{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T20:43:46Z","timestamp":1790714626444,"version":"4.1.0"},"reference-count":26,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001868","name":"National Science Council","doi-asserted-by":"publisher","award":["101-2314-B-075-070-MY2"],"award-info":[{"award-number":["101-2314-B-075-070-MY2"]}],"id":[{"id":"10.13039\/501100001868","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100011912","name":"Taipei Veterans General Hospital","doi-asserted-by":"crossref","award":["V101B1-001"],"award-info":[{"award-number":["V101B1-001"]}],"id":[{"id":"10.13039\/501100011912","id-type":"DOI","asserted-by":"crossref"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0198326","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T17:32:18Z","timestamp":1530034338000},"page":"e0198326","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":9,"title":["Corticosteroid inhibits differentiation of palmar fibromatosis-derived stem cells (FSCs) through downregulation of transforming growth factor-\u03b21 (TGF-\u03b21)"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8427-9963","authenticated-orcid":true,"given":"Jung-Pan","family":"Wang","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hsiang-Hsuan Michael","family":"Yu","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"En-Rung","family":"Chiang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jir-You","family":"Wang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Po- Hsin","family":"Chou","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shih-Chieh","family":"Hung","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"ref1","doi-asserted-by":"crossref","first-page":"604","DOI":"10.12968\/hmed.2007.68.11.27683","article-title":"Assessment of clinical severity in Dupuytren\u2019s disease","volume":"68","author":"A Bayat","year":"2007","journal-title":"Br J Hosp Med"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"269","DOI":"10.1016\/j.bbrc.2011.04.011","article-title":"Fibromatosis stem cells rather than bone-marrow mesenchymal stem cells recapitulate a murine model of fibromatosis","volume":"408","author":"JP Wang","year":"2011","journal-title":"Biochem Biophys Res Commu"},{"key":"ref3","doi-asserted-by":"crossref","first-page":"e24050","DOI":"10.1371\/journal.pone.0024050","article-title":"Recapitulation of fibromatosis nodule by multipotential stem cells in immunodeficient mice","volume":"6","author":"JP Wang","year":"2011","journal-title":"PLoS ONE"},{"key":"ref4","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1046\/j.1365-2133.1999.02700.x","article-title":"Keratinocytes suppress transforming growth factor-beta1 expression by fibroblasts in cultured skin substitutes","volume":"140","author":"IC Le Poole","year":"1999","journal-title":"Br J Dermatol"},{"key":"ref5","first-page":"69","article-title":"Transforming growth factor-beta: a key mediator of fibrosis","volume":"117","author":"A Mauviel","year":"2005","journal-title":"Methods Mol Med"},{"key":"ref6","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1136\/jcp.46.5.425","article-title":"Abnormal growth factor and cytokine expression in Dupuytren\u2019s contracture","volume":"46","author":"KS Baird","year":"1993","journal-title":"J Clin Pathol"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"1391","DOI":"10.1016\/S0022-5347(01)64223-X","article-title":"Peyronie\u2019s disease is associated with an increase in transforming growth factor-beta protein expression","volume":"158","author":"AI El-Sakka","year":"1997","journal-title":"J Urol"},{"key":"ref8","doi-asserted-by":"crossref","first-page":"585","DOI":"10.1148\/radiographics.21.3.g01ma21585","article-title":"Imaging of musculoskeletal fibromatosis","volume":"21","author":"MR Robbin","year":"2001","journal-title":"Radiographics"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"1224","DOI":"10.1097\/00006534-199405000-00018","article-title":"Effect of gamma-interferon on the clinical and biologic evolution of hypertrophic scars and Dupuytren\u2019s disease: an open pilot study","volume":"93","author":"B Pittet","year":"1994","journal-title":"Plast Reconstr Surg"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"1065","DOI":"10.1016\/S0363-5023(96)80317-0","article-title":"Pharmacologic regulation of Dupuytren\u2019s fibroblast contraction in vitro","volume":"21","author":"GM Rayan","year":"1996","journal-title":"J Hand Surg Am"},{"key":"ref11","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1053\/jhsu.2000.18493","article-title":"The injection of nodules of Dupuytren\u2019s disease with triamcinolone acetonide","volume":"25","author":"LD Ketchum","year":"2000","journal-title":"J Hand Surg Am"},{"key":"ref12","doi-asserted-by":"crossref","first-page":"678","DOI":"10.1177\/1753193417690961","article-title":"Long-term follow-up of Dupuytren disease after injection of triamcinolone acetonide in Chinese patients in Taiwan","volume":"42","author":"CY Yin","year":"2017","journal-title":"J Hand Surg Eur Vol"},{"key":"ref13","doi-asserted-by":"crossref","first-page":"284","DOI":"10.1136\/gut.2005.088690","article-title":"Emerging insights into Transforming growth factor beta Smad signal in hepatic fibrogenesis","volume":"56","author":"Y Inagaki","year":"2007","journal-title":"Gut"},{"key":"ref14","doi-asserted-by":"crossref","first-page":"463","DOI":"10.1111\/j.1365-4632.2011.05234.x","article-title":"Oxymatrine inhibits collagen synthesis in keloid fibroblasts via inhibition of transforming growth factor-beta1\/Smad signaling pathway","volume":"51","author":"DL Fan","year":"2012","journal-title":"Int J Dermatol"},{"key":"ref15","doi-asserted-by":"crossref","first-page":"265","DOI":"10.1016\/S0736-0266(02)00151-1","article-title":"Inhibition of tendon cell migration by dexamethasone is correlated with reduced alpha-smooth muscle actin gene expression: a potential mechanism of delayed tendon healing","volume":"21","author":"WC Tsai","year":"2003","journal-title":"J Orthop Res"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"106","DOI":"10.1016\/S0190-9622(99)70415-9","article-title":"Development of Peyronie\u2019s and Dupuytren\u2019s diseases in an individual after single episodes of trauma: a case report and review of the literature","volume":"41","author":"TJ Connelly","year":"1999","journal-title":"J Am Acad Dermatol"},{"key":"ref17","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/J.JHSB.2006.05.005","article-title":"Dupuytren\u2019s contracture: an audit of the outcomes of surgery","volume":"31","author":"JJ Dias","year":"2006","journal-title":"J Hand Surg Br"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.diff.2010.10.003","article-title":"Trichostatin A inhibits TGF-beta1 induced in vitro chondrogenesis of hMSCs through Sp1 suppression","volume":"81","author":"JP Wang","year":"2011","journal-title":"Differentiation"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"929","DOI":"10.1016\/j.bbrc.2005.12.100","article-title":"All-trans retinoic acid inhibited chondrogenesis of mouse embryonic palate mesenchymal cells by down-regulation of TGF-beta\/Smad signaling","volume":"340","author":"Z Yu","year":"2006","journal-title":"Biochem Biophys Res Commun"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"1264","DOI":"10.1016\/j.bbrc.2004.10.164","article-title":"Glucocorticoids decrease the bioavailability of TGF-beta which leads to a reduced TGF-beta signaling in hepatic stellate cells","volume":"325","author":"U Bolkenius","year":"2004","journal-title":"Biochem Biophys Res Commun"},{"key":"ref21","doi-asserted-by":"crossref","first-page":"285","DOI":"10.1111\/1523-1747.ep12286461","article-title":"Dexamethasone abrogates the fibrogenic effect of transforming growth factor-beta in rat granuloma and granulation tissue fibroblasts","volume":"108","author":"N Meisler","year":"1997","journal-title":"J Invest Dermatol"},{"key":"ref22","first-page":"1479","article-title":"Effect of IFN-gamma and dexamethasone on TGF-beta1-induced human fetal lung fibroblast-myofibroblast differentiation","volume":"25","author":"L Gu","year":"2004","journal-title":"Acta Pharmacol Sin"},{"key":"ref23","doi-asserted-by":"crossref","first-page":"425","DOI":"10.1007\/s00262-011-1188-y","article-title":"Gene silencing of TGF-beta1 enhances antitumor immunity induced with a dendritic cell vaccine by reducing tumor-associated regulatory T cells","volume":"61","author":"H Conroy","year":"2012","journal-title":"Cancer Immunol Immunother"},{"key":"ref24","doi-asserted-by":"crossref","first-page":"4961","DOI":"10.1158\/1078-0432.CCR-07-4604","article-title":"Silencing of transforming growth factor-beta1 in situ by RNA interference for breast cancer: implications for proliferation and migration in vitro and metastasis in vivo","volume":"14","author":"LD Moore","year":"2008","journal-title":"Clin Cancer Res"},{"key":"ref25","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1038\/sj.gt.3302480","article-title":"Exploring RNA interference as a therapeutic strategy for renal disease","volume":"12","author":"Y Takabatake","year":"2005","journal-title":"Gene Ther"},{"key":"ref26","doi-asserted-by":"crossref","first-page":"772","DOI":"10.1021\/mp9000469","article-title":"TGF-beta1 gene silencing for treating liver fibrosis","volume":"6","author":"K Cheng","year":"2009","journal-title":"Mol Pharm"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0198326","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,19]],"date-time":"2020-05-19T18:43:38Z","timestamp":1589913818000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0198326"}},"subtitle":[],"editor":[{"given":"Philip C.","family":"Trackman","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,26]]},"references-count":26,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,26]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0198326","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,26]]}}}