{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,13]],"date-time":"2026-02-13T11:09:25Z","timestamp":1770980965929,"version":"3.50.1"},"reference-count":49,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T00:00:00Z","timestamp":1522022400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"University of Padova (IT)","award":["60A07-4857\/15"],"award-info":[{"award-number":["60A07-4857\/15"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0194693","type":"journal-article","created":{"date-parts":[[2018,3,26]],"date-time":"2018-03-26T13:35:07Z","timestamp":1522071307000},"page":"e0194693","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":19,"title":["Genetics in TNF-TNFR pathway: A complex network causing spondyloarthritis and conditioning response to anti-TNF\u03b1 therapy"],"prefix":"10.1371","volume":"13","author":[{"given":"Ada","family":"Aita","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8745-6171","authenticated-orcid":true,"given":"Daniela","family":"Basso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Ramonda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Stefania","family":"Moz","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mariagrazia","family":"Lorenzin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Filippo","family":"Navaglia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo-Federico","family":"Zambon","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Andrea","family":"Padoan","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mario","family":"Plebani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Leonardo","family":"Punzi","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,3,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"663","DOI":"10.1016\/j.berh.2014.10.007","article-title":"The concept of spondyloarthritis: where are we now?","volume":"28","author":"N Garg","year":"2014","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1320","DOI":"10.1002\/acr.22831","article-title":"Global Prevalence of Spondyloarthritis: ASystematic Review and Meta-Regression Analysis","volume":"68","author":"C Stolwijk","year":"2016","journal-title":"Arthritis Care Res"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1080\/1744666X.2017.1244004","article-title":"Lessons to be learned from serum biomarkers in psoriasis and IBD\u2014the potential role in SpA","volume":"13","author":"MC Turina","year":"2017","journal-title":"Expert Rev Clin Immunol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"830","DOI":"10.3390\/ijms18040830","article-title":"Spondyloarthritis: Matrix Metalloproteinasesas Biomarkers of Pathogenesis and Response to Tumor Necrosis Factor (TNF) Inhibitors","volume":"18","author":"S Moz","year":"2017","journal-title":"Int J Mol Sci"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1007\/s00296-002-0237-4","article-title":"Age at disease onset and diagnosis delay in HLA-B27 negative vs. positive patients with ankylosing spondylitis","volume":"23","author":"E Feldtkeller","year":"2003","journal-title":"Rheumatol Int"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1002\/art.23471","article-title":"Radiographic progression of ankylosing spondylitis after up to two years of treatment with etanercept","volume":"58","author":"D Van der Heijde","year":"2008","journal-title":"Arthritis Rheum"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"464","DOI":"10.1016\/j.autrev.2011.01.011","article-title":"What is the role of HLA-B27 in spondyloarthropathies?","volume":"10","author":"A Chatzikyriakidou","year":"2011","journal-title":"Autoimmun Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.1093\/rheumatology\/kep260","article-title":"Lack of association of TNF-alpha promoter polymorphisms with ankylosing spondylitis: a meta-analysis","volume":"48","author":"YH Lee","year":"2009","journal-title":"Rheumatology"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"123","DOI":"10.1038\/ng.513","article-title":"Genome-wide association study of ankylosing spondylitis identifies non-MHC susceptibility loci","volume":"42","author":"JD Reveille","year":"2010","journal-title":"Nat Genet"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"983","DOI":"10.1007\/s10067-010-1499-y","article-title":"The association between TNF-alpha promoter polymorphisms and ankylosing spondylitis: a meta-analysis","volume":"29","author":"B Li","year":"2010","journal-title":"Clin Rheumatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1243","DOI":"10.1136\/ard.2009.115147","article-title":"The chromosome 16q region associated with ankylosing spondylitis includes the candidate gene tumour necrosis factor receptor type 1-associated death domain (TRADD)","volume":"69","author":"JJ Pointon","year":"2010","journal-title":"Ann Rheum Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1016\/j.berh.2014.10.010","article-title":"Genetics of psoriatic arthritis","volume":"28","author":"DD O'Rielly","year":"2014","journal-title":"Best Pract Res Clin Rheumatol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"2","DOI":"10.1016\/j.molimm.2013.06.013","article-title":"Genetics of ankylosing spondylitis","volume":"57","author":"PC Robinson","year":"2014","journal-title":"Mol Immunol"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1551","DOI":"10.1136\/ard.2005.050963","article-title":"Detailed analysis of the cell infiltrate and the expression of mediators of synovial inflammation and joint destruction in the synovium of patients with psoriatic arthritis: implications for treatment","volume":"65","author":"AW Van Kuijk","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"394","DOI":"10.1097\/00002281-200307000-00005","article-title":"Biologic therapies in the spondyloarthritis: new opportunities, new challenges","volume":"15","author":"J Braun","year":"2003","journal-title":"Curr Opin Rheumatol"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1038\/ng0997-25","article-title":"A candidate gene for familial Mediterranean fever","volume":"17","year":"1997","journal-title":"Nat Genet"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/S0092-8674(00)80721-7","article-title":"Germline mutations in the extracellular domains of the 55 kDa TNF receptor, TNFR1, define a family of dominantly inherited autoinflammatory syndromes","volume":"97","author":"MF McDermott","year":"1999","journal-title":"Cell"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1007\/s00296-008-0637-1","article-title":"The rate and significance of Mediterranean fever gene mutations in patients with ankylosing spondylitis: a three-month, longitudinal clinical study","volume":"29","author":"M Cinar","year":"2008","journal-title":"Rheumatol Int"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1016\/j.jbspin.2008.09.011","article-title":"Clinical significance of MEFV mutations in ankylosing spondylitis","volume":"76","author":"D Durmus","year":"2009","journal-title":"Joint Bone Spine"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"3232","DOI":"10.1002\/art.27683","article-title":"Association of familial Mediterranean fever-related MEFV variations with ankylosing spondylitis","volume":"62","author":"F Cosan","year":"2010","journal-title":"Arthritis Rheum"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"388","DOI":"10.1007\/s11926-011-0191-9","article-title":"Familial Mediterranean fever and seronegative arthritis","volume":"13","author":"N Akkoc","year":"2011","journal-title":"Curr Rheumatol Rep"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1155\/2012\/890214","article-title":"Common Mediterranean fever (MEFV) gene mutations associated with ankylosing spondylitis in Turkish population","volume":"33","author":"S Yigit","year":"2012","journal-title":"Dis Markers"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"R21","DOI":"10.1186\/ar4154","article-title":"High prevalence of spondyloarthritis and ankylosing spondylitis among familial Mediterranean fever patients and their first-degree relatives: further evidence for the connection","volume":"15","author":"S Akar","year":"2013","journal-title":"Arthritis Res Ther"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"203","DOI":"10.3906\/sag-1304-140","article-title":"MEFV mutation frequency and effect on disease severity in ankylosing spondylitis","volume":"44","author":"Y Mara\u015f","year":"2014","journal-title":"Turk J Med Sci"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1002\/art.1780270401","article-title":"Evaluation of diagnostic criteria for ankylosing spondylitis. A proposal for modification of the New York criteria","volume":"27","author":"S Van der Linden","year":"1984","journal-title":"Arthritis Rheum"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1002\/art.21972","article-title":"Classification criteria for psoriatic arthritis: development of new criteria from a large international study","volume":"54","author":"W Taylor","year":"2006","journal-title":"Arthritis Rheum"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"492","DOI":"10.1136\/annrheumdis-2013-204573","article-title":"EULAR recommendations for the management of rheumatoid arthritis with synthetic andbiological disease-modifying antirheumatic drugs: 2013 update","volume":"73","author":"JS Smolen","year":"2014","journal-title":"Ann Rheum Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"316","DOI":"10.1136\/ard.2005.040758","article-title":"First update of the international ASAS consensus statement for the use of anti-TNF agents in patients with ankylosing spondylitis","volume":"65","author":"J Braun","year":"2006","journal-title":"Ann Rheum Dis"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1016\/j.cyto.2004.10.013","article-title":"Pro- and anti-inflammatory cytokines gene polymorphisms and Helicobacter pylori infection: interactions influence outcome","volume":"29","author":"CF Zambon","year":"2005","journal-title":"Cytokine"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"e0123244","DOI":"10.1371\/journal.pone.0123244","article-title":"TNFA Haplotype Genetic Testing Improves HLA in Estimating the Risk of Celiac Disease in Children","volume":"10","author":"E Rossi","year":"2015","journal-title":"PLoS One"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","DOI":"10.1177\/1536867X0800800301","article-title":"Semiparametric analysis of case\u2013control genetic data in the presence of environmental factors","volume":"8","author":"YV Marchenko","year":"2008","journal-title":"Stata Journal"},{"key":"ref32","article-title":"Psoriasis, psoriatic arthritis, and rheumatoid arthritis: Is all inflammation the same?","author":"LC Coates","year":"2016","journal-title":"Semin Arthritis Rheum"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.imlet.2006.10.004","article-title":"HLA-B27 and the pathogenesis of spondyloarthropathies","volume":"108","author":"JA L\u00f3pez de Castro","year":"2007","journal-title":"Immunol Lett"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1167","DOI":"10.1007\/s00296-010-1434-1","article-title":"Polymorphisms of tumor necrosis factor-\u03b1 promoter region for susceptibility to HLA-B27-positive ankylosing spondylitis in Korean population","volume":"31","author":"WT Chung","year":"2011","journal-title":"Rheumatol Int"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1508","DOI":"10.1186\/s40064-016-3197-y","article-title":"TNF-\u03b1 gene polymorphisms and expression","volume":"5","author":"RR El-Tahan","year":"2016","journal-title":"Springerplus"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"1443","DOI":"10.1093\/hmg\/8.8.1443","article-title":"A common functional polymorphism (C&gt;A substitution at position -863) in the promoter region of the tumour necrosis factor-alpha (TNF-alpha) gene associated with reduced circulating levels of TNF-alpha","volume":"8","author":"T Skoog","year":"1999","journal-title":"Hum Mol Genet"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1136\/ard.60.1.36","article-title":"Low T cell production of TNFalpha and IFNgamma in ankylosing spondylitis: its relation to HLA-B27 and influence of the TNF-308 gene polymorphism","volume":"60","author":"M Rudwaleit","year":"2001","journal-title":"Ann Rheum Dis"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"163","DOI":"10.1016\/j.bbadis.2009.01.007","article-title":"Tumor necrosis factor alpha -308gene locus promoter polymorphism: an analysis of association with health and disease","volume":"1792","author":"MM Elahi","year":"2009","journal-title":"Biochim Biophys Acta"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1097\/BOR.0b013e3283364483","article-title":"Genetics of ankylosing spondylitis","volume":"22","author":"MA Brown","year":"2010","journal-title":"Curr Opin Rheumatol"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1136\/ard.2003.016386","article-title":"Prediction of a major clinical response (BASDAI 50) to tumour necrosis factor alpha blockers in ankylosing spondylitis","volume":"63","author":"M Rudwaleit","year":"2004","journal-title":"Ann Rheum Dis"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1136\/ard.2010.147744","article-title":"Predicting the outcome of ankylosing spondylitis therapy","volume":"70","author":"N Vastesaeger","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref42","first-page":"1","article-title":"Predictors of response to TNF antagonists in patients with ankylosing spondylitis and psoriatic arthritis: systematic review and meta-analysis","volume":"18","author":"JR Maneiro","year":"2015","journal-title":"RMD Open"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"896","DOI":"10.1136\/ard.2011.151027","article-title":"2010 update of the ASAS\/EULAR recommendations for the management of ankylosing spondylitis","volume":"70","author":"J Braun","year":"2011","journal-title":"Ann Rheum Dis"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1378","DOI":"10.1093\/rheumatology\/kes026","article-title":"Update of the literature review on treatment with biologics as a basis for the first update of the ASAS\/EULAR management recommendations of ankylosing spondylitis","volume":"51","author":"X Baraliakos","year":"2012","journal-title":"Rheumatology"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"1","DOI":"10.3310\/hta11280","article-title":"Adalimumab, etanercept and infliximab for the treatment of ankylosing spondylitis: a systematic review and economic evaluation","volume":"11","author":"C McLeod","year":"2007","journal-title":"Health Technol Assess"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"793","DOI":"10.1007\/s00296-013-2913-y","article-title":"Candidate&apos;s single-nucleotide polymorphism predictors of treatment nonresponse to the first anti-TNF inhibitor in ankylosing spondylitis","volume":"34","author":"R Schiotis","year":"2014","journal-title":"Rheumatol Int"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"1427","DOI":"10.2217\/pgs.15.90","article-title":"Association between TNF-\u03b1 (-308 A\/G, -238 A\/G, -857 C\/T) polymorphisms and responsiveness to TNF-\u03b1 blockers in spondyloarthropathy, psoriasis and Crohn&apos;s disease: a meta-analysis","volume":"16","author":"GG Song","year":"2015","journal-title":"Pharmacogenomics"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"32202","DOI":"10.1038\/srep32202","article-title":"TNF-\u03b1 Promoter Polymorphisms Predict the Response to Etanercept More Powerfully than that to Infliximab\/Adalimumab in Spondyloarthritis","volume":"6","author":"J Liu","year":"2016","journal-title":"Sci Rep"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"1891","DOI":"10.1212\/01.wnl.0000436612.66328.8a","article-title":"Clinical relevance and functional consequences of the TNFRSF1A multiple sclerosis locus","volume":"81","author":"L Ottoboni","year":"2013","journal-title":"Neurology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0194693","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,13]],"date-time":"2019-10-13T09:08:33Z","timestamp":1570957713000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0194693"}},"subtitle":[],"editor":[{"given":"Yu-Jia","family":"Chang","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,26]]},"references-count":49,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0194693","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,26]]}}}