{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T13:07:54Z","timestamp":1789650474134,"version":"4.0.0"},"reference-count":29,"publisher":"Public Library of Science (PLoS)","issue":"7","license":[{"start":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T00:00:00Z","timestamp":1531094400000},"content-version":"vor","delay-in-days":0,"URL":"http:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006244","name":"Stichting Kinderen Kankervrij","doi-asserted-by":"publisher","award":["197"],"award-info":[{"award-number":["197"]}],"id":[{"id":"10.13039\/501100006244","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":["www.plosone.org"],"crossmark-restriction":false},"short-container-title":["PLoS ONE"],"DOI":"10.1371\/journal.pone.0199574","type":"journal-article","created":{"date-parts":[[2018,7,9]],"date-time":"2018-07-09T13:27:58Z","timestamp":1531142878000},"page":"e0199574","update-policy":"https:\/\/doi.org\/10.1371\/journal.pone.corrections_policy","source":"Crossref","is-referenced-by-count":23,"title":["Global methylation in relation to methotrexate-induced oral mucositis in children with acute lymphoblastic leukemia"],"prefix":"10.1371","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9871-1887","authenticated-orcid":true,"given":"Natanja","family":"Oosterom","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pieter H.","family":"Griffioen","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marissa A. H.","family":"den Hoed","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rob","family":"Pieters","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert","family":"de Jonge","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wim J. E.","family":"Tissing","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marry M.","family":"van den Heuvel-Eibrink","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra G.","family":"Heil","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"340","published-online":{"date-parts":[[2018,7,9]]},"reference":[{"issue":"14","key":"ref1","doi-asserted-by":"crossref","first-page":"1663","DOI":"10.1200\/JCO.2011.37.8018","article-title":"Improved survival for children and adolescents with acute lymphoblastic leukemia between 1990 and 2005: a report from the children&apos;s oncology group","volume":"30","author":"SP Hunger","year":"2012","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"6","key":"ref2","doi-asserted-by":"crossref","first-page":"1165","DOI":"10.1182\/blood-2012-05-378943","article-title":"Pediatric acute lymphoblastic leukemia: where are we going and how do we get there?","volume":"120","author":"CH Pui","year":"2012","journal-title":"Blood"},{"issue":"2","key":"ref3","doi-asserted-by":"crossref","first-page":"309","DOI":"10.1038\/leu.2009.258","article-title":"Long-term results of Dutch Childhood Oncology Group studies for children with acute lymphoblastic leukemia from 1984 to 2004","volume":"24","author":"WA Kamps","year":"2010","journal-title":"Leukemia"},{"issue":"3","key":"ref4","doi-asserted-by":"crossref","first-page":"248","DOI":"10.1038\/tpj.2014.63","article-title":"Genetic and metabolic determinants of methotrexate-induced mucositis in pediatric acute lymphoblastic leukemia","volume":"15","author":"MA den Hoed","year":"2015","journal-title":"The pharmacogenomics journal"},{"key":"ref5","doi-asserted-by":"crossref","first-page":"423","DOI":"10.2119\/molmed.2011.00048","article-title":"Low-dose methotrexate inhibits methionine S-adenosyltransferase in vitro and in vivo","volume":"18","author":"YC Wang","year":"2012","journal-title":"Molecular medicine (Cambridge, Mass)"},{"issue":"21","key":"ref6","first-page":"5879","article-title":"Changes in plasma methionine and total homocysteine levels in patients receiving methotrexate infusions","volume":"49","author":"EH Broxson Jr.","year":"1989","journal-title":"Cancer research"},{"issue":"3","key":"ref7","doi-asserted-by":"crossref","first-page":"e0121869","DOI":"10.1371\/journal.pone.0121869","article-title":"Genomic DNA hypomethylation is associated with neural tube defects induced by methotrexate inhibition of folate metabolism","volume":"10","author":"X Wang","year":"2015","journal-title":"PloS one"},{"issue":"2","key":"ref8","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1016\/S0022-2143(96)90008-6","article-title":"DNA hypomethylation in inflammatory arthritis: reversal with methotrexate","volume":"128","author":"YI Kim","year":"1996","journal-title":"The Journal of laboratory and clinical medicine"},{"key":"ref9","doi-asserted-by":"crossref","first-page":"233","DOI":"10.1186\/s13075-015-0748-5","article-title":"Assessment of global DNA methylation in peripheral blood cell subpopulations of early rheumatoid arthritis before and after methotrexate","volume":"17","author":"MC de Andres","year":"2015","journal-title":"Arthritis research & therapy"},{"issue":"7","key":"ref10","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1038\/nrg3230","article-title":"Functions of DNA methylation: islands, start sites, gene bodies and beyond","volume":"13","author":"PA Jones","year":"2012","journal-title":"Nature reviews Genetics"},{"issue":"11","key":"ref11","doi-asserted-by":"crossref","first-page":"2811","DOI":"10.1093\/jn\/131.11.2811","article-title":"Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice","volume":"131","author":"MA Caudill","year":"2001","journal-title":"The Journal of nutrition"},{"issue":"11","key":"ref12","doi-asserted-by":"crossref","first-page":"e79044","DOI":"10.1371\/journal.pone.0079044","article-title":"Comparison of methods for quantification of global DNA methylation in human cells and tissues","volume":"8","author":"S Lisanti","year":"2013","journal-title":"PloS one"},{"issue":"5","key":"ref13","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/S0049-0172(98)80049-8","article-title":"Methotrexate in rheumatoid arthritis: an update with focus on mechanisms involved in toxicity","volume":"27","author":"AE van Ede","year":"1998","journal-title":"Seminars in arthritis and rheumatism"},{"issue":"5","key":"ref14","doi-asserted-by":"crossref","first-page":"786","DOI":"10.1161\/CIRCRESAHA.115.305298","article-title":"DNA Methylation Indicates Susceptibility to Isoproterenol-Induced Cardiac Pathology and Is Associated With Chromatin States","volume":"118","author":"H Chen","year":"2016","journal-title":"Circulation research"},{"issue":"11","key":"ref15","doi-asserted-by":"crossref","first-page":"2813","DOI":"10.1093\/annonc\/mdt370","article-title":"Association of somatic DNA methylation variability with progression-free survival and toxicity in ovarian cancer patients","volume":"24","author":"JM Flanagan","year":"2013","journal-title":"Annals of oncology: official journal of the European Society for Medical Oncology"},{"key":"ref16","doi-asserted-by":"crossref","first-page":"5472893","DOI":"10.1155\/2017\/5472893","article-title":"DNA Methylation Events as Markers for Diagnosis and Management of Acute Myeloid Leukemia and Myelodysplastic Syndrome","volume":"2017","author":"GM Dexheimer","year":"2017","journal-title":"Disease markers"},{"issue":"22","key":"ref17","doi-asserted-by":"crossref","first-page":"2591","DOI":"10.1200\/JCO.2015.64.6364","article-title":"Successful Therapy Reduction and Intensification for Childhood Acute Lymphoblastic Leukemia Based on Minimal Residual Disease Monitoring: Study ALL10 From the Dutch Childhood Oncology Group","volume":"34","author":"R Pieters","year":"2016","journal-title":"Journal of clinical oncology: official journal of the American Society of Clinical Oncology"},{"issue":"3","key":"ref18","doi-asserted-by":"crossref","first-page":"176","DOI":"10.1016\/S1053-4296(03)00031-6","article-title":"CTCAE v3.0: development of a comprehensive grading system for the adverse effects of cancer treatment","volume":"13","author":"A Trotti","year":"2003","journal-title":"Seminars in radiation oncology"},{"issue":"8","key":"ref19","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1373\/clinchem.2004.046995","article-title":"Stable-isotope dilution liquid chromatography-electrospray injection tandem mass spectrometry method for fast, selective measurement of S-adenosylmethionine and S-adenosylhomocysteine in plasma","volume":"51","author":"H Gellekink","year":"2005","journal-title":"Clinical chemistry"},{"issue":"5","key":"ref20","doi-asserted-by":"crossref","first-page":"1359","DOI":"10.3945\/ajcn.2009.28858","article-title":"Relation between hypomethylation of long interspersed nucleotide elements and risk of neural tube defects","volume":"91","author":"L Wang","year":"2010","journal-title":"The American journal of clinical nutrition"},{"issue":"5","key":"ref21","doi-asserted-by":"crossref","first-page":"e29","DOI":"10.1093\/nar\/gkl1134","article-title":"A new method for accurate assessment of DNA quality after bisulfite treatment","volume":"35","author":"M Ehrich","year":"2007","journal-title":"Nucleic acids research"},{"issue":"9","key":"ref22","doi-asserted-by":"crossref","first-page":"637","DOI":"10.1136\/ard.50.9.637","article-title":"In vitro effects of methotrexate on peripheral blood monocytes: modulation by folinic acid and S-adenosylmethionine","volume":"50","author":"G Nesher","year":"1991","journal-title":"Annals of the rheumatic diseases"},{"issue":"1","key":"ref23","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1186\/s13148-016-0262-x","article-title":"Antidepressant medication during pregnancy and epigenetic changes in umbilical cord blood: a systematic review","volume":"8","author":"AC Viuff","year":"2016","journal-title":"Clinical epigenetics"},{"issue":"15","key":"ref24","doi-asserted-by":"crossref","first-page":"5293","DOI":"10.1128\/MCB.23.15.5293-5300.2003","article-title":"Transposable elements: targets for early nutritional effects on epigenetic gene regulation","volume":"23","author":"RA Waterland","year":"2003","journal-title":"Molecular and cellular biology"},{"issue":"9370","key":"ref25","doi-asserted-by":"crossref","first-page":"1693","DOI":"10.1016\/S0140-6736(03)13372-7","article-title":"Folate treatment and unbalanced methylation and changes of allelic expression induced by hyperhomocysteinaemia in patients with uraemia","volume":"361","author":"D Ingrosso","year":"2003","journal-title":"Lancet (London, England)"},{"issue":"8","key":"ref26","doi-asserted-by":"crossref","first-page":"1024","DOI":"10.1016\/j.bcp.2008.07.026","article-title":"The effect of thiopurine drugs on DNA methylation in relation to TPMT expression","volume":"76","author":"LA Hogarth","year":"2008","journal-title":"Biochemical pharmacology"},{"issue":"3","key":"ref27","doi-asserted-by":"crossref","first-page":"e0173472","DOI":"10.1371\/journal.pone.0173472","article-title":"Methylation level of CpG islands in GGH gene promoter in pediatric acute leukemia","volume":"12","author":"Y Li","year":"2017","journal-title":"PloS one"},{"issue":"1","key":"ref28","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1186\/1756-8935-2-7","article-title":"Tissue-specific variation in DNA methylation levels along human chromosome 1","volume":"2","author":"C De Bustos","year":"2009","journal-title":"Epigenetics & chromatin"},{"issue":"9","key":"ref29","doi-asserted-by":"crossref","first-page":"R102","DOI":"10.1186\/gb-2013-14-9-r102","article-title":"Differential DNA methylation with age displays both common and dynamic features across human tissues that are influenced by CpG landscape","volume":"14","author":"K Day","year":"2013","journal-title":"Genome biology"}],"container-title":["PLOS ONE"],"original-title":[],"language":"en","link":[{"URL":"http:\/\/dx.plos.org\/10.1371\/journal.pone.0199574","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2019,10,20]],"date-time":"2019-10-20T10:30:10Z","timestamp":1571567410000},"score":1,"resource":{"primary":{"URL":"https:\/\/dx.plos.org\/10.1371\/journal.pone.0199574"}},"subtitle":[],"editor":[{"given":"Wolfgang","family":"Wagner","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"editor"}]}],"short-title":[],"issued":{"date-parts":[[2018,7,9]]},"references-count":29,"journal-issue":{"issue":"7","published-online":{"date-parts":[[2018,7,9]]}},"URL":"https:\/\/doi.org\/10.1371\/journal.pone.0199574","relation":{},"ISSN":["1932-6203"],"issn-type":[{"value":"1932-6203","type":"electronic"}],"subject":[],"published":{"date-parts":[[2018,7,9]]}}}