{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T00:18:50Z","timestamp":1792801130084,"version":"4.5.0"},"reference-count":25,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T00:00:00Z","timestamp":1528416000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0199052","type":"journal-article","created":{"date-parts":[[2018,6,8]],"date-time":"2018-06-08T13:29:21Z","timestamp":1528464561000},"page":"e0199052","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":70,"title":["Causes of death in patients with Berardinelli-Seip congenital generalized lipodystrophy"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-1627-7018","authenticated-orcid":true,"given":"Josivan Gomes","family":"Lima","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia Helena C.","family":"Nobrega","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Natalia Nobrega","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marcel Cat\u00e3o Ferreira","family":"dos Santos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pedro Henrique Dantas","family":"Silva","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maria de Fatima P.","family":"Baracho","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Debora Nobrega","family":"Lima","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julliane Tamara Ara\u00fajo","family":"de Melo Campos","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leonardo Capistrano","family":"Ferreira","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francisco Paulo","family":"Freire Neto","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carolina de O.","family":"Mendes-Aguiar","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Selma Maria B.","family":"Jeronimo","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,6,8]]},"reference":[{"issue":"9","key":"ref1","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1038\/nrendo.2015.123","article-title":"Congenital generalized lipodystrophies\u2014new insights into metabolic dysfunction","volume":"11","author":"N Patni","year":"2015","journal-title":"Nat Rev Endocrinol"},{"key":"ref2","doi-asserted-by":"crossref","DOI":"10.1210\/jcem-14-2-193","article-title":"An undiagnosed endocrinometabolic syndrome: report of 2 cases","volume":"14","author":"W Berardinelli","year":"1954","journal-title":"J Clin Endocrinol Metab"},{"key":"ref3","doi-asserted-by":"crossref","DOI":"10.1111\/j.1651-2227.1959.tb17558.x","article-title":"Lipodystrophy and gigantism with associated endocrine manifestations. A new diencephalic syndrome?","volume":"48","author":"M Seip","year":"1959","journal-title":"Acta Paediatr"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"21","DOI":"10.1038\/ng880","article-title":"AGPAT2 is mutated in congenital generalized lipodystrophy linked to chromosome 9q34","volume":"31","author":"AK Agarwal","year":"2002","journal-title":"Nat Genet"},{"issue":"4","key":"ref5","doi-asserted-by":"crossref","first-page":"365","DOI":"10.1038\/ng585","article-title":"Identification of the gene altered in Berardinelli-Seip congenital lipodystrophy on chromosome 11q13","volume":"28","author":"J Magre","year":"2001","journal-title":"Nat Genet"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"1129","DOI":"10.1210\/jc.2007-1328","article-title":"Association of a homozygous nonsense caveolin-1 mutation with Berardinelli-Seip congenital lipodystrophy","volume":"93","author":"CA Kim","year":"2008","journal-title":"J Clin Endocrinol Metab"},{"issue":"9","key":"ref7","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1172\/JCI38660","article-title":"Human PTRF mutations cause secondary deficiency of caveolins resulting in muscular dystrophy with generalized lipodystrophy","volume":"119","author":"YK Hayashi","year":"2009","journal-title":"J Clin Invest"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"227","DOI":"10.1016\/j.ymgme.2013.04.011","article-title":"Early infantile cardiomyopathy and liver disease: a multisystemic disorder caused by congenital lipodystrophy","volume":"109","author":"FG Debray","year":"2013","journal-title":"Mol Genet Metab"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1186\/s13098-016-0140-x","article-title":"Clinical and laboratory data of a large series of patients with congenital generalized lipodystrophy","volume":"8","author":"JG Lima","year":"2016","journal-title":"Diabetol Metab Syndr"},{"key":"ref10","doi-asserted-by":"crossref","first-page":"375","DOI":"10.2147\/DMSO.S130810","article-title":"Estimating the prevalence of generalized and partial lipodystrophy: findings and challenges","author":"E Chiquette","year":"2017","journal-title":"Diabetes, Metabolic Syndrome and Obesity: Targets and Therapy"},{"issue":"2","key":"ref11","doi-asserted-by":"crossref","first-page":"363","DOI":"10.1210\/jc.2016-2271","article-title":"Clinical Features and Management of Non-HIV-Related Lipodystrophy in Children: A Systematic Review","volume":"102","author":"N Gupta","year":"2017","journal-title":"J Clin Endocrinol Metab"},{"issue":"10","key":"ref12","doi-asserted-by":"crossref","first-page":"722","DOI":"10.1136\/jmg.39.10.722","article-title":"Genotype-phenotype relationships in Berardinelli-Seip congenital lipodystrophy","volume":"39","author":"L Van Maldergem","year":"2002","journal-title":"J Med Genet"},{"key":"ref13","article-title":"Mutations in Gng3lg and AGPAT2 in Berardinelli-Seip congenital lipodystrophy and Brunzell syndrome: phenotype variability suggests important modifier effects","volume":"89","author":"M Fu","year":"2004","journal-title":"J Clin Endocrinol Metab"},{"issue":"1","key":"ref14","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1186\/s13098-017-0280-7","article-title":"High prevalence of Berardinelli-Seip Congenital Lipodystrophy in Rio Grande do Norte State, Northeast Brazil","volume":"9","author":"LB de Azevedo Medeiros","year":"2017","journal-title":"Diabetology & Metabolic Syndrome"},{"key":"ref15","year":"1948"},{"key":"ref16","unstructured":"WorldBank. Life expectancy at birth, total (years) | Data. 2017 [08\/10\/2017]; Available from: https:\/\/data.worldbank.org\/indicator\/SP.DYN.LE00.IN?locations=BR<\/ext-link>."},{"issue":"2","key":"ref17","doi-asserted-by":"crossref","first-page":"301","DOI":"10.1016\/S0022-3476(86)80389-4","article-title":"Hypertrophic cardiomyopathy in total lipodystrophy","volume":"109","author":"KS Rheuban","year":"1986","journal-title":"J Pediatr"},{"key":"ref18","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1111\/j.1651-2227.1996.tb14264.x","article-title":"Cardiac findings in generalized lipodystrophy","volume":"413","author":"PG Bjornstad","year":"1996","journal-title":"Acta Paediatr Suppl"},{"key":"ref19","article-title":"Congenital generalized lipodystrophy in Taiwan","author":"RH Hsu","year":"2018","journal-title":"J Formos Med Assoc"},{"key":"ref20","doi-asserted-by":"crossref","first-page":"54","DOI":"10.1016\/j.exppara.2015.12.002","article-title":"Leptin induces the phagocytosis and protective immune response in Leishmania donovani infected THP-1 cell line and human PBMCs","volume":"160","author":"A Dayakar","year":"2016","journal-title":"Exp Parasitol"},{"issue":"2","key":"ref21","doi-asserted-by":"crossref","first-page":"607","DOI":"10.1128\/IAI.00583-13","article-title":"Liposomal cholesterol delivery activates the macrophage innate immune arm to facilitate intracellular Leishmania donovani killing","volume":"82","author":"J Ghosh","year":"2014","journal-title":"Infect Immun"},{"key":"ref22","article-title":"U-shaped relationship of HDL and risk of infectious disease: two prospective population-based cohort studies","author":"CM Madsen","year":"2017","journal-title":"Eur Heart J"},{"issue":"9","key":"ref23","doi-asserted-by":"crossref","first-page":"2969","DOI":"10.1210\/jc.2011-3213","article-title":"Evaluation and treatment of hypertriglyceridemia: an Endocrine Society clinical practice guideline","volume":"97","author":"L Berglund","year":"2012","journal-title":"J Clin Endocrinol Metab"},{"issue":"7","key":"ref24","doi-asserted-by":"crossref","first-page":"2759","DOI":"10.1210\/jc.2016-1005","article-title":"Natural History of Congenital Generalized Lipodystrophy: A Nationwide Study From Turkey","volume":"101","author":"B Akinci","year":"2016","journal-title":"J Clin Endocrinol Metab"},{"issue":"3","key":"ref25","doi-asserted-by":"crossref","first-page":"179","DOI":"10.3109\/15412555.2010.481695","article-title":"Accuracy of death certificates in COPD: analysis from the TORCH trial","volume":"7","author":"MB Drummond","year":"2010","journal-title":"COPD"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0199052","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,19]],"date-time":"2019-10-19T03:21:29Z","timestamp":1571455289000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0199052"}},"subtitle":[],"editor":[{"given":"Pavel","family":"Strnad","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,8]]},"references-count":25,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,8]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0199052","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.733419886.793565865","asserted-by":"object"}]},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,8]]}}}