{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,12]],"date-time":"2026-09-12T15:20:06Z","timestamp":1789226406113,"version":"build-2803163510"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T00:00:00Z","timestamp":1527811200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001713","name":"European and Developing Countries Clinical Trials Partnership","doi-asserted-by":"publisher","award":["SP.2011.41304.043"],"award-info":[{"award-number":["SP.2011.41304.043"]}],"id":[{"id":"10.13039\/501100001713","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0197572","type":"journal-article","created":{"date-parts":[[2018,6,1]],"date-time":"2018-06-01T17:51:12Z","timestamp":1527875472000},"page":"e0197572","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":20,"title":["A randomised trial of a contraceptive vaginal ring in women at risk of HIV infection in Rwanda: Safety of intermittent and continuous use"],"prefix":"10.1371","volume":"13","author":[{"given":"Evelyne","family":"Kestelyn","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen","family":"Agaba","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jennifer Ilo","family":"Van Nuil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mireille","family":"Uwineza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marie Michelle","family":"Umulisa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lambert","family":"Mwambarangwe","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jean Claude","family":"Ndagijimana","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irith","family":"De Baetselier","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jozefien","family":"Buyze","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Th\u00e9r\u00e8se","family":"Delvaux","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tania","family":"Crucitti","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vicky","family":"Jespers","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2728-4560","authenticated-orcid":true,"given":"Janneke H. H. M.","family":"van de Wijgert","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"name":"for the Ring Plus Study Group","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,6,1]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"418","DOI":"10.1016\/j.contraception.2010.04.012","article-title":"Contraceptive vaginal rings: a review","volume":"82","author":"V Brache","year":"2010","journal-title":"Contraception"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"441","DOI":"10.2147\/TCRM.S1964","article-title":"Review of the combined contraceptive vaginal ring, NuvaRing","volume":"4","author":"FJ Roumen","year":"2008","journal-title":"Ther Clin Risk Manag"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1783\/147118908786000370","article-title":"Review of the vaginal contraceptive ring (NuvaRing\u00ae)","volume":"34","author":"N Shimoni","year":"2008","journal-title":"J Fam Plann Reprod Health Care"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"415","DOI":"10.3109\/13625187.2012.713535","article-title":"The contraceptive vaginal ring, NuvaRing \u00ae, a decade after its introduction","volume":"17","author":"FJME Roumen","year":"2012","journal-title":"Eur J Contracept Reprod Health Care"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"253","DOI":"10.1016\/j.contraception.2015.04.001","article-title":"Safety of the progesterone-releasing vaginal ring (PVR) among lactating women: A systematic review","volume":"94","author":"SL Carr","year":"2016","journal-title":"Contraception"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1055\/s-0034-1395273","article-title":"Unmet need for family planning: past achievements and remaining challenges","volume":"33","author":"J Cleland","year":"2015","journal-title":"Semin Reprod Med"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"2121","DOI":"10.1056\/NEJMoa1506110","article-title":"Use of a vaginal ring containing dapivirine for HIV-1 prevention in women","volume":"375","author":"JM Baeten","year":"2016","journal-title":"N Engl J Med"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"2133","DOI":"10.1056\/NEJMoa1602046","article-title":"Safety and efficacy of a dapivirine vaginal ring for HIV prevention in women","volume":"375","author":"A Nel","year":"2016","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1016\/j.tim.2015.02.006","article-title":"Multipurpose prevention technologies: the future of HIV and STI protection","volume":"23","author":"JA Fern\u00e1ndez-Romero","year":"2015","journal-title":"Trends Microbiol"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"169","DOI":"10.1111\/j.1728-4457.2013.00558.x","article-title":"The recent fertility transition in Rwanda","volume":"38","author":"CF Westhoff","year":"2013","journal-title":"Population and Development Review"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"2665","DOI":"10.1097\/QAD.0000000000001228","article-title":"An updated systematic review of epidemiological evidence on hormonal contraceptive methods and HIV acquisition in women","volume":"30","author":"CB Polis","year":"2016","journal-title":"AIDS"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"1531","DOI":"10.1097\/QAD.0b013e32832c413d","article-title":"Safety, tolerability, and systemic absorption of dapivirine vaginal microbicide gel in healthy, HIV-negative women","volume":"23","author":"AM Nel","year":"2009","journal-title":"AIDS"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"348","DOI":"10.1186\/s12889-015-1680-y","article-title":"The ring plus project: safety and acceptability of vaginal rings that protect women from unintended pregnancy","volume":"15","author":"C Schurmans","year":"2015","journal-title":"BMC Public Health"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1128\/JCM.29.2.297-301.1991","article-title":"Reliability of diagnosing bacterial vaginosis is improved by a standardized method of Gram stain interpretation","volume":"29","author":"RP Nugent","year":"1991","journal-title":"J Clin Microbiol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"109","DOI":"10.2165\/00002018-199920020-00002","article-title":"The medical dictionary for regulatory activities (MedDRA)","volume":"20","author":"EG Brown","year":"1999","journal-title":"Drug-Safety"},{"key":"ref16","article-title":"Rwanda Demographic and Health Survey 2010","year":"2012"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"469","DOI":"10.1093\/humrep\/16.3.469","article-title":"Efficacy, tolerability and acceptability of a novel contraceptive vaginal ring releasing etonogestrel and ethinyl oestradiol","volume":"16","author":"FJ Roumen","year":"2001","journal-title":"Hum Reprod"},{"key":"ref18","first-page":"585","article-title":"Efficacy, cycle control, and user acceptability of a novel combined contraceptive vaginal ring","volume":"100","author":"TO Dieben","year":"2002","journal-title":"Obstet Gynecol"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/j.contraception.2004.09.001","article-title":"Efficacy and safety of a contraceptive vaginal ring (NuvaRing) compared with a combined oral contraceptive: a 1-year randomized trial","volume":"71","author":"K Oddsson","year":"2005","journal-title":"Contraception"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1016\/j.contraception.2006.03.022","article-title":"Comparison profiles of cycle control, side effects and sexual satisfaction of three hormonal contraceptives","volume":"74","author":"R Sabatini","year":"2006","journal-title":"Contraception"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1007\/s13224-014-0559-7","article-title":"Multicenter Study of contraceptive vaginal ring (NuvaRing\u00ae) in normal daily practice in Indian women","volume":"64","author":"SN Pandit","year":"2014","journal-title":"J Obstet Gynaecol India"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"555","DOI":"10.1097\/01.AOG.0000136082.59644.13","article-title":"A comparison between the vaginal ring and oral contraceptives","volume":"104","author":"S Veres","year":"2004","journal-title":"Obstet Gynecol"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"511","DOI":"10.1016\/0010-7824(92)90163-N","article-title":"The effects of a combined contraceptive vaginal ring releasing ethinyloestradiol and 3-ketodesogestrel on vaginal flora","volume":"45","author":"GC Davies","year":"1992","journal-title":"Contraception"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"439","DOI":"10.1016\/j.contraception.2007.07.012","article-title":"Vaginal yeast adherence to the combined contraceptive vaginal ring (CCVR)","volume":"76","author":"DP Camacho","year":"2007","journal-title":"Contraception"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2141","DOI":"10.1097\/QAD.0b013e32836290b6","article-title":"Hormonal contraception decreases bacterial vaginosis but oral contraception may increase candidiasis: implications for HIV transmission","volume":"27","author":"JH van de Wijgert","year":"2013","journal-title":"AIDS"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1097\/01.AOG.0000175144.08035.74","article-title":"Extended regimens of the contraceptive vaginal ring: a randomized trial","volume":"106","author":"L Miller","year":"2005","journal-title":"Obstet Gynecol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0197572","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,3]],"date-time":"2020-11-03T01:25:56Z","timestamp":1604366756000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0197572"}},"subtitle":[],"editor":[{"given":"Patricia Evelyn","family":"Fast","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,1]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,1]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0197572","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,1]]}}}