{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,13]],"date-time":"2026-01-13T07:10:13Z","timestamp":1768288213136,"version":"3.49.0"},"reference-count":45,"publisher":"Public Library of Science (PLoS)","issue":"5","license":[{"start":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T00:00:00Z","timestamp":1527120000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0197915","type":"journal-article","created":{"date-parts":[[2018,5,24]],"date-time":"2018-05-24T18:08:02Z","timestamp":1527185282000},"page":"e0197915","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Identification of peculiar gene expression profile in peripheral blood mononuclear cells (PBMC) of celiac patients on gluten free diet"],"prefix":"10.1371","volume":"13","author":[{"given":"Moris","family":"Sangineto","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giusi","family":"Graziano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Simona","family":"D\u2019Amore","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberto","family":"Salvia","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Giuseppe","family":"Palasciano","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carlo","family":"Sabb\u00e0","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michele","family":"Vacca","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7537-6657","authenticated-orcid":true,"given":"Marica","family":"Cariello","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,5,24]]},"reference":[{"issue":"25","key":"ref1","doi-asserted-by":"crossref","first-page":"2419","DOI":"10.1056\/NEJMcp1113994","article-title":"Clinical practice. Celiac disease","volume":"367","author":"A Fasano","year":"2012","journal-title":"N Engl J Med"},{"issue":"4","key":"ref2","doi-asserted-by":"crossref","first-page":"S57","DOI":"10.1053\/j.gastro.2005.02.014","article-title":"The prevalence of celiac disease in average-risk and at-risk Western European populations: a systematic review","volume":"128","author":"C Dube","year":"2005","journal-title":"Gastroenterology"},{"issue":"9673","key":"ref3","doi-asserted-by":"crossref","first-page":"1480","DOI":"10.1016\/S0140-6736(09)60254-3","article-title":"Coeliac disease","volume":"373","author":"SA Di","year":"2009","journal-title":"Lancet"},{"issue":"5","key":"ref4","doi-asserted-by":"crossref","first-page":"1099","DOI":"10.1016\/j.jaci.2015.01.044","article-title":"Celiac disease","volume":"135","author":"PH Green","year":"2015","journal-title":"J Allergy Clin Immunol"},{"issue":"12","key":"ref5","doi-asserted-by":"crossref","first-page":"1193","DOI":"10.1038\/ng.998","article-title":"Dense genotyping identifies and localizes multiple common and rare variant association signals in celiac disease","volume":"43","author":"G Trynka","year":"2011","journal-title":"Nat Genet"},{"issue":"5","key":"ref6","doi-asserted-by":"crossref","first-page":"1298","DOI":"10.1093\/hmg\/ddt520","article-title":"Coregulation and modulation of NFkappaB-related genes in celiac disease: uncovered aspects of gut mucosal inflammation","volume":"23","author":"N Fernandez-Jimenez","year":"2014","journal-title":"Hum Mol Genet"},{"issue":"2","key":"ref7","doi-asserted-by":"crossref","first-page":"121","DOI":"10.1097\/MCG.0b013e31827a6f83","article-title":"World Gastroenterology Organisation global guidelines on celiac disease","volume":"47","author":"JC Bai","year":"2013","journal-title":"J Clin Gastroenterol"},{"issue":"11","key":"ref8","doi-asserted-by":"crossref","first-page":"1171","DOI":"10.1001\/jama.2009.1320","article-title":"Small-intestinal histopathology and mortality risk in celiac disease","volume":"302","author":"JF Ludvigsson","year":"2009","journal-title":"JAMA"},{"issue":"7","key":"ref9","doi-asserted-by":"crossref","first-page":"2718","DOI":"10.3390\/nu6072718","article-title":"Long term follow up of celiac disease-is atherosclerosis a problem?","volume":"6","author":"A Rybak","year":"2014","journal-title":"Nutrients"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1186\/1755-8794-3-15","article-title":"Peripheral blood gene expression patterns discriminate among chronic inflammatory diseases and healthy controls and identify novel targets","volume":"3","author":"B Mesko","year":"2010","journal-title":"BMC Med Genomics"},{"issue":"12","key":"ref11","doi-asserted-by":"crossref","first-page":"2289","DOI":"10.1016\/j.bbadis.2013.09.006","article-title":"Nuclear receptors expression chart in peripheral blood mononuclear cells identifies patients with Metabolic Syndrome","volume":"1832","author":"S D'Amore","year":"2013","journal-title":"Biochim Biophys Acta"},{"issue":"5","key":"ref12","doi-asserted-by":"crossref","first-page":"428","DOI":"10.1089\/ars.2011.4062","article-title":"Coagulation activation is associated with nicotinamide adenine dinucleotide phosphate oxidase-dependent reactive oxygen species generation in hemodialysis patients","volume":"16","author":"M Cariello","year":"2012","journal-title":"Antioxid Redox Signal"},{"issue":"2","key":"ref13","doi-asserted-by":"crossref","first-page":"228","DOI":"10.1093\/cvr\/cvv266","article-title":"Integrative miRNA and whole-genome analyses of epicardial adipose tissue in patients with coronary atherosclerosis","volume":"109","author":"M Vacca","year":"2016","journal-title":"Cardiovasc Res"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"289","DOI":"10.1111\/j.2517-6161.1995.tb02031.x","article-title":"Controlling the False Discovery Rate: A Practical and Powerful Approach to Multiple Testing","volume":"57","author":"J Benjamini","year":"1995","journal-title":"Journal of the Royal Statistical Society"},{"issue":"1","key":"ref15","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1038\/nrg1749","article-title":"Microarray data analysis: from disarray to consolidation and consensus","volume":"7","author":"DB Allison","year":"2006","journal-title":"Nat Rev Genet"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"3","DOI":"10.1186\/1471-2105-7-3","article-title":"Gene selection and classification of microarray data using random forest","volume":"7","author":"R Diaz-Uriarte","year":"2006","journal-title":"BMC Bioinformatics"},{"issue":"Suppl 5","key":"ref17","doi-asserted-by":"crossref","first-page":"S1","DOI":"10.1186\/1471-2164-12-S5-S1","article-title":"Gene selection and classification for cancer microarray data based on machine learning and similarity measures","volume":"12","author":"Q Liu","year":"2011","journal-title":"BMC Genomics"},{"issue":"1","key":"ref18","first-page":"330","article-title":"Gluten, major histocompatibility complex, and the small intestine. A molecular and immunobiologic approach to the spectrum of gluten sensitivity (&apos;celiac sprue&apos;)","volume":"102","author":"MN Marsh","year":"1992","journal-title":"Gastroenterology"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/011542650602100101","article-title":"Gluten-free diet: the medical and nutrition management of celiac disease","volume":"21","author":"J See","year":"2006","journal-title":"Nutr Clin Pract"},{"issue":"3","key":"ref20","doi-asserted-by":"crossref","first-page":"332","DOI":"10.1111\/apt.12164","article-title":"Mucosal healing and mortality in coeliac disease","volume":"37","author":"B Lebwohl","year":"2013","journal-title":"Aliment Pharmacol Ther"},{"issue":"3","key":"ref21","doi-asserted-by":"crossref","first-page":"371","DOI":"10.2337\/dc15-2117","article-title":"Celiac Disease Increases Risk of Thyroid Disease in Patients With Type 1 Diabetes: A Nationwide Cohort Study","volume":"39","author":"M Kurien","year":"2016","journal-title":"Diabetes Care"},{"issue":"1","key":"ref22","doi-asserted-by":"crossref","first-page":"50","DOI":"10.1016\/j.humimm.2009.09.351","article-title":"Serum cytokine elevations in celiac disease: association with disease presentation","volume":"71","author":"JS Manavalan","year":"2010","journal-title":"Hum Immunol"},{"issue":"4","key":"ref23","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1038\/pr.2015.112","article-title":"Overexpression of Hsp70 confers cytoprotection during gliadin exposure in Caco-2 cells","volume":"78","author":"B Bidmon-Fliegenschnee","year":"2015","journal-title":"Pediatr Res"},{"issue":"6","key":"ref24","doi-asserted-by":"crossref","first-page":"1181","DOI":"10.1093\/carcin\/bgt111","article-title":"The HSP70 family and cancer","volume":"34","author":"ME Murphy","year":"2013","journal-title":"Carcinogenesis"},{"issue":"5","key":"ref25","doi-asserted-by":"crossref","first-page":"689","DOI":"10.1002\/ijc.2910600520","article-title":"Over-expression of hsp70 confers tumorigenicity to mouse fibrosarcoma cells","volume":"60","author":"M Jaattela","year":"1995","journal-title":"Int J Cancer"},{"issue":"1","key":"ref26","doi-asserted-by":"crossref","first-page":"43","DOI":"10.1023\/A:1005706110275","article-title":"Proliferating cell nuclear antigen and heat shock protein 70 immunolocalization in invasive ductal breast cancer not otherwise specified","volume":"43","author":"AC Lazaris","year":"1997","journal-title":"Breast Cancer Res Treat"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"164","DOI":"10.1016\/j.tibs.2006.01.006","article-title":"Heat shock proteins in cancer: chaperones of tumorigenesis","volume":"31","author":"SK Calderwood","year":"2006","journal-title":"Trends Biochem Sci"},{"issue":"2","key":"ref28","doi-asserted-by":"crossref","first-page":"86","DOI":"10.1379\/CSC-99r.1","article-title":"Heat shock proteins in cancer: diagnostic, prognostic, predictive, and treatment implications","volume":"10","author":"DR Ciocca","year":"2005","journal-title":"Cell Stress Chaperones"},{"issue":"8","key":"ref29","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1016\/S0198-8859(01)00277-4","article-title":"Heat-shock protein 70\u20131 and HLA class II gene polymorphisms associated with celiac disease susceptibility in Navarra (Spain)","volume":"62","author":"MA Ramos-Arroyo","year":"2001","journal-title":"Hum Immunol"},{"issue":"1","key":"ref30","doi-asserted-by":"crossref","first-page":"15","DOI":"10.1111\/j.1399-0039.1993.tb01971.x","article-title":"HLA-linked heat-shock protein 70 (HSP70-2) gene polymorphism and celiac disease","volume":"41","author":"J Partanen","year":"1993","journal-title":"Tissue Antigens"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"275","DOI":"10.1007\/s00281-007-0078-z","article-title":"TLR5 and Ipaf: dual sensors of bacterial flagellin in the innate immune system","volume":"29","author":"EA Miao","year":"2007","journal-title":"Semin Immunopathol"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1097\/MPG.0b013e318241cfa8","article-title":"Expression of microbiota, Toll-like receptors, and their regulators in the small intestinal mucosa in celiac disease","volume":"54","author":"M Kalliomaki","year":"2012","journal-title":"J Pediatr Gastroenterol Nutr"},{"issue":"4","key":"ref33","doi-asserted-by":"crossref","first-page":"e62426","DOI":"10.1371\/journal.pone.0062426","article-title":"Pepsin digest of wheat gliadin fraction increases production of IL-1beta via TLR4\/MyD88\/TRIF\/MAPK\/NF-kappaB signaling pathway and an NLRP3 inflammasome activation","volume":"8","author":"L Palova-Jelinkova","year":"2013","journal-title":"PLoS One"},{"issue":"6","key":"ref34","doi-asserted-by":"crossref","first-page":"1270","DOI":"10.1007\/s10620-008-0480-y","article-title":"Evidence for aberrant regulation of MAP kinase signal transduction pathway in peripheral blood mononuclear cells in patients with active celiac disease","volume":"54","author":"E Broide","year":"2009","journal-title":"Dig Dis Sci"},{"key":"ref35","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1146\/annurev.immunol.20.091301.131133","article-title":"MAP kinases in the immune response","volume":"20","author":"C Dong","year":"2002","journal-title":"Annu Rev Immunol"},{"issue":"1","key":"ref36","first-page":"20","article-title":"MAP kinases in immune responses","volume":"2","author":"YL Zhang","year":"2005","journal-title":"Cell Mol Immunol"},{"issue":"3","key":"ref37","doi-asserted-by":"crossref","first-page":"430","DOI":"10.1016\/j.clim.2010.01.003","article-title":"Monocytes differentiated with IL-15 support Th17 and Th1 responses to wheat gliadin: implications for celiac disease","volume":"135","author":"KM Harris","year":"2010","journal-title":"Clin Immunol"},{"issue":"4","key":"ref38","first-page":"170","article-title":"Forecasting the nursing workforce in a dynamic health care market","volume":"16","author":"ML Dumpe","year":"1998","journal-title":"Nurs Econ"},{"key":"ref39","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1186\/1471-2350-6-29","article-title":"Association study of functional genetic variants of innate immunity related genes in celiac disease","volume":"6","author":"B Rueda","year":"2005","journal-title":"BMC Med Genet"},{"issue":"1","key":"ref40","doi-asserted-by":"crossref","first-page":"141","DOI":"10.1046\/j.1365-2249.1997.d01-892.x","article-title":"Increased proinflammatory cytokine gene expression in the colonic mucosa of coeliac disease patients in the early period after gluten challenge","volume":"107","author":"Y Chowers","year":"1997","journal-title":"Clin Exp Immunol"},{"issue":"4","key":"ref41","article-title":"Triptolide Modulates TREM-1 Signal Pathway to Inhibit the Inflammatory Response in Rheumatoid Arthritis","volume":"17","author":"D Fan","year":"2016","journal-title":"Int J Mol Sci"},{"issue":"2","key":"ref42","doi-asserted-by":"crossref","first-page":"209","DOI":"10.1189\/jlb.0312145","article-title":"TREM-1: intracellular signaling pathways and interaction with pattern recognition receptors","volume":"93","author":"RJ Arts","year":"2013","journal-title":"J Leukoc Biol"},{"issue":"10","key":"ref43","doi-asserted-by":"crossref","first-page":"4991","DOI":"10.4049\/jimmunol.164.10.4991","article-title":"Cutting edge: inflammatory responses can be triggered by TREM-1, a novel receptor expressed on neutrophils and monocytes","volume":"164","author":"A Bouchon","year":"2000","journal-title":"J Immunol"},{"issue":"7\u20138","key":"ref44","doi-asserted-by":"crossref","first-page":"777","DOI":"10.1016\/j.nut.2016.01.021","article-title":"Is it gluten-free? Relationship between self-reported gluten-free diet adherence and knowledge of gluten content of foods","volume":"32","author":"JA Silvester","year":"2016","journal-title":"Nutrition"},{"issue":"3","key":"ref45","doi-asserted-by":"crossref","first-page":"681","DOI":"10.1053\/j.gastro.2015.05.013","article-title":"Distinct and Synergistic Contributions of Epithelial Stress and Adaptive Immunity to Functions of Intraepithelial Killer Cells and Active Celiac Disease","volume":"149","author":"M Setty","year":"2015","journal-title":"Gastroenterology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0197915","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2024,7,6]],"date-time":"2024-07-06T23:57:06Z","timestamp":1720310226000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0197915"}},"subtitle":[],"editor":[{"given":"Jean-Marc A","family":"Lobaccaro","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,5,24]]},"references-count":45,"journal-issue":{"issue":"5","published-online":{"date-parts":[[2018,5,24]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0197915","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,5,24]]}}}