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Available from: <ext-link xmlns:xlink=\"http:\/\/www.w3.org\/1999\/xlink\" ext-link-type=\"uri\" xlink:href=\"http:\/\/dhsprogram.com\/data\/available-datasets.cfm\" xlink:type=\"simple\">http:\/\/dhsprogram.com\/data\/available-datasets.cfm<\/ext-link>"},{"issue":"10032","key":"ref30","doi-asserted-by":"crossref","first-page":"2049","DOI":"10.1016\/S0140-6736(15)00519-X","article-title":"Countdown to 2015: a decade of tracking progress for maternal, newborn, and child survival","volume":"387","author":"CG Victora","year":"2016","journal-title":"Lancet"},{"issue":"2","key":"ref31","doi-asserted-by":"crossref","first-page":"173","DOI":"10.9745\/GHSP-D-13-00176","article-title":"The quality-coverage gap in antenatal care: toward better measurement of effective coverage","volume":"2","author":"S Hodgins","year":"2014","journal-title":"Glob Heal Sci Pract"},{"issue":"16","key":"ref32","first-page":"1","article-title":"Quality of basic maternal care functions in health facilities of five African countries: an analysis of national health system surveys","author":"ME Kruk","year":"2016","journal-title":"Lancet Glob Heal"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1186\/s12961-017-0212-x","article-title":"Spanning maternal, newborn and child health (MNCH) and health systems research boundaries: conducive and limiting health systems factors to improving MNCH outcomes in West Africa","volume":"15","author":"IA Agyepong","year":"2017","journal-title":"Heal Res Policy Syst"},{"issue":"3","key":"ref34","doi-asserted-by":"crossref","first-page":"e40","DOI":"10.1097\/QAI.0b013e318267bc94","article-title":"Introduction of rapid syphilis testing within prevention of mother-to-child transmission of HIV programs in Uganda and Zambia: a field acceptability and feasibility study","volume":"61","author":"S Strasser","year":"2012","journal-title":"J Acquir Immune Defic Syndr"},{"key":"ref35","unstructured":"UNAIDS. 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