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Mplus Technical Appendices. [Internet]. Los Angeles, CA; 1998 2004. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/statmodel.com\/download\/techappen.pdf\" xlink:type=\"simple\">http:\/\/statmodel.com\/download\/techappen.pdf<\/ext-link>"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v048.i02","article-title":"lavaan: An R Package for Structural Equation Modeling","volume":"48","author":"Y Rosseel","year":"2012","journal-title":"J Stat Softw"},{"year":"2016","key":"ref35","article-title":"R: A language and environment for statistical computing"},{"article-title":"Mplus user\u2019s guide","year":"1998","author":"L Muth\u00e9n","key":"ref36"},{"key":"ref37","first-page":"1","article-title":"Weighted least squares estimation with missing data","author":"T Asparouhov","year":"2010","journal-title":"Mplus Tech Append"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"135","DOI":"10.3102\/10769986028002135","article-title":"Estimating multilevel linear models as structural equation models","volume":"28","author":"DJ Bauer","year":"2003","journal-title":"J Educ Behav Stat"},{"key":"ref39","first-page":"135","article-title":"Recent developments on structural equation models","author":"J Hox","year":"2004"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"481","DOI":"10.3102\/1076998616646200","article-title":"Construct meaning in multilevel settings","volume":"41","author":"L Stapleton","year":"2016","journal-title":"J Educ Behav Stat"},{"key":"ref41","first-page":"1","article-title":"Latent variable analysis with categorical outcomes: Multiple-group and growth modeling in Mplus","volume":"4","author":"BO Muth\u00e9n","year":"2002","journal-title":"Mplus Web Notes"},{"key":"ref42","first-page":"1","article-title":"Robust inference using weighted least squares and quadratic estimating equations in latent variable modeling with categorical and continuous outcomes","volume":"75","author":"B Muth\u00e9n","year":"1997","journal-title":"Psychometrika"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1207\/S15328007SEM0702_1","article-title":"Point estimation, hypothesis testing, and interval estimation using the RMSEA: Some comments and a reply to Hayduk and Glaser","volume":"7","author":"J Steiger","year":"2000","journal-title":"Struct Equ Model"},{"key":"ref44","unstructured":"Steiger J, Lind J. Statistically-based tests for the number of common factors. Paper presented at: Meeting of the Psychometric Society; 1980 May; Iowa City, IA, USA."},{"key":"ref45","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1037\/0033-2909.88.3.588","article-title":"Significance tests and goodness of fit in the analysis of covariance structures","volume":"88","author":"PM Bentler","year":"1980","journal-title":"Psychol Bull"},{"key":"ref46","doi-asserted-by":"crossref","first-page":"369","DOI":"10.1080\/10705519609540052","article-title":"CFI versus RMSEA: A comparison of two fit indexes for structural equation modeling","volume":"3","author":"E Rigdon","year":"1996","journal-title":"Struct Equ Model Multidiscip J"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"462","DOI":"10.1177\/0049124108314720","article-title":"An empirical evaluation of the use of fixed cutoff points in RMSEA test statistic in structural equation models","volume":"36","author":"F Chen","year":"2008","journal-title":"Sociol Methods 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