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Progress Report on the Global Plan towards elimination of new HIV infections among children by 2015 and keeping their mothers alive. In: JC2509\/2\/E JUNPoHAaWHOU, editor. 2013."},{"issue":"9879","key":"ref3","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/S0140-6736(13)60803-X","article-title":"Effect of HIV infection on pregnancy-related mortality in sub-Saharan Africa: secondary analyses of pooled community-based data from the network for Analysing Longitudinal Population-based HIV\/AIDS data on Africa (ALPHA)","volume":"381","author":"B Zaba","year":"2013","journal-title":"Lancet"},{"issue":"2","key":"ref4","doi-asserted-by":"crossref","first-page":"206","DOI":"10.1086\/317918","article-title":"Correlates of mother-to-child human immunodeficiency virus type 1 (HIV-1) transmission: association with maternal plasma HIV-1 RNA load, genital HIV-1 DNA shedding, and breast infections","volume":"183","author":"GC John","year":"2001","journal-title":"J Infect Dis"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1001\/jama.285.6.709","article-title":"Understanding the timing of HIV transmission from mother to infant","volume":"285","author":"AP Kourtis","year":"2001","journal-title":"JAMA"},{"issue":"9","key":"ref6","doi-asserted-by":"crossref","first-page":"638","DOI":"10.1089\/apc.2006.0169","article-title":"Maternal HIV-1 DNA load and mother-to-child transmission","volume":"21","author":"ND Arvold","year":"2007","journal-title":"AIDS Patient Care STDS"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1097\/00002030-199902250-00014","article-title":"Maternal viral load and timing of mother-to-child HIV transmission, Bangkok, Thailand. Bangkok Collaborative Perinatal HIV Transmission Study Group","volume":"13","author":"PA Mock","year":"1999","journal-title":"AIDS"},{"issue":"7","key":"ref8","first-page":"Cd003510","article-title":"Antiretrovirals for reducing the risk of mother-to-child transmission of HIV infection","author":"N Siegfried","year":"2011","journal-title":"The Cochrane database of systematic reviews"},{"key":"ref9","year":"2012"},{"key":"ref10","year":"2013"},{"issue":"9","key":"ref11","doi-asserted-by":"crossref","first-page":"2639","DOI":"10.1093\/jac\/dkv143","article-title":"Determinants of virological failure and antiretroviral drug resistance in Mozambique","volume":"70","author":"M Ruperez","year":"2015","journal-title":"J Antimicrob Chemother"},{"issue":"Suppl 4","key":"ref12","doi-asserted-by":"crossref","first-page":"S369","DOI":"10.1093\/cid\/cis006","article-title":"Surveillance of HIV drug resistance in children receiving antiretroviral therapy: a pilot study of the World Health Organization&apos;s generic protocol in Maputo, Mozambique","volume":"54","author":"P Vaz","year":"2012","journal-title":"Clinical infectious diseases: an official publication of the Infectious Diseases Society of America"},{"issue":"9","key":"ref13","doi-asserted-by":"crossref","first-page":"e1001735","DOI":"10.1371\/journal.pmed.1001735","article-title":"Intermittent preventive treatment of malaria in pregnancy with mefloquine in HIV-infected women receiving cotrimoxazole prophylaxis: a multicenter randomized placebo-controlled trial","volume":"11","author":"R Gonzalez","year":"2014","journal-title":"PLoS medicine"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1309","DOI":"10.1093\/ije\/dyt148","article-title":"Profile: Manhica Health Research Centre (Manhica HDSS)","volume":"42","author":"C Sacoor","year":"2013","journal-title":"International journal of epidemiology"},{"issue":"7","key":"ref15","doi-asserted-by":"crossref","first-page":"e0132053","DOI":"10.1371\/journal.pone.0132053","article-title":"HIV Incidence and Spatial Clustering in a Rural Area of Southern Mozambique","volume":"10","author":"R Gonzalez","year":"2015","journal-title":"PloS one"},{"key":"ref16","unstructured":"Calverton M, EUA:INS,INE e ICF. Inqu\u00e9rito Nacional de Preval\u00eancia, Riscos Comportamentais e Informa\u00e7ao sobre o HIV e SIDA em Mo\u00e7ambique 2009. In: Instituto-Nacional-de-, Instituto-Nacional-de-Sa\u00fade E, editors. 2010."},{"issue":"7","key":"ref17","doi-asserted-by":"crossref","first-page":"e68213","DOI":"10.1371\/journal.pone.0068213","article-title":"Evolution of primary HIV drug resistance in a subtype C dominated epidemic in Mozambique","volume":"8","author":"DC Bila","year":"2013","journal-title":"PloS one"},{"issue":"2","key":"ref18","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1089\/aid.2007.0134","article-title":"Rapid spread and genetic diversification of HIV type 1 subtype C in a rural area of southern Mozambique","volume":"24","author":"M Lahuerta","year":"2008","journal-title":"AIDS research and human retroviruses"},{"key":"ref19","unstructured":"Sa\u00fade RdMMd. Guia de tratamento antiretroviral e infec\u00e7\u00f5es oportunistas no adulto, adolescente, gr\u00e0vida e crian\u00e7a 2014. In: M\u00e9dica DNdA, editor. 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