{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,24]],"date-time":"2026-06-24T23:44:37Z","timestamp":1782344677701,"version":"3.54.5"},"reference-count":41,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T00:00:00Z","timestamp":1528934400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Qilu Pharmaceuticals, Inc."}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0199189","type":"journal-article","created":{"date-parts":[[2018,6,14]],"date-time":"2018-06-14T13:39:19Z","timestamp":1528983559000},"page":"e0199189","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":73,"title":["Altered expression of genes involved in ganglioside biosynthesis in substantia nigra neurons in Parkinson\u2019s disease"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4565-146X","authenticated-orcid":true,"given":"Jay S.","family":"Schneider","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,6,14]]},"reference":[{"issue":"4","key":"ref1","first-page":"879","article-title":"Aggregation of alpha-synuclein in Lewy bodies of sporadic Parkinson\u2019s disease and dementia with Lewy bodies","volume":"152","author":"M Baba","year":"1998","journal-title":"Am J Pathol"},{"key":"ref2","doi-asserted-by":"crossref","first-page":"393","DOI":"10.1016\/j.freeradbiomed.2016.10.008","article-title":"Contribution of cholesterol and oxysterols to the pathophysiology of Parkinson\u2019s disease","volume":"101","author":"M Doria","year":"2016","journal-title":"Free Radic Biol Med"},{"issue":"7113","key":"ref3","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1038\/nature05291","article-title":"The roles of intracellular protein-degradation pathways in neurodegeneration","volume":"443","author":"DC Rubinsztein","year":"2006","journal-title":"Nature"},{"issue":"1","key":"ref4","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1001\/archneur.1975.00490430047006","article-title":"Interaction between dopamine and phospholipids. Studies of the substantia nigra in Parkinson disease patients","volume":"32","author":"P Riekkinen","year":"1975","journal-title":"Arch Neurol"},{"issue":"6","key":"ref5","doi-asserted-by":"crossref","first-page":"615","DOI":"10.1001\/archneur.1969.00480180071006","article-title":"Sphingomyelin in Lewy inclusion bodies in Parkinson\u2019s disease","volume":"21","author":"WA den Jager","year":"1969","journal-title":"Arch Neurol"},{"issue":"4","key":"ref6","doi-asserted-by":"crossref","first-page":"518","DOI":"10.1002\/mds.25729","article-title":"Altered ceramide acyl chain length and ceramide synthase gene expression in Parkinson\u2019s disease","volume":"29","author":"SK Abbott","year":"2014","journal-title":"Mov Disord"},{"key":"ref7","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jchromb.2018.01.025","article-title":"Potential biomarkers of Parkinson\u2019s disease revealed by plasma metabolic profiling","volume":"1081-1082","author":"H Zhao","year":"2018","journal-title":"J Chromatogr B Analyt Technol Biomed Life Sci"},{"issue":"17","key":"ref8","doi-asserted-by":"crossref","first-page":"1651","DOI":"10.1056\/NEJMoa0901281","article-title":"Multicenter analysis of glucocerebrosidase mutations in Parkinson\u2019s disease","volume":"361","author":"E Sidransky","year":"2009","journal-title":"N Engl J Med"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/j.1749-6632.1998.tb09662.x","article-title":"Sphingolipids as receptor modulators","volume":"845","author":"AJ Yates","year":"1998","journal-title":"Ann N Y Acad Sci"},{"issue":"4","key":"ref10","doi-asserted-by":"crossref","first-page":"432","DOI":"10.1111\/jnc.12088","article-title":"Gangliosides as regulators of cell signaling: ganglioside-protein interactions or ganglioside-driven membrane organization?","volume":"124","author":"S Sonnino","year":"2013","journal-title":"J Neurochem"},{"issue":"8","key":"ref11","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0166-2236(02)02215-4","article-title":"Lipid rafts in neuronal signaling and function","volume":"25","author":"BA Tsui-Pierchala","year":"2002","journal-title":"Trends Neurosci"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"1824","DOI":"10.1007\/s12035-015-9136-z","article-title":"GM1 Ganglioside: Past Studies and Future Potential","volume":"53","author":"M Aureli","year":"2016","journal-title":"Mol Neurobiol"},{"issue":"11","key":"ref13","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1038\/ng1104-1147","article-title":"Gangliosides help stabilize the brain","volume":"36","author":"RL Proia","year":"2004","journal-title":"Nat Genet"},{"issue":"3","key":"ref14","doi-asserted-by":"crossref","first-page":"583","DOI":"10.1042\/bst0210583","article-title":"Structure and function of sphingoglycolipids in transmembrane signalling and cell-cell interactions","volume":"21","author":"S Hakomori","year":"1993","journal-title":"Biochem Soc Trans"},{"issue":"7\u20138","key":"ref15","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1023\/A:1020224016830","article-title":"Ganglioside function in calcium homeostasis and signaling","volume":"27","author":"RW Ledeen","year":"2002","journal-title":"Neurochem Res"},{"issue":"7","key":"ref16","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.tibs.2015.03.007","article-title":"Gangliosides: glycosphingolipids essential for normal neural development and function","volume":"40","author":"CL Schengrund","year":"2015","journal-title":"Trends Biochem Sci"},{"issue":"6","key":"ref17","doi-asserted-by":"crossref","first-page":"860","DOI":"10.4161\/auto.8825","article-title":"Gangliosides' protection against lysosomal pathology of synucleinopathies","volume":"5","author":"J Wei","year":"2009","journal-title":"Autophagy"},{"issue":"10","key":"ref18","doi-asserted-by":"crossref","first-page":"1997","DOI":"10.1002\/jnr.23090","article-title":"Deficiency of ganglioside GM1 correlates with Parkinson\u2019s disease in mice and humans","volume":"90","author":"G Wu","year":"2012","journal-title":"J Neurosci Res"},{"key":"ref19","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.expneurol.2014.10.010","article-title":"GDNF signaling implemented by GM1 ganglioside; failure in Parkinson\u2019s disease and GM1-deficient murine model","volume":"263","author":"P Hadaczek","year":"2015","journal-title":"Exp Neurol"},{"key":"ref20","article-title":"Sex-related abnormalities in substantia nigra lipids in Parkinson\u2019s disease","author":"TN Seyfried","year":"2018","journal-title":"ASN Neuro"},{"key":"ref21","doi-asserted-by":"crossref","DOI":"10.1016\/bs.pmbts.2018.01.002","article-title":"Ganglioside metabolism in health and disease","author":"R Sandhoff","year":"2018","journal-title":"Progress in Molecular Biology and Translational Science"},{"issue":"7","key":"ref22","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1016\/j.tibs.2015.04.005","article-title":"The multi-tasked life of GM1 ganglioside, a true factotum of nature","volume":"40","author":"RW Ledeen","year":"2015","journal-title":"Trends Biochem Sci"},{"issue":"5","key":"ref23","doi-asserted-by":"crossref","first-page":"783","DOI":"10.1194\/jlr.R300020-JLR200","article-title":"Regulation of ganglioside biosynthesis in the nervous system","volume":"45","author":"RK Yu","year":"2004","journal-title":"J Lipid Res"},{"issue":"2\u20133","key":"ref24","doi-asserted-by":"crossref","first-page":"459","DOI":"10.1002\/jnr.490120229","article-title":"Effects of GM1 ganglioside on developing and mature serotonin and noradrenaline neurons lesioned by selective neurotoxins","volume":"12","author":"G Jonsson","year":"1984","journal-title":"J Neurosci Res"},{"issue":"2\u20133","key":"ref25","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1002\/jnr.490120225","article-title":"Effect of GM1 ganglioside treatment on postlesion responses of cholinergic enzymes in rat hippocampus after various partial deafferentations","volume":"12","author":"B Oderfeld-Nowak","year":"1984","journal-title":"J Neurosci Res"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"298","DOI":"10.1016\/S0039-6060(98)70134-5","article-title":"Monosialoganglioside GM1 inhibits neurotoxicity after hypothermic circulatory arrest","volume":"124","author":"EE Tseng","year":"1998","journal-title":"Surgery"},{"issue":"9","key":"ref27","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0028-3908(86)90206-6","article-title":"Administration of GM1 ganglioside restores the dopamine content in striatum after chronic treatment with MPTP","volume":"25","author":"M Hadjiconstantinou","year":"1986","journal-title":"Neuropharmacology"},{"issue":"4","key":"ref28","doi-asserted-by":"crossref","first-page":"1190","DOI":"10.1111\/j.1471-4159.1988.tb03086.x","article-title":"Treatment with GM1 ganglioside restores striatal dopamine in the 1-methyl-4-phenyl-1,2,3,6-tetrahydropyridine-treated mouse","volume":"51","author":"M Hadjiconstantinou","year":"1988","journal-title":"J Neurochem"},{"issue":"1\u20132","key":"ref29","doi-asserted-by":"crossref","first-page":"297","DOI":"10.1016\/0006-8993(89)90373-9","article-title":"GM1 ganglioside-induced recovery of nigrostriatal dopaminergic neurons after MPTP: an immunohistochemical study","volume":"484","author":"M Hadjiconstantinou","year":"1989","journal-title":"Brain Res"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/0014-4886(89)90117-9","article-title":"GM1 ganglioside treatment promotes recovery of striatal dopamine concentrations in the mouse model of MPTP-induced parkinsonism","volume":"105","author":"JS Schneider","year":"1989","journal-title":"Exp Neurol"},{"issue":"1","key":"ref31","doi-asserted-by":"crossref","first-page":"117","DOI":"10.1002\/jnr.490420113","article-title":"GM1 ganglioside rescues substantia nigra pars compacta neurons and increases dopamine synthesis in residual nigrostriatal dopaminergic neurons in MPTP-treated mice","volume":"42","author":"JS Schneider","year":"1995","journal-title":"J Neurosci Res"},{"issue":"5058","key":"ref32","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1126\/science.1350379","article-title":"Recovery from experimental parkinsonism in primates with GM1 ganglioside treatment","volume":"256","author":"JS Schneider","year":"1992","journal-title":"Science"},{"issue":"1","key":"ref33","doi-asserted-by":"crossref","first-page":"88","DOI":"10.1002\/jnr.490190112","article-title":"Ganglioside interactions with the dopaminergic system of rats","volume":"19","author":"HA Tilson","year":"1988","journal-title":"J Neurosci Res"},{"issue":"4","key":"ref34","doi-asserted-by":"crossref","first-page":"965","DOI":"10.1016\/0306-4522(93)90142-3","article-title":"GM-1 ganglioside promotes the recovery of surviving midbrain dopaminergic neurons in MPTP-treated monkeys","volume":"56","author":"MT Herrero","year":"1993","journal-title":"Neuroscience"},{"issue":"4","key":"ref35","first-page":"255","article-title":"Effects of Chronic GM1 Ganglioside Treatment on Cognitieve and Motor Deficits in a Slowly Progressing Model of Parkinsonism in Non-Human Primates","volume":"12","author":"A Pope-Coleman","year":"1998","journal-title":"Restor Neurol Neurosci"},{"issue":"6","key":"ref36","doi-asserted-by":"crossref","first-page":"1630","DOI":"10.1212\/WNL.50.6.1630","article-title":"Parkinson\u2019s disease: improved function with GM1 ganglioside treatment in a randomized placebo-controlled study","volume":"50","author":"JS Schneider","year":"1998","journal-title":"Neurology"},{"issue":"1\u20132","key":"ref37","doi-asserted-by":"crossref","first-page":"45","DOI":"10.1016\/j.jns.2010.02.009","article-title":"GM1 ganglioside in Parkinson\u2019s disease: Results of a five year open study","volume":"292","author":"JS Schneider","year":"2010","journal-title":"J Neurol Sci"},{"issue":"1\u20132","key":"ref38","doi-asserted-by":"crossref","first-page":"140","DOI":"10.1016\/j.jns.2012.10.024","article-title":"A randomized, controlled, delayed start trial of GM1 ganglioside in treated Parkinson\u2019s disease patients","volume":"324","author":"JS Schneider","year":"2013","journal-title":"J Neurol Sci"},{"issue":"1\u20132","key":"ref39","doi-asserted-by":"crossref","first-page":"118","DOI":"10.1016\/j.jns.2015.06.028","article-title":"GM1 ganglioside in Parkinson\u2019s disease: Pilot study of effects on dopamine transporter binding","volume":"356","author":"JS Schneider","year":"2015","journal-title":"J Neurol Sci"},{"key":"ref40","doi-asserted-by":"crossref","first-page":"45","DOI":"10.3389\/fnins.2018.00045","article-title":"Ganglioside Metabolism and Parkinson\u2019s Disease","volume":"12","author":"J Forsayeth","year":"2018","journal-title":"Front Neurosci"},{"issue":"7","key":"ref41","doi-asserted-by":"crossref","first-page":"e103727","DOI":"10.1371\/journal.pone.0103727","article-title":"N-alpha-acetylation of alpha-synuclein increases its helical folding propensity, GM1 binding specificity and resistance to aggregation","volume":"9","author":"T Bartels","year":"2014","journal-title":"PLoS One"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0199189","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T09:24:12Z","timestamp":1540200252000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0199189"}},"subtitle":[],"editor":[{"given":"Gary L.","family":"Dunbar","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,14]]},"references-count":41,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,14]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0199189","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,6,14]]}}}