{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,1]],"date-time":"2026-06-01T21:38:12Z","timestamp":1780349892151,"version":"3.54.1"},"reference-count":63,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T00:00:00Z","timestamp":1528761600000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"CIBERONC-ISCIII"},{"name":"ISCIII-MINECO AES-FEDER"},{"name":"Asociaci\u00f3n Espa\u00f1ola Contra el C\u00e1ncer,"},{"name":"SODERCAN"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0198477","type":"journal-article","created":{"date-parts":[[2018,6,12]],"date-time":"2018-06-12T13:33:05Z","timestamp":1528810385000},"page":"e0198477","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":16,"title":["Mycosis fungoides progression could be regulated by microRNAs"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5450-4146","authenticated-orcid":true,"given":"Rebeca","family":"Manso","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nerea","family":"Mart\u00ednez-Magunacelaya","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Itziar","family":"Era\u00f1a-Tom\u00e1s","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ver\u00f3nica","family":"Monsalvez","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jos\u00e9 L.","family":"Rodr\u00edguez-Peralto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pablo-L","family":"Ortiz-Romero","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1335-0339","authenticated-orcid":true,"given":"Carlos","family":"Santonja","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ion","family":"Crist\u00f3bal","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Miguel A.","family":"Piris","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Socorro M.","family":"Rodr\u00edguez-Pinilla","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,6,12]]},"reference":[{"issue":"2","key":"ref1","doi-asserted-by":"crossref","first-page":"376","DOI":"10.1111\/j.1365-2133.2008.08852.x","article-title":"Incidence of primary cutaneous T-cell lymphoma in Norway","volume":"160","author":"M Saunes","year":"2009","journal-title":"Br J Dermatol"},{"issue":"10","key":"ref2","doi-asserted-by":"crossref","first-page":"3768","DOI":"10.1182\/blood-2004-09-3502","article-title":"WHO-EORTC classification for cutaneous lymphomas","volume":"105","author":"R Willemze","year":"2005","journal-title":"Blood"},{"issue":"308","key":"ref3","doi-asserted-by":"crossref","first-page":"308ra158","DOI":"10.1126\/scitranslmed.aaa9122","article-title":"TCR sequencing facilitates diagnosis and identifies mature T cells as the cell of origin in CTCL","volume":"7","author":"IR Kirsch","year":"2015","journal-title":"Sci Transl Med"},{"issue":"13","key":"ref4","doi-asserted-by":"crossref","first-page":"2034","DOI":"10.1182\/blood-2013-05-504308","article-title":"PLCG1 mutations in cutaneous T-cell lymphomas","volume":"123","author":"JP Vaque","year":"2014","journal-title":"Blood"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"508","DOI":"10.1182\/blood-2014-11-611194","article-title":"Whole-genome sequencing reveals oncogenic mutations in mycosis fungoides","volume":"126","author":"LY McGirt","year":"2015","journal-title":"Blood"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"2506","DOI":"10.4049\/jimmunol.181.4.2506","article-title":"Gamma c-signaling cytokines induce a regulatory T cell phenotype in malignant CD4+ T lymphocytes","volume":"181","author":"M Kasprzycka","year":"2008","journal-title":"J Immunol"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"424","DOI":"10.1038\/leu.2011.237","article-title":"Regulatory T cells and immunodeficiency in mycosis fungoides and Sezary syndrome","volume":"26","author":"T Krejsgaard","year":"2012","journal-title":"Leukemia"},{"issue":"4","key":"ref8","doi-asserted-by":"crossref","first-page":"709","DOI":"10.1046\/j.1365-2133.2003.05224.x","article-title":"The relevance of peripheral blood T-helper 1 and 2 cytokine pattern in the evaluation of patients with mycosis fungoides and Sezary syndrome","volume":"148","author":"E Papadavid","year":"2003","journal-title":"Br J Dermatol"},{"issue":"7318","key":"ref9","doi-asserted-by":"crossref","first-page":"967","DOI":"10.1038\/nature09447","article-title":"Generation of pathogenic T(H)17 cells in the absence of TGF-beta signalling","volume":"467","author":"K Ghoreschi","year":"2010","journal-title":"Nature"},{"issue":"5543","key":"ref10","doi-asserted-by":"crossref","first-page":"853","DOI":"10.1126\/science.1064921","article-title":"Identification of novel genes coding for small expressed RNAs","volume":"294","author":"M Lagos-Quintana","year":"2001","journal-title":"Science"},{"issue":"4","key":"ref11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1038\/ng865","article-title":"Micro RNAs are complementary to 3&apos; UTR sequence motifs that mediate negative post-transcriptional regulation","volume":"30","author":"EC Lai","year":"2002","journal-title":"Nat Genet"},{"issue":"5740","key":"ref12","doi-asserted-by":"crossref","first-page":"1573","DOI":"10.1126\/science.1115079","article-title":"Inhibition of translational initiation by Let-7 MicroRNA in human cells","volume":"309","author":"RS Pillai","year":"2005","journal-title":"Science"},{"issue":"5631","key":"ref13","doi-asserted-by":"crossref","first-page":"336","DOI":"10.1126\/science.1085242","article-title":"Role of microRNAs in plant and animal development","volume":"301","author":"JC Carrington","year":"2003","journal-title":"Science"},{"issue":"23","key":"ref14","doi-asserted-by":"crossref","first-page":"e118","DOI":"10.1182\/blood-2010-05-285403","article-title":"Deep sequencing of the small RNA transcriptome of normal and malignant human B cells identifies hundreds of novel microRNAs","volume":"116","author":"DD Jima","year":"2010","journal-title":"Blood"},{"issue":"17","key":"ref15","doi-asserted-by":"crossref","first-page":"1768","DOI":"10.1056\/NEJMp058190","article-title":"MicroRNAs as oncogenes and tumor suppressors","volume":"353","author":"CZ Chen","year":"2005","journal-title":"N Engl J Med"},{"issue":"5A","key":"ref16","doi-asserted-by":"crossref","first-page":"1432","DOI":"10.1111\/j.1582-4934.2008.00399.x","article-title":"MicroRNA expression in lymphoid malignancies: new hope for diagnosis and therapy?","volume":"12","author":"CH Lawrie","year":"2008","journal-title":"J Cell Mol Med"},{"issue":"23","key":"ref17","doi-asserted-by":"crossref","first-page":"5896","DOI":"10.1182\/blood-2008-09-181024","article-title":"Ectopic expression of B-lymphoid kinase in cutaneous T-cell lymphoma","volume":"113","author":"T Krejsgaard","year":"2009","journal-title":"Blood"},{"issue":"4","key":"ref18","doi-asserted-by":"crossref","first-page":"266","DOI":"10.1097\/MOH.0b013e3283476012","article-title":"Role of microRNAs in lymphoid biology and disease","volume":"18","author":"M Fabbri","year":"2011","journal-title":"Curr Opin Hematol"},{"issue":"7","key":"ref19","doi-asserted-by":"crossref","first-page":"1105","DOI":"10.1182\/blood-2009-12-256719","article-title":"MicroRNA expression in Sezary syndrome: identification, function, and diagnostic potential","volume":"116","author":"E Ballabio","year":"2010","journal-title":"Blood"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"e151","DOI":"10.1038\/cddis.2011.32","article-title":"MicroRNA profiling reveals that miR-21, miR486 and miR-214 are upregulated and involved in cell survival in Sezary syndrome","volume":"2","author":"MG Narducci","year":"2011","journal-title":"Cell Death Dis"},{"issue":"22","key":"ref21","doi-asserted-by":"crossref","first-page":"5891","DOI":"10.1182\/blood-2011-06-358382","article-title":"Diagnostic microRNA profiling in cutaneous T-cell lymphoma (CTCL)","volume":"118","author":"U Ralfkiaer","year":"2011","journal-title":"Blood"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1016\/j.molonc.2011.02.003","article-title":"miRNA expression profiling of mycosis fungoides","volume":"5","author":"MS van Kester","year":"2011","journal-title":"Mol Oncol"},{"issue":"2","key":"ref23","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1111\/j.1365-2133.2011.10669.x","article-title":"Altered microRNA expression in mycosis fungoides","volume":"166","author":"J Maj","year":"2012","journal-title":"Br J Dermatol"},{"issue":"12","key":"ref24","doi-asserted-by":"crossref","first-page":"1939","DOI":"10.4161\/cc.24987","article-title":"STAT5-mediated expression of oncogenic miR-155 in cutaneous T-cell lymphoma","volume":"12","author":"KL Kopp","year":"2013","journal-title":"Cell Cycle"},{"issue":"4","key":"ref25","doi-asserted-by":"crossref","first-page":"1101","DOI":"10.1038\/jid.2013.461","article-title":"miR-223 regulates cell growth and targets proto-oncogenes in mycosis fungoides\/cutaneous T-cell lymphoma","volume":"134","author":"LY McGirt","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"12","key":"ref26","first-page":"7207","article-title":"MicroRNA expression in early mycosis fungoides is distinctly different from atopic dermatitis and advanced cutaneous T-cell lymphoma","volume":"34","author":"U Ralfkiaer","year":"2014","journal-title":"Anticancer Res"},{"key":"ref27","article-title":"microRNA signatures in diagnosis and prognosis of cutaneous T cell lymphoma","author":"X Shen","year":"2018","journal-title":"J Invest Dermatol"},{"key":"ref28","article-title":"WHO Classification of Tumours of Haematopoietic and Lymphoid Tissues","author":"CE Swerdlow SH","year":"2017"},{"issue":"31","key":"ref29","doi-asserted-by":"crossref","first-page":"4730","DOI":"10.1200\/JCO.2009.27.7665","article-title":"Survival outcomes and prognostic factors in mycosis fungoides\/Sezary syndrome: validation of the revised International Society for Cutaneous Lymphomas\/European Organisation for Research and Treatment of Cancer staging proposal","volume":"28","author":"NS Agar","year":"2010","journal-title":"J Clin Oncol"},{"key":"ref30","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1186\/1472-6750-8-69","article-title":"Measuring microRNAs: comparisons of microarray and quantitative PCR measurements, and of different total RNA prep methods","volume":"8","author":"RA Ach","year":"2008","journal-title":"BMC Biotechnol"},{"issue":"6","key":"ref31","doi-asserted-by":"crossref","first-page":"1681","DOI":"10.1002\/eji.200526189","article-title":"Analysis of FOXP3 protein expression in human CD4+CD25+ regulatory T cells at the single-cell level","volume":"35","author":"G Roncador","year":"2005","journal-title":"Eur J Immunol"},{"issue":"2","key":"ref32","doi-asserted-by":"crossref","first-page":"1071","DOI":"10.4049\/jimmunol.1000082","article-title":"Genome-wide identification of human FOXP3 target genes in natural regulatory T cells","volume":"185","author":"TJ Sadlon","year":"2010","journal-title":"J Immunol"},{"issue":"5","key":"ref33","doi-asserted-by":"crossref","first-page":"727","DOI":"10.1309\/3JK2H6Y988NUAY37","article-title":"Usefulness (or lack thereof) of immunophenotyping in atypical cutaneous T-cell infiltrates","volume":"125","author":"SR Florell","year":"2006","journal-title":"Am J Clin Pathol"},{"key":"ref34","article-title":"Prognostic miRNA classifier in early-stage mycosis fungoides: development and validation in a Danish nationwide study","author":"LM Lindahl","year":"2017","journal-title":"Blood"},{"issue":"3","key":"ref35","doi-asserted-by":"crossref","first-page":"821","DOI":"10.1007\/s12253-015-9897-8","article-title":"Altered microRNA expression in folliculotropic and transformed mycosis fungoides","volume":"21","author":"D Marosvari","year":"2015","journal-title":"Pathol Oncol Res"},{"issue":"4","key":"ref36","doi-asserted-by":"crossref","first-page":"957","DOI":"10.3109\/10428194.2013.815352","article-title":"Validation of a diagnostic microRNA classifier in cutaneous T-cell lymphomas","volume":"55","author":"T Marstrand","year":"2014","journal-title":"Leuk Lymphoma"},{"issue":"10","key":"ref37","doi-asserted-by":"crossref","DOI":"10.3390\/ijms18102136","article-title":"Plasma miR-155, miR-203, and miR-205 are Biomarkers for Monitoring of Primary Cutaneous T-Cell Lymphomas","volume":"18","author":"N Dusilkova","year":"2017","journal-title":"Int J Mol Sci"},{"issue":"7","key":"ref38","doi-asserted-by":"crossref","first-page":"1931","DOI":"10.1038\/jid.2014.89","article-title":"MiR-146a negatively regulates TLR2-induced inflammatory responses in keratinocytes","volume":"134","author":"F Meisgen","year":"2014","journal-title":"J Invest Dermatol"},{"issue":"4","key":"ref39","doi-asserted-by":"crossref","first-page":"281","DOI":"10.1111\/exd.12361","article-title":"Activation of toll-like receptors alters the microRNA expression profile of keratinocytes","volume":"23","author":"F Meisgen","year":"2014","journal-title":"Exp Dermatol"},{"issue":"11","key":"ref40","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.4049\/jimmunol.1102371","article-title":"Integrin CD11b negatively regulates TLR9-triggered dendritic cell cross-priming by upregulating microRNA-146a","volume":"188","author":"Y Bai","year":"2012","journal-title":"J Immunol"},{"issue":"9","key":"ref41","first-page":"1764","article-title":"The functional analysis of MicroRNAs involved in NF-kappaB signaling","volume":"20","author":"Y Yang","year":"2016","journal-title":"Eur Rev Med Pharmacol Sci"},{"issue":"5","key":"ref42","doi-asserted-by":"crossref","first-page":"333","DOI":"10.1038\/gene.2014.24","article-title":"MiRNA-181a regulates Toll-like receptor agonist-induced inflammatory response in human fibroblasts","volume":"15","author":"JC Galicia","year":"2014","journal-title":"Genes Immun"},{"issue":"2","key":"ref43","doi-asserted-by":"crossref","first-page":"647","DOI":"10.1016\/j.bbrc.2012.11.097","article-title":"miR-181a and inflammation: miRNA homeostasis response to inflammatory stimuli in vivo","volume":"430","author":"W Xie","year":"2013","journal-title":"Biochem Biophys Res Commun"},{"issue":"2","key":"ref44","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1046\/j.1523-1747.1998.00263.x","article-title":"Epidermal interferon-gamma inducible protein-10 (IP-10) and monokine induced by gamma-interferon (Mig) but not IL-8 mRNA expression is associated with epidermotropism in cutaneous T cell lymphomas","volume":"111","author":"CP Tensen","year":"1998","journal-title":"J Invest Dermatol"},{"issue":"1","key":"ref45","doi-asserted-by":"crossref","first-page":"95","DOI":"10.1093\/intimm\/13.1.95","article-title":"Inducible expression of a CC chemokine liver- and activation-regulated chemokine (LARC)\/macrophage inflammatory protein (MIP)-3 alpha\/CCL20 by epidermal keratinocytes and its role in atopic dermatitis","volume":"13","author":"T Nakayama","year":"2001","journal-title":"Int Immunol"},{"issue":"12","key":"ref46","doi-asserted-by":"crossref","first-page":"6621","DOI":"10.4049\/jimmunol.164.12.6621","article-title":"Up-regulation of macrophage inflammatory protein-3 alpha\/CCL20 and CC chemokine receptor 6 in psoriasis","volume":"164","author":"B Homey","year":"2000","journal-title":"J Immunol"},{"issue":"9","key":"ref47","doi-asserted-by":"crossref","first-page":"1820","DOI":"10.1016\/j.jid.2016.04.035","article-title":"Cross-Disease Transcriptomics: Unique IL-17A Signaling in Psoriasis Lesions and an Autoimmune PBMC Signature","volume":"136","author":"WR Swindell","year":"2016","journal-title":"J Invest Dermatol"},{"issue":"10","key":"ref48","doi-asserted-by":"crossref","first-page":"2217","DOI":"10.1038\/sj.jid.5700371","article-title":"Lack of suppressive CD4+CD25+FOXP3+ T cells in advanced stages of primary cutaneous T-cell lymphoma","volume":"126","author":"MM Tiemessen","year":"2006","journal-title":"J Invest Dermatol"},{"issue":"2","key":"ref49","doi-asserted-by":"crossref","first-page":"274","DOI":"10.1158\/1078-0432.CCR-14-0830","article-title":"Reduction of regulatory T cells by Mogamulizumab, a defucosylated anti-CC chemokine receptor 4 antibody, in patients with aggressive\/refractory mycosis fungoides and Sezary syndrome","volume":"21","author":"X Ni","year":"2015","journal-title":"Clin Cancer Res"},{"issue":"5","key":"ref50","doi-asserted-by":"crossref","first-page":"535","DOI":"10.1111\/j.1600-0560.2009.01381.x","article-title":"Paucity of intraepidermal FoxP3-positive T cells in cutaneous T-cell lymphoma in contrast with spongiotic and lichenoid dermatitis","volume":"37","author":"DA Wada","year":"2010","journal-title":"J Cutan Pathol"},{"issue":"5","key":"ref51","doi-asserted-by":"crossref","first-page":"1201","DOI":"10.1189\/jlb.5A0316-119RR","article-title":"Protection of CD4+ T cells from hepatitis C virus infection-associated senescence via DeltaNp63-miR-181a-Sirt1 pathway","volume":"100","author":"Y Zhou","year":"2016","journal-title":"J Leukoc Biol"},{"issue":"8","key":"ref52","doi-asserted-by":"crossref","first-page":"1703","DOI":"10.1158\/0008-5472.CAN-14-2108","article-title":"FOXP3 Controls an miR-146\/NF-kappaB Negative Feedback Loop That Inhibits Apoptosis in Breast Cancer Cells","volume":"75","author":"R Liu","year":"2015","journal-title":"Cancer Res"},{"issue":"8","key":"ref53","doi-asserted-by":"crossref","first-page":"1714","DOI":"10.1158\/0008-5472.CAN-14-2109","article-title":"FOXP3-miR-146-NF-kappaB Axis and Therapy for Precancerous Lesions in Prostate","volume":"75","author":"R Liu","year":"2015","journal-title":"Cancer Res"},{"issue":"2","key":"ref54","first-page":"65","article-title":"STAT1 and STAT3 in tumorigenesis: A matter of balance","volume":"1","author":"L Avalle","year":"2012","journal-title":"JAKSTAT"},{"issue":"11","key":"ref55","doi-asserted-by":"crossref","first-page":"1431","DOI":"10.1111\/jdv.12299","article-title":"Genetic markers associated with progression in early mycosis fungoides","volume":"28","author":"VE Johnson","year":"2014","journal-title":"J Eur Acad Dermatol Venereol"},{"issue":"1","key":"ref56","doi-asserted-by":"crossref","first-page":"260","DOI":"10.1002\/eji.201444667","article-title":"MicroRNA-146a controls Th1-cell differentiation of human CD4+ T lymphocytes by targeting PRKCepsilon","volume":"45","author":"P Mohnle","year":"2015","journal-title":"Eur J Immunol"},{"issue":"2","key":"ref57","doi-asserted-by":"crossref","first-page":"243","DOI":"10.4161\/15384101.2014.977112","article-title":"miR-146a is directly regulated by STAT3 in human hepatocellular carcinoma cells and involved in anti-tumor immune suppression","volume":"14","author":"X Sun","year":"2015","journal-title":"Cell Cycle"},{"issue":"12","key":"ref58","doi-asserted-by":"crossref","first-page":"1482","DOI":"10.1053\/hupa.2000.20370","article-title":"Constitutive expression of NF-kappa B is a characteristic feature of mycosis fungoides: implications for apoptosis resistance and pathogenesis","volume":"31","author":"KF Izban","year":"2000","journal-title":"Hum Pathol"},{"issue":"5","key":"ref59","doi-asserted-by":"crossref","first-page":"735","DOI":"10.1038\/sj.leu.2401415","article-title":"Inhibition of constitutively activated Stat3 correlates with altered Bcl-2\/Bax expression and induction of apoptosis in mycosis fungoides tumor cells","volume":"13","author":"M Nielsen","year":"1999","journal-title":"Leukemia"},{"issue":"13","key":"ref60","doi-asserted-by":"crossref","first-page":"6764","DOI":"10.1073\/pnas.94.13.6764","article-title":"Constitutive activation of a slowly migrating isoform of Stat3 in mycosis fungoides: tyrphostin AG490 inhibits Stat3 activation and growth of mycosis fungoides tumor cell lines","volume":"94","author":"M Nielsen","year":"1997","journal-title":"Proc Natl Acad Sci U S A"},{"issue":"8","key":"ref61","doi-asserted-by":"crossref","first-page":"e1002855","DOI":"10.1371\/journal.pgen.1002855","article-title":"Modulating the strength and threshold of NOTCH oncogenic signals by mir-181a-1\/b-1","volume":"8","author":"R Fragoso","year":"2012","journal-title":"PLoS Genet"},{"issue":"14","key":"ref62","doi-asserted-by":"crossref","first-page":"2504","DOI":"10.1182\/blood-2009-12-260216","article-title":"Notch1 as a potential therapeutic target in cutaneous T-cell lymphoma","volume":"116","author":"MR Kamstrup","year":"2010","journal-title":"Blood"},{"issue":"1","key":"ref63","doi-asserted-by":"crossref","first-page":"53","DOI":"10.1016\/j.jdermsci.2009.02.005","article-title":"The role of apoptosis and cell-proliferation regulating genes in mycosis fungoides","volume":"55","author":"L Kandolf Sekulovic","year":"2009","journal-title":"J Dermatol Sci"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0198477","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T15:34:16Z","timestamp":1540222456000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0198477"}},"subtitle":[],"editor":[{"given":"Klaus","family":"Roemer","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,12]]},"references-count":63,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,12]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0198477","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,12]]}}}