{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T23:10:08Z","timestamp":1751670608072,"version":"3.41.0"},"reference-count":36,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T00:00:00Z","timestamp":1527724800000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003042","name":"Else Kr\u00f6ner-Fresenius-Stiftung","doi-asserted-by":"publisher","award":["2014_A193"],"award-info":[{"award-number":["2014_A193"]}],"id":[{"id":"10.13039\/501100003042","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100004937","name":"Bundesministerium f\u00fcr Forschung und Technologie","doi-asserted-by":"publisher","award":["01KU1402B"],"award-info":[{"award-number":["01KU1402B"]}],"id":[{"id":"10.13039\/501100004937","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF) in the Faculty of Medicine at the RWTH Aachen University","award":["O1-1"],"award-info":[{"award-number":["O1-1"]}]},{"name":"Interdisciplinary Center for Clinical Research (IZKF) in the Faculty of Medicine at the RWTH Aachen University","award":["O1-2"],"award-info":[{"award-number":["O1-2"]}]},{"DOI":"10.13039\/501100005677","name":"Jos\u00e9 Carreras Leuk\u00e4mie-Stiftung","doi-asserted-by":"publisher","id":[{"id":"10.13039\/501100005677","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0197233","type":"journal-article","created":{"date-parts":[[2018,5,31]],"date-time":"2018-05-31T17:56:02Z","timestamp":1527789362000},"page":"e0197233","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Serum of myeloproliferative neoplasms stimulates hematopoietic stem and progenitor cells"],"prefix":"10.1371","volume":"13","author":[{"given":"Richard K.","family":"Lubberich","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Thomas","family":"Walenda","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tamme W.","family":"Goecke","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Klaus","family":"Strathmann","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susanne","family":"Isfort","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tim H.","family":"Br\u00fcmmendorf","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Steffen","family":"Koschmieder","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1971-3217","authenticated-orcid":true,"given":"Wolfgang","family":"Wagner","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,5,31]]},"reference":[{"issue":"23","key":"ref1","doi-asserted-by":"crossref","first-page":"2452","DOI":"10.1056\/NEJMra063728","article-title":"The myeloproliferative disorders","volume":"355","author":"PJ Campbell","year":"2006","journal-title":"N Engl J Med"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"1841","DOI":"10.1038\/leu.2008.233","article-title":"Genetic complexity of myeloproliferative neoplasms","volume":"22","author":"R Kralovics","year":"2008","journal-title":"Leukemia"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"145293","DOI":"10.1155\/2015\/145293","article-title":"Pathogenesis of Myeloproliferative Neoplasms: Role and Mechanisms of Chronic Inflammation","volume":"2015","author":"S Hermouet","year":"2015","journal-title":"Mediators Inflamm"},{"issue":"13","key":"ref4","doi-asserted-by":"crossref","first-page":"2176","DOI":"10.1182\/blood-2013-03-460154","article-title":"Myeloproliferative neoplasms and thrombosis","volume":"122","author":"T Barbui","year":"2013","journal-title":"Blood"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"387","DOI":"10.1016\/j.ccr.2005.03.023","article-title":"Activating mutation in the tyrosine kinase JAK2 in polycythemia vera, essential thrombocythemia, and myeloid metaplasia with myelofibrosis","volume":"7","author":"RL Levine","year":"2005","journal-title":"Cancer Cell"},{"issue":"1","key":"ref6","doi-asserted-by":"crossref","first-page":"268","DOI":"10.1182\/asheducation-2014.1.268","article-title":"How does JAK2V617F contribute to the pathogenesis of myeloproliferative neoplasms?","volume":"2014","author":"E Chen","year":"2014","journal-title":"Hematology Am Soc Hematol Educ Program"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1016\/j.stem.2013.06.009","article-title":"Myeloproliferative neoplasia remodels the endosteal bone marrow niche into a self-reinforcing leukemic niche","volume":"13","author":"K Schepers","year":"2013","journal-title":"Cell Stem Cell"},{"issue":"17","key":"ref8","doi-asserted-by":"crossref","first-page":"3345","DOI":"10.1182\/blood-2012-06-439661","article-title":"Characterization of the TGF-beta1 signaling abnormalities in the Gata1low mouse model of myelofibrosis","volume":"121","author":"M Zingariello","year":"2013","journal-title":"Blood"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"2579","DOI":"10.1172\/JCI77347","article-title":"IL-33 signaling contributes to the pathogenesis of myeloproliferative neoplasms","volume":"125","author":"LF Mager","year":"2015","journal-title":"J Clin Invest"},{"issue":"8","key":"ref10","doi-asserted-by":"crossref","first-page":"972","DOI":"10.1182\/blood-2014-12-618595","article-title":"Lipocalin produced by myelofibrosis cells affects the fate of both hematopoietic and marrow microenvironmental cells","volume":"126","author":"M Lu","year":"2015","journal-title":"Blood"},{"issue":"24","key":"ref11","doi-asserted-by":"crossref","first-page":"6392","DOI":"10.1182\/blood-2011-04-348144","article-title":"TNFalpha facilitates clonal expansion of JAK2V617F positive cells in myeloproliferative neoplasms","volume":"118","author":"AG Fleischman","year":"2011","journal-title":"Blood"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"1018","DOI":"10.1038\/leu.2016.12","article-title":"Myeloproliferative neoplasms and inflammation: whether to target the malignant clone or the inflammatory process or both","volume":"30","author":"S Koschmieder","year":"2016","journal-title":"Leukemia"},{"issue":"3","key":"ref13","doi-asserted-by":"crossref","first-page":"e18012","DOI":"10.1371\/journal.pone.0018012","article-title":"Serum after autologous transplantation stimulates proliferation and expansion of human hematopoietic progenitor cells","volume":"6","author":"T Walenda","year":"2011","journal-title":"PloS one"},{"issue":"4","key":"ref14","doi-asserted-by":"crossref","first-page":"e1003599","DOI":"10.1371\/journal.pcbi.1003599","article-title":"Feedback signals in myelodysplastic syndromes: increased self-renewal of the malignant clone suppresses normal hematopoiesis","volume":"10","author":"T Walenda","year":"2014","journal-title":"PLoS computational biology"},{"issue":"1\u20132","key":"ref15","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1582-4934.2009.00776.x","article-title":"Co-culture with mesenchymal stromal cells increases proliferation and maintenance of haematopoietic progenitor cells","volume":"14","author":"T Walenda","year":"2010","journal-title":"J Cell Mol Med"},{"issue":"6","key":"ref16","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.exphem.2011.02.011","article-title":"Synergistic effects of growth factors and mesenchymal stromal cells for expansion of hematopoietic stem and progenitor cells","volume":"39","author":"T Walenda","year":"2011","journal-title":"Experimental hematology"},{"issue":"1","key":"ref17","doi-asserted-by":"crossref","first-page":"337","DOI":"10.1111\/j.1582-4934.2009.00776.x","article-title":"Co-Culture with Mesenchymal Stromal Cells Increases Proliferation and Maintenance of Hematopoietic Progenitor Cells","volume":"14","author":"T Walenda","year":"2010","journal-title":"J Cell Mol Med"},{"issue":"6","key":"ref18","doi-asserted-by":"crossref","first-page":"617","DOI":"10.1016\/j.exphem.2011.02.011","article-title":"Synergistic effects of growth factors and mesenchymal stromal cells for expansion of hematopoietic stem and progenitor cells","volume":"39","author":"T Walenda","year":"2011","journal-title":"Experimental Hematology"},{"issue":"9","key":"ref19","doi-asserted-by":"crossref","first-page":"1408","DOI":"10.1016\/j.exphem.2007.05.016","article-title":"CD133-enriched CD34(-) (CD33\/CD38\/CD71)(-) cord blood cells acquire CD34 prior to cell division and hematopoietic activity is exclusively associated with CD34 expression","volume":"35","author":"KS Gotze","year":"2007","journal-title":"Experimental hematology"},{"issue":"1","key":"ref20","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/0022-1759(94)90236-4","article-title":"Determination of lymphocyte division by flow cytometry","volume":"171","author":"AB Lyons","year":"1994","journal-title":"J Immunol Methods"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"855","DOI":"10.1182\/blood.V95.3.855.003k41_855_862","article-title":"High-resolution tracking of cell division suggests similar cell cycle kinetics of hematopoietic stem cells stimulated in vitro and in vivo","volume":"95","author":"RA Oostendorp","year":"2000","journal-title":"Blood"},{"issue":"11","key":"ref22","doi-asserted-by":"crossref","first-page":"1003","DOI":"10.1002\/ajh.23295","article-title":"Plasma cytokines in polycythemia vera: phenotypic correlates, prognostic relevance, and comparison with myelofibrosis","volume":"87","author":"R Vaidya","year":"2012","journal-title":"Am J Hematol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1016\/j.cytogfr.2013.01.004","article-title":"The role of cytokines in the initiation and progression of myelofibrosis","volume":"24","author":"HC Hasselbalch","year":"2013","journal-title":"Cytokine Growth Factor Rev"},{"issue":"5","key":"ref24","doi-asserted-by":"crossref","first-page":"e0128231","DOI":"10.1371\/journal.pone.0128231","article-title":"MicroRNAs and Metabolites in Serum Change after Chemotherapy: Impact on Hematopoietic Stem and Progenitor Cells","volume":"10","author":"T Walenda","year":"2015","journal-title":"PloS one"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"377","DOI":"10.1089\/scd.2008.0143","article-title":"Modeling of Asymmetric Cell Division in Hematopoietic Stem Cells\u2014Regulation of Self-Renewal is Essential for Efficient Repopulation","volume":"18","author":"A Marciniak-Czochra","year":"2009","journal-title":"Stem Cells Dev"},{"issue":"10","key":"ref26","doi-asserted-by":"crossref","first-page":"1356","DOI":"10.1200\/JCO.2010.32.9490","article-title":"Circulating interleukin (IL)-8, IL-2R, IL-12, and IL-15 levels are independently prognostic in primary myelofibrosis: a comprehensive cytokine profiling study","volume":"29","author":"A Tefferi","year":"2011","journal-title":"J Clin Oncol"},{"issue":"5","key":"ref27","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1111\/j.1365-2141.2005.05674.x","article-title":"Serum interleukin (IL)-1, IL-2, sIL-2Ra, IL-6 and thrombopoietin levels in patients with chronic myeloproliferative diseases","volume":"130","author":"KE Panteli","year":"2005","journal-title":"Br J Haematol"},{"issue":"5","key":"ref28","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1016\/j.exphem.2014.01.006","article-title":"Cytokine profiles in polycythemia vera and essential thrombocythemia patients: clinical implications","volume":"42","author":"E Pourcelot","year":"2014","journal-title":"Experimental hematology"},{"issue":"10","key":"ref29","doi-asserted-by":"crossref","first-page":"1389","DOI":"10.1016\/j.leukres.2006.12.024","article-title":"Global cytokine analysis in myeloproliferative disorders","volume":"31","author":"CL Ho","year":"2007","journal-title":"Leuk Res"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"453020","DOI":"10.1155\/2015\/453020","article-title":"Proinflammatory Cytokine IL-6 and JAK-STAT Signaling Pathway in Myeloproliferative Neoplasms","volume":"2015","author":"VP Cokic","year":"2015","journal-title":"Mediators Inflamm"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"344","DOI":"10.1038\/leu.2012.224","article-title":"miR-433 is aberrantly expressed in myeloproliferative neoplasms and suppresses hematopoietic cell growth and differentiation","volume":"27","author":"X Lin","year":"2013","journal-title":"Leukemia"},{"issue":"25","key":"ref32","doi-asserted-by":"crossref","first-page":"4977","DOI":"10.1182\/blood-2013-01-480079","article-title":"Circulating microRNAs in hematological diseases: principles, challenges, and perspectives","volume":"121","author":"S Grasedieck","year":"2013","journal-title":"Blood"},{"issue":"8","key":"ref33","doi-asserted-by":"crossref","first-page":"1563","DOI":"10.1084\/jem.20110752","article-title":"Tumor necrosis factor restricts hematopoietic stem cell activity in mice: involvement of two distinct receptors","volume":"208","author":"CJ Pronk","year":"2011","journal-title":"J Exp Med"},{"issue":"5","key":"ref34","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1038\/nri3433","article-title":"The ageing haematopoietic stem cell compartment","volume":"13","author":"H Geiger","year":"2013","journal-title":"Nat Rev Immunol"},{"issue":"50","key":"ref35","doi-asserted-by":"crossref","first-page":"20012","DOI":"10.1073\/pnas.1116110108","article-title":"Human bone marrow hematopoietic stem cells are increased in frequency and myeloid-biased with age","volume":"108","author":"WW Pang","year":"2011","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref36","doi-asserted-by":"crossref","first-page":"502","DOI":"10.3389\/fimmu.2016.00502","article-title":"Inflamm-Aging of Hematopoiesis, Hematopoietic Stem Cells, and the Bone Marrow Microenvironment","volume":"7","author":"LV Kovtonyuk","year":"2016","journal-title":"Frontiers in immunology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0197233","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,7,4]],"date-time":"2025-07-04T22:29:01Z","timestamp":1751668141000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0197233"}},"subtitle":[],"editor":[{"given":"Zilong","family":"Wen","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,31]]},"references-count":36,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,31]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0197233","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,5,31]]}}}