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leishmaniasis in the Guiana Shield, Brazil","volume":"24","author":"AAA Souza","year":"2017","journal-title":"Parasite"},{"key":"ref23","unstructured":"Lima ACS (2016). Caracteriza\u00e7\u00e3o biol\u00f3gica e molecular de cepas h\u00edbridas de Leishmania (Viannia) guyanensis X Leishmania (Viannia) shawi shawi isoladas de pacientes com leishmaniose tegumentar oriundos da regi\u00e3o amaz\u00f4nica, Santar\u00e9m-PA, Brasil. pHD thesis. Universidade de S\u00e3o Paulo. <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.teses.usp.br\/teses\/disponiveis\/5\/5160\/tde20092010\" xlink:type=\"simple\">www.teses.usp.br\/teses\/disponiveis\/5\/5160\/tde20092010<\/ext-link>."},{"key":"ref24","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1007\/s00403-013-1396-8","article-title":"Expression of Foxp3, TGF-\u03b2 and IL-10 in American cutaneous leishmaniasis lesions","volume":"306","author":"FMD Rodrigues","year":"2014","journal-title":"Arch Dermatol Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"1156","DOI":"10.1111\/j.1365-2559.2011.04046.x","article-title":"Endometrial cells counting in recurrent miscarriage: a comparasion of couting methods","volume":"59","author":"JA Drury","year":"2011","journal-title":"Histopathol"},{"key":"ref26","first-page":"241","article-title":"<italic>In situ<\/italic> characterization of the cellular immune response 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Mart\u00ednez-Arends","year":"1991","journal-title":"Acta Tropica"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1007\/BF01611181","article-title":"Cell populations in the lesion of humancutaneous leishmaniasis: a light microscopical, immunohistochemical and ultrastructural study","volume":"421","author":"P Esterre","year":"1992","journal-title":"Virchows Arch A Pathol Anat Histopathol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"365","DOI":"10.4269\/ajtmh.1996.55.365","article-title":"Immunocytochemical and histopathologic characterization of lesions from patientes withlocalized cutaneous leishmaniasis caused by <italic>Leishmania panamensis<\/italic>","volume":"55","author":"DM Isaza","year":"1996","journal-title":"Am J Trop Med Hyg"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"979","DOI":"10.1590\/S0074-02762002000700009","article-title":"B-cell infiltration and frequency of cytokine producing cells differ between localized 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