{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,2]],"date-time":"2026-06-02T01:01:00Z","timestamp":1780362060955,"version":"3.54.1"},"reference-count":33,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T00:00:00Z","timestamp":1528675200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0197342","type":"journal-article","created":{"date-parts":[[2018,6,11]],"date-time":"2018-06-11T17:33:23Z","timestamp":1528738403000},"page":"e0197342","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":48,"title":["Sleepiness, fatigue, anxiety and depression in Chronic Obstructive Pulmonary Disease and Obstructive Sleep Apnea \u2013 Overlap \u2013 Syndrome, before and after continuous positive airways pressure therapy"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2537-6624","authenticated-orcid":true,"given":"Nicholas-Tiberio","family":"Economou","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ioannis","family":"Ilias","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lemonia","family":"Velentza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yiannis","family":"Papachatzakis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul","family":"Zarogoulidis","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anastasios","family":"Kallianos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgia","family":"Trakada","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,6,11]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1016\/S0272-5231(21)00402-0","article-title":"Sleep in chronic obstructive lung disease","volume":"6","author":"DC Flenley","year":"1985","journal-title":"Clin Chest Med"},{"key":"ref2","unstructured":"GOLD\u2013Global Strategy for the diagnosis, management, and prevention of Chronic Obstructive Pulmonary Disease (updated 2016)\u2013 <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.goldcopd.org\/guidelines-globalstrategy-for-diagnosis-management.html\" xlink:type=\"simple\">www.goldcopd.org\/guidelines-globalstrategy-for-diagnosis-management.html<\/ext-link>"},{"issue":"3","key":"ref3","first-page":"263","article-title":"Adult Obstructive Sleep Apnea Task Force of the American Academy of Sleep Medicine","volume":"5","author":"LJ Epstein","year":"2009","journal-title":"Clinical Guideline for the Evaluation, Management and Long-term Care of Obstructive Sleep Apnea in Adults J Clin Sleep Med"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"237","DOI":"10.1513\/pats.200706-077MG","article-title":"Overlap syndrome. Obstructive sleep apnea in patients with chronic obstructive pulmonary disease","volume":"5","author":"E Weitzenblum","year":"2008","journal-title":"Proc Am Thorac Soc"},{"key":"ref5","unstructured":"Price D, Small M, Milligan G. The prevalence and impact of night-time symptoms in COPD patients\u2013results of a cross-sectional study in five European countries. Proc of the IV World Asthma and COPD Forum 2011"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"410","DOI":"10.1177\/1753465816661930","article-title":"Factors associated with experience of fatigue, and functional limitations due to fatigue in patients with stable COPD","volume":"10","author":"M Kentson","year":"2016","journal-title":"Ther Adv Respir Dis"},{"issue":"2","key":"ref7","first-page":"OC24","article-title":"Occurrence of Anxiety and Depression among Stable COPD Patients and its Impact on Functional Capability","volume":"11","author":"D Swas","year":"2017","journal-title":"Journal of Clinical and Diagnostic Research"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/sleep\/28.4.472","article-title":"Sleepiness in patients with moderate to severe sleep-disordered breathing","volume":"28","author":"VK Kapur","year":"2005","journal-title":"Sleep"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1111\/j.1600-0404.2007.00901.x","article-title":"Depression and anxiety in obstructive sleep apnea syndrome: a review","volume":"116","author":"T Saunamaki","year":"2007","journal-title":"Acta Neurol Scand"},{"issue":"3","key":"ref10","doi-asserted-by":"crossref","first-page":"263","DOI":"10.5664\/jcsm.27497","article-title":"Clinical guideline for the evaluation, management and long-term care of obstructive sleep apnea in adults","volume":"5","author":"LJ Epstein","year":"2009","journal-title":"J Clin Sleep Med"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"207","DOI":"10.1111\/j.1742-1241.2006.01213.x","article-title":"Health-related quality of life in patients with obstructive sleep apnoea and chronic obstructive pulmonary disease (overlap syndrome)","volume":"61","author":"C Mermigkis","year":"2007","journal-title":"Int J Clin Pract"},{"key":"ref12","first-page":"275","article-title":"Sleep Apnea Clinical Score, Berlin Questionnaire, or Epworth Sleepiness Scale: which is the best obstructive sleep apnea predictor in patients with COPD?","volume":"8","author":"AC Faria","year":"2015","journal-title":"Int J of Gen Med"},{"key":"ref13","article-title":"International Classification of Sleep Disorders: Diagnostic and Coding Manual","year":"2014"},{"issue":"6","key":"ref14","first-page":"540","article-title":"A new method for measuring daytime sleepiness: the Epworth Sleepiness Scale","volume":"14","author":"MW Johns","year":"1991"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"1601","DOI":"10.1093\/sleep\/31.11.1601","article-title":". Validation of the Fatigue Severity Scale in a Swiss cohort","volume":"31","author":"PO Valko","year":"2008","journal-title":"Sleep"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"361","DOI":"10.1111\/j.1600-0447.1983.tb09716.x","article-title":"The hospital anxiety and depression scale","volume":"67","author":"AS Zigmond","year":"1983","journal-title":"Acta Psychiatr Scand"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"597","DOI":"10.5664\/jcsm.2172","article-title":"Rules for scoring respiratory events in sleep: update of the 2007 AASM Manual for the Scoring of Sleep and Associated Events","volume":"8","author":"RB Berry","year":"2012","journal-title":"J Clin Sleep Med"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"711","DOI":"10.1093\/sleep\/30.6.711","article-title":"Relationship between hours of CPAP use and achieving normal levels of sleepiness and daily functioning","volume":"30","author":"TE Weaver","year":"2007","journal-title":"Sleep"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"4510","DOI":"10.1210\/jc.2005-0035","article-title":"Excessive daytime sleepiness in a general population sample: the role of sleep apnea, age, obesity, diabetes, and depression","volume":"90","author":"EO Bixler","year":"2005","journal-title":"J Clin Endocrinol Metab"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"472","DOI":"10.1093\/sleep\/28.4.472","article-title":"Sleepiness in patients with moderate to severe sleep-disordered breathing","volume":"28","author":"VK Kapur","year":"2005","journal-title":"Sleep"},{"key":"ref21","first-page":"265","article-title":"Sleep apnea: pathogenesis, diagnosis, and treatment","author":"DK Chugh","year":"2002"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"540","DOI":"10.1378\/chest.91.4.540","article-title":"Prevalence of reported sleep disturbances in a general adult population and their relationship to obstructive airways diseases","volume":"91","author":"M Klink","year":"1987","journal-title":"Chest"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"755","DOI":"10.1378\/chest.83.5.755","article-title":"Symptoms and experiences in chronic bronchitis and emphysema","volume":"83","author":"RA Kinsman","year":"1983","journal-title":"Chest"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"712","DOI":"10.1016\/j.sleep.2008.05.001","article-title":"Excessive Daytime Sleepiness in Sleep Apnea: It\u2019s Not Just Apnea Hypopnea Index","volume":"9","author":"AN Vgontzas","year":"2008","journal-title":"Sleep Med"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"372","DOI":"10.1378\/chest.118.2.372","article-title":"Sleepiness, fatigue, tiredness, and lack of energy in obstructive sleep apnea","volume":"118","author":"RD Chervin","year":"2000","journal-title":"Chest"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1093\/sleep\/34.1.121","article-title":"Effects of continuous positive airway pressure on fatigue and sleepiness in patients with obstructive sleep apnea: data from a randomized controlled trial","volume":"34","author":"LM Tomfohr","year":"2011","journal-title":"Sleep"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1186\/2049-6958-5-3-162","article-title":"Fatigue and multidimensional disease severity in chronic obstructive pulmonary disease","volume":"5","author":"D Inal-Ince","year":"2010","journal-title":"Multidiscip Respir Med"},{"issue":"9","key":"ref28","doi-asserted-by":"crossref","first-page":"655","DOI":"10.1016\/j.euroneuro.2011.07.018","article-title":"The size and burden of mental disorders and other disorders of the brain in Europe 2010","volume":"21","author":"HU Wittchen","year":"2011","journal-title":"Eur Neuropsychopharmacol"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"683","DOI":"10.5664\/jcsm.3802","article-title":"Validation of two depression screening instruments in a sleep disorders clinic","volume":"10","author":"M Law","year":"2014","journal-title":"J Clin Sleep Med"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"65","DOI":"10.1080\/08039480310000824","article-title":"Anxiety and depression in patients with chronic obstructive pulmonary disease (COPD). A review","volume":"58","author":"RL Mikkelsen","year":"2004","journal-title":"Nord J Psychiatry"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"163","DOI":"10.5664\/jcsm.3444","article-title":"Depression may reduce adherence during CPAP titration trial","volume":"10","author":"M Law","year":"2014","journal-title":"J Clin Sleep Med"},{"key":"ref32","first-page":"279","article-title":"Hospital anxiety and depression scale. A quantitative analysis in medical outpatients, psychiatric outpatients and normal subjects","volume":"21","author":"C Christodoulou","year":"2010","journal-title":"Psychiatriki"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1016\/j.smrv.2015.07.002","article-title":"The effect of treating obstructive sleep apnea with positive airway pressure on depression and other subjective symptoms: A systematic review and meta-analysis","volume":"28","author":"MA Gupta","year":"2016","journal-title":"Sleep Medicine Reviews"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0197342","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,8,25]],"date-time":"2022-08-25T13:22:06Z","timestamp":1661433726000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0197342"}},"subtitle":[],"editor":[{"given":"Andrea","family":"Romigi","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,11]]},"references-count":33,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,11]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0197342","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,11]]}}}