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National Population Projections. I. Summary files. Total population by age, sex, race and Hispanic origin. (NP-T4-F). Projections of the total resident population by 5-year age groups, race and Hispanic origin with special age categories: middle series. 2025 to 2045. https:\/\/www2.census.gov\/programs-surveys\/popproj\/tables\/2000\/2000-national-summary-tables\/np-t4-f.pdf<\/ext-link>: U.S. Census Bureau; 2000 [cited 2018 01\/18\/2018]."},{"key":"ref27","unstructured":"Facts about Medicare. https:\/\/www.ehealthmedicare.com\/about-medicare\/<\/ext-link>: eHealth Medicare; 2017 [04\/03\/2018]."},{"issue":"8","key":"ref28","doi-asserted-by":"crossref","first-page":"573","DOI":"10.7326\/0003-4819-147-8-200710160-00010","article-title":"The Strengthening the Reporting of Observational Studies in Epidemiology (STROBE) statement: guidelines for reporting observational studies","volume":"147","author":"E von Elm","year":"2007","journal-title":"Ann Intern Med"},{"issue":"1","key":"ref29","doi-asserted-by":"crossref","first-page":"30","DOI":"10.1007\/s12177-010-9052-4","article-title":"The need for validation of large administrative databases: Veterans Health Administration ICD-9CM coding of exudative age-related macular degeneration and ranibizumab usage","volume":"3","author":"P Latkany","year":"2010","journal-title":"J Ocul Biol Dis Infor"},{"issue":"5","key":"ref30","doi-asserted-by":"crossref","first-page":"822","DOI":"10.1002\/art.22767","article-title":"Quality of care for gout in the US needs improvement","volume":"57","author":"JA Singh","year":"2007","journal-title":"Arthritis Rheum"},{"issue":"10","key":"ref31","doi-asserted-by":"crossref","first-page":"1075","DOI":"10.1016\/0895-4356(93)90103-8","article-title":"Adapting a clinical comorbidity index for use with ICD-9-CM administrative data: differing perspectives","volume":"46","author":"PS Romano","year":"1993","journal-title":"J Clin Epidemiol"},{"issue":"5","key":"ref32","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/0021-9681(87)90171-8","article-title":"A new method of classifying prognostic comorbidity in longitudinal studies: development and validation","volume":"40","author":"ME Charlson","year":"1987","journal-title":"J Chronic Dis"},{"issue":"2","key":"ref33","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1080\/15376520590918766","article-title":"Statins and modulation of oxidative stress","volume":"15","author":"J Beltowski","year":"2005","journal-title":"Toxicol Mech Methods"},{"issue":"1","key":"ref34","doi-asserted-by":"crossref","first-page":"265","DOI":"10.2147\/VHRM.S4265","article-title":"Role of urate, xanthine oxidase and the effects of allopurinol in vascular oxidative stress","volume":"5","author":"J George","year":"2009","journal-title":"Vasc Health Risk Manag"},{"issue":"23","key":"ref35","doi-asserted-by":"crossref","first-page":"2508","DOI":"10.1161\/CIRCULATIONAHA.106.651117","article-title":"High-dose allopurinol improves endothelial function by profoundly reducing vascular oxidative stress and not by lowering uric acid","volume":"114","author":"J George","year":"2006","journal-title":"Circulation"},{"issue":"5","key":"ref36","first-page":"443","article-title":"Clinical practice. 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