{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T03:37:52Z","timestamp":1790653072877,"version":"4.1.0"},"reference-count":83,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T00:00:00Z","timestamp":1522972800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1R01AI104944"],"award-info":[{"award-number":["1R01AI104944"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["1K22AI072072"],"award-info":[{"award-number":["1K22AI072072"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000060","name":"National Institute of Allergy and Infectious Diseases","doi-asserted-by":"publisher","award":["T32 AI 060519"],"award-info":[{"award-number":["T32 AI 060519"]}],"id":[{"id":"10.13039\/100000060","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0195165","type":"journal-article","created":{"date-parts":[[2018,4,6]],"date-time":"2018-04-06T17:32:13Z","timestamp":1523035933000},"page":"e0195165","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Toll-like receptor 3 (TLR3) promotes the resolution of Chlamydia muridarum genital tract infection in congenic C57BL\/6N mice"],"prefix":"10.1371","volume":"13","author":[{"given":"Sebastian E.","family":"Carrasco","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sishun","family":"Hu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denise M.","family":"Imai","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramesh","family":"Kumar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"George E.","family":"Sandusky","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"X. Frank","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-6261","authenticated-orcid":true,"given":"Wilbert A.","family":"Derbigny","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,4,6]]},"reference":[{"key":"ref1","first-page":"20","article-title":"Global incidence and prevalence of selected curable sexually transmitted infections\u20132008","year":"2012"},{"issue":"2","key":"ref2","doi-asserted-by":"crossref","first-page":"149","DOI":"10.1038\/nri1551","article-title":"Immunology of Chlamydia infection: implications for a Chlamydia trachomatis vaccine","volume":"5","author":"RC Brunham","year":"2005","journal-title":"Nature reviews Immunology"},{"issue":"9","key":"ref3","doi-asserted-by":"crossref","first-page":"2664","DOI":"10.4161\/hv.29683","article-title":"Immunity, immunopathology, and human vaccine development against sexually transmitted Chlamydia trachomatis","volume":"10","author":"J Rey-Ladino","year":"2014","journal-title":"Hum Vaccin Immunother"},{"issue":"6","key":"ref4","doi-asserted-by":"crossref","first-page":"2741","DOI":"10.1128\/IAI.70.6.2741-2751.2002","article-title":"Immunity to murine chlamydial genital infection","volume":"70","author":"RP Morrison","year":"2002","journal-title":"Infection and immunity"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"4661","DOI":"10.1128\/IAI.63.12.4661-4668.1995","article-title":"Gene knockout mice establish a primary protective role for major histocompatibility complex class II-restricted responses in Chlamydia trachomatis genital tract infection","volume":"63","author":"RP Morrison","year":"1995","journal-title":"Infection and immunity"},{"issue":"3","key":"ref6","doi-asserted-by":"crossref","first-page":"221","DOI":"10.1111\/2049-632X.12032","article-title":"OT-1 mice display minimal upper genital tract pathology following primary intravaginal Chlamydia muridarum infection","volume":"67","author":"S Manam","year":"2013","journal-title":"Pathogens and disease"},{"issue":"7","key":"ref7","doi-asserted-by":"crossref","first-page":"2928","DOI":"10.1128\/IAI.05022-11","article-title":"Tumor necrosis factor alpha production from CD8+ T cells mediates oviduct pathological sequelae following primary genital Chlamydia muridarum infection","volume":"79","author":"AK Murthy","year":"2011","journal-title":"Infection and immunity"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"534","DOI":"10.3389\/fimmu.2014.00534","article-title":"The Role of the Immune Response in Chlamydia trachomatis Infection of the Male Genital Tract: A Double-Edged Sword","volume":"5","author":"KA Redgrove","year":"2014","journal-title":"Front Immunol"},{"issue":"9","key":"ref9","doi-asserted-by":"crossref","first-page":"3060","DOI":"10.1128\/IAI.00357-13","article-title":"Animal models for studying female genital tract infection with Chlamydia trachomatis","volume":"81","author":"E De Clercq","year":"2013","journal-title":"Infection and immunity"},{"issue":"5","key":"ref10","doi-asserted-by":"crossref","first-page":"2870","DOI":"10.1128\/IAI.68.5.2870-2879.2000","article-title":"In situ analysis of the evolution of the primary immune response in murine Chlamydia trachomatis genital tract infection","volume":"68","author":"SG Morrison","year":"2000","journal-title":"Infection and immunity"},{"issue":"5","key":"ref11","doi-asserted-by":"crossref","first-page":"2094","DOI":"10.1128\/IAI.62.5.2094-2097.1994","article-title":"Intravaginal inoculation of mice with the Chlamydia trachomatis mouse pneumonitis biovar results in infertility","volume":"62","author":"LM de la Maza","year":"1994","journal-title":"Infection and immunity"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"49","DOI":"10.1097\/01.olq.0000148299.14513.11","article-title":"Histopathologic changes related to fibrotic oviduct occlusion after genital tract infection of mice with Chlamydia muridarum","volume":"32","author":"AA Shah","year":"2005","journal-title":"Sex Transm Dis"},{"issue":"6","key":"ref13","doi-asserted-by":"crossref","first-page":"385","DOI":"10.1038\/nrmicro.2016.30","article-title":"Chlamydia cell biology and pathogenesis","volume":"14","author":"C Elwell","year":"2016","journal-title":"Nat Rev Microbiol"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"77","DOI":"10.1172\/JCI119136","article-title":"Secretion of proinflammatory cytokines by epithelial cells in response to Chlamydia infection suggests a central role for epithelial cells in chlamydial pathogenesis","volume":"99","author":"SJ Rasmussen","year":"1997","journal-title":"The Journal of clinical investigation"},{"issue":"6","key":"ref15","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1016\/S1286-4579(03)00063-7","article-title":"The Gram-negative bacterium Chlamydia trachomatis L2 stimulates tumor necrosis factor secretion by innate immune cells independently of its endotoxin","volume":"5","author":"S Prebeck","year":"2003","journal-title":"Microbes Infect"},{"issue":"3","key":"ref16","doi-asserted-by":"crossref","first-page":"1435","DOI":"10.4049\/jimmunol.168.3.1435","article-title":"Chlamydial heat shock protein 60 activates macrophages and endothelial cells through Toll-like receptor 4 and MD2 in a MyD88-dependent pathway","volume":"168","author":"Y Bulut","year":"2002","journal-title":"J Immunol"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1172\/JCI5310","article-title":"Chlamydial and human heat shock protein 60s activate human vascular endothelium, smooth muscle cells, and macrophages","volume":"103","author":"A Kol","year":"1999","journal-title":"The Journal of clinical investigation"},{"issue":"11","key":"ref18","doi-asserted-by":"crossref","first-page":"6187","DOI":"10.4049\/jimmunol.171.11.6187","article-title":"Toll-like receptor-2, but not Toll-like receptor-4, is essential for development of oviduct pathology in chlamydial genital tract infection","volume":"171","author":"T Darville","year":"2003","journal-title":"J Immunol"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1074\/jbc.M510182200","article-title":"Localization of TLR2 and MyD88 to Chlamydia trachomatis inclusions. Evidence for signaling by intracellular TLR2 during infection with an obligate intracellular pathogen","volume":"281","author":"CM O\u2019Connell","year":"2006","journal-title":"The Journal of biological chemistry"},{"issue":"39","key":"ref20","doi-asserted-by":"crossref","first-page":"26789","DOI":"10.1074\/jbc.M109.026823","article-title":"Inflammasome-dependent caspase-1 activation in cervical epithelial cells stimulates growth of the intracellular pathogen Chlamydia trachomatis","volume":"284","author":"AA Abdul-Sater","year":"2009","journal-title":"The Journal of biological chemistry"},{"issue":"6","key":"ref21","doi-asserted-by":"crossref","first-page":"1047","DOI":"10.1111\/j.1462-5822.2006.00686.x","article-title":"Stimulation of the cytosolic receptor for peptidoglycan, Nod1, by infection with Chlamydia trachomatis or Chlamydia muridarum","volume":"8","author":"L Welter-Stahl","year":"2006","journal-title":"Cell Microbiol"},{"issue":"6857","key":"ref22","doi-asserted-by":"crossref","first-page":"732","DOI":"10.1038\/35099560","article-title":"Recognition of double-stranded RNA and activation of NF-kappaB by Toll-like receptor 3","volume":"413","author":"L Alexopoulou","year":"2001","journal-title":"Nature"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"1364","DOI":"10.1016\/S0006-291X(02)00380-7","article-title":"Establishment of a monoclonal antibody against human Toll-like receptor 3 that blocks double-stranded RNA-mediated signaling","volume":"293","author":"M Matsumoto","year":"2002","journal-title":"Biochemical and biophysical research communications"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1111\/imm.12143","article-title":"Toll-like receptor 3 in viral pathogenesis: friend or foe?","volume":"140","author":"R Perales-Linares","year":"2013","journal-title":"Immunology"},{"issue":"11","key":"ref25","doi-asserted-by":"crossref","first-page":"6689","DOI":"10.4049\/jimmunol.1001548","article-title":"The Chlamydia muridarum-induced IFN-beta response is TLR3-dependent in murine oviduct epithelial cells","volume":"185","author":"WA Derbigny","year":"2010","journal-title":"J Immunol"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1128\/IAI.05549-11","article-title":"Identifying a role for Toll-like receptor 3 in the innate immune response to Chlamydia muridarum infection in murine oviduct epithelial cells","volume":"80","author":"WA Derbigny","year":"2012","journal-title":"Infection and immunity"},{"issue":"7","key":"ref27","doi-asserted-by":"crossref","first-page":"3951","DOI":"10.1128\/IAI.72.7.3951-3960.2004","article-title":"Murine oviduct epithelial cell cytokine responses to Chlamydia muridarum infection include interleukin-12-p70 secretion","volume":"72","author":"RM Johnson","year":"2004","journal-title":"Infection and immunity"},{"key":"ref28","article-title":"Chlamydiae (Psittacosis-lymphogranuloma venereum-trachoma group)","author":"J Schachter","year":"1980"},{"issue":"3","key":"ref29","doi-asserted-by":"crossref","first-page":"1161","DOI":"10.1128\/IAI.31.3.1161-1176.1981","article-title":"Purification and partial characterization of the major outer membrane protein of Chlamydia trachomatis","volume":"31","author":"HD Caldwell","year":"1981","journal-title":"Infection and immunity"},{"issue":"12","key":"ref30","doi-asserted-by":"crossref","first-page":"4976","DOI":"10.1128\/IAI.64.12.4976-4983.1996","article-title":"Initial route of antigen administration alters the T-cell cytokine profile produced in response to the mouse pneumonitis biovar of Chlamydia trachomatis following genital infection","volume":"64","author":"KA Kelly","year":"1996","journal-title":"Infection and immunity"},{"issue":"5","key":"ref31","doi-asserted-by":"crossref","first-page":"2551","DOI":"10.4049\/jimmunol.0903704","article-title":"Stimulator of IFN gene is critical for induction of IFN-beta during Chlamydia muridarum infection","volume":"184","author":"D Prantner","year":"2010","journal-title":"J Immunol"},{"key":"ref32","first-page":"e4391","article-title":"Isolation of lymphocytes from mouse genital tract mucosa","volume":"67","author":"J Jiang","year":"2012","journal-title":"J Vis Exp"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"3065","DOI":"10.1128\/IAI.65.8.3065-3073.1997","article-title":"Mouse strain-dependent variation in the course and outcome of chlamydial genital tract infection is associated with differences in host response","volume":"65","author":"T Darville","year":"1997","journal-title":"Infection and immunity"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"e0124840","DOI":"10.1371\/journal.pone.0124840","article-title":"Plasmid-Encoded Pgp5 Is a Significant Contributor to Chlamydia muridarum Induction of Hydrosalpinx","volume":"10","author":"Y Huang","year":"2015","journal-title":"PLoS One"},{"issue":"6","key":"ref35","doi-asserted-by":"crossref","first-page":"883","DOI":"10.1177\/0192623315587593","article-title":"Introduction of Zinc-salt Fixation for Effective Detection of Immune Cell-related Markers by Immunohistochemistry","volume":"43","author":"H Mori","year":"2015","journal-title":"Toxicologic pathology"},{"issue":"2","key":"ref36","doi-asserted-by":"crossref","first-page":"184","DOI":"10.1177\/1040638715625729","article-title":"Chlamydia pecorum: fetal and placental lesions in sporadic caprine abortion","volume":"28","author":"F Giannitti","year":"2016","journal-title":"J Vet Diagn Invest"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","first-page":"4427","DOI":"10.1128\/IAI.60.10.4427-4429.1992","article-title":"Effect of gamma interferon on resolution of murine chlamydial genital infection","volume":"60","author":"RG Rank","year":"1992","journal-title":"Infection and immunity"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"847","DOI":"10.1128\/IAI.48.3.847-849.1985","article-title":"Chronic chlamydial genital infection in congenitally athymic nude mice","volume":"48","author":"RG Rank","year":"1985","journal-title":"Infection and immunity"},{"issue":"9","key":"ref39","doi-asserted-by":"crossref","first-page":"3302","DOI":"10.1128\/IAI.63.9.3302-3308.1995","article-title":"CD4+ T cells play a significant role in adoptive immunity to Chlamydia trachomatis infection of the mouse genital tract","volume":"63","author":"H Su","year":"1995","journal-title":"Infection and immunity"},{"issue":"2","key":"ref40","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1111\/imm.12248","article-title":"An atypical CD8 T-cell response to Chlamydia muridarum genital tract infections includes T cells that produce interleukin-13","volume":"142","author":"RM Johnson","year":"2014","journal-title":"Immunology"},{"issue":"2","key":"ref41","doi-asserted-by":"crossref","first-page":"208","DOI":"10.1038\/icb.2015.74","article-title":"The contribution of Chlamydia-specific CD8(+) T cells to upper genital tract pathology","volume":"94","author":"KR Vlcek","year":"2016","journal-title":"Immunol Cell Biol"},{"issue":"11","key":"ref42","doi-asserted-by":"crossref","first-page":"3546","DOI":"10.1172\/JCI36130","article-title":"The cytokine network in asthma and chronic obstructive pulmonary disease","volume":"118","author":"PJ Barnes","year":"2008","journal-title":"The Journal of clinical investigation"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1196\/annals.1358.026","article-title":"Pathogenic T-cell recruitment into the airway in human disease","volume":"1062","author":"BD Medoff","year":"2005","journal-title":"Annals of the New York Academy of Sciences"},{"issue":"4","key":"ref44","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1038\/icb.2009.3","article-title":"Effects of inoculating dose on the kinetics of Chlamydia muridarum genital infection in female mice","volume":"87","author":"AJ Carey","year":"2009","journal-title":"Immunol Cell Biol"},{"issue":"5","key":"ref45","doi-asserted-by":"crossref","first-page":"2602","DOI":"10.4049\/jimmunol.0901593","article-title":"Mice deficient in MyD88 Develop a Th2-dominant response and severe pathology in the upper genital tract following Chlamydia muridarum infection","volume":"184","author":"L Chen","year":"2010","journal-title":"J Immunol"},{"issue":"1","key":"ref46","doi-asserted-by":"crossref","first-page":"450","DOI":"10.4049\/jimmunol.175.1.450","article-title":"Chlamydia trachomatis induces expression of IFN-gamma-inducible protein 10 and IFN-beta independent of TLR2 and TLR4, but largely dependent on MyD88","volume":"175","author":"UM Nagarajan","year":"2005","journal-title":"J Immunol"},{"issue":"1","key":"ref47","doi-asserted-by":"crossref","first-page":"486","DOI":"10.1128\/IAI.00843-10","article-title":"MyD88 deficiency leads to decreased NK cell gamma interferon production and T cell recruitment during Chlamydia muridarum genital tract infection, but a predominant Th1 response and enhanced monocytic inflammation are associated with infection resolution","volume":"79","author":"UM Nagarajan","year":"2011","journal-title":"Infection and immunity"},{"issue":"1","key":"ref48","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1046\/j.1365-2567.1996.d01-655.x","article-title":"Molecular mechanism of T-cell control of Chlamydia in mice: role of nitric oxide in vivo","volume":"88","author":"JU Igietseme","year":"1996","journal-title":"Immunology"},{"issue":"5","key":"ref49","doi-asserted-by":"crossref","first-page":"656","DOI":"10.1002\/jlb.59.5.656","article-title":"Integrin-mediated epithelial-T cell interaction enhances nitric oxide production and increased intracellular inhibition of Chlamydia","volume":"59","author":"JU Igietseme","year":"1996","journal-title":"J Leukoc Biol"},{"issue":"4","key":"ref50","doi-asserted-by":"crossref","first-page":"1896","DOI":"10.4049\/jimmunol.1102764","article-title":"Plac8-dependent and inducible NO synthase-dependent mechanisms clear Chlamydia muridarum infections from the genital tract","volume":"188","author":"RM Johnson","year":"2012","journal-title":"J Immunol"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"e63340","DOI":"10.1371\/journal.pone.0063340","article-title":"Perforin is detrimental to controlling [corrected] C. muridarum replication in vitro, but not in vivo","volume":"8","author":"RM Johnson","year":"2013","journal-title":"PLoS One"},{"issue":"10","key":"ref52","doi-asserted-by":"crossref","first-page":"e46949","DOI":"10.1371\/journal.pone.0046949","article-title":"Actin recruitment to the Chlamydia inclusion is spatiotemporally regulated by a mechanism that requires host and bacterial factors","volume":"7","author":"E Chin","year":"2012","journal-title":"PLoS One"},{"issue":"8","key":"ref53","doi-asserted-by":"crossref","first-page":"e0160511","DOI":"10.1371\/journal.pone.0160511","article-title":"Host Nectin-1 Promotes Chlamydial Infection in the Female Mouse Genital Tract, but Is Not Required for Infection in a Novel Male Murine Rectal Infection Model","volume":"11","author":"JA Slade","year":"2016","journal-title":"PLoS One"},{"issue":"6","key":"ref54","doi-asserted-by":"crossref","first-page":"e01648","DOI":"10.1128\/mBio.01648-15","article-title":"Chlamydial Lytic Exit from Host Cells Is Plasmid Regulated","volume":"6","author":"C Yang","year":"2015","journal-title":"MBio"},{"issue":"6","key":"ref55","doi-asserted-by":"crossref","first-page":"3556","DOI":"10.1128\/IAI.69.6.3556-3561.2001","article-title":"Early local cytokine profiles in strains of mice with different outcomes from chlamydial genital tract infection","volume":"69","author":"T Darville","year":"2001","journal-title":"Infection and immunity"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"108","DOI":"10.1111\/j.1574-695X.2010.00668.x","article-title":"A link between neutrophils and chronic disease manifestations of Chlamydia muridarum urogenital infection of mice","volume":"59","author":"HY Lee","year":"2010","journal-title":"FEMS Immunol Med Microbiol"},{"issue":"12","key":"ref57","doi-asserted-by":"crossref","first-page":"5334","DOI":"10.1128\/IAI.00883-09","article-title":"Critical role for interleukin-1beta (IL-1beta) during Chlamydia muridarum genital infection and bacterial replication-independent secretion of IL-1beta in mouse macrophages","volume":"77","author":"D Prantner","year":"2009","journal-title":"Infection and immunity"},{"issue":"9","key":"ref58","doi-asserted-by":"crossref","first-page":"5299","DOI":"10.1128\/IAI.68.9.5299-5305.2000","article-title":"Does inhibition of tumor necrosis factor alpha affect chlamydial genital tract infection in mice and guinea pigs?","volume":"68","author":"T Darville","year":"2000","journal-title":"Infection and immunity"},{"issue":"6","key":"ref59","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1128\/IAI.65.6.2145-2152.1997","article-title":"Dissemination of Chlamydia trachomatis chronic genital tract infection in gamma interferon gene knockout mice","volume":"65","author":"TW Cotter","year":"1997","journal-title":"Infection and immunity"},{"issue":"10","key":"ref60","doi-asserted-by":"crossref","first-page":"5518","DOI":"10.1128\/IAI.67.10.5518-5521.1999","article-title":"Role of gamma interferon in controlling murine chlamydial genital tract infection","volume":"67","author":"JI Ito","year":"1999","journal-title":"Infection and immunity"},{"issue":"6","key":"ref61","first-page":"317","article-title":"Resolution of murine chlamydial genital infection by the adoptive transfer of a biovar-specific, Th1 lymphocyte clone","volume":"5","author":"JU Igietseme","year":"1993","journal-title":"Reg Immunol"},{"issue":"7","key":"ref62","doi-asserted-by":"crossref","first-page":"3344","DOI":"10.4049\/jimmunol.158.7.3344","article-title":"Immunity to Chlamydia trachomatis is mediated by T helper 1 cells through IFN-gamma-dependent and -independent pathways","volume":"158","author":"LL Perry","year":"1997","journal-title":"J Immunol"},{"issue":"5424","key":"ref63","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1126\/science.285.5424.107","article-title":"Inhibition of the interferon-inducible protein kinase PKR by HCV E2 protein","volume":"285","author":"DR Taylor","year":"1999","journal-title":"Science"},{"key":"ref64","first-page":"39","article-title":"The role of IL-10 in regulating immunity to persistent viral infections","volume":"350","author":"EB Wilson","year":"2011","journal-title":"Curr Top Microbiol Immunol"},{"issue":"4","key":"ref65","doi-asserted-by":"crossref","first-page":"374","DOI":"10.1016\/j.chom.2008.08.016","article-title":"Persistent virus infection inhibits type I interferon production by plasmacytoid dendritic cells to facilitate opportunistic infections","volume":"4","author":"EI Zuniga","year":"2008","journal-title":"Cell host & microbe"},{"issue":"3","key":"ref66","doi-asserted-by":"crossref","first-page":"818","DOI":"10.1007\/s10753-013-9801-1","article-title":"Significant roles played by IL-10 in Chlamydia infections","volume":"37","author":"H Hakimi","year":"2014","journal-title":"Inflammation"},{"issue":"11","key":"ref67","doi-asserted-by":"crossref","first-page":"e1001179","DOI":"10.1371\/journal.ppat.1001179","article-title":"The female lower genital tract is a privileged compartment with IL-10 producing dendritic cells and poor Th1 immunity following Chlamydia trachomatis infection","volume":"6","author":"E Marks","year":"2010","journal-title":"PLoS Pathog"},{"issue":"11","key":"ref68","doi-asserted-by":"crossref","first-page":"901","DOI":"10.1089\/jir.2015.0013","article-title":"Role of STAT1 in Chlamydia-Induced Type-1 Interferon Production in Oviduct Epithelial Cells","volume":"35","author":"KL Hosey","year":"2015","journal-title":"J Interferon Cytokine Res"},{"issue":"Suppl 2","key":"ref69","doi-asserted-by":"crossref","first-page":"S114","DOI":"10.1086\/652397","article-title":"Pathogenesis of genital tract disease due to Chlamydia trachomatis","volume":"201","author":"T Darville","year":"2010","journal-title":"J Infect Dis"},{"issue":"10","key":"ref70","doi-asserted-by":"crossref","first-page":"3922","DOI":"10.1128\/IAI.00140-11","article-title":"Interferon regulatory transcription factor 3 protects mice from uterine horn pathology during Chlamydia muridarum genital infection","volume":"79","author":"D Prantner","year":"2011","journal-title":"Infection and immunity"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1186\/1471-2172-14-50","article-title":"The IL-6 response to Chlamydia from primary reproductive epithelial cells is highly variable and may be involved in differential susceptibility to the immunopathological consequences of chlamydial infection","volume":"14","author":"K Cunningham","year":"2013","journal-title":"BMC immunology"},{"issue":"11","key":"ref72","doi-asserted-by":"crossref","first-page":"536","DOI":"10.1016\/j.micinf.2017.08.007","article-title":"IL-6-mediated signaling pathways limit Chlamydia muridarum infection and exacerbate its pathogenicity in the mouse genital tract","volume":"19","author":"X Sun","year":"2017","journal-title":"Microbes Infect"},{"issue":"9","key":"ref73","doi-asserted-by":"crossref","first-page":"6065","DOI":"10.4049\/jimmunol.175.9.6065","article-title":"Pattern recognition molecules activated by Chlamydia muridarum infection of cloned murine oviduct epithelial cell lines","volume":"175","author":"WA Derbigny","year":"2005","journal-title":"J Immunol"},{"issue":"12","key":"ref74","doi-asserted-by":"crossref","first-page":"7419","DOI":"10.1128\/IAI.69.12.7419-7424.2001","article-title":"Mouse strain-dependent chemokine regulation of the genital tract T helper cell type 1 immune response","volume":"69","author":"T Darville","year":"2001","journal-title":"Infection and immunity"},{"issue":"12","key":"ref75","doi-asserted-by":"crossref","first-page":"5198","DOI":"10.1128\/IAI.65.12.5198-5208.1997","article-title":"Identification of homing receptors that mediate the recruitment of CD4 T cells to the genital tract following intravaginal infection with Chlamydia trachomatis","volume":"65","author":"KA Kelly","year":"1997","journal-title":"Infection and immunity"},{"issue":"4","key":"ref76","doi-asserted-by":"crossref","first-page":"868","DOI":"10.1128\/IAI.01378-15","article-title":"Tissue-Resident T Cells as the Central Paradigm of Chlamydia Immunity","volume":"84","author":"RM Johnson","year":"2016","journal-title":"Infection and immunity"},{"issue":"12","key":"ref77","doi-asserted-by":"crossref","first-page":"6979","DOI":"10.1128\/IAI.68.12.6979-6987.2000","article-title":"Immunity to murine Chlamydia trachomatis genital tract reinfection involves B cells and CD4(+) T cells but not CD8(+) T cells","volume":"68","author":"SG Morrison","year":"2000","journal-title":"Infection and immunity"},{"issue":"8","key":"ref78","doi-asserted-by":"crossref","first-page":"e71649","DOI":"10.1371\/journal.pone.0071649","article-title":"Oviduct infection and hydrosalpinx in DBA1\/j mice is induced by intracervical but not intravaginal inoculation with Chlamydia muridarum","volume":"8","author":"L Tang","year":"2013","journal-title":"PLoS One"},{"issue":"4","key":"ref79","doi-asserted-by":"crossref","first-page":"e95076","DOI":"10.1371\/journal.pone.0095076","article-title":"Chlamydial induction of hydrosalpinx in 11 strains of mice reveals multiple host mechanisms for preventing upper genital tract pathology","volume":"9","author":"J Chen","year":"2014","journal-title":"PLoS One"},{"issue":"12","key":"ref80","doi-asserted-by":"crossref","first-page":"6929","DOI":"10.4049\/jimmunol.0902419","article-title":"The microtubule regulator stathmin is an endogenous protein agonist for TLR3","volume":"184","author":"M Bsibsi","year":"2010","journal-title":"J Immunol"},{"issue":"9","key":"ref81","doi-asserted-by":"crossref","first-page":"R80","DOI":"10.1186\/gb-2006-7-9-r80","article-title":"The human urinary proteome contains more than 1500 proteins, including a large proportion of membrane proteins","volume":"7","author":"J Adachi","year":"2006","journal-title":"Genome biology"},{"issue":"9","key":"ref82","doi-asserted-by":"crossref","first-page":"806","DOI":"10.1111\/j.1469-0691.2009.02960.x","article-title":"Helicobacter pylori and gastric cancer: possible role of microRNAs in this intimate relationship","volume":"15","author":"C Belair","year":"2009","journal-title":"Clinical microbiology and infection: the official publication of the European Society of Clinical Microbiology and Infectious Diseases"},{"issue":"18","key":"ref83","doi-asserted-by":"crossref","first-page":"2679","DOI":"10.1016\/j.febslet.2008.06.053","article-title":"Endogenous small RNAs and antibacterial immunity in plants","volume":"582","author":"H Jin","year":"2008","journal-title":"FEBS letters"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0195165","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,9,1]],"date-time":"2023-09-01T23:32:41Z","timestamp":1693611161000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0195165"}},"subtitle":[],"editor":[{"given":"David M.","family":"Ojcius","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,6]]},"references-count":83,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0195165","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,6]]}}}