{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,12]],"date-time":"2026-05-12T21:52:35Z","timestamp":1778622755911,"version":"3.51.4"},"reference-count":28,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T00:00:00Z","timestamp":1522886400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0195680","type":"journal-article","created":{"date-parts":[[2018,4,5]],"date-time":"2018-04-05T22:01:40Z","timestamp":1522965700000},"page":"e0195680","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":40,"title":["Hypocomplementemia is associated with worse renal survival in ANCA-positive granulomatosis with polyangiitis and microscopic polyangiitis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8887-3233","authenticated-orcid":true,"given":"Samuel","family":"Deshayes","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Achille","family":"Aouba","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathy","family":"Khoy","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Delphine","family":"Mariotte","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thierry","family":"Lobbedez","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolas","family":"Martin Silva","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,4,5]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","unstructured":"Jennette JC, Falk RJ, Bacon PA, Basu N, Cid MC, Ferrario F, et al. 2012 revised International Chapel Hill Consensus Conference Nomenclature of Vasculitides. Arthritis Rheum. 2013;65: 1\u201311. <comment>doi: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"https:\/\/doi.org\/10.1002\/art.37715\" xlink:type=\"simple\">10.1002\/art.37715<\/ext-link><\/comment>","DOI":"10.1002\/art.37715"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"359","DOI":"10.1038\/nrneph.2017.37","article-title":"Complement in ANCA-associated vasculitis: mechanisms and implications for management","volume":"13","author":"M Chen","year":"2017","journal-title":"Nat Rev Nephrol"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"52","DOI":"10.2353\/ajpath.2007.060573","article-title":"Alternative complement pathway in the pathogenesis of disease mediated by anti-neutrophil cytoplasmic autoantibodies","volume":"170","author":"H Xiao","year":"2007","journal-title":"Am J Pathol"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1681\/ASN.2008050497","article-title":"C5a receptor mediates neutrophil activation and ANCA-induced glomerulonephritis","volume":"20","author":"A Schreiber","year":"2009","journal-title":"J Am Soc Nephrol"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"e38317","DOI":"10.1371\/journal.pone.0038317","article-title":"p38MAPK, ERK and PI3K signaling pathways are involved in C5a-primed neutrophils for ANCA-mediated activation","volume":"7","author":"J Hao","year":"2012","journal-title":"PloS One"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"R140","DOI":"10.1186\/ar3873","article-title":"C5a and its receptors in human anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis","volume":"14","author":"J Yuan","year":"2012","journal-title":"Arthritis Res Ther"},{"key":"ref7","article-title":"Necroptosis controls NET generation and mediates complement activation, endothelial damage, and autoimmune vasculitis","author":"A Schreiber","year":"2017","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1038\/sj.ki.5002103","article-title":"Inhibition of complement factor C5 protects against anti-myeloperoxidase antibody-mediated glomerulonephritis in mice","volume":"71","author":"D Huugen","year":"2007","journal-title":"Kidney Int"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1681\/ASN.2013020143","article-title":"C5a receptor (CD88) blockade protects against MPO-ANCA GN","volume":"25","author":"H Xiao","year":"2014","journal-title":"J Am Soc Nephrol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"e4871","DOI":"10.1097\/MD.0000000000004871","article-title":"Antineutrophilic cytoplasmic antibody-associated vasculitis with hypocomplementemia has a higher incidence of serious organ damage and a poor prognosis","volume":"95","author":"S Fukui","year":"2016","journal-title":"Medicine (Baltimore)"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2145","DOI":"10.1111\/j.1523-1755.2004.00632.x","article-title":"Immune complex deposits in ANCA-associated crescentic glomerulonephritis: a study of 126 cases","volume":"65","author":"M Haas","year":"2004","journal-title":"Kidney Int"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"74","DOI":"10.1111\/j.1440-1797.2006.00713.x","article-title":"Clinical and pathological characteristics and outcomes of Chinese patients with primary anti-neutrophil cytoplasmic antibodies-associated systemic vasculitis with immune complex deposition in kidney","volume":"12","author":"F Yu","year":"2007","journal-title":"Nephrology"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1038\/ki.2012.313","article-title":"Circulating complement activation in patients with anti-neutrophil cytoplasmic antibody\u2013associated vasculitis","volume":"83","author":"S-J Gou","year":"2013","journal-title":"Kidney Int"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"1884","DOI":"10.2215\/CJN.02790313","article-title":"Alternative Complement Pathway Activation Products in Urine and Kidneys of Patients with ANCA-Associated GN","volume":"8","author":"S-J Gou","year":"2013","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"129","DOI":"10.1186\/s13075-015-0656-8","article-title":"Plasma complement factor H is associated with disease activity of patients with ANCA-associated vasculitis","volume":"17","author":"S-F Chen","year":"2015","journal-title":"Arthritis Res Ther"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"41","DOI":"10.1016\/j.clim.2016.11.013","article-title":"The functional activities of complement factor H are impaired in patients with ANCA-positive vasculitis","volume":"175","author":"S-F Chen","year":"2017","journal-title":"Clin Immunol"},{"key":"ref17","article-title":"Complement regulatory proteins in kidneys of patients with anti-neutrophil cytoplasmic antibody (ANCA)-associated vasculitis","author":"L Cheng","year":"2017","journal-title":"Clin Exp Immunol"},{"key":"ref18","article-title":"Complement blockade in ANCA-associated vasculitis: an index case, current concepts and future perspectives","author":"L Manenti","year":"2017","journal-title":"Intern Emerg Med"},{"key":"ref19","article-title":"Randomized Trial of C5a Receptor Inhibitor Avacopan in ANCA-Associated Vasculitis","author":"DRW Jayne","year":"2017","journal-title":"J Am Soc Nephrol"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e0158871","DOI":"10.1371\/journal.pone.0158871","article-title":"Low Serum Complement C3 Levels at Diagnosis of Renal ANCA-Associated Vasculitis Is Associated with Poor Prognosis","volume":"11","author":"J-F Augusto","year":"2016","journal-title":"PLoS ONE"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"67","DOI":"10.1159\/000357154","article-title":"Association of Low Serum Complement C3 with Reduced Patient and Renal Survival in Antimyeloperoxidase-Associated Small-Vessel Vasculitis","volume":"126","author":"Y Molad","year":"2014","journal-title":"Nephron Clin Pract"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"2143","DOI":"10.2215\/CJN.00120115","article-title":"Association of Serum C3 Concentration and Histologic Signs of Thrombotic Microangiopathy with Outcomes among Patients with ANCA-Associated Renal Vasculitis","volume":"10","author":"L Manenti","year":"2015","journal-title":"Clin J Am Soc Nephrol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2733","DOI":"10.1007\/s10067-016-3384-9","article-title":"Circulating C3 levels predict renal and global outcome in patients with renal vasculitis","volume":"35","author":"J Villacorta","year":"2016","journal-title":"Clin Rheumatol"},{"key":"ref24","article-title":"Serum C3 complement levels in ANCA associated vasculitis at diagnosis is a predictor of patient and renal outcome","author":"M Crnogorac","year":"2017","journal-title":"J Nephrol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1136\/ard.2006.054593","article-title":"Development and validation of a consensus methodology for the classification of the ANCA-associated vasculitides and polyarteritis nodosa for epidemiological studies","volume":"66","author":"R Watts","year":"2007","journal-title":"Ann Rheum Dis"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"450","DOI":"10.1016\/S0197-2456(02)00209-X","article-title":"Design of the Wegener\u2019s Granulomatosis Etanercept Trial (WGET)","volume":"23","year":"2002","journal-title":"Control Clin Trials"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"1827","DOI":"10.1136\/ard.2008.101279","article-title":"Modification and validation of the Birmingham Vasculitis Activity Score (version 3)","volume":"68","author":"C Mukhtyar","year":"2009","journal-title":"Ann Rheum Dis"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"2299","DOI":"10.1002\/art.11075","article-title":"Wegener\u2019s Granulomatosis Etanercept Trial Research Group. Limited versus severe Wegener\u2019s granulomatosis: baseline data on patients in the Wegener\u2019s granulomatosis etanercept trial","volume":"48","author":"JH Stone","year":"2003","journal-title":"Arthritis Rheum"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0195680","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,23]],"date-time":"2018-10-23T07:26:56Z","timestamp":1540279616000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0195680"}},"subtitle":[],"editor":[{"given":"Masataka","family":"Kuwana","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,5]]},"references-count":28,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,5]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0195680","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,5]]}}}