels","volume":"355","author":"Y Kharel","year":"2015","journal-title":"J Pharmacol Exp Ther"},{"issue":"8","key":"ref27","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1038\/ki.2012.224","article-title":"Proximal tubule sphingosine kinase-1 has a critical role in A1 adenosine receptor-mediated renal protection from ischemia","volume":"82","author":"SW Park","year":"2012","journal-title":"Kidney international"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1016\/j.prro.2014.10.012","article-title":"Safety Profile Assessment: An online tool to gauge safety-critical performance in radiation oncology","volume":"5","author":"P Dunscombe","year":"2015","journal-title":"Practical radiation oncology"},{"issue":"15","key":"ref29","doi-asserted-by":"crossref","first-page":"3397","DOI":"10.1093\/hmg\/dds172","article-title":"Loss of GM3 synthase gene, but not sphingosine kinase 1, is protective against murine nephronophthisis-related polycystic kidney disease","volume":"21","author":"TA Natoli","year":"2012","journal-title":"Hum Mol Genet"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1038\/ki.2008.400","article-title":"Divergent roles of sphingosine kinases in kidney ischemia-reperfusion injury","volume":"75","author":"SK Jo","year":"2009","journal-title":"Kidney Int"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1016\/j.jhep.2011.05.025","article-title":"Sphingosine kinase-2 inhibition improves mitochondrial function and survival after hepatic ischemia-reperfusion","volume":"56","author":"Y Shi","year":"2012","journal-title":"J Hepatol"},{"issue":"4","key":"ref32","doi-asserted-by":"crossref","first-page":"997","DOI":"10.1007\/s10620-007-0133-6","article-title":"Suppression of ulcerative colitis in mice by orally available inhibitors of sphingosine kinase","volume":"53","author":"LW Maines","year":"2008","journal-title":"Dig Dis Sci"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"73","DOI":"10.1007\/s10787-010-0032-x","article-title":"Efficacy of a novel sphingosine kinase inhibitor in experimental Crohn's disease","volume":"18","author":"LW Maines","year":"2010","journal-title":"Inflammopharmacology"},{"issue":"3\u20134","key":"ref34","doi-asserted-by":"crossref","first-page":"135","DOI":"10.1159\/000323911","article-title":"Experimental osteoarthritis in rats is attenuated by ABC294640, a selective inhibitor of sphingosine kinase-2","volume":"87","author":"LR Fitzpatrick","year":"2011","journal-title":"Pharmacology"},{"issue":"24","key":"ref35","doi-asserted-by":"crossref","first-page":"11113","DOI":"10.1128\/MCB.25.24.11113-11121.2005","article-title":"Essential role for sphingosine kinases in neural and vascular development","volume":"25","author":"K Mizugishi","year":"2005","journal-title":"Mol Cell Biol"},{"issue":"3","key":"ref36","doi-asserted-by":"crossref","first-page":"2097","DOI":"10.4049\/jimmunol.0804376","article-title":"Distinct roles of sphingosine kinase 1 and 2 in murine collagen-induced arthritis","volume":"183","author":"WQ Lai","year":"2009","journal-title":"J Immunol"},{"issue":"2","key":"ref37","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1007\/s10787-010-0060-6","article-title":"Attenuation of arthritis in rodents by a novel orally-available inhibitor of sphingosine kinase","volume":"19","author":"LR Fitzpatrick","year":"2011","journal-title":"Inflammopharmacology"},{"issue":"10","key":"ref38","doi-asserted-by":"crossref","first-page":"2600","DOI":"10.1097\/01.ASN.0000033611.79556.AE","article-title":"TGF-beta signaling in renal disease","volume":"13","author":"EP Bottinger","year":"2002","journal-title":"J Am Soc Nephrol"},{"issue":"6","key":"ref39","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/j.bbadis.2013.02.016","article-title":"Bone marrow-derived cells play a major role in kidney fibrosis via proliferation and differentiation in the infiltrated site","volume":"1832","author":"HS Jang","year":"2013","journal-title":"Biochimica et biophysica acta"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"F69","DOI":"10.1152\/ajprenal.00484.2014","article-title":"HMGB1 exacerbates renal tubulointerstitial fibrosis through facilitating M1 macrophage phenotype at the early stage of obstructive injury","volume":"308","author":"S Tian","year":"2015","journal-title":"Am J Physiol Renal Physiol"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.freeradbiomed.2016.01.011","article-title":"Sinomenine activation of Nrf2 signaling prevents hyperactive inflammation and kidney injury in a mouse model of obstructive nephropathy","volume":"92","author":"T Qin","year":"2016","journal-title":"Free radical biology & medicine"},{"issue":"6","key":"ref42","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1038\/ki.2013.525","article-title":"Ablation of proximal tubular suppressor of cytokine signaling 3 enhances tubular cell cycling and modifies macrophage phenotype during acute kidney injury","volume":"85","author":"N Susnik","year":"2014","journal-title":"Kidney Int"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"292","DOI":"10.1681\/ASN.2013020152","article-title":"Macrophage phenotype controls long-term AKI outcomes\u2014kidney regeneration versus atrophy","volume":"25","author":"M Lech","year":"2014","journal-title":"J Am Soc Nephrol"},{"issue":"7","key":"ref44","doi-asserted-by":"crossref","first-page":"F948","DOI":"10.1152\/ajprenal.00580.2012","article-title":"Netrin-1-treated macrophages protect the kidney against ischemia-reperfusion injury and suppress inflammation by inducing M2 polarization","volume":"304","author":"PV Ranganathan","year":"2013","journal-title":"Am J Physiol Renal Physiol"},{"issue":"12","key":"ref45","doi-asserted-by":"crossref","first-page":"2856","DOI":"10.1161\/ATVBAHA.111.237198","article-title":"Macrophage polarization by angiotensin II-type 1 receptor aggravates renal injury-acceleration of atherosclerosis","volume":"31","author":"S Yamamoto","year":"2011","journal-title":"Arteriosclerosis, thrombosis, and vascular biology"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1159\/000430106","article-title":"Enhanced M1 and Impaired M2 Macrophage Polarization and Reduced Mitochondrial Biogenesis via Inhibition of AMP Kinase in Chronic Kidney Disease","volume":"36","author":"C Li","year":"2015","journal-title":"Cell Physiol Biochem"},{"issue":"6","key":"ref47","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1093\/ckj\/sfw096","article-title":"Macrophage in chronic kidney disease","volume":"9","author":"R Guiteras","year":"2016","journal-title":"Clin Kidney J"},{"issue":"2","key":"ref48","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1159\/000431214","article-title":"Macrophage Phenotype in Kidney Injury and Repair","volume":"1","author":"XM Meng","year":"2015","journal-title":"Kidney Dis (Basel)"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1111\/j.1440-1797.2010.01439.x","article-title":"Alteration in the phenotype of macrophages in the repair of renal interstitial fibrosis in mice","volume":"16","author":"T Kushiyama","year":"2011","journal-title":"Nephrology (Carlton)"},{"issue":"15","key":"ref50","doi-asserted-by":"crossref","first-page":"1556","DOI":"10.1016\/j.jacc.2013.11.023","article-title":"In vivo silencing of the transcription factor IRF5 reprograms the macrophage phenotype and improves infarct healing","volume":"63","author":"G Courties","year":"2014","journal-title":"J Am Coll Cardiol"},{"key":"ref51","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1186\/s12950-015-0053-8","article-title":"Silencing collapsin response mediator protein-2 reprograms macrophage phenotype and improves infarct healing in experimental myocardial infarction model","volume":"12","author":"LS Zhou","year":"2015","journal-title":"J Inflamm (Lond)"},{"issue":"4","key":"ref52","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1111\/1755-5922.12193","article-title":"Atorvastatin attenuates sympathetic hyperinnervation together with the augmentation of M2 macrophages in rats postmyocardial infarction","volume":"34","author":"N Yang","year":"2016","journal-title":"Cardiovascular therapeutics"},{"issue":"7","key":"ref53","doi-asserted-by":"crossref","first-page":"1028","DOI":"10.1038\/nm.2807","article-title":"Mechanisms of fibrosis: therapeutic translation for fibrotic disease","volume":"18","author":"TA Wynn","year":"2012","journal-title":"Nat Med"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.yjmcc.2014.07.020","article-title":"Caveolin-1 deletion exacerbates cardiac interstitial fibrosis by promoting M2 macrophage activation in mice after myocardial infarction","volume":"76","author":"P Shivshankar","year":"2014","journal-title":"J Mol Cell Cardiol"},{"issue":"3","key":"ref55","doi-asserted-by":"crossref","first-page":"1062","DOI":"10.1159\/000373932","article-title":"Regulation of renal fibrosis by macrophage polarization","volume":"35","author":"B Pan","year":"2015","journal-title":"Cell Physiol Biochem"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1189\/jlb.1112587","article-title":"MMP28 promotes macrophage polarization toward M2 cells and augments pulmonary fibrosis","volume":"95","author":"SA Gharib","year":"2014","journal-title":"J Leukoc Biol"},{"issue":"5","key":"ref57","doi-asserted-by":"crossref","first-page":"768","DOI":"10.1165\/rcmb.2012-0377OC","article-title":"Tissue inhibitor of metalloproteinases-3 moderates the proinflammatory status of macrophages","volume":"49","author":"SE Gill","year":"2013","journal-title":"Am J Respir Cell Mol Biol"},{"issue":"3","key":"ref58","doi-asserted-by":"crossref","first-page":"414","DOI":"10.1161\/CIRCRESAHA.116.309194","article-title":"Abandoning M1\/M2 for a Network Model of Macrophage Function","volume":"119","author":"M Nahrendorf","year":"2016","journal-title":"Circ Res"},{"issue":"1","key":"ref59","doi-asserted-by":"crossref","first-page":"14","DOI":"10.1016\/j.immuni.2014.06.008","article-title":"Macrophage activation and polarization: nomenclature and experimental guidelines","volume":"41","author":"PJ Murray","year":"2014","journal-title":"Immunity"},{"issue":"7","key":"ref60","doi-asserted-by":"crossref","first-page":"1229","DOI":"10.1681\/ASN.2010070693","article-title":"IL-25 induces M2 macrophages and reduces renal injury in proteinuric kidney disease","volume":"22","author":"Q Cao","year":"2011","journal-title":"J Am Soc Nephrol"},{"issue":"12","key":"ref61","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1038\/ki.2008.555","article-title":"First responders: understanding monocyte-lineage traffic in the acutely injured kidney","volume":"74","author":"S Swaminathan","year":"2008","journal-title":"Kidney international"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"13","DOI":"10.12703\/P6-13","article-title":"The M1 and M2 paradigm of macrophage activation: time for reassessment","volume":"6","author":"FO Martinez","year":"2014","journal-title":"F1000Prime Rep"},{"issue":"10","key":"ref63","doi-asserted-by":"crossref","first-page":"2249","DOI":"10.1016\/j.cellsig.2014.07.009","article-title":"Sphingosine 1-phosphate induced anti-atherogenic and atheroprotective M2 macrophage polarization through IL-4","volume":"26","author":"SJ Park","year":"2014","journal-title":"Cell Signal"},{"issue":"9","key":"ref64","doi-asserted-by":"crossref","first-page":"2114","DOI":"10.1002\/ijc.24594","article-title":"Sphingosine kinase 2 deficient tumor xenografts show impaired growth and fail to polarize macrophages towards an anti-inflammatory phenotype","volume":"125","author":"A Weigert","year":"2009","journal-title":"Int J Cancer"},{"issue":"9","key":"ref65","doi-asserted-by":"crossref","first-page":"553","DOI":"10.1038\/nri.2016.70","article-title":"A guide to immunometabolism for immunologists","volume":"16","author":"LA O'Neill","year":"2016","journal-title":"Nat Rev Immunol"},{"issue":"7","key":"ref66","doi-asserted-by":"crossref","first-page":"771","DOI":"10.1038\/cr.2015.68","article-title":"Metabolic reprogramming in macrophages and dendritic cells in innate immunity","volume":"25","author":"B Kelly","year":"2015","journal-title":"Cell Res"},{"issue":"1","key":"ref67","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1002\/eji.201445427","article-title":"Reprogramming mitochondrial metabolism in macrophages as an anti-inflammatory signal","volume":"46","author":"EL Mills","year":"2016","journal-title":"European journal of immunology"},{"key":"ref68","first-page":"420","article-title":"Metabolic reprograming in macrophage polarization","volume":"5","author":"S Galvan-Pena","year":"2014","journal-title":"Front Immunol"},{"issue":"7444","key":"ref69","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1038\/nature11986","article-title":"Succinate is an inflammatory signal that induces IL-1beta through HIF-1alpha","volume":"496","author":"GM Tannahill","year":"2013","journal-title":"Nature"},{"issue":"6","key":"ref70","doi-asserted-by":"crossref","first-page":"1174","DOI":"10.1038\/ki.2014.205","article-title":"TREM-1 regulates macrophage polarization in ureteral obstruction","volume":"86","author":"TH Lo","year":"2014","journal-title":"Kidney Int"},{"issue":"11","key":"ref71","doi-asserted-by":"crossref","first-page":"3356","DOI":"10.1681\/ASN.2015020177","article-title":"Mitochondrial Pathology and Glycolytic Shift during Proximal Tubule Atrophy after Ischemic AKI","volume":"27","author":"R Lan","year":"2016","journal-title":"J Am Soc Nephrol"},{"issue":"8","key":"ref72","doi-asserted-by":"crossref","first-page":"1765","DOI":"10.1681\/ASN.2015010006","article-title":"Failed Tubule Recovery, AKI-CKD Transition, and Kidney Disease Progression","volume":"26","author":"MA Venkatachalam","year":"2015","journal-title":"J Am Soc Nephrol"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"e108678","DOI":"10.1371\/journal.pone.0108678","article-title":"Serum metabonomic analysis of protective effects of Curcuma aromatica oil on renal fibrosis rats","volume":"9","author":"L Zhao","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"ref74","doi-asserted-by":"crossref","first-page":"3037","DOI":"10.1084\/jem.20070885","article-title":"The healing myocardium sequentially mobilizes two monocyte subsets with divergent and complementary functions","volume":"204","author":"M Nahrendorf","year":"2007","journal-title":"J Exp Med"},{"issue":"6","key":"ref75","doi-asserted-by":"crossref","first-page":"353","DOI":"10.1016\/j.smim.2016.03.016","article-title":"A stratified myeloid system, the challenge of understanding macrophage diversity","volume":"27","author":"F Geissmann","year":"2015","journal-title":"Semin Immunol"},{"issue":"5","key":"ref76","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1002\/wsbm.133","article-title":"Ischemic kidney injury and mechanisms of tissue repair","volume":"3","author":"M El Sabbahy","year":"2011","journal-title":"Wiley interdisciplinary reviews Systems biology and medicine"},{"issue":"3","key":"ref77","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1016\/j.cytogfr.2014.11.009","article-title":"CXCR3 ligands in disease and therapy","volume":"26","author":"K Van Raemdonck","year":"2015","journal-title":"Cytokine Growth Factor Rev"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0194053","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T12:08:12Z","timestamp":1540296492000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0194053"}},"subtitle":[],"editor":[{"given":"David","family":"Long","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,8]]},"references-count":77,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0194053","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,8]]}}}