{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,8]],"date-time":"2026-09-08T23:39:53Z","timestamp":1788910793791,"version":"build-2803163510"},"reference-count":67,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T00:00:00Z","timestamp":1526256000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"KNOW Consortium: \u201eHealthy Animal \u2013 Safe Food\u201d","award":["Dec: 05-1\/KNOW2\/2015"],"award-info":[{"award-number":["Dec: 05-1\/KNOW2\/2015"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0197083","type":"journal-article","created":{"date-parts":[[2018,5,14]],"date-time":"2018-05-14T17:35:48Z","timestamp":1526319348000},"page":"e0197083","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":75,"title":["Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the copper biodistribution and gastrointestinal and hepatic morphology and function in a rat model"],"prefix":"10.1371","volume":"13","author":[{"given":"Ewelina","family":"Cholewi\u0144ska","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katarzyna","family":"Ognik","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Fotschki","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zenon","family":"Zdu\u0144czyk","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0068-5970","authenticated-orcid":true,"given":"Jerzy","family":"Ju\u015bkiewicz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,5,14]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"R877","DOI":"10.1016\/j.cub.2011.09.040","article-title":"Copper: an essential metal in biology","volume":"21","author":"RA Festa","year":"2011","journal-title":"Curr Biol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"1011","DOI":"10.1152\/physrev.00004.2006","article-title":"Function and regulation of human copper-transporting ATPases","volume":"87","author":"S Lutsenko","year":"2007","journal-title":"Physiol Rev"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"673","DOI":"10.1136\/jmg.2007.052746","article-title":"Molecular pathogenesis of Wilson and Menkes disease: correlation of mutations with molecular defects and disease phenotypes","volume":"44","author":"P de Bie","year":"2007","journal-title":"J Med Genet"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"1125","DOI":"10.4155\/fmc.09.84","article-title":"Human copper transporters: mechanism, role in human disease and therapeutic potential","volume":"1","author":"A Gupta","year":"2009","journal-title":"Future Med Chem"},{"key":"ref5","article-title":"Effect of dietary copper nanoparticles versus one copper (II) salt: analysis of vasoreactivity in a rat model","author":"M Majewski","year":"2017","journal-title":"Pharmacol Rep"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1038\/ejhg.2009.187","article-title":"Menkes disease","volume":"18","author":"Z T\u00fcmer","year":"2010","journal-title":"Eur J Hum Genet"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"279","DOI":"10.1016\/B978-0-444-63233-3.00018-X","article-title":"Wilson disease and related copper disorders","volume":"147","author":"MT Lorincz","year":"2018","journal-title":"Handb Clin Neurol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"816","DOI":"10.1039\/b711118p","article-title":"Wilson disease: not just a copper disorder. Analysis of a Wilson disease model demonstrates the link between copper and lipid metabolism","volume":"3","author":"D Huster","year":"2007","journal-title":"Mol Biosyst"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"8343","DOI":"10.1074\/jbc.M607496200","article-title":"High copper selectively alters lipid metabolism and cell cycle machinery in the mouse model of Wilson disease","volume":"282","author":"D Huster","year":"2007","journal-title":"J Biol Chem"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"2045","DOI":"10.3382\/ps\/pew200","article-title":"The effect of administration of copper nanoparticles to chickens in drinking water on estimated intestinal absorption of iron, zinc, and calcium","volume":"95","author":"K Ognik","year":"2016","journal-title":"Poult Sci"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1079\/PNS2003316","article-title":"Molecular regulation of copper excretion in the liver","volume":"63","author":"C Wijmenga","year":"2004","journal-title":"Proc Nutr Soc"},{"key":"ref12","first-page":"36","article-title":"Selected aspects of nanotechnology applications in food production","volume":"5","author":"D G\u0142\u00f3d","year":"2014","journal-title":"\u017byw. Nauka Technol Jako\u015b\u0107"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"375","DOI":"10.1016\/j.molliq.2017.12.031","article-title":"Hyperbranched polyglycerol coated on copper oxide nanoparticles as a novel core-shell nano-carrier hydrophilic drug delivery model","volume":"250","author":"Z Assadi","year":"2018","journal-title":"J Mol Liq"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jtemb.2018.03.017","article-title":"Comparison of the effect of dietary copper nanoparticles and one copper (II) salt on the metabolic and immune status in a rat model","volume":"48","author":"E Cholewi\u0144ska","year":"2018","journal-title":"J Trace Elem Med Biol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"167","DOI":"10.5567\/sciintl.2013.167.174","article-title":"Synthesis, Characterization and Biomedical Applications of Nanoparticles","volume":"1","author":"V Gupta","year":"2013","journal-title":"Science International"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.jphotobiol.2017.05.001","article-title":"Biosynthesis and characterization of copper oxide nanoparticles and its anticancer activity on human colon cancer cell lines (HCT-116)","volume":"171","author":"V Gnanavel","year":"2017","journal-title":"J Photochem Photobiol B"},{"key":"ref17","first-page":"1","article-title":"Copper Based Nanoparticle: A Way towards Future Cancer Therapy","volume":"1","author":"A Pramanik","year":"2017","journal-title":"Glob J Nanomed"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"493","DOI":"10.1016\/j.actbio.2017.04.012","article-title":"Copper-containing mesoporous bioactive glass nanoparticles as multifunctional agent for bone regeneration","volume":"55","author":"A Bari","year":"2017","journal-title":"Acta Biomater"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"2313","DOI":"10.1007\/s11051-010-9911-8","article-title":"Toxicity and cellular uptake of gold nanoparticles: what we have learned so far?","volume":"12","author":"AM Alkilany","year":"2010","journal-title":"J Nanopart Res"},{"key":"ref20","first-page":"400","article-title":"The toxicity of gold nanoparticles in relation to their physicochemical properties","volume":"24","author":"CS Yah","year":"2013","journal-title":"Biomed Res"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"835","DOI":"10.3390\/nano5020835","article-title":"Toxicity and biokinetics of colloidal gold nanoparticles","volume":"5","author":"MR Jo","year":"2015","journal-title":"Nanomaterials"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"7776","DOI":"10.1016\/j.biomaterials.2013.06.052","article-title":"The mechanisms of surface chemistry effects of mesoporous silicon nanoparticles on immunotoxicity and biocompatibility","volume":"31","author":"MA Shahbazi","year":"2013","journal-title":"Biomaterials"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"2493","DOI":"10.1007\/s11051-014-2493-0","article-title":"Detecting the oxidative reactivity of nanoparticles: a new protocol for reducing artifacts","volume":"16","author":"J Zhao","year":"2014","journal-title":"J Nanopart Res"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1021\/ja808033w","article-title":"Potential oxidative stress of gold nanoparticles by induced-NO releasing in serum","volume":"131","author":"HY Jia","year":"2009","journal-title":"J Am Chem Soc"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"450","DOI":"10.17221\/80\/2015-CJAS","article-title":"Effect of silver nanoparticles on the immune, redox, and lipid status of chicken blood","volume":"61","author":"K Ognik","year":"2016","journal-title":"Czech J Anim Sci"},{"key":"ref26","first-page":"2883","article-title":"Comparative toxicity and biodistribution of copper nanoparticles and cupric ions in rats","volume":"11","author":"IC Lee","year":"2016","journal-title":"Int J Nanomed"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"898","DOI":"10.1016\/j.nut.2012.11.006","article-title":"An anthocyanin-rich extract from Kamchatka honeysuckle increases enzymatic activity within the gut and ameliorates abnormal lipid and glucose metabolism in rats","volume":"29","author":"A Jurgonski","year":"2013","journal-title":"Nutrition"},{"key":"ref28","doi-asserted-by":"crossref","first-page":"96","DOI":"10.1016\/j.nut.2013.06.009","article-title":"Copper-induced alterations in rat brain depends on route of overload and basal copper levels","volume":"30","author":"N Arnal","year":"2014","journal-title":"Nutrition"},{"key":"ref29","doi-asserted-by":"crossref","first-page":"56","DOI":"10.1186\/s12989-016-0169-x","article-title":"Comparative toxicity and biodistribution assessments in rats following subchronic oral exposure to copper nanoparticles and microparticles","volume":"13","author":"IC Lee","year":"2016","journal-title":"Part Fibre Toxicol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"103","DOI":"10.1016\/j.jtemb.2017.05.002","article-title":"Comparison of the effect of dietary copper nanoparticles with copper (II) salt on bone geometric and structural parameters as well as material characteristics in a rat model","volume":"42","author":"E Tomaszewska","year":"2017","journal-title":"J Trace Elem Med"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1186\/1743-8977-4-10","article-title":"Kupffer cells are central in the removal of nanoparticles from the organism","volume":"4","author":"E Sadauskas","year":"2007","journal-title":"Part Fibre Toxicol"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"737","DOI":"10.3109\/03639045.2010.539231","article-title":"In vitro evaluation of idebenone-loaded solid lipid nanoparticles for drug delivery to the brain","volume":"37","author":"L Montenegro","year":"2011","journal-title":"Drug Dev Ind Pharm"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1016\/j.fct.2016.09.026","article-title":"Oxidative stress in rat brain but not in liver following oral administration of a low dose of nanoparticulate silver","volume":"97","author":"J Skalska","year":"2016","journal-title":"Food Chem Toxicol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"1373","DOI":"10.3923\/javaa.2011.1373.1377","article-title":"Effects of High Levels of Dietary Copper Sulfate and Copper Proteinate on Growth Performance, Retention for Copper and Zinc of Rats","volume":"10","author":"H Ozkul","year":"2011","journal-title":"J Anim Vet Adv"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1007\/s12011-013-9665-0","article-title":"Biochemical, histological, and memory impairment effects of chronic copper toxicity: a model for non-Wilsonian brain copper toxicosis in Wistar rat","volume":"153","author":"A Pal","year":"2013","journal-title":"Biol Trace Elem Res"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"G1007","DOI":"10.1152\/ajpgi.00210.2004","article-title":"Effects of copper supplementation on copper absorption, tissue distribution, and copper transporter expression in an infant rat model","volume":"288","author":"KA Bauerly","year":"2005","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1007\/s12011-008-8219-3","article-title":"Copper intoxication; antioxidant defenses and oxidative damage in rat brain","volume":"127","author":"D Ozcelik","year":"2009","journal-title":"Biol Trace Elem Res"},{"key":"ref38","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.jtemb.2014.06.004","article-title":"A study of dose response and organ susceptibility of copper toxicity in a rat model","volume":"29","author":"V Kumar","year":"2015","journal-title":"J Trace Elem Med Biol"},{"key":"ref39","first-page":"97","article-title":"Morphological and biochemical assessment of the liver response to excess dietary copper in Fischer 344 rats","volume":"65","author":"EM Aburto","year":"2001","journal-title":"Can J Vet Res"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"3","DOI":"10.13041\/jpvm.2015.39.1.3","article-title":"Comparison of the bioavailability of nano- and micro-sized copper oxide particles in copper-deficient mice","volume":"39","author":"JK Seol","year":"2015","journal-title":"J Prev Vet Med"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1081\/CLT-100102384","article-title":"Effect of age and sex on liver damage due to excess dietary copper in Fischer 344 rats","volume":"38","author":"IC Fuentealba","year":"2000","journal-title":"J Toxicol Clin Toxicol"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"6335","DOI":"10.1166\/jnn.2009.1320","article-title":"Potential Health Impact on Mice after Nasal Instillation of Nano-Sized Copper Particles and Their Translocation in Mice","volume":"9","author":"Y Liu","year":"2009","journal-title":"J Nanosci Nanotechnol"},{"key":"ref43","first-page":"158","article-title":"A study of two weeks administration of copper sulphate on markers of renal function and feeding pattern of Wistar rats","volume":"8","author":"RO Akomolafe","year":"2014","journal-title":"Afr J Enviro. Sci Technol"},{"key":"ref44","first-page":"1469","article-title":"Effect of Long Term Administration of Copper Pyrazinate on Copper Levels in Serum, Liver and Muscle with Reference to Some, Haematological and Biochemical Constituents in Rats","volume":"12","author":"AH Atta","year":"2011","journal-title":"World Appl Sci J"},{"key":"ref45","first-page":"124","article-title":"Explore in vivo toxicity assessment of copper oxide nanoparticle in Wistar rats","volume":"3","author":"A Mohammadyari","year":"2014","journal-title":"J Biol Today\u2019s World"},{"key":"ref46","first-page":"41","article-title":"Effect of Sub Chronic Exposure of Copper on Some Hematological and Hepatological Parameters in Male Wistar Rats","volume":"4","author":"S Shukla","year":"2015","journal-title":"IIS Univ J Sc Tech"},{"key":"ref47","first-page":"331","article-title":"Acute effect of nano-copper on liver tissue and function in rat","volume":"1","author":"M Doudi","year":"2015","journal-title":"Nanomed J"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"541","DOI":"10.1007\/s10534-005-1244-1","article-title":"Early histological and functional effects of chronic copper exposure in rat liver","volume":"18","author":"FA Cisternas","year":"2005","journal-title":"BioMetal.s"},{"key":"ref49","first-page":"1","article-title":"Toxicopathological study due to effect of different doses of Copper Sulfate ingested in rat","volume":"3","author":"RA Al-Naimi","year":"2010","journal-title":"Al-Anbar J Vet Sci"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"479","DOI":"10.2478\/bvip-2014-0073","article-title":"Alterations of liver histomorphology in relation to copper supplementation in inorganic and organic form in growing rats","volume":"58","author":"E Tomaszewska","year":"2014","journal-title":"Bull Vet Inst Pulawy"},{"key":"ref51","first-page":"323","article-title":"Sublethal effects of copper nanoparticles on the histology of gill, liver and kidney of the Caspian roach, <italic>Rutilus rutilus caspicus<\/italic>","volume":"3","author":"S Aghamirkarimi","year":"2017","journal-title":"Global J Environ Sci Manage"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1016\/j.aaf.2016.09.003","article-title":"Effect of copper nanoparticles exposure in the physiology of the common carp (<italic>Cyprinus carpio<\/italic>): Biochemical, histological and proteomic approaches","volume":"1","author":"YR Gupta","year":"2016","journal-title":"Aquaculture and Fisheries"},{"key":"ref53","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1007\/s12011-015-0522-1","article-title":"Intestinal Alterations, Basal Hematology, and Biochemical Parameters in Adolescent Rats Fed Different Sources of Dietary Copper","volume":"171","author":"E Tomaszewska","year":"2016","journal-title":"Biol Trace Elem Res"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1007\/s12011-011-9191-x","article-title":"Changes in small intestinal morphology and digestive enzyme activity with oral administration of copper-loaded chitosan nanoparticles in rats","volume":"145","author":"XY Han","year":"2012","journal-title":"Biol Trace Elem Res"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"89","DOI":"10.1080\/00039420310001656703","article-title":"Physiological effects of lactulose and inulin in the caecum of rats","volume":"58","author":"Z Zdunczyk","year":"2004","journal-title":"Arch Anim Nut.r"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1079\/WPS20040013","article-title":"Selected parameters of gastrointestinal tract metabolism of turkeys fed diets with flavomycin and different inulin content","volume":"60","author":"J Juskiewicz","year":"2004","journal-title":"World Poult Sci J"},{"key":"ref57","first-page":"155","article-title":"Human Colonic Bacteria: Role in Nutrition, Physiology and Pathology","author":"IR Rowland","year":"1995"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1002\/jez.1954","article-title":"Nutrient digestibility and colonic fermentation processes in species of the families Mustelidae and Canidae fed the same diet","volume":"323","author":"A. Gugolek","year":"2015","journal-title":"J Exp Zool"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"185","DOI":"10.1080\/17458080802395460","article-title":"Ultrafine dispersed CuO nanoparticles and their antibacterial activity","volume":"3","author":"O Mahapatra","year":"2008","journal-title":"J Exp Nanosci"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"3527","DOI":"10.2147\/IJN.S29020","article-title":"Size-dependent antimicrobial properties of CuO nanoparticles against Gram-positive and-negative bacterial strains","volume":"7","author":"A Azam","year":"2012","journal-title":"Int J Nanomedicine"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.tifs.2016.10.013","article-title":"Nanoparticles in feed: progress and prospects in poultry nutrition","volume":"58","author":"S Gangadoo","year":"2016","journal-title":"Trends Food Sci Technol"},{"key":"ref62","first-page":"1843","article-title":"Copper silicate Nanoparticles: Effects of intestinal microflora, nitrogen metabolism and ammonia emission from excreta of yellow-feathered broilers","volume":"25","author":"S Minglei","year":"2013","journal-title":"Anim Feed Sci Technol"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"278","DOI":"10.1016\/j.msec.2014.08.031","article-title":"Antimicrobial activity of the metals and metal oxide nanoparticles","volume":"44","author":"SM Dizaj","year":"2014","journal-title":"Mater Sci Eng C"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"331","DOI":"10.2147\/IJN.S16964","article-title":"Fabrication of silver nanoparticles doped in the zeolite framework and antibacterial activity","volume":"6","author":"K Shameli","year":"2011","journal-title":"Int J Nanomedicine"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.taap.2015.12.017","article-title":"New frontiers in nanotoxicology: gut microbiota\/microbiome-mediated effects of engineered nanomaterials","volume":"299","author":"A Pietroiusti","year":"2016","journal-title":"Toxicol Appl Pharmacol"},{"key":"ref66","first-page":"5","article-title":"Nanosilver-mediated change in human intestinal microbiota","volume":"5","author":"P Das","year":"2014","journal-title":"J Nanosci Nanotechnol"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"MR17","DOI":"10.1116\/1.2815690","article-title":"Nanomaterials and nanoparticles: sources and toxicity","volume":"2","author":"C Bueza","year":"2007","journal-title":"Biointerphases"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0197083","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,9]],"date-time":"2020-05-09T10:14:54Z","timestamp":1589019294000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0197083"}},"subtitle":[],"editor":[{"given":"Juan J","family":"Loor","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,14]]},"references-count":67,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0197083","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,14]]}}}