{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,25]],"date-time":"2026-08-25T17:30:49Z","timestamp":1787679049775,"version":"build-2784847793"},"reference-count":62,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003593","name":"Conselho Nacional de Desenvolvimento Cient\u00edfico e Tecnol\u00f3gico","doi-asserted-by":"publisher","award":["442837-2014-3"],"award-info":[{"award-number":["442837-2014-3"]}],"id":[{"id":"10.13039\/501100003593","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0197841","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T13:31:10Z","timestamp":1528464670000},"page":"e0197841","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":25,"title":["MLST reveals a clonal population structure for Cryptococcus neoformans molecular type VNI isolates from clinical sources in Amazonas, Northern-Brazil"],"prefix":"10.1371","volume":"13","author":[{"given":"Diego Fernando Silva","family":"Rocha","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Katia Santana","family":"Cruz","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carla Silvana da Silva","family":"Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lizandra Stephanny Fernandes","family":"Menescal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jo\u00e3o Ricardo da Silva","family":"Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silviane Bezerra","family":"Pinheiro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucyane Mendes","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana","family":"Trilles","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3163-7499","authenticated-orcid":true,"given":"Jo\u00e3o Vicente","family":"Braga de Souza","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"513","DOI":"10.1590\/S0074-02762009000300019","article-title":"Mortality due to systemic mycoses as a primary cause of death or in association with AIDS in Brazil: A review from 1996 to 2006","volume":"104","author":"M Prado","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"525","DOI":"10.1097\/QAD.0b013e328322ffac","article-title":"Estimation of the current global burden of cryptococcal meningitis among persons living with HIV\/AIDS","volume":"23","author":"BJ Park","year":"2009","journal-title":"AIDS"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"79","DOI":"10.1590\/0037-8682-0116-2014","article-title":"Epidemiology of infectious meningitis in the state of Amazonas, Brazil","volume":"48","author":"MDGG Saraiva","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1590\/0037-8682-0121-2013","article-title":"HIV\/AIDS epidemic in the state of Amazonas: characteristics and trends from 2001 to 2012","volume":"48","author":"RDSM De Oliveira","year":"2015","journal-title":"Rev Soc Bras Med Trop"},{"key":"ref5","first-page":"1","article-title":"The Case for Adopting the \u201cSpecies Complex\u201d Nomenclature for the Etiologic Agents of Cryptococcosis","volume":"2","author":"KJ Kwon-chung","year":"2017","journal-title":"mSphere"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"509","DOI":"10.1111\/myc.12499","article-title":"Molecular typing of environmental <italic>Cryptococcus neoformans\/C<\/italic>. <italic>gattii<\/italic> species complex isolates from Manaus, Amazonas, Brazil","volume":"59","author":"GSB Alves","year":"2016","journal-title":"Mycoses"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"662","DOI":"10.1590\/S0074-02762009000400023","article-title":"First isolation of <italic>Cryptococcus gattii<\/italic> molecular type VGII and <italic>Cryptococcus neoformans<\/italic> molecular type VNI from environmental sources in the city of Bel\u00e9m, Par\u00e1, Brazil","volume":"104","author":"S Costa","year":"2009","journal-title":"Mem Inst Oswaldo Cruz"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"646","DOI":"10.1111\/myc.12084","article-title":"<italic>Cryptococcus gattii<\/italic> in urban trees from cities in North-eastern Argentina","volume":"56","author":"M Mazza","year":"2013","journal-title":"Mycoses"},{"key":"ref9","article-title":"Isolation, Identification and Molecular Typing of <italic>Cryptococcus neoformans<\/italic> from Pigeon Droppings and Other Environmental Sources in Tripoli, Libya","author":"MS Ellabib","year":"2016","journal-title":"Mycopathologia"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"4345","DOI":"10.1128\/IAI.00542-09","article-title":"Spores as infectious propagules of <italic>Cryptococcus neoformans<\/italic>","volume":"77","author":"R Velagapudi","year":"2009","journal-title":"Infect Immun"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"789","DOI":"10.1093\/cid\/cis529","article-title":"Clinical manifestations of <italic>Cryptococcus gattii<\/italic> infection: Determinants of neurological sequelae and death","volume":"55","author":"SCA Chen","year":"2012","journal-title":"Clin Infect Dis"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"132","DOI":"10.1016\/j.jns.2016.06.069","article-title":"Spectrum of neuroimaging findings in cryptococcal meningitis in immunocompetent patients in China\u2014A series of 18 cases","volume":"368","author":"ZR Tan","year":"2016","journal-title":"J Neurol Sci"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"120","DOI":"10.1128\/IAI.01065-08","article-title":"Evidence of a role for monocytes in dissemination and brain invasion by <italic>Cryptococcus neoformans<\/italic>","volume":"77","author":"C Charlier","year":"2009","journal-title":"Infect Immun"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"873","DOI":"10.1016\/S1473-3099(17)30243-8","article-title":"Global burden of disease of HIV-associated cryptococcal meningitis: an updated analysis","volume":"17","author":"R Rajasingham","year":"2017","journal-title":"Lancet Infect Dis"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/myc.12427","article-title":"The burden of serious human fungal infections in Brazil","volume":"59","author":"J Giacomazzi","year":"2016","journal-title":"Mycoses"},{"key":"ref16","unstructured":"Minist\u00e9rio da Sa\u00fade. Vigil\u00e2ncia epidemiologica da Criptococose. In: Minist\u00e9rio da Sa\u00fade [Internet]. Bras\u00edlia (DF), Brazil; 2012 pp. 1\u201318. Available: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/www.sgc.goias.gov.br\/upload\/arquivos\/2012-05\/proposta_ve-criptococose1.pdf\" xlink:type=\"simple\">www.sgc.goias.gov.br\/upload\/arquivos\/2012-05\/proposta_ve-criptococose1.pdf<\/ext-link>"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"187","DOI":"10.1016\/j.ijmm.2016.03.010","article-title":"The absence of microbiota delays the inflammatory response to <italic>Cryptococcus gattii<\/italic>","volume":"306","author":"MC Costa","year":"2016","journal-title":"Int J Med Microbiol"},{"key":"ref18","first-page":"e00912","article-title":"Anti-granulocyte-macrophage colony-stimulating fator autoantibodies are a risk factor for central nervous system infection by <italic>Cryptococcus gattii<\/italic> in otherwise immunocompetent patients","volume":"5","author":"T Saijo","year":"2014","journal-title":"2mBio"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"1790","DOI":"10.1002\/(SICI)1522-2683(19990101)20:8<1790::AID-ELPS1790>3.0.CO;2-2","article-title":"Molecular typing of global isolates of <italic>Cryptococcus neoformans<\/italic> var. <italic>neoformans<\/italic> by polymerase chain reaction fingerprinting and randomly amplified polymorphic DNA\u2014A pilot study to standardize techniques on which to base a detailed epidemiological survey","volume":"20","author":"W Meyer","year":"1999","journal-title":"Electrophoresis"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"189","DOI":"10.3201\/eid0902.020246","article-title":"Molecular typing of IberoAmerican <italic>Cryptococcus neoformans<\/italic> isolates","volume":"9","author":"W Meyer","year":"2003","journal-title":"Emerg Infect Dis"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"561","DOI":"10.1080\/13693780902953886","article-title":"Consensus multi-locus sequence typing scheme for <italic>Cryptococcus neoformans<\/italic> and <italic>Cryptococcus gattii<\/italic>","volume":"47","author":"W Meyer","year":"2009","journal-title":"Med Mycol"},{"key":"ref22","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0115866","article-title":"Environmental isolation of <italic>Cryptococcus gattii<\/italic> VGII from indoor dust from typical wooden houses in the deep Amazonas of the rio Negro basin","volume":"10","author":"F Brito-Santos","year":"2015","journal-title":"PLoS One"},{"key":"ref23","first-page":"1","article-title":"Population Genetic Analysis Reveals a High Genetic Diversity in the Brazilian <italic>Cryptococcus gattii<\/italic> VGII Population and Shifts the Global Origin from the Amazon Rainforest to the Semi-arid Desert in the Northeast of Brazil","volume":"10","author":"ACP Souto","year":"2016","journal-title":"PLoS Negl Trop Dis"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"40","DOI":"10.1016\/j.riam.2011.05.003","article-title":"Characterization of clinical isolates of the <italic>Cryptococcus neoformans-Cryptococcus gattii<\/italic> species complex from the Amazonas State in Brazil","volume":"29","author":"BK Da Silva","year":"2012","journal-title":"Rev Iberoam Micol"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"2873","DOI":"10.1128\/JCM.39.8.2873-2879.2001","article-title":"Detection and identification of fungal pathogens by PCR and by ITS2 and 5.8S ribosomal DNA typing in ocular infections","volume":"39","author":"C Ferrer","year":"2001","journal-title":"J Clin Microbiol"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"2677","DOI":"10.1093\/nar\/15.6.2677","article-title":"Charons 36 to 40: multi enzyme, high capacity, recombination deficient replacement vectors with polylinkers and polystuffers","volume":"15","author":"IS Dunn","year":"1987","journal-title":"Nucleic Acids Res"},{"key":"ref27","doi-asserted-by":"crossref","first-page":"2725","DOI":"10.1093\/molbev\/mst197","article-title":"EGA6: Molecular evolutionary genetics analysis version 6.0","volume":"30","author":"K Tamura","year":"2013","journal-title":"Mol Biol Evol"},{"key":"ref28","unstructured":"Clinical and Laboratory Standard Institute (CLSI). Reference Method for Broth Dilution Antifungal Susceptibility Testing of Yeasts -Third Edition. CLSI document M27-A3. 2008."},{"key":"ref29","doi-asserted-by":"crossref","first-page":"5898","DOI":"10.1128\/AAC.01115-12","article-title":"<italic>Cryptococcus neoformans-Cryptococcus gattii<\/italic> species complex: An international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for fluconazole, itraconazole, posaconazole, and voriconazole","volume":"56","author":"A Espinel-Ingroff","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"3107","DOI":"10.1128\/AAC.06252-11","article-title":"<italic>Cryptococcus neoformans-Cryptococcus gattii<\/italic> species complex: an international study of wild-type susceptibility endpoint distributions and epidemiological cutoff values for amphotericin B and flucytosine","volume":"56","author":"A Espinel-Ingroff","year":"2012","journal-title":"Antimicrob Agents Chemother"},{"key":"ref31","doi-asserted-by":"crossref","first-page":"294","DOI":"10.1111\/j.1439-0507.2010.01901.x","article-title":"Genotyping of <italic>Cryptococcus neoformans<\/italic> isolated from captive birds in Uberaba, Minas Gerais, Brazil","volume":"54","author":"K Ferreira-Paim","year":"2011","journal-title":"Mycoses"},{"key":"ref32","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1371\/journal.pntd.0005223","article-title":"MLST-Based population genetic analysis in a global context reveals clonality amongst <italic>Cryptococcus neoformans<\/italic> var. <italic>grubii<\/italic> VNI isolates from HIV patients in Southeastern Brazil","volume":"11","author":"K Ferreira-Paim","year":"2017","journal-title":"PLoS Negl Trop Dis"},{"key":"ref33","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1007\/s00430-014-0341-6","article-title":"Molecular typing of clinical <italic>Cryptococcus neoformans<\/italic> isolates collected in Germany from 2004 to 2010","volume":"203","author":"A Sanchini","year":"2014","journal-title":"Med Microbiol Immunol"},{"key":"ref34","doi-asserted-by":"crossref","first-page":"2223","DOI":"10.1534\/genetics.105.046672","article-title":"Multilocus Sequence Typing Reveals Three Genetic Subpopulations of <italic>Cryptococcus neoformans<\/italic> var. <italic>grubii<\/italic> (Serotype A), Including a Unique Population in Botswana","volume":"172","author":"AP Litvintseva","year":"2006","journal-title":"Genetics"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pntd.0003847","article-title":"Genotypic diversity is associated with clinical outcome and phenotype in cryptococcal meningitis across Southern Africa","volume":"9","author":"MA Beale","year":"2015","journal-title":"PLoS Negl Trop Dis"},{"key":"ref36","first-page":"1","article-title":"Cryptococcal Genotype Influences Immunological Response and Human Clinical Outcome after Meningitis","volume":"3","author":"DL Wiesner","year":"2012","journal-title":"MbioAsmOrg"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1371\/journal.pone.0072222","article-title":"Geographically Structured Populations of <italic>Cryptococcus neoformans<\/italic> Variety <italic>grubii<\/italic> in Asia Correlate with HIV Status and Show a Clonal Population Structure","volume":"8","author":"K Khayhan","year":"2013","journal-title":"PLoS One"},{"key":"ref38","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0016936","article-title":"Clonality and a -a Recombination in the Australian <italic>Cryptococcus gattii<\/italic> VGII Population\u2014An Emerging Outbreak in Australia","volume":"6","author":"F Carriconde","year":"2011","journal-title":"PLoS One"},{"key":"ref39","doi-asserted-by":"crossref","DOI":"10.1128\/mBio.01464-14","article-title":"<italic>Cryptococcus gattii<\/italic> in North American Pacific Northwest: Whole-Population Genome Analysis Provides Insights into Species Evolution and Dispersal","volume":"5","author":"DM Engelthaler","year":"2014","journal-title":"MBio"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"e145","DOI":"10.1111\/j.1439-0507.2012.02173.x","article-title":"Molecular characterisation of the causative agents of Cryptococcosis in patients of a tertiary healthcare facility in the state of Amazonas-Brazil","volume":"55","author":"AKL Freire","year":"2012","journal-title":"Mycoses"},{"key":"ref41","doi-asserted-by":"crossref","first-page":"736","DOI":"10.1093\/cid\/cit794","article-title":"Determinants of mortality in a combined cohort of 501 patients with HIV-associated cryptococcal meningitis: Implications for improving outcomes","volume":"58","author":"JN Jarvis","year":"2014","journal-title":"Clin Infect Dis"},{"key":"ref42","doi-asserted-by":"crossref","first-page":"251","DOI":"10.7196\/SAMJ.4378","article-title":"Poor long-term outcomes for cryptococcal meningitis in rural South Africa","volume":"101","author":"RJ Lessells","year":"2011","journal-title":"S Afr Med J"},{"key":"ref43","doi-asserted-by":"crossref","first-page":"e85","DOI":"10.1097\/QAI.0b013e31824c837e","article-title":"Integrating cryptococcal antigen screening and pre-emptive treatment into routine HIV care","volume":"59","author":"R Rajasingham","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref44","doi-asserted-by":"crossref","first-page":"1539","DOI":"10.1111\/tmi.12790","article-title":"Asymptomatic cryptococcal antigen prevalence detected by lateral flow assay in hospitalised HIV-infected patients in S\u00e3o Paulo, Brazil","volume":"21","author":"JE Vidal","year":"2016","journal-title":"Trop Med Int Heal"},{"key":"ref45","doi-asserted-by":"crossref","first-page":"321","DOI":"10.1007\/s11046-011-9504-9","article-title":"Clinical, Epidemiological and Outcome Features of Patients with Cryptococcosis in Uberaba, Minas Gerais, Brazil","author":"DJ Mora","year":"2012","journal-title":"Mycopathologia"},{"key":"ref46","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0060431","article-title":"Predictors of Mortality and Differences in Clinical Features among Patients with Cryptococcosis According to Immune Status","volume":"8","author":"KD Brizendine","year":"2013","journal-title":"PLoS One"},{"key":"ref47","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1016\/j.jmii.2010.08.011","article-title":"Comparisons of clinical features and mortality of cryptococcal meningitis between patients with and without human immunodeficiency virus infection","volume":"44","author":"Y Lee","year":"2011","journal-title":"J Microbiol Immunol Infect"},{"key":"ref48","doi-asserted-by":"crossref","first-page":"217","DOI":"10.1177\/1941874415569072","article-title":"Direct Invasion of the Optic Nerves, Chiasm, and Tracts by <italic>Cryptococcus neoformans<\/italic> in an Immunocompetent Host","volume":"5","author":"AE Merkler","year":"2015","journal-title":"The Neurohospitalist"},{"key":"ref49","doi-asserted-by":"crossref","first-page":"124","DOI":"10.3109\/01658107.2013.792359","article-title":"The Optic Nerve Compartment Syndrome in <italic>Cryptococcus<\/italic> -Induced Visual Loss","volume":"37","author":"A Moodley","year":"2013","journal-title":"Neuro-Ophthalmology"},{"key":"ref50","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1016\/j.jcjo.2014.06.012","article-title":"Neuro-ophthalmic presentations and treatment of Cryptococcal meningitis-related increased intracranial pressure","volume":"49","author":"AEB Palau","year":"2014","journal-title":"Can J Ophthalmol"},{"key":"ref51","doi-asserted-by":"crossref","DOI":"10.1371\/journal.ppat.1001343","article-title":"Low diversity <italic>Cryptococcus neoformans<\/italic> variety <italic>grubii<\/italic> multilocus sequence types from Thailand are consistent with an ancestral African origin","volume":"7","author":"SP Simwami","year":"2011","journal-title":"PLoS Pathog"},{"key":"ref52","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1371\/journal.ppat.1002495","article-title":"Population genetic analyses reveal the African origin and strain variation of <italic>Cryptococcus neoformans<\/italic> var. <italic>grubii<\/italic>","volume":"8","author":"AP Litvintseva","year":"2012","journal-title":"PLoS Pathog"},{"key":"ref53","doi-asserted-by":"crossref","DOI":"10.1371\/journal.pone.0019688","article-title":"Evidence that the human pathogenic fungus <italic>Cryptococcus neoformans<\/italic> var. <italic>grubii<\/italic> may have evolved in Africa","volume":"6","author":"AP Litvintseva","year":"2011","journal-title":"PLoS One"},{"key":"ref54","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1534\/genetics.117.203836","article-title":"Tracing Genetic Exchange and Biogeography of <italic>Cryptococcus neoformans<\/italic> var. <italic>grubii<\/italic> at the Global Population Level","volume":"207","author":"J Rhodes","year":"2017","journal-title":"Genetics"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"328","DOI":"10.3109\/13693786.2011.602126","article-title":"Correlation of antifungal susceptibility and molecular type within the <italic>Cryptococcus neoformans\/C<\/italic>. <italic>gattii<\/italic> species complex","volume":"50","author":"L Trilles","year":"2011","journal-title":"Med Mycol"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1803","DOI":"10.1007\/s10096-016-2731-8","article-title":"Molecular characterisation and antifungal susceptibility of clinical <italic>Cryptococcus deuterogattii<\/italic> (AFLP6\/VGII) isolates from Southern Brazil","volume":"35","author":"PF Herkert","year":"2016","journal-title":"European Journal of Clinical Microbiology & Infectious Diseases"},{"key":"ref57","doi-asserted-by":"crossref","first-page":"4115","DOI":"10.1128\/JCM.01271-10","article-title":"In vitro susceptibility of the yeast pathogen <italic>Cryptococcus<\/italic> to fluconazole and other azoles varies with molecular genotype","volume":"48","author":"HS Chong","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"539","DOI":"10.1128\/JCM.01505-09","article-title":"Correlation of genotype and in vitro susceptibilities of <italic>Cryptococcus gattii<\/italic> strains from the Pacific Northwest of the United States","volume":"48","author":"N Iqbal","year":"2010","journal-title":"J Clin Microbiol"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"2804","DOI":"10.1128\/AAC.00295-09","article-title":"Heteroresistance to fluconazole in <italic>Cryptococcus neoformans<\/italic> is intrinsic and associated with virulence","volume":"53","author":"E Sionov","year":"2009","journal-title":"Antimicrob Agents Chemother"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"5127","DOI":"10.1128\/AAC.00694-13","article-title":"Azole heteroresistance in <italic>Cryptococcus neoformans<\/italic>: Emergence of resistant clones with chromosomal disomy in the mouse brain during fluconazole treatment","volume":"57","author":"E Sionov","year":"2013","journal-title":"Antimicrob Agents Chemother"},{"key":"ref61","doi-asserted-by":"crossref","first-page":"2303","DOI":"10.1128\/AAC.00153-10","article-title":"Heteroresistance of <italic>Cryptococcus gattii<\/italic> to fluconazole","volume":"54","author":"A Varma","year":"2010","journal-title":"Antimicrob Agents Chemother"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1099\/jmm.0.031344-0","article-title":"In vitro antifungal susceptibilities and molecular typing of sequentially isolated clinical <italic>Cryptococcus neoformans<\/italic> strains from Croatia","volume":"60","author":"E Mlinari\u0107-Missoni","year":"2011","journal-title":"J Med Microbiol"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0197841","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,24]],"date-time":"2018-10-24T01:08:33Z","timestamp":1540343313000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0197841"}},"subtitle":[],"editor":[{"given":"Robin Charles","family":"May","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,8]]},"references-count":62,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0197841","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,8]]}}}