{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T01:41:46Z","timestamp":1787794906383,"version":"build-2784847793"},"reference-count":21,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T00:00:00Z","timestamp":1527552000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"International Partnership for Microbicides","award":["IPM Global"],"award-info":[{"award-number":["IPM Global"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0196904","type":"journal-article","created":{"date-parts":[[2018,5,29]],"date-time":"2018-05-29T17:29:12Z","timestamp":1527614952000},"page":"e0196904","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":5,"title":["Safety of a silicone elastomer vaginal ring as potential microbicide delivery method in African women: A Phase 1 randomized trial"],"prefix":"10.1371","volume":"13","author":[{"given":"Annal\u00e9ne","family":"Nel","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2195-7314","authenticated-orcid":true,"given":"Janine","family":"Martins","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Linda-Gail","family":"Bekker","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gita","family":"Ramjee","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gileard","family":"Masenga","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Helen","family":"Rees","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Neli\u00ebtte","family":"van Niekerk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,5,29]]},"reference":[{"key":"ref1","unstructured":"United Nations Programme on HIV\/AIDS (UNAIDS), Global AIDS update. 2016. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/global-AIDS-update-2016_en.pdf\" xlink:type=\"simple\">http:\/\/www.unaids.org\/sites\/default\/files\/media_asset\/global-AIDS-update-2016_en.pdf<\/ext-link>."},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"562","DOI":"10.3109\/10837450903369879","article-title":"Pharmaceutical development of microbicide drug products","volume":"15","author":"DR Friend","year":"2010","journal-title":"Pharm Dev Technol"},{"issue":"6","key":"ref3","doi-asserted-by":"crossref","first-page":"1025","DOI":"10.1089\/jwh.2007.0529","article-title":"An evaluation of intravaginal rings as a potential HIV prevention device in urban Kenya: behaviors and attitudes that might influence uptake within a high-risk population","volume":"17","author":"DJ Smith","year":"2008","journal-title":"J Womens Health"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1089\/aid.2008.0184","article-title":"Safety and availability of dapivirine (TMC120) delivered from an intravaginal ring","volume":"25","author":"J Romano","year":"2009","journal-title":"AIDS Res Hum Retroviruses"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"416","DOI":"10.1097\/QAI.0b013e3181acb536","article-title":"Safety and pharmacokinetics of dapivirine delivery from matrix and reservoir intravaginal rings to HIV-negative women","volume":"51","author":"A Nel","year":"2009","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref6","unstructured":"Nel A, Kamupira M, Hetro C, Nuttall J, Romano J. Safety and pharmacokinetics trial of dapivirine matrix vaginal ring. 18th International AIDS Conference, Vienna, Austria, 2010 Jul 18\u201323, Abstract #15023."},{"issue":"10","key":"ref7","first-page":"355","article-title":"Pharmacokinetics and safety assessment of anti-HIV dapivirine vaginal microbicide rings with multiple dosing","volume":"5","author":"AM Nel","year":"2014","journal-title":"J AIDS Clin Res"},{"issue":"10","key":"ref8","doi-asserted-by":"crossref","first-page":"1479","DOI":"10.1097\/QAD.0000000000000280","article-title":"A safety and pharmacokinetic trial assessing delivery of dapivirine from a vaginal ring in healthy women","volume":"28","author":"A Nel","year":"2014","journal-title":"AIDS"},{"issue":"22","key":"ref9","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJMoa1602046","article-title":"Safety and Efficacy of a Dapivirine Vaginal Ring for HIV Prevention in Women","volume":"375","author":"A Nel","year":"2016","journal-title":"NEJM"},{"issue":"22","key":"ref10","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa1506110","article-title":"Use of a Vaginal Ring Containing Dapivirine for HV-1 Prevention in Women","volume":"375","author":"JM Baetin","year":"2016","journal-title":"NEJM"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"1775","DOI":"10.1007\/s10461-012-0215-0","article-title":"High acceptability of a vaginal ring intended as a microbicide delivery method for HIV prevention in African women","volume":"16","author":"A Van der Straten","year":"2012","journal-title":"AIDS Behav"},{"issue":"7","key":"ref12","doi-asserted-by":"crossref","first-page":"1787","DOI":"10.1007\/s10461-012-0248-4","article-title":"Vaginal ring adherence in sub-Saharan Africa: expulsion, removal, and perfect use","volume":"16","author":"ET Montgomery","year":"2012","journal-title":"AIDS Behav"},{"key":"ref13","unstructured":"Division of AIDS table for grading the severity of adult and pediatric adverse events. Version 1.0, 2004 Dec 28. Addendum 1: female genital grading table for use in microbicide studies. Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/rsc.tech-res.com\/Document\/safetyandpharmacovigilance\/Addendum_1_Female_Genital_Grading_Table_v1_Nov_2007.pdf\" xlink:type=\"simple\">http:\/\/rsc.tech-res.com\/Document\/safetyandpharmacovigilance\/Addendum_1_Female_Genital_Grading_Table_v1_Nov_2007.pdf<\/ext-link>."},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1093\/jac\/dki326","article-title":"Long-term, controlled release of the HIV microbicide TMC120 from silicone elastomer vaginal rings","volume":"56","author":"RK Malcolm","year":"2005","journal-title":"J Antimicrob Chemother"},{"issue":"5","key":"ref15","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.contraception.2010.04.012","article-title":"Contraceptive vaginal rings: a review","volume":"82","author":"V Brache","year":"2010","journal-title":"Contraception"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"451","DOI":"10.1016\/j.contraception.2006.07.004","article-title":"Efficacy, acceptability and tolerability of the combined contraceptive ring, NuvaRing, compared with an oral contraceptive containing 30 microg of ethinyl estradiol and 3 mg of drospirenone","volume":"74","author":"HJ Ahrendt","year":"2006","journal-title":"Contraception"},{"issue":"3","key":"ref17","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.contraception.2004.09.001","article-title":"Efficacy and safety of a contraceptive vaginal ring (NuvaRing) compared with a combined oral contraceptive: a 1-year randomized trial","volume":"71","author":"K Oddsson","year":"2005","journal-title":"Contraception"},{"issue":"3","key":"ref18","first-page":"585","article-title":"Efficacy, cycle control, and user acceptability of a novel combined contraceptive vaginal ring","volume":"100","author":"TO Dieben","year":"2002","journal-title":"Obstet Gynecol"},{"issue":"3","key":"ref19","doi-asserted-by":"crossref","first-page":"e0147743","DOI":"10.1371\/journal.pone.0147743","article-title":"Safety, Acceptability and Adherence of Dapivirine Vaginal Ring in a Microbicide Clinical Trial Conducted in Multiple Countries in Sub-Saharan Africa","volume":"11","author":"A Nel","year":"2016","journal-title":"PLoS One"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1038\/nature08757","article-title":"Targeting early infection to prevent HIV-1 mucosal transmission","volume":"464","author":"AT Haase","year":"2010","journal-title":"Nature"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"594","DOI":"10.1097\/OLQ.0b013e3181e15f0b","article-title":"Baseline factors associated with incident HIV and STI in four microbicide trials","volume":"37","author":"PJ Feldblum","year":"2010","journal-title":"Sex Transm Dis"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0196904","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,24]],"date-time":"2022-08-24T15:37:13Z","timestamp":1661355433000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0196904"}},"subtitle":[],"editor":[{"given":"Gilda","family":"Tachedjian","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,29]]},"references-count":21,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,29]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0196904","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,29]]}}}