{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,23]],"date-time":"2026-08-23T15:52:22Z","timestamp":1787500342827,"version":"build-2736575974"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"3","license":[{"start":{"date-parts":[[2018,3,19]],"date-time":"2018-03-19T00:00:00Z","timestamp":1521417600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0194752","type":"journal-article","created":{"date-parts":[[2018,3,20]],"date-time":"2018-03-20T17:17:46Z","timestamp":1521566266000},"page":"e0194752","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":36,"title":["Effect of leukocyte-reduced platelet-rich plasma on osteoarthritis caused by cranial cruciate ligament rupture: A canine gait analysis model"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2060-2274","authenticated-orcid":true,"given":"Jos\u00e9 M.","family":"Vilar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria E.","family":"Manera","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Angelo","family":"Santana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Spinella","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4040-1266","authenticated-orcid":true,"given":"Oliver","family":"Rodriguez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2689-8862","authenticated-orcid":true,"given":"M\u00f3nica","family":"Rubio","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 M.","family":"Carrillo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3601-9745","authenticated-orcid":true,"given":"Joaqu\u00edn","family":"Sopena","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel","family":"Batista","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,3,19]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"51","DOI":"10.1186\/1746-6148-10-51","article-title":"Evaluation of vertical forces in the pads of Pitbulls with cranial cruciate ligament rupture","volume":"10","author":"AN Souza","year":"2014","journal-title":"BMC Vet Res"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"91","DOI":"10.3415\/VCOT-10-04-0055","article-title":"Update on the aetiopathogenesis of canine cranial cruciate ligament disease","volume":"24","author":"EJ Comerford","year":"2011","journal-title":"Vet Comp Orthop Traumatol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"3","DOI":"10.3415\/VCOT-11-04-0063","article-title":"Special issue on canine cruciate ligament disease","volume":"24","author":"KA Johnson","year":"2011","journal-title":"Vet Comp Orthop Traumatol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"87","DOI":"10.3415\/VCOT-09-06-0068","article-title":"Effect of exercise on kinetic gait analysis of dogs afflicted by osteoarthritis","volume":"23","author":"R Beraud","year":"2010","journal-title":"Vet Comp Orthop Traumatol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1136\/vr.147.12.325","article-title":"Long-term outcome of surgery for dogs with cranial cruciate ligament deficiency","volume":"147","author":"JF Innes","year":"2000","journal-title":"Vet Rec"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"98","DOI":"10.1186\/ar3373","article-title":"Tiludronate treatment improves structural changes and symptoms of osteoarthritis in the canine anterior cruciate ligament model","volume":"13","author":"M Moreau","year":"2011","journal-title":"Arthritis Res Ther"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"5405","DOI":"10.4081\/or.2014.5405","article-title":"Does intra articular platelet rich plasma injection improve function, pain and quality of life in patients with osteoarthritis of the knee? A randomized clinical trial","volume":"6","author":"SM Rayegani","year":"2014","journal-title":"Orthop Rev"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"1627","DOI":"10.1016\/j.joca.2013.07.017","article-title":"Basic science and clinical application of platelet rich plasma for cartilage defects and osteoarthritis: a review","volume":"21","author":"Y Zhu","year":"2013","journal-title":"Osteoarthritis Cartilage"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"488","DOI":"10.3415\/VCOT-12-03-0031","article-title":"Reducing susceptibility artefacts in magnetic resonance images of the canine stifle following surgery for cranial cruciate ligament deficiency","volume":"25","author":"FH David","year":"2012","journal-title":"Vet Comp Orthop Traumatol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"192","DOI":"10.3415\/VCOT-10-03-0030","article-title":"An investigation into risk factors for bilateral canine cruciate ligament rupture","volume":"24","author":"J Grierson","year":"2011","journal-title":"Vet Comp Orthop Traumatol"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jnutbio.2007.01.008","article-title":"Fish oil decreases matrix metalloproteinases in knee synovia of dogs with inflammatory joint disease","volume":"19","author":"RA Hansen","year":"2008","journal-title":"J Nutr Biochem"},{"key":"ref12","first-page":"229","article-title":"Long-term valuation of oral mavacoxib in osteoarthrosic dogs using force platform analysis","volume":"33","author":"JM Vilar","year":"2013","journal-title":"Pak Vet J"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1186\/1746-6148-9-131","article-title":"Controlled, blinded force platform analysis of the effect of intraarticular injection of autologous adipose-derived mesenchymal stem cells associated to PRGF-Endoret in osteoarthritic dogs","volume":"9","author":"JM Vilar","year":"2013","journal-title":"BMC Vet Res"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1186\/2052-1847-6-12","article-title":"Is platelet-rich plasma superior to whole blood in the management of chronic tennis elbow: one year randomized clinical trial","volume":"6","author":"SA Raeissadat","year":"2014","journal-title":"BMC Sports Sci Med. Rehabil"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"214","DOI":"10.1016\/j.jss.2013.01.020","article-title":"Platelet-rich plasma enhances autograft revascularization and reinnervation in a dog model of anterior cruciate ligament reconstruction","volume":"183","author":"X Xiaoxing","year":"2013","journal-title":"J Surg Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"285","DOI":"10.3415\/VCOT-12-06-0075","article-title":"Intra-articular injections of autologous platelet concentrates in dogs with surgical reparation of cranial cruciate ligament rupture: a pilot study","volume":"26","author":"RF Silva","year":"2013","journal-title":"Vet Comp Orthop Traumatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"1291","DOI":"10.2460\/javma.243.9.1291","article-title":"A randomized controlled trial of the efficacy of autologous platelet therapy for the treatment of osteoarthritis in dogs","volume":"243","author":"MA Fahie","year":"2013","journal-title":"J Am Vet Med Assoc"},{"key":"ref18","first-page":"5","article-title":"Intraarticular injections of platelet-rich plasma (PRP) in the management of knee osteoarthritis","volume":"1","author":"C Rodriguez-Merchan","year":"2013","journal-title":"Arch Bone Joint Surg"},{"key":"ref19","first-page":"857","article-title":"Force plate analysis: A noninvasive tool for gait evaluation","volume":"16","author":"MA Anderson","year":"1994","journal-title":"Compend Contin Educ Pract Vet"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"973","DOI":"10.1111\/j.1532-950X.2012.01042.x","article-title":"Pelvic limb kinetic and kinematic analysis in Labrador retrievers predisposed or at a low risk for cranial cruciate ligament disease","volume":"41","author":"CA Ragetly","year":"2012","journal-title":"Vet Surg"},{"issue":"Suppl 1","key":"ref21","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1080\/10255840701479230","article-title":"Dog limbs electrogoniometric study at walking gait","author":"A Colin","year":"2007","journal-title":"Comput Methods Biomech Biomed Engin"},{"key":"ref22","first-page":"562","article-title":"The Stifle Joint, handbook of Small Animal Orthopedics and Fracture Repair","author":"D L Piermattei","year":"2006"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1186\/s12917-014-0266-8","article-title":"Long-term functional outcome after surgical repair of cranial cruciate ligament disease in dogs","volume":"10","author":"SH M\u00f6ls\u00e4","year":"2014","journal-title":"BMC Vet Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"584","DOI":"10.1136\/vr.160.17.584","article-title":"Pelletier JP: Efficacy of licofelone in dogs with clinical osteoarthritis","volume":"160","author":"M Moreau","year":"2007","journal-title":"Vet Rec"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"966","DOI":"10.2460\/ajvr.1996.57.07.966","article-title":"Kinematic gait analysis in dogs with hip dysplasia","volume":"57","author":"RL Bennett","year":"1996","journal-title":"Am J Vet Res"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"120","DOI":"10.2460\/ajvr.1996.57.01.120","article-title":"Kinematic evaluation of gait in dogs with cranial cruciate ligament rupture","volume":"57","author":"CE DeCamp","year":"1996","journal-title":"Am J Vet Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"19623","DOI":"10.1038\/srep19623","article-title":"Autologous leukocyte-reduced platelet-rich plasma therapy for Achilles tendinopathy induced by collagenase in a rabbit model","volume":"6","author":"JC Gonz\u00e1lez","year":"2016","journal-title":"Sci Rep"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"205","DOI":"10.32098\/mltj.02.2016.07","article-title":"Efficacy of autologous leukocyte-reduced platelet-rich plasma therapy for patellar tendinopathy in a rat treadmill model","volume":"6","author":"M Yoshida","year":"2016","journal-title":"Muscles Ligaments Tendons J"},{"key":"ref29","first-page":"CD010071","article-title":"Platelet-rich therapies for musculoskeletal soft tissue injuries","volume":"4","author":"VY Moraes","year":"2014","journal-title":"Cochrane Database Syst Rev"},{"key":"ref30","first-page":"910","article-title":"Intra- articular injection of an autologous preparation rich in growth factors for the treatment of knee OA: a retrospective cohort study","volume":"26","author":"M S\u00e1nchez","year":"2008","journal-title":"Clin Exp Rheumatol"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"822","DOI":"10.2460\/ajvr.76.9.822","article-title":"Characteristics of canine platelet-rich plasma prepared with five commercially available systems","volume":"76","author":"SP Franklin","year":"2015","journal-title":"Am J Vet Res"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1002\/jor.23054","article-title":"Multiple injections of leukoreduced platelet rich plasma reduce pain and functional impairment in a canine model of ACL and meniscal deficiency","volume":"34","author":"JL Cook","year":"2016","journal-title":"Orthop Res"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"1295","DOI":"10.1007\/s00402-013-1782-x","article-title":"Platelet-rich plasma in patients with tibiofemoral cartilage degeneration","volume":"133","author":"R Hart","year":"2013","journal-title":"Arch Orthop Trauma Surg"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1007\/s00167-009-0940-8","article-title":"Platelet-rich plasma: intraarticular knee injections produced favorable results on degenerative cartilage lesions","volume":"18","author":"E Kon","year":"2010","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"528","DOI":"10.1007\/s00167-010-1238-6","article-title":"Platelet-rich plasma intra-articular knee injections for the treatment of degenerative cartilage lesions and osteoarthritis","volume":"19","author":"G Filardo","year":"2011","journal-title":"Knee Surg Sports Traumatol Arthrosc"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"384","DOI":"10.1111\/j.1532-950X.1995.tb01348.x","article-title":"Redistribution of vertical ground reaction force in dogs with experimentally induced chronic hindlimb lameness","volume":"24","author":"PF Rumph","year":"1995","journal-title":"Vet Surg"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0194752","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,2]],"date-time":"2024-07-02T01:02:45Z","timestamp":1719882165000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0194752"}},"subtitle":[],"editor":[{"given":"Dennis F.","family":"Lawler","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,3,19]]},"references-count":36,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2018,3,19]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0194752","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,3,19]]}}}