{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,2,21]],"date-time":"2025-02-21T13:58:42Z","timestamp":1740146322346,"version":"3.37.3"},"reference-count":39,"publisher":"Public Library of Science (PLoS)","issue":"6","license":[{"start":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T00:00:00Z","timestamp":1530144000000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Progetti di Rilevante Interesse Nazionale (PRIN)","award":["2015XCR88M"],"award-info":[{"award-number":["2015XCR88M"]}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0199299","type":"journal-article","created":{"date-parts":[[2018,6,28]],"date-time":"2018-06-28T13:54:06Z","timestamp":1530194046000},"page":"e0199299","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":4,"title":["Could chronic Vardenafil administration influence the cardiovascular risk in men with type 2 diabetes mellitus?"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-6607-7105","authenticated-orcid":true,"given":"Daniele","family":"Santi","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michela","family":"Locaso","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Antonio R.","family":"Granata","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tommaso","family":"Trenti","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Laura","family":"Roli","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chiara","family":"Pacchioni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vincenzo","family":"Rochira","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cesare","family":"Carani","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Manuela","family":"Simoni","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"340","published-online":{"date-parts":[[2018,6,28]]},"reference":[{"issue":"5","key":"ref1","doi-asserted-by":"crossref","first-page":"837","DOI":"10.1016\/S0002-8703(99)70407-2","article-title":"How generalizable are coronary risk prediction models? Comparison of Framingham and two national cohorts","volume":"137","author":"Y Liao","year":"1999","journal-title":"American heart journal"},{"issue":"1","key":"ref2","doi-asserted-by":"crossref","first-page":"69","DOI":"10.1097\/00043798-199602000-00010","article-title":"Comparison of multivariate predictive power of major risk factors for coronary heart diseases in different countries: results from eight nations of the Seven Countries Study, 25-year follow-up","volume":"3","author":"A Menotti","year":"1996","journal-title":"Journal of cardiovascular risk"},{"issue":"10","key":"ref3","doi-asserted-by":"crossref","first-page":"937","DOI":"10.1016\/S0195-668X(03)00081-2","article-title":"Framingham risk function overestimates risk of coronary heart disease in men and women from Germany\u2014results from the MONICA Augsburg and the PROCAM cohorts","volume":"24","author":"HW Hense","year":"2003","journal-title":"European heart journal"},{"issue":"7426","key":"ref4","doi-asserted-by":"crossref","first-page":"1267","DOI":"10.1136\/bmj.327.7426.1267","article-title":"Predictive accuracy of the Framingham coronary risk score in British men: prospective cohort study","volume":"327","author":"P Brindle","year":"2003","journal-title":"BMJ (Clinical research ed)"},{"issue":"18","key":"ref5","doi-asserted-by":"crossref","first-page":"1837","DOI":"10.1161\/01.CIR.97.18.1837","article-title":"Prediction of coronary heart disease using risk factor categories","volume":"97","author":"PW Wilson","year":"1998","journal-title":"Circulation"},{"issue":"7236","key":"ref6","doi-asserted-by":"crossref","first-page":"659","DOI":"10.1136\/bmj.320.7236.659","article-title":"Guidelines on preventing cardiovascular disease in clinical practice","volume":"320","author":"R Jackson","year":"2000","journal-title":"BMJ (Clinical research ed)"},{"issue":"10","key":"ref7","doi-asserted-by":"crossref","first-page":"1434","DOI":"10.1053\/euhj.1998.1243","article-title":"Prevention of coronary heart disease in clinical practice. Recommendations of the Second Joint Task Force of European and other Societies on coronary prevention","volume":"19","year":"1998","journal-title":"European heart journal"},{"issue":"9 Pt 2","key":"ref8","doi-asserted-by":"crossref","first-page":"26S","DOI":"10.1592\/phco.23.11.26S.32710","article-title":"Update on the National Cholesterol Education Program Adult Treatment Panel III guidelines: getting to goal","volume":"23","author":"JM McKenney","year":"2003","journal-title":"Pharmacotherapy"},{"issue":"3","key":"ref9","doi-asserted-by":"crossref","first-page":"310","DOI":"10.1161\/hc0302.102575","article-title":"Simple scoring scheme for calculating the risk of acute coronary events based on the 10-year follow-up of the prospective cardiovascular Munster (PROCAM) study","volume":"105","author":"G Assmann","year":"2002","journal-title":"Circulation"},{"issue":"11","key":"ref10","doi-asserted-by":"crossref","first-page":"987","DOI":"10.1016\/S0195-668X(03)00114-3","article-title":"Estimation of ten-year risk of fatal cardiovascular disease in Europe: the SCORE project","volume":"24","author":"RM Conroy","year":"2003","journal-title":"European heart journal"},{"issue":"1 Pt 2","key":"ref11","doi-asserted-by":"crossref","first-page":"293","DOI":"10.1016\/0002-8703(91)90861-B","article-title":"Cardiovascular disease risk profiles","volume":"121","author":"KM Anderson","year":"1991","journal-title":"American heart journal"},{"issue":"3","key":"ref12","doi-asserted-by":"crossref","first-page":"238","DOI":"10.1136\/heart.84.3.238","article-title":"Coronary heart disease incidence in northern and southern European populations: a reanalysis of the seven countries study for a European coronary risk chart","volume":"84","author":"A Menotti","year":"2000","journal-title":"Heart (British Cardiac Society)"},{"issue":"3","key":"ref13","first-page":"263","article-title":"The prediction of coronary heart disease mortality as a function of major risk factors in over 30 000 men in the Italian RIFLE pooling Project. A comparison with the MRFIT primary screenees","volume":"1","author":"A Menotti","year":"1994","journal-title":"The RIFLE research group. Journal of cardiovascular risk"},{"issue":"2","key":"ref14","doi-asserted-by":"crossref","first-page":"413","DOI":"10.1093\/ije\/dyh405","article-title":"Prediction of coronary events in a low incidence population. Assessing accuracy of the CUORE Cohort Study prediction equation","volume":"34","author":"M Ferrario","year":"2005","journal-title":"International journal of epidemiology"},{"issue":"4","key":"ref15","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1536\/ihj.17-191","article-title":"Coronary Artery Disease and Type 2 Diabetes Mellitus","volume":"58","author":"R Naito","year":"2017","journal-title":"International heart journal"},{"issue":"4","key":"ref16","doi-asserted-by":"crossref","first-page":"229","DOI":"10.1056\/NEJM199807233390404","article-title":"Mortality from coronary heart disease in subjects with type 2 diabetes and in nondiabetic subjects with and without prior myocardial infarction","volume":"339","author":"SM Haffner","year":"1998","journal-title":"The New England journal of medicine"},{"issue":"5","key":"ref17","doi-asserted-by":"crossref","first-page":"876","DOI":"10.1160\/TH15-03-0202","article-title":"Aspirin for primary prevention in diabetes mellitus: from the calculation of cardiovascular risk and risk\/benefit profile to personalised treatment","volume":"114","author":"F Santilli","year":"2015","journal-title":"Thrombosis and haemostasis"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"488","DOI":"10.1124\/pr.58.3.5","article-title":"Cyclic nucleotide phosphodiesterases: molecular regulation to clinical use","volume":"58","author":"AT Bender","year":"2006","journal-title":"Pharmacological reviews"},{"issue":"1","key":"ref19","doi-asserted-by":"crossref","first-page":"S4","DOI":"10.1038\/sj.ijir.3901205","article-title":"Mechanisms of action of PDE5 inhibition in erectile dysfunction","volume":"16","author":"JD Corbin","year":"2004","journal-title":"International journal of impotence research"},{"issue":"9A","key":"ref20","doi-asserted-by":"crossref","first-page":"9M","DOI":"10.1016\/S0002-9149(03)00824-5","article-title":"Overview of phosphodiesterase 5 inhibition in erectile dysfunction","volume":"92","author":"RC Rosen","year":"2003","journal-title":"The American journal of cardiology"},{"issue":"3","key":"ref21","first-page":"187","article-title":"The relationship between erectile dysfunction and cardiovascular disease. Part II: The role of PDE-5 inhibition in sexual dysfunction and cardiovascular disease","volume":"9","author":"V Kapur","year":"2008","journal-title":"Reviews in cardiovascular medicine"},{"issue":"3","key":"ref22","doi-asserted-by":"crossref","first-page":"331","DOI":"10.1016\/j.cellsig.2004.07.007","article-title":"The effect of Sildenafil on human platelet secretory function is controlled by a complex interplay between phosphodiesterases 2, 3 and 5","volume":"17","author":"TR Dunkern","year":"2005","journal-title":"Cellular signalling"},{"issue":"2","key":"ref23","first-page":"251","article-title":"Reduction of diabetes-induced oxidative stress by phosphodiesterase inhibitors in rats. Comparative biochemistry and physiology Toxicology & pharmacology","volume":"140","author":"E Milani","year":"2005","journal-title":"CBP"},{"issue":"3","key":"ref24","doi-asserted-by":"crossref","first-page":"R103","DOI":"10.1530\/EJE-14-0700","article-title":"THERAPY OF ENDOCRINE DISEASE: Effects of chronic use of phosphodiesterase inhibitors on endothelial markers in type 2 diabetes mellitus: a meta-analysis","volume":"172","author":"D Santi","year":"2015","journal-title":"European journal of endocrinology \/ European Federation of Endocrine Societies"},{"key":"ref25","article-title":"Six months of daily treatment with Vardenafil improves parameters of endothelial inflammation and of hypogonadism in male patients with type 2 diabetes and erectile dysfunction: a randomized, double-blind, prospective trial","author":"D Santi","year":"2016","journal-title":"European journal of endocrinology \/ European Federation of Endocrine Societies"},{"issue":"2","key":"ref26","doi-asserted-by":"crossref","first-page":"172","DOI":"10.1136\/hrt.2006.108167","article-title":"Adding social deprivation and family history to cardiovascular risk assessment: the ASSIGN score from the Scottish Heart Health Extended Cohort (SHHEC)","volume":"93","author":"M Woodward","year":"2007","journal-title":"Heart (British Cardiac Society)"},{"issue":"3","key":"ref27","first-page":"177","article-title":"[The global cardiovascular risk chart]","volume":"5","author":"S Giampaoli","year":"2004","journal-title":"Italian heart journal Supplement: official journal of the Italian Federation of Cardiology"},{"issue":"5 Suppl 3","key":"ref28","first-page":"20S","article-title":"[The CUORE Project: preliminary analysis for the updating of the cardiovascular risk charts and individual scores]","volume":"11","author":"C Donfrancesco","year":"2010","journal-title":"Giornale italiano di cardiologia (2006)"},{"issue":"4","key":"ref29","first-page":"393","article-title":"[Evaluation of the global cardiovascular absolute risk: the Progetto CUORE individual score]","volume":"40","author":"L Palmieri","year":"2004","journal-title":"Annali dell'Istituto superiore di sanita"},{"issue":"2","key":"ref30","doi-asserted-by":"crossref","first-page":"257","DOI":"10.1016\/S0735-1097(01)01746-6","article-title":"Guidelines for the ultrasound assessment of endothelial-dependent flow-mediated vasodilation of the brachial artery: a report of the International Brachial Artery Reactivity Task Force","volume":"39","author":"MC Corretti","year":"2002","journal-title":"Journal of the American College of Cardiology"},{"issue":"3","key":"ref31","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.jacc.2005.06.089","article-title":"Plasma nitroso compounds are decreased in patients with endothelial dysfunction","volume":"47","author":"C Heiss","year":"2006","journal-title":"Journal of the American College of Cardiology"},{"issue":"6","key":"ref32","doi-asserted-by":"crossref","first-page":"2536","DOI":"10.1210\/jc.2009-2354","article-title":"Testosterone therapy in men with androgen deficiency syndromes: an Endocrine Society clinical practice guideline","volume":"95","author":"S Bhasin","year":"2010","journal-title":"The Journal of clinical endocrinology and metabolism"},{"issue":"19","key":"ref33","doi-asserted-by":"crossref","first-page":"2323","DOI":"10.1161\/CIRCULATIONAHA.111.063412","article-title":"Chronic Inhibition of cGMP phosphodiesterase 5A improves diabetic cardiomyopathy: a randomized, controlled clinical trial using magnetic resonance imaging with myocardial tagging","volume":"125","author":"E Giannetta","year":"2012","journal-title":"Circulation"},{"issue":"24","key":"ref34","doi-asserted-by":"crossref","first-page":"2206","DOI":"10.1016\/j.ehj.2003.09.021","article-title":"Sildenafil citrate does not reduce exercise tolerance in men with erectile dysfunction and chronic stable angina","volume":"24","author":"KM Fox","year":"2003","journal-title":"European heart journal"},{"issue":"11","key":"ref35","doi-asserted-by":"crossref","first-page":"1200","DOI":"10.1161\/CIRCULATIONAHA.112.000056","article-title":"Sildenafil and diastolic dysfunction after acute myocardial infarction in patients with preserved ejection fraction: the Sildenafil and Diastolic Dysfunction After Acute Myocardial Infarction (SIDAMI) trial","volume":"127","author":"MJ Andersen","year":"2013","journal-title":"Circulation"},{"key":"ref36","article-title":"Everything you ever wanted to know about phosphodiesterase 5 inhibitors and the heart (but never dared ask): How do they work?","author":"R Pofi","year":"2015","journal-title":"Journal of endocrinological investigation"},{"key":"ref37","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.atherosclerosis.2016.12.009","article-title":"High density lipoprotein (HDL)-associated sphingosine 1-phosphate (S1P) inhibits macrophage apoptosis by stimulating STAT3 activity and survivin expression","volume":"257","author":"R Feuerborn","year":"2017","journal-title":"Atherosclerosis"},{"issue":"1\u20132","key":"ref38","doi-asserted-by":"crossref","first-page":"39","DOI":"10.1016\/j.vph.2012.08.005","article-title":"Effects of the radiocontrast agent iodixanol on endothelial cell morphology and function","volume":"58","author":"N Ronda","year":"2013","journal-title":"Vascular pharmacology"},{"issue":"3","key":"ref39","doi-asserted-by":"crossref","first-page":"307","DOI":"10.1136\/hrt.2005.077289","article-title":"By neglecting deprivation, cardiovascular risk scoring will exacerbate social gradients in disease","volume":"92","author":"H Tunstall-Pedoe","year":"2006","journal-title":"Heart (British Cardiac Society)"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0199299","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2018,10,22]],"date-time":"2018-10-22T12:06:05Z","timestamp":1540209965000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0199299"}},"subtitle":[],"editor":[{"given":"Maria Ida","family":"Maiorino","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,6,28]]},"references-count":39,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2018,6,28]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0199299","relation":{},"ISSN":["1932-6203"],"issn-type":[{"type":"electronic","value":"1932-6203"}],"subject":[],"published":{"date-parts":[[2018,6,28]]}}}