{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T17:09:32Z","timestamp":1790788172312,"version":"4.1.0"},"reference-count":24,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T00:00:00Z","timestamp":1525824000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG032438"],"award-info":[{"award-number":["AG032438"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/100000049","name":"National Institute on Aging","doi-asserted-by":"publisher","award":["AG051348"],"award-info":[{"award-number":["AG051348"]}],"id":[{"id":"10.13039\/100000049","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0195838","type":"journal-article","created":{"date-parts":[[2018,5,9]],"date-time":"2018-05-09T13:36:19Z","timestamp":1525872979000},"page":"e0195838","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":68,"title":["White matter hyperintensities and the mediating role of cerebral amyloid angiopathy in dominantly-inherited Alzheimer\u2019s disease"],"prefix":"10.1371","volume":"13","author":[{"given":"Seonjoo","family":"Lee","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Molly E.","family":"Zimmerman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Atul","family":"Narkhede","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sara E.","family":"Nasrabady","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Tosto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene B.","family":"Meier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tammie L. S.","family":"Benzinger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel S.","family":"Marcus","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anne M.","family":"Fagan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nick C.","family":"Fox","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nigel J.","family":"Cairns","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David M.","family":"Holtzman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Virginia","family":"Buckles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernardino","family":"Ghetti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eric","family":"McDade","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ralph N.","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew J.","family":"Saykin","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Colin L.","family":"Masters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John M.","family":"Ringman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stefan","family":"F\u04e7rster","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter R.","family":"Schofield","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reisa A.","family":"Sperling","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Keith A.","family":"Johnson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jasmeer P.","family":"Chhatwal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Salloway","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Correia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Clifford R.","family":"Jack","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Weiner","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Randall J.","family":"Bateman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Morris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard","family":"Mayeux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5125-8226","authenticated-orcid":true,"given":"Adam M.","family":"Brickman","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"Dominantly Inherited Alzheimer Network","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,5,9]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"795","DOI":"10.1056\/NEJMoa1202753","article-title":"Clinical and biomarker changes in dominantly inherited Alzheimer&apos;s disease","volume":"367","author":"RJ Bateman","year":"2012","journal-title":"The New England journal of medicine"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1002\/ana.24647","article-title":"White matter hyperintensities are a core feature of Alzheimer&apos;s disease: Evidence from the dominantly inherited Alzheimer network","volume":"79","author":"S Lee","year":"2016","journal-title":"Ann Neurol"},{"issue":"8","key":"ref3","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1016\/S1474-4422(13)70124-8","article-title":"Neuroimaging standards for research into small vessel disease and its contribution to ageing and neurodegeneration","volume":"12","author":"JM Wardlaw","year":"2013","journal-title":"Lancet Neurol"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/j.neurobiolaging.2014.07.019","article-title":"Reconsidering harbingers of dementia: progression of parietal lobe white matter hyperintensities predicts Alzheimer&apos;s disease incidence","volume":"36","author":"AM Brickman","year":"2015","journal-title":"Neurobiol Aging"},{"issue":"3","key":"ref5","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1055\/s-0036-1581993","article-title":"Sporadic Cerebral Amyloid Angiopathy: Pathophysiology, Neuroimaging Features, and Clinical Implications","volume":"36","author":"G Boulouis","year":"2016","journal-title":"Semin Neurol"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1212\/WNL.0000000000000732","article-title":"Posterior white matter disease distribution as a predictor of amyloid angiopathy","volume":"83","author":"S Thanprasertsuk","year":"2014","journal-title":"Neurology"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1093\/brain\/awq321","article-title":"Brain microbleeds and Alzheimer\u2019s disease: innocent observation or key player?","volume":"134","author":"C Cordonnier","year":"2011","journal-title":"Brain"},{"issue":"Pt 1","key":"ref8","doi-asserted-by":"crossref","first-page":"e201","DOI":"10.1093\/brain\/awr126","article-title":"Cerebral microbleeds in familial Alzheimer&apos;s disease","volume":"135","author":"NS Ryan","year":"2012","journal-title":"Brain"},{"issue":"10","key":"ref9","doi-asserted-by":"crossref","first-page":"975","DOI":"10.4155\/cli.12.93","article-title":"Developing an international network for Alzheimer research: The Dominantly Inherited Alzheimer Network","volume":"2","author":"JC Morris","year":"2012","journal-title":"Clinical investigation"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"2412","DOI":"10.1212\/WNL.43.11.2412-a","article-title":"The Clinical Dementia Rating (CDR): current version and scoring rules","volume":"43","author":"JC Morris","year":"1993","journal-title":"Neurology"},{"issue":"5 Suppl","key":"ref11","doi-asserted-by":"crossref","first-page":"S116","DOI":"10.1016\/j.jalz.2012.10.011","article-title":"Focal hemosiderin deposits and beta-amyloid load in the ADNI cohort","volume":"9","author":"K Kantarci","year":"2013","journal-title":"Alzheimers Dement"},{"issue":"4","key":"ref12","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1037\/a0036434","article-title":"Interpretation and identification of causal mediation","volume":"19","author":"J Pearl","year":"2014","journal-title":"Psychol Methods"},{"issue":"4","key":"ref13","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1037\/a0020761","article-title":"A general approach to causal mediation analysis","volume":"15","author":"K Imai","year":"2010","journal-title":"Psychol Methods"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"457","DOI":"10.4310\/SII.2009.v2.n4.a7","article-title":"Conceptual issues concerning mediation, interventions and composition","volume":"2","author":"T VanderWeele","year":"2009","journal-title":"Statistics and its Interface"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1007\/s00401-009-0501-8","article-title":"Genetics and molecular pathogenesis of sporadic and hereditary cerebral amyloid angiopathies","volume":"118","author":"T Revesz","year":"2009","journal-title":"Acta Neuropathol"},{"issue":"2","key":"ref16","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1016\/S1474-4422(12)70291-0","article-title":"Tracking pathophysiological processes in Alzheimer&apos;s disease: an updated hypothetical model of dynamic biomarkers","volume":"12","author":"CR Jack Jr.","year":"2013","journal-title":"Lancet Neurol"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.jalz.2011.03.003","article-title":"Toward defining the preclinical stages of Alzheimer&apos;s disease: recommendations from the National Institute on Aging-Alzheimer&apos;s Association workgroups on diagnostic guidelines for Alzheimer&apos;s disease","volume":"7","author":"RA Sperling","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"270","DOI":"10.1016\/j.jalz.2011.03.008","article-title":"The diagnosis of mild cognitive impairment due to Alzheimer&apos;s disease: recommendations from the National Institute on Aging-Alzheimer&apos;s Association workgroups on diagnostic guidelines for Alzheimer&apos;s disease","volume":"7","author":"MS Albert","year":"2011","journal-title":"Alzheimers Dement"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"263","DOI":"10.1016\/j.jalz.2011.03.005","article-title":"The diagnosis of dementia due to Alzheimer&apos;s disease: recommendations from the National Institute on Aging-Alzheimer&apos;s Association workgroups on diagnostic guidelines for Alzheimer&apos;s disease","volume":"7","author":"GM McKhann","year":"2011","journal-title":"Alzheimers Dement"},{"key":"ref20","article-title":"Impact of multiple pathologies on the threshold for clinically overt dementia","author":"A Kapasi","year":"2017","journal-title":"Acta Neuropathol"},{"issue":"8","key":"ref21","doi-asserted-by":"crossref","first-page":"1275","DOI":"10.1016\/j.neurobiolaging.2010.04.007","article-title":"Amyloid imaging results from the Australian Imaging, Biomarkers and Lifestyle (AIBL) study of aging","volume":"31","author":"CC Rowe","year":"2010","journal-title":"Neurobiol Aging"},{"key":"ref22","first-page":"1","article-title":"White Matter Hyperintensities and Cerebral Amyloidosis: Necessary and Sufficient for Clinical Expression of Alzheimer Disease?","author":"FA Provenzano","year":"2013","journal-title":"JAMA Neurol"},{"issue":"12","key":"ref23","doi-asserted-by":"crossref","first-page":"3140","DOI":"10.1016\/j.neurobiolaging.2015.08.026","article-title":"Genetic determinants of white matter hyperintensities and amyloid angiopathy in familial Alzheimer&apos;s disease","volume":"36","author":"NS Ryan","year":"2015","journal-title":"Neurobiol Aging"},{"key":"ref24","article-title":"Solanezumab and the amyloid hypothesis for Alzheimer\u2019s disease","volume":"355","author":"DG Le Couteur","year":"2016","journal-title":"BMJ"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0195838","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T12:05:56Z","timestamp":1540037156000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0195838"}},"subtitle":[],"editor":[{"given":"Stephen D.","family":"Ginsberg","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,9]]},"references-count":24,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0195838","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,9]]}}}