{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,22]],"date-time":"2026-07-22T03:00:53Z","timestamp":1784689253310,"version":"3.55.0"},"reference-count":47,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["PA 2365\/1-1"],"award-info":[{"award-number":["PA 2365\/1-1"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001661","name":"Universit\u00e4t Heidelberg","doi-asserted-by":"publisher","award":["N\/A - Olympia Morata Postdoctoral Fellowship"],"award-info":[{"award-number":["N\/A - Olympia Morata Postdoctoral Fellowship"]}],"id":[{"id":"10.13039\/501100001661","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0197836","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T17:53:54Z","timestamp":1527184434000},"page":"e0197836","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":12,"title":["Anti-inflammatory properties of ursodeoxycholyl lysophosphatidylethanolamide in endotoxin-mediated inflammatory liver injury"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0838-8831","authenticated-orcid":true,"given":"Johannes Maximilian","family":"Ludwig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8956-2808","authenticated-orcid":true,"given":"Yuling","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Walee","family":"Chamulitrat","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wolfgang","family":"Stremmel","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anita","family":"Pathil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"key":"ref1","article-title":"Comparison of different bile acid-phospholipid conjugates in acute hepatitis","author":"A Pathil","year":"2011","journal-title":"Eur J Clin Invest"},{"issue":"22","key":"ref2","doi-asserted-by":"crossref","first-page":"5113","DOI":"10.1111\/bph.12837","article-title":"Ursodeoxycholyl lysophosphatidylethanolamide attenuates hepatofibrogenesis by impairment of TGF-beta1\/Smad2\/3 signalling","volume":"171","author":"A Pathil","year":"2014","journal-title":"British journal of pharmacology"},{"issue":"4","key":"ref3","doi-asserted-by":"crossref","first-page":"339","DOI":"10.1055\/s-2007-991511","article-title":"Innate immune response and hepatic inflammation","volume":"27","author":"G Szabo","year":"2007","journal-title":"Semin Liver Dis"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1186\/1755-1536-3-21","article-title":"Toll-like receptor 4 signaling in liver injury and hepatic fibrogenesis","volume":"3","author":"J Guo","year":"2010","journal-title":"Fibrogenesis Tissue Repair"},{"issue":"1","key":"ref5","doi-asserted-by":"crossref","first-page":"322","DOI":"10.1002\/hep.22306","article-title":"Toll-like receptors and adaptor molecules in liver disease: update","volume":"48","author":"E Seki","year":"2008","journal-title":"Hepatology"},{"issue":"11","key":"ref6","doi-asserted-by":"crossref","first-page":"1509","DOI":"10.1136\/gut.35.11.1509","article-title":"Cell biology of liver endothelial and Kupffer cells","volume":"35","author":"B Smedsrod","year":"1994","journal-title":"Gut"},{"key":"ref7","article-title":"Contribution of gut bacteria to liver pathobiology","volume":"2010","author":"G Son","year":"2010","journal-title":"Gastroenterol Res Pract"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"571","DOI":"10.1016\/j.jhep.2007.04.019","article-title":"Toll-like receptor-4 signaling and Kupffer cells play pivotal roles in the pathogenesis of non-alcoholic steatohepatitis","volume":"47","author":"CA Rivera","year":"2007","journal-title":"J Hepatol"},{"issue":"11","key":"ref9","doi-asserted-by":"crossref","first-page":"1324","DOI":"10.1038\/nm1663","article-title":"TLR4 enhances TGF-beta signaling and hepatic fibrosis","volume":"13","author":"E Seki","year":"2007","journal-title":"Nat Med"},{"issue":"2\u20133","key":"ref10","doi-asserted-by":"crossref","first-page":"87","DOI":"10.1016\/S1388-1981(02)00328-1","article-title":"Phosphatidylcholine and cell death","volume":"1585","author":"Z Cui","year":"2002","journal-title":"Biochim Biophys Acta"},{"issue":"7","key":"ref11","doi-asserted-by":"crossref","first-page":"817","DOI":"10.1016\/S0092-8674(03)00471-9","article-title":""Recruitment signals" from apoptotic cells: invitation to a quiet meal","volume":"113","author":"KS Ravichandran","year":"2003","journal-title":"Cell"},{"issue":"1","key":"ref12","doi-asserted-by":"crossref","first-page":"143","DOI":"10.1002\/hep.22955","article-title":"Bile salt-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide as a hepatoprotective agent","volume":"50","author":"W Chamulitrat","year":"2009","journal-title":"Hepatology"},{"key":"ref13","article-title":"The synthetic bile acid-phospholipid conjugate ursodeoxycholyl lysophosphatidylethanolamide suppresses TNFalpha-induced liver injury","author":"A Pathil","year":"2010","journal-title":"J Hepatol"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"1369","DOI":"10.1002\/hep.25531","article-title":"Ursodeoxycholyl lysophosphatidylethanolamide improves steatosis and inflammation in murine models of nonalcoholic fatty liver disease","volume":"55","author":"A Pathil","year":"2012","journal-title":"Hepatology"},{"issue":"3","key":"ref15","doi-asserted-by":"crossref","first-page":"209","DOI":"10.4196\/kjpp.2013.17.3.209","article-title":"Protective effect of phosphatidylcholine on lipopolysaccharide-induced acute inflammation in multiple organ injury","volume":"17","author":"YY Jung","year":"2013","journal-title":"Korean J Physiol Pharmacol"},{"issue":"5","key":"ref16","doi-asserted-by":"crossref","first-page":"466","DOI":"10.1016\/S0022-2143(99)90167-1","article-title":"Dilinoleoylphosphatidylcholine selectively modulates lipopolysaccharide-induced Kupffer cell activation","volume":"134","author":"CM Oneta","year":"1999","journal-title":"J Lab Clin Med"},{"issue":"4","key":"ref17","doi-asserted-by":"crossref","first-page":"849","DOI":"10.1016\/S0006-291X(02)00586-7","article-title":"Dilinoleoylphosphatidylcholine decreases LPS-induced TNF-alpha generation in Kupffer cells of ethanol-fed rats: respective roles of MAPKs and NF-kappaB","volume":"294","author":"Q Cao","year":"2002","journal-title":"Biochem Biophys Res Commun"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"342","DOI":"10.1016\/S0022-2143(99)90064-1","article-title":"Dilinoleoylphosphatidylcholine decreases hepatic stellate cell activation","volume":"133","author":"J Poniachik","year":"1999","journal-title":"J Lab Clin Med"},{"issue":"5","key":"ref19","doi-asserted-by":"crossref","first-page":"G1069","DOI":"10.1152\/ajpgi.90689.2008","article-title":"Role of the perforin\/granzyme cell death pathway in D-Gal\/LPS-induced inflammatory liver injury","volume":"296","author":"A Kuhla","year":"2009","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jhep.2008.08.009","article-title":"The importance of immune dysfunction in determining outcome in acute liver failure","volume":"49","author":"CG Antoniades","year":"2008","journal-title":"J Hepatol"},{"issue":"10","key":"ref21","doi-asserted-by":"crossref","first-page":"2127","DOI":"10.1021\/tx300228d","article-title":"Functionalization density dependent toxicity of oxidized multiwalled carbon nanotubes in a murine macrophage cell line","volume":"25","author":"RP Singh","year":"2012","journal-title":"Chem Res Toxicol"},{"issue":"5","key":"ref22","doi-asserted-by":"crossref","first-page":"G949","DOI":"10.1152\/ajpgi.00215.2003","article-title":"Human hepatic stellate cells express CCR5 and RANTES to induce proliferation and migration","volume":"285","author":"RF Schwabe","year":"2003","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"key":"ref23","article-title":"Pharmacological inhibition of the chemokine CCL2 (MCP-1) diminishes liver macrophage infiltration and steatohepatitis in chronic hepatic injury","author":"C Baeck","year":"2011","journal-title":"Gut"},{"issue":"2","key":"ref24","doi-asserted-by":"crossref","first-page":"220","DOI":"10.1111\/j.1600-6143.2009.02826.x","article-title":"Connective tissue growth factor promotes fibrosis downstream of TGFbeta and IL-6 in chronic cardiac allograft rejection","volume":"10","author":"AJ Booth","year":"2010","journal-title":"Am J Transplant"},{"issue":"5","key":"ref25","first-page":"353","article-title":"The effect of Kupffer cell elimination on ethanol-induced liver damage in mice","volume":"76","author":"RD Goldin","year":"1995","journal-title":"Int J Exp Pathol"},{"issue":"4","key":"ref26","doi-asserted-by":"crossref","first-page":"379","DOI":"10.1097\/SHK.0000000000000312","article-title":"Ursodeoxycholyl lysophosphatidylethanolamide protects against hepatic ischemia and reperfusion injury in mice","volume":"43","author":"J Wang","year":"2015","journal-title":"Shock"},{"issue":"5","key":"ref27","first-page":"1220","article-title":"Tumor necrosis factor-induced hepatocyte apoptosis precedes liver failure in experimental murine shock models","volume":"146","author":"M Leist","year":"1995","journal-title":"Am J Pathol"},{"issue":"3","key":"ref28","doi-asserted-by":"crossref","first-page":"734","DOI":"10.1128\/IAI.64.3.734-738.1996","article-title":"Apoptotic cell death in the response of D-galactosamine-sensitized mice to lipopolysaccharide as an experimental endotoxic shock model","volume":"64","author":"A Morikawa","year":"1996","journal-title":"Infect Immun"},{"issue":"6","key":"ref29","doi-asserted-by":"crossref","first-page":"757","DOI":"10.1080\/01926230701584163","article-title":"Role of neutrophils in the pathogenesis of acute inflammatory liver injury","volume":"35","author":"SK Ramaiah","year":"2007","journal-title":"Toxicol Pathol"},{"issue":"3","key":"ref30","doi-asserted-by":"crossref","first-page":"506","DOI":"10.1002\/hep.510230315","article-title":"The role of cytokine networks in the local liver injury following hepatic ischemia\/reperfusion in the rat","volume":"23","author":"LM Colletti","year":"1996","journal-title":"Hepatology"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"335","DOI":"10.1002\/path.1298","article-title":"Early up-regulation of chemokine expression in fulminant hepatic failure","volume":"199","author":"L Leifeld","year":"2003","journal-title":"J Pathol"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"e36614","DOI":"10.1371\/journal.pone.0036614","article-title":"Interference with oligomerization and glycosaminoglycan binding of the chemokine CCL5 improves experimental liver injury","volume":"7","author":"A Nellen","year":"2012","journal-title":"PLoS One"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1007\/s00534-010-0304-2","article-title":"Molecular mechanisms of liver regeneration and protection for treatment of liver dysfunction and diseases","volume":"18","author":"M Fujiyoshi","year":"2011","journal-title":"J Hepatobiliary Pancreat Sci"},{"issue":"2 Suppl 1","key":"ref34","doi-asserted-by":"crossref","first-page":"S45","DOI":"10.1002\/hep.20969","article-title":"Liver regeneration","volume":"43","author":"N Fausto","year":"2006","journal-title":"Hepatology"},{"issue":"4","key":"ref35","doi-asserted-by":"crossref","first-page":"1036","DOI":"10.1111\/j.1572-0241.2007.01709.x","article-title":"Cytokines in the pathogenesis of fatty liver and disease progression to steatohepatitis: implications for treatment","volume":"103","author":"C Carter-Kent","year":"2008","journal-title":"Am J Gastroenterol"},{"issue":"11","key":"ref36","doi-asserted-by":"crossref","first-page":"4129","DOI":"10.1172\/JCI41732","article-title":"Antagonism of the chemokine Ccl5 ameliorates experimental liver fibrosis in mice","volume":"120","author":"ML Berres","year":"2010","journal-title":"J Clin Invest"},{"issue":"1","key":"ref37","doi-asserted-by":"crossref","first-page":"4","DOI":"10.1007\/s12016-008-8091-0","article-title":"Inflammatory pathways in liver homeostasis and liver injury","volume":"36","author":"F Tacke","year":"2009","journal-title":"Clin Rev Allergy Immunol"},{"issue":"3","key":"ref38","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1182\/blood-2007-01-066027","article-title":"Lysosome-associated small Rab GTPase Rab7b negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4","volume":"110","author":"Y Wang","year":"2007","journal-title":"Blood"},{"key":"ref39","article-title":"Cicletanine stimulates eNOS phosphorylation and NO production via Akt and MAP kinase\/Erk signaling in sinusoidal endothelial cells","author":"S Liu","year":"2013","journal-title":"Am J Physiol Gastrointest Liver Physiol"},{"issue":"5 Pt 1","key":"ref40","first-page":"G1069","article-title":"Nitric Oxide. IV. Determinants of nitric oxide protection and toxicity in liver","volume":"276","author":"J Li","year":"1999","journal-title":"Am J Physiol"},{"issue":"1","key":"ref41","doi-asserted-by":"crossref","first-page":"9","DOI":"10.3164\/jcbn.11-06SR","article-title":"Physiological roles of NOX\/NADPH oxidase, the superoxide-generating enzyme","volume":"50","author":"M Katsuyama","year":"2012","journal-title":"J Clin Biochem Nutr"},{"issue":"Suppl 1","key":"ref42","first-page":"99","article-title":"Interaction of hepatic stellate cells with diverse types of immune cells: foe or friend?","volume":"28","author":"HS Yi","year":"2013","journal-title":"J Gastroenterol Hepatol"},{"issue":"9","key":"ref43","doi-asserted-by":"crossref","first-page":"4214","DOI":"10.1091\/mbc.e05-02-0149","article-title":"Smad2 and Smad3 play different roles in rat hepatic stellate cell function and alpha-smooth muscle actin organization","volume":"16","author":"M Uemura","year":"2005","journal-title":"Mol Biol Cell"},{"key":"ref44","article-title":"TGF-beta mediated connective tissue growth factor (CTGF) expression in hepatic stellate cells requires Stat3 activation","author":"Y Liu","year":"2013","journal-title":"J Biol Chem"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"212","DOI":"10.1016\/j.cyto.2007.03.013","article-title":"Glutathione depletion is involved in the inhibition of procollagen alpha1(I) mRNA levels caused by TNF-alpha on hepatic stellate cells","volume":"37","author":"M Varela-Rey","year":"2007","journal-title":"Cytokine"},{"issue":"8","key":"ref46","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1111\/j.1478-3231.2008.01826.x","article-title":"Connective tissue growth factor: a fibrogenic master switch in fibrotic liver diseases","volume":"28","author":"OA Gressner","year":"2008","journal-title":"Liver Int"},{"issue":"2","key":"ref47","doi-asserted-by":"crossref","first-page":"533","DOI":"10.1002\/hep.22637","article-title":"Fibrogenesis in pediatric cholestatic liver disease: role of taurocholate and hepatocyte-derived monocyte chemotaxis protein-1 in hepatic stellate cell recruitment","volume":"49","author":"GA Ramm","year":"2009","journal-title":"Hepatology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0197836","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T23:56:23Z","timestamp":1720310183000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0197836"}},"subtitle":[],"editor":[{"given":"Matias A","family":"Avila","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,24]]},"references-count":47,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0197836","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,24]]}}}