{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,8]],"date-time":"2026-01-08T21:59:11Z","timestamp":1767909551942,"version":"3.49.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T00:00:00Z","timestamp":1522108800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81102722"],"award-info":[{"award-number":["81102722"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["81273933"],"award-info":[{"award-number":["81273933"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"International Science and Technology Cooperation Program of China","award":["2014DFG32700"],"award-info":[{"award-number":["2014DFG32700"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0194082","type":"journal-article","created":{"date-parts":[[2018,3,27]],"date-time":"2018-03-27T13:32:45Z","timestamp":1522157565000},"page":"e0194082","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":13,"title":["Panax quinquefolius saponins combined with dual antiplatelet drug therapy alleviate gastric mucosal injury and thrombogenesis through the COX\/PG pathway in a rat model of acute myocardial infarction"],"prefix":"10.1371","volume":"13","author":[{"given":"Na","family":"Kou","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mei","family":"Xue","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Xuan","family":"Zang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Qu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Ming","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yu","family":"Miao","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bin","family":"Yang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5357-8936","authenticated-orcid":true,"given":"Da-Zhuo","family":"Shi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,3,27]]},"reference":[{"issue":"1","key":"ref1","doi-asserted-by":"crossref","first-page":"62","DOI":"10.1182\/asheducation-2011.1.62","article-title":"Advances in antiplatelet therapy","volume":"2011","author":"AD Michelson","year":"2011","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"19","key":"ref2","doi-asserted-by":"crossref","first-page":"2411","DOI":"10.1001\/jama.288.19.2411","article-title":"Early and sustained dual oral antiplatelet therapy following percutaneous coronary intervention: a randomized controlled trial","volume":"288","author":"SR Steinhubl","year":"2002","journal-title":"JAMA"},{"issue":"16","key":"ref3","doi-asserted-by":"crossref","first-page":"1706","DOI":"10.1056\/NEJMoa060989","article-title":"Clopidogrel and aspirin versus aspirin alone for the prevention of atherothrombotic events","volume":"354","author":"DL Bhatt","year":"2006","journal-title":"N Engl J Med"},{"issue":"4","key":"ref4","doi-asserted-by":"crossref","first-page":"591","DOI":"10.1016\/j.ahj.2007.12.034","article-title":"Antiplatelet drug nonresponsiveness","volume":"155","author":"P Gladding","year":"2008","journal-title":"Am Heart J"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1016\/j.jacc.2015.05.012","article-title":"The multifaceted clinical readouts of platelet inhibition by low-dose aspirin","volume":"66","author":"C Patrono","year":"2015","journal-title":"J Am Coll Cardiol"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"75","DOI":"10.1038\/nrd1929","article-title":"COX isoforms in the cardiovascular system: understanding the activities of non-steroidal anti-inflammatory drugs","volume":"5","author":"JA Mitchell","year":"2006","journal-title":"Nat Rev Drug Discov"},{"issue":"18","key":"ref7","doi-asserted-by":"crossref","first-page":"1502","DOI":"10.1016\/j.jacc.2008.08.002","article-title":"ACCF\/ACG\/AHA 2008 expert consensus document on reducing the gastrointestinal risks of antiplatelet therapy and NSAID use: A report of the American College of Cardiology Foundation Task Force on Clinical Expert Consensus Documents","volume":"52","author":"DL Bhatt","year":"2008","journal-title":"J Am Coll Cardiol"},{"issue":"12","key":"ref8","first-page":"1942","article-title":"Identification of ginsenosides from Panax quinquefolius in Xinyue Capsula by LC-ESI-MSn","volume":"41","author":"Y Lin","year":"2010","journal-title":"Chinese Traditional & Herbal Drugs"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1186\/s13063-016-1531-x","article-title":"Effect of Xinyue Capsules on patients with coronary heart disease after percutaneous coronary intervention:study protocol for a randomized controlled trial","volume":"17","author":"M Guo","year":"2016","journal-title":"Trial"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1133","DOI":"10.1360\/972013-188","article-title":"Reparative effects of <italic>Panax quinquefolius<\/italic> saponin on gastric mucosal lesions induced by dual antiplatelet drugs in AMI model rats","volume":"59","author":"QX Zhang","year":"2014","journal-title":"Chin Sci Bull"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"675","DOI":"10.1097\/00000658-195411000-00006","article-title":"Experimental myocardial infarction. I. A method of coronary occlusion in small animals","volume":"140","author":"TN Johns","year":"1954","journal-title":"Ann Surg"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"s557","DOI":"10.4103\/0973-1296.139782","article-title":"<italic>Strophanthus hispidus<\/italic> attenuates the Ischemia-Reperfusion induced myocardial Infarction and reduces mean arterial pressure in renal artery occlusion","volume":"10","author":"R Gundamaraju","year":"2014","journal-title":"Pharmacogn Mag"},{"key":"ref13","first-page":"93275","article-title":"Interaction of <italic>Panax quinquefolius<\/italic> saponin and dual antiplatelets on vascular endothelial function in rats with acute myocardial infarction","volume":"2015","author":"B Wang","year":"2015","journal-title":"Biomed Res Int"},{"issue":"5","key":"ref14","first-page":"796","article-title":"Panax quinquefolium saponin attenuates ventricular remodeling after acute myocardial infarction in rats by inhibiting endoplasmic reticulum stress-related apoptosis","volume":"29","author":"M Liu","year":"2013","journal-title":"Chinese Journal of Pathophysiology"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1097\/SHK.0b013e3182a3f9e5","article-title":"Panax quinquefolium saponin attenuates ventricular remodeling after acute myocardial infarction by inhibiting chop-mediated apoptosis","volume":"40","author":"M Liu","year":"2013","journal-title":"Shock"},{"issue":"18","key":"ref16","doi-asserted-by":"crossref","first-page":"2147","DOI":"10.3748\/wjg.v18.i18.2147","article-title":"Pathogenesis of NSAID-induced gastric damage: importance of cyclooxygenase inhibition and gastric hypermotility","volume":"18","author":"K Takeuchi","year":"2012","journal-title":"World J Gastroenterol"},{"issue":"5579","key":"ref17","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1038\/263663a0","article-title":"An enzyme isolated from arteries transforms prostaglandin endoperoxides to an unstable substance that inhibits platelet-aggregation","volume":"263","author":"S Moncada","year":"1976","journal-title":"Nature"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1159\/000177500","article-title":"The endothelium in coronary artery disease","volume":"88","author":"FT Ruschitzka","year":"1997","journal-title":"Cardiology"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1182\/asheducation-2011.1.70","article-title":"The clinical relevance of response variability to antiplatelet therapy","volume":"2011","author":"M Cattaneo","year":"2011","journal-title":"Hematology"},{"issue":"50","key":"ref20","doi-asserted-by":"crossref","first-page":"6473","DOI":"10.1038\/onc.2008.313","article-title":"PI3K\/Akt: getting it right matters","volume":"27","author":"TF Franke","year":"2008","journal-title":"Oncogene"},{"issue":"4","key":"ref21","doi-asserted-by":"crossref","first-page":"457","DOI":"10.2460\/ajvr.69.4.457","article-title":"Cyclooxygenase expression and prostanoid production in pyloric and duodenal mucosae in dogs after administration of nonsteroidal anti-inflammatory drugs","volume":"69","author":"JG Wooten","year":"2008","journal-title":"Am J Vet Res"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"e110124","DOI":"10.1371\/journal.pone.0110124","article-title":"Effects of danshensu on platelet aggregation and thrombosis: in vivo arteriovebous shuntand venous thrombosis models in rats","volume":"9","author":"C Yu","year":"2014","journal-title":"PloS One"},{"issue":"1","key":"ref23","first-page":"125","article-title":"Clinical significance of vascular endothelial growth factor expression in gastric cancer","volume":"21","author":"Y Kakeji","year":"2002","journal-title":"J Exp Clin Cancer Res"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"706","DOI":"10.1053\/gast.2000.16510","article-title":"NSAID-induced gastric damage in rats: Requirement for inhibition of both cyclooxygenase 1 and 2","volume":"119","author":"JL Wallace","year":"2000","journal-title":"Gastroenterology"},{"key":"ref25","article-title":"Preventive and therapeutic strategies for gastrointestinal injury associated with antiplatelet therapy","author":"Y Lan","year":"2012","journal-title":"World Chinese Journal of Digestology"},{"issue":"9","key":"ref26","first-page":"764","article-title":"Clopidogrel inhibits angiogenesis of gastric ulcer healing via downregulation of vascular endothelial growth factor receptor 2","volume":"15","author":"JC Luo","year":"2016","journal-title":"J Formos Med Assoc"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0194082","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T10:44:02Z","timestamp":1570963442000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0194082"}},"subtitle":[],"editor":[{"given":"Xianwu","family":"Cheng","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,27]]},"references-count":26,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,27]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0194082","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,27]]}}}