{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:39:49Z","timestamp":1792802389163,"version":"4.5.0"},"reference-count":30,"publisher":"Public Library of Science (PLoS)","issue":"4","license":[{"start":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T00:00:00Z","timestamp":1524700800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100004440","name":"Wellcome Trust","doi-asserted-by":"publisher","award":["00019\/Z\/15\/Z"],"award-info":[{"award-number":["00019\/Z\/15\/Z"]}],"id":[{"id":"10.13039\/100004440","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Theiler Haag Stiftung"},{"name":"Harvard MD PhD Social Sciences Program"},{"name":"Harvard Department of the Classics"},{"name":"Maxi Foundation","id":[{"id":"https:\/\/ror.org\/003egza52","id-type":"ROR","asserted-by":"crossref"}]},{"name":"Westengard Fund"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0196448","type":"journal-article","created":{"date-parts":[[2018,4,26]],"date-time":"2018-04-26T13:42:28Z","timestamp":1524750148000},"page":"e0196448","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Evaluating the relationship between lesion burden and aging among the skeletons of an 18th-19th century London cemetery using osteological and radiological analysis"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-7600-5233","authenticated-orcid":true,"given":"Katherine","family":"van Schaik","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ronald","family":"Eisenberg","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jelena","family":"Bekvalac","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"R\u00fchli","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,4,26]]},"reference":[{"key":"ref1","unstructured":"National Institute on Aging and National Institutes of Health. Global Health and Aging. Washington, D.C.: National Institutes of Health; 2011. publication no. 11\u20137737."},{"key":"ref2","first-page":"484","article-title":"Health in an ageing world\u2014what do we know?","volume":"385","author":"R Suzman","year":"2014"},{"key":"ref3","first-page":"1196","article-title":"Ageing populations: the challenges ahead","volume":"374","author":"K Christensen","year":"2009"},{"key":"ref4","first-page":"2554","article-title":"Genetic mutations you want","volume":"113","author":"SCP Williams","year":"2016"},{"key":"ref5","first-page":"4493","article-title":"Endocrine and metabolic systems in aging","volume":"95","author":"N Barzilai","year":"2010"},{"key":"ref6","first-page":"470","article-title":"The search for longevity and healthy aging genes: insights from epidemiological studies and samples of long-lived individuals","volume":"67","author":"JM Murabito","year":"2012"},{"key":"ref7","first-page":"1323","article-title":"Genetics of healthy aging and longevity","volume":"132","author":"AR Brooks-Wilson","year":"2013"},{"key":"ref8","first-page":"436","article-title":"The quest for genetic determinants of human longevity: challenges and insights","volume":"7","author":"K Christensen","year":"2006"},{"key":"ref9","first-page":"1002","article-title":"Whole-genome sequencing of a healthy aging cohort","volume":"165","author":"GA Erikson","year":"2016"},{"key":"ref10","first-page":"1213","article-title":"Loneliness and the health of older people","volume":"23","author":"CO Luanaigh","year":"2008"},{"key":"ref11","first-page":"265","article-title":"Long-standing and limiting long-standing illness in older people: associations with chronic diseases, psychosocial and environmental factors","volume":"32","author":"S Ayis","year":"2003"},{"key":"ref12","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0175909","article-title":"Mortality is associated with inflammation, anemia, specific diseases and treatments, and molecular markers","author":"M Moeller","year":"2017"},{"key":"ref13","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0116206","article-title":"Systemic inflammation predicts all-cause mortality: a Glasgow inflammation outcome study","author":"M Proctor","year":"2015"},{"key":"ref14","first-page":"8","article-title":"Innate immunity and inflammation in ageing: a key for understanding age-related diseases","volume":"2","author":"F Licastro","year":"2005"},{"key":"ref15","first-page":"519","article-title":"Canonical Nlrp3 inflammasome links systemic low-grade inflammation to functional decline in aging","volume":"12","author":"Y-H Youm","year":"2013"},{"key":"ref16","first-page":"1211","article-title":"Atherosclerosis across 4000 years of human history: the Horus study of four ancient populations","volume":"381","author":"RC Thompson","year":"2013"},{"key":"ref17","first-page":"203","article-title":"Genomic correlates of atherosclerosis in ancient humans","volume":"3","author":"A Zink","year":"2014"},{"key":"ref18","first-page":"570","article-title":"Atherosclerotic cardiovascular disease in Egyptian women: 1570 BCE-2011 CE","volume":"167","author":"A Abdelfattah","year":"2013"},{"key":"ref19","first-page":"329","article-title":"Is atherosclerosis fundamental to human aging? Lessons from ancient mummies","volume":"63","author":"EM Clarke","year":"2014"},{"key":"ref20","first-page":"728","article-title":"Cancer: an old disease, a new disease or something in between?","volume":"10","author":"AR David","year":"2010"},{"key":"ref21","first-page":"397","article-title":"The osteological paradox 20 years later: past perspectives, future directions","volume":"23","author":"SN DeWitte","year":"2015"},{"key":"ref22","first-page":"285","article-title":"Sex differentials in frailty in medieval England","volume":"143","author":"SN DeWitte","year":"2010"},{"key":"ref23","first-page":"1436","article-title":"Selectivity of Black Death mortality with respect to preexisting health","volume":"105","author":"SN DeWitte","year":"2008"},{"key":"ref24","first-page":"172","article-title":"<italic>The Dead Tell Tales<\/italic>: <italic>Essays in Honor of Jane E<\/italic>. <italic>Buikstra<\/italic>","author":"G Milner","year":"2013"},{"key":"ref25","unstructured":"Milne G (English Heritage). St. Bride\u2019s Church London, archaeological research 1952\u201360 and 1992\u20135. London: English Heritage Archaeological Report no. 11, 1997."},{"key":"ref26","first-page":"49","article-title":"<italic>Grave Reflections<\/italic>. <italic>Portraying the Past through Cemetery Studies<\/italic>","author":"JL Scheuer","year":"1995"},{"key":"ref27","article-title":"(Museum of London). Human osteology method statement","author":"N Powers","year":"2012"},{"key":"ref28","article-title":"(Museum of London). A rapid method for recording human skeletal data","author":"B Connell","year":"2003"},{"key":"ref29","first-page":"34","article-title":"<italic>The Archaeology of Disease<\/italic>","author":"C Roberts","year":"2005"},{"key":"ref30","article-title":"<italic>A Compantion to Paleopathology<\/italic>","author":"A Grauer","year":"2011"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0196448","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,20]],"date-time":"2018-10-20T10:45:05Z","timestamp":1540032305000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0196448"}},"subtitle":[],"editor":[{"given":"Mark","family":"Spigelman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,4,26]]},"references-count":30,"journal-issue":{"issue":"4","published-online":{"date-parts":[[2018,4,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0196448","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,4,26]]}}}