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Cambridge, UK: Cambridge University Press; 1966. p. 192\u2013212"},{"issue":"2","key":"ref15","doi-asserted-by":"crossref","first-page":"76","DOI":"10.1159\/000458761","article-title":"Phototoxicity of Doxycycline: A Systematic Review on Clinical Manifestations, Frequency, Cofactors, and Prevention","volume":"30","author":"S Goetze","year":"2017","journal-title":"Skin Pharmacol Physiol"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"648","DOI":"10.2144\/97234bm22","article-title":"Simplified agar plate method for quantifying viable bacteria","volume":"23","author":"BD Jett","year":"1997","journal-title":"Biotechniques"},{"key":"ref17","unstructured":"Performance Standards for Antimicrobial Susceptibility Testing; Twenty-Fifth Informational. Supplement. 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