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levels in pediatric sickle cell disease patients during vasoocclusive crisis and steady state condition","volume":"72","author":"S Sarray","year":"2015","journal-title":"Cytokine"},{"key":"ref55","doi-asserted-by":"crossref","first-page":"195","DOI":"10.1177\/1076029611420992","article-title":"Biomarkers of inflammation, growth factor, and coagulation activation in patients with sickle cell disease","volume":"18","author":"MH Qari","year":"2012","journal-title":"Clin Appl Thromb Hemost"},{"key":"ref56","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1080\/03630260802625709","article-title":"Newer aspects of the pathophysiology of sickle cell disease vaso-occlusion","author":"N Conran","year":"2009","journal-title":"Hemoglobin"},{"key":"ref57","first-page":"1320","article-title":"Key issues in conducting a meta-analysis of gene expression microarray datasets","author":"A Ramasamy","year":"2008","journal-title":"PLoS Medicine"},{"key":"ref58","doi-asserted-by":"crossref","first-page":"3785","DOI":"10.1093\/nar\/gkr1265","article-title":"Comprehensive literature review and statistical considerations for microarray meta-analysis","author":"GC Tseng","year":"2012","journal-title":"Nucleic Acids Research"},{"key":"ref59","doi-asserted-by":"crossref","first-page":"867","DOI":"10.2337\/db14-0149","article-title":"Anti-CD44 antibody treatment lowers hyperglycemia and improves insulin resistance, adipose inflammation, and hepatic steatosis in diet- induced obese mice","volume":"64","author":"K Kodama","year":"2015","journal-title":"Diabetes"},{"key":"ref60","doi-asserted-by":"crossref","first-page":"7049","DOI":"10.1073\/pnas.1114513109","article-title":"Expression-based genome-wide association study links the receptor CD44 in adipose tissue with type 2 diabetes","volume":"109","author":"K Kodama","year":"2012","journal-title":"Proc Natl Acad Sci U S A"},{"key":"ref61","article-title":"Targeting KLF1 for the Treatment of Sickle Cell Disease Using Antisense Oligonucleotides","author":"R Peralta","year":"2014","journal-title":"Blood"},{"key":"ref62","doi-asserted-by":"crossref","first-page":"340","DOI":"10.3324\/haematol.2011.055442","article-title":"Ten novel mutations in the erythroid transcription factor KLF1 gene associated with increased fetal hemoglobin levels in adults","volume":"97","author":"AE Gallienne","year":"2012","journal-title":"Haematologica"},{"key":"ref63","doi-asserted-by":"crossref","first-page":"17822","DOI":"10.1038\/srep17822","article-title":"Role of innate immunity-triggered pathways in the pathogenesis of Sickle Cell Disease: a meta-analysis of gene expression studies","volume":"5","author":"BW Hounkpe","year":"2015","journal-title":"Sci Rep"},{"key":"ref64","doi-asserted-by":"crossref","first-page":"973","DOI":"10.3324\/haematol.2013.091991","article-title":"Heme and erythropoieis: More than a structural role","author":"D Chiabrando","year":"2014","journal-title":"Haematologica"},{"key":"ref65","doi-asserted-by":"crossref","first-page":"3034","DOI":"10.3390\/nu5083034","article-title":"Out of balance-systemic iron homeostasis in iron-related disorders","author":"AU Steinbicker","year":"2013","journal-title":"Nutrients"},{"key":"ref66","first-page":"975","article-title":"Heme concentration as a biomarker of sickle cell disease severity: Its role in steady-state and in crisis patients","author":"M.O.S. C","year":"2015","journal-title":"Blood"},{"key":"ref67","doi-asserted-by":"crossref","first-page":"1802","DOI":"10.1182\/blood.V98.6.1802","article-title":"Heme is a potent inducer of inflammation in mice and is counteracted by heme oxygenase","volume":"98","author":"FADTG Wagener","year":"2001","journal-title":"Blood"},{"key":"ref68","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1089\/ars.2009.2822","article-title":"Heme degradation and vascular injury","volume":"12","author":"JD Belcher","year":"2010","journal-title":"Antioxid Redox Signal"},{"key":"ref69","doi-asserted-by":"crossref","first-page":"e002272","DOI":"10.1161\/JAHA.115.002272","article-title":"Increased Heme Levels in the Heart Lead to Exacerbated Ischemic Injury","volume":"4","author":"KT Sawicki","year":"2015","journal-title":"J Am Heart Assoc"},{"key":"ref70","doi-asserted-by":"crossref","first-page":"2235 LP","DOI":"10.1182\/blood.V122.21.2235.2235","article-title":"Determinants Of Heme-Oxygenase-1 Upregulation In Patients With Sickle Cell Disease","volume":"122","author":"BY Owusu","year":"2013","journal-title":"Blood"},{"key":"ref71","doi-asserted-by":"crossref","first-page":"2757","DOI":"10.1182\/blood-2013-02-486282","article-title":"MP4CO, a pegylated hemoglobin saturated with carbon monoxide, is a modulator of HO-1, inflammation, and vaso-occlusion in transgenic sickle mice","volume":"122","author":"JD Belcher","year":"2013","journal-title":"Blood"},{"key":"ref72","doi-asserted-by":"crossref","first-page":"808","DOI":"10.1172\/JCI26857","article-title":"Heme oxygenase-1 is a modulator of inflammation and vaso-occlusion in transgenic sickle mice","volume":"116","author":"JD Belcher","year":"2006","journal-title":"J Clin Invest"},{"key":"ref73","doi-asserted-by":"crossref","first-page":"919","DOI":"10.1161\/CIRCRESAHA.107.154781","article-title":"Carbon monoxide induces heme oxygenase-1 via activation of protein kinase R-like endoplasmic reticulum kinase and inhibits endothelial cell apoptosis triggered by endoplasmic reticulum stress","volume":"101","author":"KM Kim","year":"2007","journal-title":"Circ Res"},{"key":"ref74","article-title":"Heme oxygenase-1, oxidation, inflammation, and atherosclerosis","author":"JA Araujo","year":"2012","journal-title":"Frontiers in Pharmacology"},{"key":"ref75","doi-asserted-by":"crossref","first-page":"2535","DOI":"10.1182\/blood-2013-08-521922","article-title":"HO-1 and CO: Fighters vs sickle cell disease?","author":"JA Araujo","year":"2013","journal-title":"Blood"},{"key":"ref76","doi-asserted-by":"crossref","first-page":"872","DOI":"10.1074\/jbc.M410413200","article-title":"Endoplasmic reticulum stress stimulates heme oxygenase-1 gene expression in vascular smooth muscle. Role in cell survival","volume":"280","author":"X Liu","year":"2005","journal-title":"J Biol Chem"},{"key":"ref77","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/S0002-9440(10)64037-0","article-title":"Oxidative stress and induction of heme oxygenase-1 in the kidney in sickle cell disease","volume":"158","author":"K a Nath","year":"2001","journal-title":"Am J Pathol"},{"key":"ref78","doi-asserted-by":"crossref","first-page":"6853","DOI":"10.1038\/sj.onc.1203239","article-title":"Activators and target genes of Rel\/NF-kappaB transcription factors","volume":"18","author":"HL Pahl","year":"1999","journal-title":"Oncogene"},{"key":"ref79","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1002\/ajh.23629","article-title":"Partial dysfunction of Treg activation in sickle cell disease","volume":"89","author":"B Vingert","year":"2014","journal-title":"Am J Hematol"},{"key":"ref80","doi-asserted-by":"crossref","first-page":"938","DOI":"10.1002\/ajh.24438","article-title":"Alteration of lymphocyte phenotype and function in sickle cell anemia: Implications for vaccine responses","author":"E Balandya","year":"2016","journal-title":"American Journal of Hematology"},{"key":"ref81","doi-asserted-by":"crossref","first-page":"273","DOI":"10.1111\/bjh.13553","article-title":"Bacteraemia in sickle cell anaemia is associated with low haemoglobin: A report of 890 admissions to a tertiary hospital in Tanzania","volume":"171","author":"J Makani","year":"2015","journal-title":"Br J Haematol"},{"key":"ref82","doi-asserted-by":"crossref","first-page":"329","DOI":"10.1016\/S1473-3099(10)70055-4","article-title":"Increased risk of invasive bacterial infections in African people with sickle-cell disease: A systematic review and meta-analysis","author":"M Ramakrishnan","year":"2010","journal-title":"The Lancet Infectious Diseases"},{"key":"ref83","article-title":"Lymphocyte blast transformation and peripheral lymphocyte percentages in patients with sickle cell disease","volume":"10","author":"AB Glassman","year":"1980","journal-title":"Ann O F Clin L A N D Lab SC IE N C E"},{"key":"ref84","doi-asserted-by":"crossref","first-page":"2940","DOI":"10.1182\/blood-2007-04-086751","article-title":"Inactivation of PI3Kgamma and PI3Kdelta distorts T-cell development and causes multiple organ inflammation","volume":"110","author":"H Ji","year":"2007","journal-title":"Blood"},{"key":"ref85","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1006\/smim.2001.0337","article-title":"Phosphoinositide 3-kinase in immunological systems","volume":"14","author":"DA Fruman","year":"2002","journal-title":"Semin Immunol"},{"key":"ref86","doi-asserted-by":"crossref","first-page":"1073","DOI":"10.3324\/haematol.2012.071183","article-title":"Transcription factor nuclear factor erythroid-2 mediates expression of the cytokine interleukin 8, a known predictor of inferior outcome in patients with myeloproliferative Neoplasms","volume":"98","author":"J Wehrle","year":"2013","journal-title":"Haematologica"},{"key":"ref87","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1084\/jem.20110540","article-title":"A novel murine model of myeloproliferative disorders generated by overexpression of the transcription factor NF-E2","volume":"209","author":"KB Kaufmann","year":"2012","journal-title":"J Exp Med"},{"key":"ref88","doi-asserted-by":"crossref","first-page":"276","DOI":"10.1002\/cyto.b.20160","article-title":"The apoptosis of blood polymorphonuclear leukocytes in sickle cell disease","volume":"72","author":"H Ozdogu","year":"2007","journal-title":"Cytom Part B\u2014Clin Cytom"},{"key":"ref89","doi-asserted-by":"crossref","first-page":"11579","DOI":"10.1074\/jbc.M111.336032","article-title":"Calcium\/calmodulin-dependent protein kinase kinase 2 regulates macrophage-mediated inflammatory responses","volume":"287","author":"L Racioppi","year":"2012","journal-title":"J Biol Chem"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0199461","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,11,5]],"date-time":"2020-11-05T07:24:48Z","timestamp":1604561088000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0199461"}},"subtitle":[],"editor":[{"given":"Keiko","family":"Abe","sequence":"first","affiliation":[],"role":[{"role":"editor","vocabulary":"crossref"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,6]]},"references-count":89,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,6]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0199461","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,6]]}}}